Neuroscience and Disease

Neuromodulation

Adenosine receptors

Ageing

Brain Diseases

Caffeine

Neuroprotection


Research lines

Coffee, caffeine and adenosine receptors controlling synaptic plasticity in brain diseases | Rodrigo A. Cunha & Ângelo R. Tomé

Adenosine A2A receptors as biomarker and triggers of ageing | Rodrigo A. Cunha

Impact of purines on astrocyte-neuron communication and memory | Paula Agostinho

Adenosine receptors in psychiatric disorders and neurodegenerative diseases | Paula Canas & Samira Ferreira

Role of adenosine A2A receptors in fear memory extinction | Ana P. Simões & Paula Canas

Overview

Adequate brain function depends on a balanced excitatory and inhibitory transmission fine-tuned by modulation systems. Inspired by the impact of coffee, which bolsters attention, normalizes mood and increases healthspan on ageing with a striking ability to prevent the onset of different neurodegenerative disorders (Alzheimer’s, Parkinson’s diseases), the aim of the group is to study modulation systems operated by purines (adenosine and ATP), known to be targeted by caffeine, to interfere with the evolution of neurodegenerative diseases. We have identified adenosine A2A receptors (A2AR) as the main targets of caffeine to control of brain disorders, using a combination of pharmacological, genetic and opto-genetic tools. We have established that A2AR are necessary and sufficient to trigger symptoms in different animal models of Alzheimer’s or Parkinson’s diseases, depression, epilepsy or diabetic encephalopathy, through a combined ability to restore synaptic plasticity, control neuroinflammation and bolster the metabolic support by astrocytes.

We have in-house different transgenic mice and pharmacologically-induced models of brain disease, as well as a toolbox to interfere with A2AR (cell-specific transgenic mice and viral mediated systems to bolster or decrease A2AR function) and access to human brain tissue. We follow an holistic approach to scientific questions, integrating our expertise in: i) behavior studies assessing learning and memory, motor performance, mood alterations and fear processing; ii) stereotaxic brain surgery; iii) ex-vivo (brain slices) electrophysiological studies to assess the function of brain circuits (extracellular recordings) and ionic currents (patch-clamp); iv) imaging of functional (live cell Ca2+), morphological (histochemistry) and neurochemical alterations (receptor expression binding and trafficking), combining PCR, radioligands, FRET, proximity ligation assay and Western-blot techniques); v) subcellular fractionation of synaptosomes and gliosomes and use of cell cultures (neurons and astrocytes) to study neurotransmitters release and uptake.
The group has a track record of over 250 publications in high-impact factor journals with more than 12,000 citations and an h-factor of 62, based on numerous worldwide collaborations. The group has a large experience in post-graduate training (over 15 post-doc, 40 PhD and 25 Master students), with research funds obtained from American and European agencies and private corporations and pharma.

Publications

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Information about journal articles, updated at 26-05-2024, from platform CIÊNCIAVITAE.

40 Hz light flickering promotes sleep through cortical adenosine signaling

Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al, 2024. Cell Research. 2024. http://dx.doi.org/10.1038/s41422-023-00920-1 . 10.1038/s41422-023-00920-1 . accepted Cell Research

The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity

Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al, 2024. Molecular Psychiatry. 2024. http://dx.doi.org/10.1038/s41380-024-02412-z . 10.1038/s41380-024-02412-z . accepted Molecular Psychiatry

Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes, 2023. Biomolecules. 2023. https://doi.org/10.3390/biom13040715 . 10.3390/biom13040715 . Biomolecules

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease

Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes, 2023. Biomolecules. 2023. https://doi.org/10.3390/biom13081173 . 10.3390/biom13081173 . Biomolecules

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al, 2023. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/1/106 . 10.3390/biom13010106 . Biomolecules

The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors

Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes, 2023. Purinergic Signalling. 2023. https://doi.org/10.1007/s11302-022-09899-7 . 10.1007/s11302-022-09899-7 . Purinergic Signalling

Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2023. Glia. 2023. https://doi.org/10.1002/glia.24384 . 10.1002/glia.24384 . Glia

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al, 2023. ACS Chemical Neuroscience. 1299 - 1309. 7. 14. 2023. http://dx.doi.org/10.1021/acschemneuro.2c00810 . 10.1021/acschemneuro.2c00810 . published ACS Chemical Neuroscience

Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors

Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2023. Cellular and Molecular Life Sciences. 2023. https://doi.org/10.1007/s00018-023-04983-6 . 10.1007/s00018-023-04983-6 . Cellular and Molecular Life Sciences

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula

Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al, 2023. Nature Communications. 1. 14. 2023. http://dx.doi.org/10.1038/s41467-023-37601-x . 10.1038/s41467-023-37601-x . published Nature Communications

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al, 2023. International Journal of Molecular Sciences. 8. 24. 2023. http://dx.doi.org/10.3390/ijms24086968 . 10.3390/ijms24086968 . published International Journal of Molecular Sciences

Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices

Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R., 2023. Neuroscience Letters. 808. 2023. http://dx.doi.org/10.1016/j.neulet.2023.137292 . 10.1016/j.neulet.2023.137292 . published Neuroscience Letters

Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest

Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al, 2023. Frontiers in Behavioral Neuroscience. 17. 2023. http://dx.doi.org/10.3389/fnbeh.2023.1176382 . 10.3389/fnbeh.2023.1176382 . published Frontiers in Behavioral Neuroscience

Targeting corticostriatal transmission for the treatment of cannabinoid use disorder

Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis, 2023. Trends in Pharmacological Sciences. 495 - 506. 8. 44. 2023. http://dx.doi.org/10.1016/j.tips.2023.05.003 . 10.1016/j.tips.2023.05.003 . Trends in Pharmacological Sciences

Adenosine A2A receptors control generalization of contextual fear in rats

Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al, 2023. Translational Psychiatry. 1. 13. 2023. http://dx.doi.org/10.1038/s41398-023-02613-0 . 10.1038/s41398-023-02613-0 . published Translational Psychiatry

Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals

Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R., 2023. Purinergic Signalling. 2023. http://dx.doi.org/10.1007/s11302-023-09937-y . 10.1007/s11302-023-09937-y . accepted Purinergic Signalling

The striatum drives the ergogenic effects of caffeine

Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al, 2023. Purinergic Signalling. 2023. https://doi.org/10.1007/s11302-023-09922-5 . 10.1007/s11302-023-09922-5 . Purinergic Signalling

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Margarida Beatriz; Rodrigues, Ricardo J.; Rita Vilaça; Conceição Egas; Paulo S. Pinheiro; George Q. Daley; Thorsten M. Schlaeger; et al, 2023. Theranostics. 3707 - 3724. 11. 13. 2023. http://dx.doi.org/10.7150/thno.81981 . 10.7150/thno.81981 . published Theranostics

Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha, 2023. Neuropharmacology. 2023. https://doi.org/10.1016/j.neuropharm.2023.109421 . 10.1016/j.neuropharm.2023.109421 . Neuropharmacology

The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine

Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al, 2022. Pharmaceuticals. 2022. https://doi.org/10.3390/ph15111323 . 10.3390/ph15111323 . Pharmaceuticals

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update

IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A., 2022. Pharmacological Reviews. 340 - 372. 2. 74. 2022. http://dx.doi.org/10.1124/pharmrev.121.000445 . 10.1124/pharmrev.121.000445 . published Pharmacological Reviews

Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease

Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A., 2022. Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.835885 . 10.3389/fnagi.2022.835885 . published Frontiers in Aging Neuroscience

Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes

Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas, 2022. Purinergic Signalling. 2022. https://doi.org/10.1007/s11302-022-09864-4 . 10.1007/s11302-022-09864-4 . Purinergic Signalling

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage

Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231810510 . 10.3390/ijms231810510 . International Journal of Molecular Sciences

Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes

Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho, 2022. Cellular and Molecular Life Sciences. 2022. https://doi.org/10.1007/s00018-022-04492-y . 10.1007/s00018-022-04492-y . Cellular and Molecular Life Sciences

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al, 2022. Molecular Neurobiology. 1659 - 1674. 3. 60. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . accepted Molecular Neurobiology

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

Lígia Fão; Patrícia Coelho; Rodrigues, Ricardo J.; A. Cristina Rego, 2022. Cells. 2022. https://doi.org/10.3390/cells11193063 . 10.3390/cells11193063 . Cells

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232112826 . 10.3390/ijms232112826 . International Journal of Molecular Sciences

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Rodrigues, Ricardo J.; Jean-Pierre Oses; et al, 2022. Molecular Neurobiology. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . Molecular Neurobiology

Adenosine A2A receptors control synaptic remodeling in the adult brain

Rodrigues, Ricardo J.; Joana M Marques, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports

Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al, 2022. Journal of Clinical Investigation. 12. 132. 2022. http://dx.doi.org/10.1172/jci149371 . 10.1172/jci149371 . published Journal of Clinical Investigation

Adenosine A2A receptors control synaptic remodeling in the adult brain

Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports

Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al, 2022. Journal of Clinical Investigation. 22. 132. 2022. http://dx.doi.org/10.1172/jci152924 . 10.1172/jci152924 . published Journal of Clinical Investigation

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure

Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2022. Journal of Neurochemistry. 2022. https://doi.org/10.1111/jnc.15575 . 10.1111/jnc.15575 . Journal of Neurochemistry

P2Y1 Receptor as a Catalyst of Brain Neurodegeneration

Rodrigues, Ricardo J.; Ana S. Figueira; Joana M. Marques, 2022. NeuroSci. 604 - 615. 3. 2022. https://doi.org/10.3390/neurosci3040043 . 10.3390/neurosci3040043 . published NeuroSci

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, 2021. Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . published Science

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, 2021. Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.

Rodrigues, Ricardo J.; Joana M Marques, 2021. Cerebral cortex (New York, N.Y. : 1991). 5652 - 5663. 12. 31. 2021. https://doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral cortex (New York, N.Y. : 1991)

Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease

Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula, 2021. Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.666710 . 10.3389/fnins.2021.666710 . Frontiers in Neuroscience

Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.

Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology

Binge-Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood

Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al, 2021. Alcoholism: Clinical and Experimental Research. 56 - 63. 1. 45. 2021. https://doi.org/10.1111/acer.14501 . 10.1111/acer.14501 . Alcoholism: Clinical and Experimental Research

Adenosine A2A Receptors as Biomarkers of Brain Diseases

Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A., 2021. Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.702581 . 10.3389/fnins.2021.702581 . Frontiers in Neuroscience

l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al, 2021. The FASEB Journal. 8. 35. 2021. https://doi.org/10.1096/fj.202100336R . 10.1096/fj.202100336R . The FASEB Journal

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A. A.; Porciúncula, Lisiane O.; et al, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-89964-0 . 10.1038/s41598-021-89964-0 . Scientific Reports

Clustering of adenosine A<sub>2B</sub>receptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by<i>Leishmania amazonensis</i>

Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al, 2021. The FASEB Journal. 5. 35. 2021. http://dx.doi.org/10.1096/fj.202002396rr . 10.1096/fj.202002396rr . published The FASEB Journal

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation

Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al, 2021. Cerebral Cortex. 5652 - 5663. 12. 31. 2021. http://dx.doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral Cortex

Deletion of CD73 increases exercise power in mice

Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A., 2021. Purinergic Signalling. 393 - 397. 3. 17. 2021. http://dx.doi.org/10.1007/s11302-021-09797-4 . 10.1007/s11302-021-09797-4 . published Purinergic Signalling

Exercise decreases aberrant corticostriatal plasticity in an animal model of <scp>l</scp>-DOPA-induced dyskinesia

Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D., 2021. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. R541 - R546. 4. 320. 2021. http://dx.doi.org/10.1152/ajpregu.00295.2020 . 10.1152/ajpregu.00295.2020 . published American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Use of knockout mice to explore CNS effects of adenosine

Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M., 2021. Biochemical Pharmacology. 187. 2021. http://dx.doi.org/10.1016/j.bcp.2020.114367 . 10.1016/j.bcp.2020.114367 . published Biochemical Pharmacology

Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al, 2021. Neurobiology of Disease. 157. 2021. http://dx.doi.org/10.1016/j.nbd.2021.105441 . 10.1016/j.nbd.2021.105441 . published Neurobiology of Disease

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, 2021. Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . Science

Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides

Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho, 2021. Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-021-02538-z . 10.1007/s12035-021-02538-z . Molecular Neurobiology

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A., 2021. Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.639322 . 10.3389/fncel.2021.639322 . published Frontiers in Cellular Neuroscience

Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape

Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa, 2021. Frontiers in Cellular and Infection Microbiology. 11. 2021. http://dx.doi.org/10.3389/fcimb.2021.678568 . 10.3389/fcimb.2021.678568 . Frontiers in Cellular and Infection Microbiology

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, 2020. Neurobiology of Disease. 105137 - 105137. 146. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of Disease

Purinergic signaling orchestrating neuron-glia communication

Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M., 2020. Pharmacological Research. 162. 2020. http://dx.doi.org/10.1016/j.phrs.2020.105253 . 10.1016/j.phrs.2020.105253 . published Pharmacological Research

Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder

de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly, Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo, 2020. Neuroscience. 140 - 148. 448. 2020. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030 . 10.1016/j.neuroscience.2020.09.030 . published Neuroscience

The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease

Cunha, Rodrigo, 2020. Purinergic Signalling. 2020. http://dx.doi.org/10.1007/s11302-020-09694-2 . 10.1007/s11302-020-09694-2 . Purinergic Signalling

Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities

Cunha, Rodrigo, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . European Journal of Neuroscience

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig, Astrid; Cunha, Rodrigo, 2020. Nutrients. 10. 12. 2020. http://dx.doi.org/10.3390/nu12103141 . 10.3390/nu12103141 . published Nutrients

Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice

Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger; Fernandes, Pedro Augusto; et al, 2020. NeuroToxicology. 144 - 154. 80. 2020. http://dx.doi.org/10.1016/j.neuro.2020.07.008 . 10.1016/j.neuro.2020.07.008 . NeuroToxicology

ATP Signaling Controlling Dyskinesia Through P2X7 Receptors

Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M., 2020. Frontiers in Molecular Neuroscience. 13. 2020. http://dx.doi.org/10.3389/fnmol.2020.00111 . 10.3389/fnmol.2020.00111 . published Frontiers in Molecular Neuroscience

Role of Adenosine in Epilepsy and Seizures

Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha, Rodrigo A.; Ana M. Sebastião; Boison, Detlev, 2020. Journal of Caffeine and Adenosine Research. 45 - 60. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0022 . 10.1089/caff.2019.0022 . Journal of Caffeine and Adenosine Research

Control of NMDA Receptor-Mediated Currents by Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors Within the Basolateral Amygdala

Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G., 2020. Journal of Caffeine and Adenosine Research. 61 - 70. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0024 . 10.1089/caff.2019.0024 . published Journal of Caffeine and Adenosine Research

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi, 2020. European Journal of Neuroscience. 2020. https://doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . published Brain Research Bulletin

Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder

França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al, 2020. Molecular Neurobiology. 3902 - 3919. 9. 57. 2020. http://dx.doi.org/10.1007/s12035-020-02002-4 . 10.1007/s12035-020-02002-4 . published Molecular Neurobiology

Control of glutamate release by complexes of adenosine and cannabinoid receptors

Cunha, Rodrigo, 2020. BMC Biology. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology

The Yin and Yang of Adenosine Receptors: A Piquant Story

Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Control of glutamate release by complexes of adenosine and cannabinoid receptors

Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience

Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Rodrigo A Cunha, 2019. Brain. 2019. https://doi.org/10.1093/brain/awz335 . 10.1093/brain/awz335 . Brain

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease

Cunha, Rodrigo, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14771 . 10.1111/bph.14771 . British Journal of Pharmacology

Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus

Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas, 2019. Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14816 . 10.1111/jnc.14816 . Journal of Neurochemistry

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Cunha, Rodrigo, 2019. Neurobiology of Disease. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology

Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Rodrigues, Ricardo J.; Sara Xapelli, 2019. Journal of Caffeine and Adenosine Research. 129 - 144. 4. 9. 2019. https://doi.org/10.1089%2Fcaff.2019.0010 . 10.1089/caff.2019.0010 . published Journal of Caffeine and Adenosine Research

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve

Cunha, Rodrigo, 2019. Molecules. 2019. http://dx.doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Cunha, Rodrigo, 2019. Glia. 2019. http://dx.doi.org/10.1002/glia.23476 . 10.1002/glia.23476 . Glia

Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain

Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Cunha, Rodrigo, 2019. Frontiers in Neuroscience. 2019. http://dx.doi.org/10.3389/fnins.2018.01015 . 10.3389/fnins.2018.01015 . Frontiers in Neuroscience

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A. Cunha; Francisco Ciruela, 2019. Journal of Neurochemistry. 796 - 809. 6. 148. 2019. https://doi.org/10.1111/jnc.14653 . 10.1111/jnc.14653 . Journal of Neurochemistry

Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice

Cunha, Rodrigo, 2019. Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1278-3 . 10.1007/s12035-018-1278-3 . Molecular Neurobiology

Signaling by adenosine receptors—Homeostatic or allostatic control?

Rodrigo A. Cunha, 2019. PLOS Biology. e3000213 - e3000213. 4. 17. 2019. https://doi.org/10.1371/journal.pbio.3000213 . 10.1371/journal.pbio.3000213 . PLOS Biology

Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors

Cunha, Rodrigo, 2019. Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1296-1 . 10.1007/s12035-018-1296-1 . Molecular Neurobiology

What is the extracellular calcium concentration within brain synapses?

João Pedro Lopes; Rodrigo A. Cunha, 2019. Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry

Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder

Cunha, Rodrigo, 2019. European Journal of Neuroscience. 2019. http://dx.doi.org/10.1111/ejn.14348 . 10.1111/ejn.14348 . European Journal of Neuroscience

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, 2019. Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology

G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum

Cunha, Rodrigo, 2019. Neural Regeneration Research. 2019. http://dx.doi.org/10.4103/1673-5374.259610 . 10.4103/1673-5374.259610 . Neural Regeneration Research

Purinergic signalling and brain development

Cunha, Rodrigo, 2019. Seminars in Cell & Developmental Biology. 2019. http://dx.doi.org/10.1016/j.semcdb.2018.12.001 . 10.1016/j.semcdb.2018.12.001 . Seminars in Cell & Developmental Biology

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Cunha, Rodrigo, 2018. eneuro. 2018. http://dx.doi.org/10.1523/eneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making

Cunha, Rodrigo, 2018. Frontiers in Molecular Neuroscience. 2018. http://dx.doi.org/10.3389/fnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice

Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-29050-0 . 10.1038/s41598-018-29050-0 . Scientific Reports

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making

Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M. Canas; et al, 2018. Neurobiology of Disease. 72 - 81. 117. 2018. https://doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al, 2018. Cell Death and Disease. 3. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS . 10.1038/s41419-018-0351-1 . published Cell Death and Disease

Purinergic signalling and brain development.

Rodrigues, Ricardo J.; Joana M Marques; Cunha RA, 2018. Seminars in cell & developmental biology. 34 - 41. 95. 2018. http://europepmc.org/abstract/med/30529149 . 10.1016/j.semcdb.2018.12.001 . published Seminars in cell & developmental biology

Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice

Cunha, Rodrigo, 2018. Journal of Caffeine and Adenosine Research. 2018. http://dx.doi.org/10.1089/caff.2018.0016 . 10.1089/caff.2018.0016 . Journal of Caffeine and Adenosine Research

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro

Chronic coffee consumption and respiratory disease: A systematic review

Cunha, Rodrigo, 2018. The Clinical Respiratory Journal. 2018. http://dx.doi.org/10.1111/crj.12662 . 10.1111/crj.12662 . The Clinical Respiratory Journal

Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats

Cunha, Rodrigo, 2018. Frontiers in Neuroscience. 2018. http://dx.doi.org/10.3389/fnins.2018.00653 . 10.3389/fnins.2018.00653 . Frontiers in Neuroscience

Distinct sensitivity to caffeine-induced insomnia related to age

Cunha, Rodrigo, 2018. Journal of Psychopharmacology. 2018. http://dx.doi.org/10.1177/0269881117722997 . 10.1177/0269881117722997 . Journal of Psychopharmacology

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Cunha, Rodrigo, 2018. Human Molecular Genetics. 2018. http://dx.doi.org/10.1093/hmg/ddy264 . 10.1093/hmg/ddy264 . Human Molecular Genetics

Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex

Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00133 . 10.3389/fphar.2018.00133 . Frontiers in Pharmacology

Elevated Pressure Changes the Purinergic System of Microglial Cells

Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00016 . 10.3389/fphar.2018.00016 . Frontiers in Pharmacology

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

Cunha, Rodrigo, 2018. Cell Death & Disease. 2018. http://dx.doi.org/10.1038/s41419-018-0351-1 . 10.1038/s41419-018-0351-1 . Cell Death & Disease

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2017.00899 . 10.3389/fphar.2017.00899 . Frontiers in Pharmacology

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

Cunha, Rodrigo, 2018. Molecular Psychiatry. 2018. http://dx.doi.org/10.1038/s41380-018-0110-9 . 10.1038/s41380-018-0110-9 . Molecular Psychiatry

Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats

Cunha, Rodrigo, 2018. Behavioural Brain Research. 2018. http://dx.doi.org/10.1016/j.bbr.2018.05.007 . 10.1016/j.bbr.2018.05.007 . Behavioural Brain Research

Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex

Cunha, Rodrigo, 2018. European Journal of Neuroscience. 2018. http://dx.doi.org/10.1111/ejn.13912 . 10.1111/ejn.13912 . European Journal of Neuroscience

Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.

Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al, 2017. 2017. http://europepmc.org/abstract/med/26534909 . 10.1093/cercor/bhv268 .

Brain Membrane Fractionation: An <em>Ex Vivo </em>Approach to Assess Subsynaptic Protein Localization

Cunha, Rodrigo, 2017. Journal of Visualized Experiments. 2017. http://dx.doi.org/10.3791/55661 . 10.3791/55661 . Journal of Visualized Experiments

Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages

Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro, 2017. Pulmonary Pharmacology & Therapeutics. 90 - 94. 45. 2017. https://doi.org/10.1016/j.pupt.2017.04.009 . 10.1016/j.pupt.2017.04.009 . Pulmonary Pharmacology & Therapeutics

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F, 2017. 2017. http://europepmc.org/abstract/med/28007645 . 10.1016/j.neulet.2016.12.040 .

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2017. 2017. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .

Boosting brain glucose metabolism to fight neurodegeneration?

de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al, 2017. Journal of Controlled Release. 58 - 71. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025167046&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.007 . published Journal of Controlled Release

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L, 2017. 2017. http://europepmc.org/abstract/med/28032667 . 10.1002/ana.24867 .

Conference Paper: Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression.

Leal, Ermelindo C; Pirzgalska R; Dorinda Marques-da-Silva; Moura, Liane; Espinoza D; Ledent, C.; Köfalvi, Attila; Carvalho, Eugenia, 2017. Diabetologia. 119 - 119. S1. 60. 2017. http://dx.doi.org/10.1007/s00125-017-4350-z . 10.1007/s00125-017-4350-z . Diabetologia

Cannabis: A Treasure Trove or Pandora's Box?

Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry

P2 receptors control the migration of medial ganglionic eminence-derived interneurons

Ferreira, S.; Joana M Marques; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, Ricardo J., 2017. Journal of Neurochemistry. 2017. https://publons.com/publon/33584030/ . Journal of Neurochemistry

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Cunha, Rodrigo, 2017. Journal of Controlled Release. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.07.007 . 10.1016/j.jconrel.2017.07.007 . Journal of Controlled Release

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al, 2017. Molecular Psychiatry. 1035 - 1043. 7. 22. 2017. https://doi.org/10.1038/mp.2016.173 . 10.1038/mp.2016.173 . Molecular Psychiatry

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al, 2017. 2017. http://europepmc.org/abstract/med/26860412 . 10.1007/s12035-016-9774-9 .

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

Cunha, Rodrigo, 2017. Cell Death & Disease. 2017. http://dx.doi.org/10.1038/cddis.2017.451 . 10.1038/cddis.2017.451 . Cell Death & Disease

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease

Cunha, Rodrigo, 2017. Journal of Alzheimer's Disease. 2017. http://doi.org/10.3233/JAD-170356 . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

Cunha, Rodrigo, 2017. Scientific Reports. 2017. http://dx.doi.org/10.1038/s41598-017-10147-x . 10.1038/s41598-017-10147-x . Scientific Reports

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aß1-40) administration in mice.

Santos VV; Stark R; Rial D; Silva HB; Bayliss JA; Lemus MB; Davies JS; et al, 2017. 2017. http://europepmc.org/abstract/med/28380673 . 10.1111/jne.12476 .

Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

Rodrigues RJ; Almeida T; Díaz-Hernández M; Marques JM; Franco R; Solsona C; Miras-Portugal MT; Ciruela F; Cunha RA, 2016. 2016. http://europepmc.org/abstract/med/26801076 . 10.1016/j.neuropharm.2016.01.022 .

Selective A(2A) receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury

Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago, Ana Raquel, 2016. Translational Research. 112 - 128. 169. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370392700010&KeyUID=WOS:000370392700010 . 10.1016/j.trsl.2015.11.005 . Translational Research

HIGH SUCROSE CONSUMPTION INDUCES MEMORY IMPAIRMENT IN RATS ASSOCIATED WITH ELECTROPHYSIOLOGICAL MODIFICATIONS BUT NOT WITH METABOLIC CHANGES IN THE HIPPOCAMPUS

Lemos, C.; Rial, D.; Goncalves, F. Q.; Pires, J.; Silva, H. B.; Matheus, F. C.; Da Silva, A. C.; et al, 2016. Neuroscience. 196 - 205. 315. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368312700015&KeyUID=WOS:000368312700015 . 10.1016/j.neuroscience.2015.12.018 . Neuroscience

How does adenosine control neuronal dysfunction and neurodegeneration?

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Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices

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Depression as a Glial-Based Synaptic Dysfunction

Rial, Daniel; Lemos, Cristina; Pinheiro, Helena; Duarte, Joana M.; Goncalves, Francisco Q.; Real, Joana I.; Prediger, Rui D.; et al, 2016. Frontiers in Cellular Neuroscience. 9. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368534000001&KeyUID=WOS:000368534000001 . 10.3389/fncel.2015.00521 . Frontiers in Cellular Neuroscience

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats

Matheus, Filipe C.; Rial, Daniel; Real, Joana I.; Lemos, Cristina; Ben, Juliana; Guaita, Gisele O.; Pita, Ines R.; et al, 2016. Behavioural Brain Research. 43 - 54. 301. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370108600006&KeyUID=WOS:000370108600006 . 10.1016/j.bbr.2015.12.011 . Behavioural Brain Research

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Ardais, Ana Paula; Rocha, Andreia S.; Borges, Mauricio Felisberto; Fioreze, Gabriela T.; Sallaberry, Cassia; Mioranzza, Sabrina; Nunes, Fernanda; et al, 2016. Behavioural Brain Research. 76 - 84. 303. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372688900010&KeyUID=CCC:000372688900010 . Behavioural Brain Research

Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.

Ardais AP; Rocha AS; Borges MF; Fioreze GT; Sallaberry C; Mioranzza S; Nunes F; et al, 2016. 2016. http://europepmc.org/abstract/med/26774980 . 10.1016/j.bbr.2016.01.026 .

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

Viana da Silva S; Haberl MG; Zhang P; Bethge P; Lemos C; Gonçalves N; Gorlewicz A; et al, 2016. 2016. http://europepmc.org/abstract/med/27312972 . 10.1038/ncomms11915 .

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.

Moidunny S; Matos M; Wesseling E; Banerjee S; Volsky DJ; Cunha RA; Agostinho P; Boddeke HW; Roy S, 2016. 2016. http://europepmc.org/abstract/med/27287400 . 10.1186/s12974-016-0613-8 .

Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.

Harmatz ES; Stone L; Lim SH; Lee G; McGrath A; Gisabella B; Peng X; et al, 2016. 2016. http://europepmc.org/abstract/med/28010876 . 10.1016/j.biopsych.2016.11.009 .

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.

Rodrigues L; Miranda IM; Andrade GM; Mota M; Cortes L; Rodrigues AG; Cunha RA; Gonçalves T, 2016. 2016. http://europepmc.org/abstract/med/27590517 . 10.18632/oncotarget.11760 .

Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.

Matheus FC; Rial D; Real JI; Lemos C; Takahashi RN; Bertoglio LJ; Cunha RA; Prediger RD, 2016. 2016. http://europepmc.org/abstract/med/26164273 . 10.1007/s12035-015-9330-z .

Age-Related Changes in the Synaptic Density of Amyloid-ß Protein Precursor and Secretases in the Human Cerebral Cortex.

Pliássova A; Canas PM; Xavier AC; da Silva BS; Cunha RA; Agostinho P, 2016. 2016. http://europepmc.org/abstract/med/27104908 . 10.3233/jad-160213 .

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Pinheiro BS; Lemos C; Neutzling Kaufmann F; Marques JM; da Silva-Santos CS; Carvalho E; Mackie K; et al, 2016. 2016. http://europepmc.org/abstract/med/27208730 . 10.1016/j.brainresbull.2016.05.009 .

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.

George J; Cunha RA; Mulle C; Amédée T, 2016. 2016. http://europepmc.org/abstract/med/27199162 . 10.1111/ejn.13191 .

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP, 2016. 2016. http://europepmc.org/abstract/med/27848069 .

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Köfalvi A; Lemos C; Martín-Moreno AM; Pinheiro BS; García-García L; Pozo MA; Valério-Fernandes Â; et al, 2016. 2016. http://europepmc.org/abstract/med/26976670 . 10.1016/j.neuropharm.2016.03.015 .

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

Ana Patrícia Simões; Nuno J Machado; Nélio Gonçalves; Manuella P Kaster; Ana T Simões; Ana Nunes; Luís Pereira de Almeida; et al, 2016. Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. https://doi.org/10.1038/npp.2016.98 . 10.1038/npp.2016.98 . Neuropsychopharmacology

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. https://doi.org/10.1016/j.neuropharm.2016.03.015 . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology

Stimulation of brain glucose uptake by cannabinoid CB<inf>2</inf> receptors and its therapeutic potential in Alzheimer's disease

Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.03.015 . published Neuropharmacology

Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Díaz-Hernández, M.; Joana M Marques; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A., 2016. Neuropharmacology. 241 - 257. 105. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.01.022 . published Neuropharmacology

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. https://doi.org/10.1016/j.brainresbull.2016.05.009 . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2016. 2016. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS . 10.1016/j.brainresbull.2016.05.009 . published Brain Research Bulletin

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al, 2016. Molecular Neurobiology. 1552 - 1563. 2. 54. 2016. https://doi.org/10.1007%2Fs12035-016-9774-9 . 10.1007/s12035-016-9774-9 . Molecular Neurobiology

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus

Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al, 2016. Neuroscience. 196 - 205. 315. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS . 10.1016/j.neuroscience.2015.12.018 . published Neuroscience

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system

Lopes, Joao P.; Morato, Xavier; Souza, Carolina; Pinhal, Cindy; Machado, Nuno J.; Canas, Paula M.; Silva, Henrique B.; et al, 2015. Journal of Neurochemistry. 135 - 146. 1. 134. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356368800014&KeyUID=WOS:000356368800014 . 10.1111/jnc.13109 . Journal of Neurochemistry

Caffeine acts through neuronal adenosine A(2A) receptors to prevent mood and memory dysfunction triggered by chronic stress

Kaster, Manuella P.; Machado, Nuno J.; Silva, Henrique B.; Nunes, Ana; Ardais, Ana Paula; Santana, Magda; Baqi, Younis; et al, 2015. Proceedings of the National Academy of Sciences of the United States of America. 7833 - 7838. 25. 112. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356731300082&KeyUID=WOS:000356731300082 . 10.1073/pnas.1423088112 . Proceedings of the National Academy of Sciences of the United States of America

Adenosine A(2b) receptors control A(1) receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Goncalves, Francisco Q.; Pires, Johny; Pliassova, Anna; Beleza, Rui; Lemos, Cristina; Marques, Joana M.; Rodrigues, Ricardo J.; et al, 2015. European Journal of Neuroscience. 876 - 886. 7. 41. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352540800002&KeyUID=WOS:000352540800002 . 10.1111/ejn.12851 . European Journal of Neuroscience

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones, 2015. NMR Biomed.. 1111 - 1116. 9. 28. 2015. http://dx.doi.org/10.1002/nbm.3355 . 10.1002/nbm.3355 . NMR Biomed.

Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://dx.doi.org/10.1007/s11302-015-9474-3 . 10.1007/s11302-015-9474-3 . Purinergic Signalling

Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents

Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al, 2015. Neurochemistry International. 2015. http://dx.doi.org/10.1016/j.neuint.2015.07.014 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.

Li P; Rial D; Canas PM; Yoo JH; Li W; Zhou X; Wang Y; et al, 2015. 2015. http://europepmc.org/abstract/med/25802981 . 10.1038/mp.2015.43 .

Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology

Caffeine consumption and exacerbations of chronic obstructive pulmonary disease: Retrospective study

Lopes, P. O.; Alfaro, T. M.; Lopes, P.; Cunha, R. A.; Robalo Cordeiro, C., 2015. Revista Portuguesa De Pneumologia. 271 - 275. 5. 21. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360705800009&KeyUID=WOS:000360705800009 . 10.1016/j.rppnen.2015.05.001 . Revista Portuguesa De Pneumologia

Adenosine A(2B) receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, Cristina; Pinheiro, Barbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Koefalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365171800013&KeyUID=WOS:000365171800013 . 10.1007/s11302-015-9474-3 . Purinergic Signalling

Deletion of Adenosine A(2A) Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Matos, Marco; Shen, Hai-Ying; Augusto, Elisabete; Wang, Yumei; Wei, Catherine J.; Wang, Yu Tian; Agostinho, Paula; et al, 2015. Biological Psychiatry. 763 - 774. 11. 78. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365046200008&KeyUID=WOS:000365046200008 . 10.1016/j.biopsych.2015.02.026 . Biological Psychiatry

Adenosine A(2A)R blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Goncalves, Francisco Q.; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago, Ana Raquel, 2015. Journal of Neuroinflammation. 12. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356056700001&KeyUID=WOS:000356056700001 . 10.1186/s12974-015-0333-5 . Journal of Neuroinflammation

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

George, Jimmy; Goncalves, Francisco Q.; Cristovao, Goncalo; Rodrigues, Lisa; Meyer Fernandes, Jose Roberto; Goncalves, Teresa; Cunha, Rodrigo A.; Gomes, Catarina A., 2015. Glia. 1636 - 1645. 9. 63. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357958100011&KeyUID=WOS:000357958100011 . 10.1002/glia.22833 . Glia

Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice

Pagnussat, N.; Almeida, A. S.; Marques, D. M.; Nunes, F.; Chenet, G. C.; Botton, P. H. S.; Mioranzza, S.; et al, 2015. British Journal of Pharmacology. 3831 - 3845. 15. 172. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357952500011&KeyUID=WOS:000357952500011 . 10.1111/bph.13180 . British Journal of Pharmacology

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-beta Levels in Patients with Alzheimer's Disease?

Travassos, Maria; Santana, Isabel; Baldeiras, Ines; Tsolaki, Magda; Gkatzima, Olymbia; Genc, Sermin; Yener, Gorsev G.; et al, 2015. Journal of Alzheimers Disease. 1069 - 1078. 4. 47. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360931300024&KeyUID=WOS:000360931300024 . 10.3233/jad-150374 . Journal of Alzheimers Disease

Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience

ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J.; Tome, AngeloR; Cunha, Rodrigo A., 2015. Frontiers in Neuroscience. 9. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353649000001&KeyUID=WOS:000353649000001 . 10.3389/fnins.2015.00148 . Frontiers in Neuroscience

Hyperactivation of D1 and A(2A) receptors contributes to cognitive dysfunction in Huntington's disease

Tyebji, Shiraz; Saavedra, Ana; Canas, Paula M.; Pliassova, Anna; Delgado-Garcia, Jose M.; Alberch, Jordi; Cunha, Rodrigo A.; Gruart, Agnes; Perez-Navarro, Esther, 2015. Neurobiology of Disease. 41 - 57. 74. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349655900005&KeyUID=WOS:000349655900005 . 10.1016/j.nbd.2014.11.004 . Neurobiology of Disease

Optogenetic activation of intracellular adenosine A(2A) receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Li, P.; Rial, D.; Canas, P. M.; Yoo, J. H.; Li, W.; Zhou, X.; Wang, Y.; et al, 2015. Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363465300009&KeyUID=WOS:000363465300009 . 10.1038/mp.2014.182 . Molecular Psychiatry

Adenosine A<inf>2b</inf> receptors control A<inf>1</inf> receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Joana M Marques; Rodrigues, Ricardo J.; et al, 2015. European Journal of Neuroscience. 876 - 886. 7. 41. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS . 10.1111/ejn.12851 . published European Journal of Neuroscience

Adenosine A<inf>2B</inf> receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Joana M Marques; Rodrigues, Ricardo J.; Cunha, R.A.; Rial, D.; Köfalvi, A., 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS . 10.1007/s11302-015-9474-3 . published Purinergic Signalling

Inactivation of adenosine A(2A) receptors reverses working memory deficits at early stages of Huntington's disease models

Li, Wei; Silva, Henrique B.; Real, Joana; Wang, Yu-Mei; Rial, Daniel; Li, Ping; Payen, Marie-Pierce; et al, 2015. Neurobiology of Disease. 70 - 80. 79. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356110700007&KeyUID=WOS:000356110700007 . 10.1016/j.nbd.2015.03.030 . Neurobiology of Disease

Presynaptic adenosine A(2A) receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S. G.; Goncalves, F. Q.; Marques, J. M.; Tome, A. R.; Rodrigues, R. J.; Nunes-Correia, I.; Ledent, C.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348507700009&KeyUID=WOS:000348507700009 . 10.1111/bph.12970 . British Journal of Pharmacology

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G., 2015. Nmr in Biomedicine. 1111 - 1116. 9. 28. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006 . 10.1002/nbm.3355 . Nmr in Biomedicine

ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J.; Tomé, A.R.; Cunha, R.A., 2015. Frontiers in Neuroscience. APR. 9. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS . 10.3389/fnins.2015.00148 . published Frontiers in Neuroscience

Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Gonc¸alves, F.Q.; Joana M Marques; Tomé, Â.R.; Rodrigues, Ricardo J.; Nunes-Correia, I.; Ledent, C.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . published British Journal of Pharmacology

The Effects of Different Concentrations of the alpha(2)-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice

Ribeiro, Patricia O.; Antunes, Luis M.; Nunes, Catarina S.; Silva, Henrique B.; Cunha, Rodrigo A.; Tome, Angelo R., 2015. Anesthesia and Analgesia. 1130 - 1137. 5. 120. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353342800031&KeyUID=WOS:000353342800031 . 10.1213/ane.0000000000000636 . Anesthesia and Analgesia

Localization and Trafficking of Amyloid-beta Protein Precursor and Secretases: Impact on Alzheimer's Disease

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Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents

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CAFFEINE TRIGGERS BEHAVIORAL AND NEUROCHEMICAL ALTERATIONS IN ADOLESCENT RATS

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Synaptic and glia involvement in the purinergic control of neurodegenerative diseases

Canas, Paula M.; Rial, Daniel; Simoes, Ana Patricia; Lopes, Joao Pedro; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al, 2014. Purinergic Signalling. 2014. https://publons.com/publon/8181585/ . Purinergic Signalling

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

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Activation of microglia bolsters synapse formation

Cristovao, Goncalo; Pinto, Maria J.; Cunha, Rodrigo A.; Almeida, Ramiro D.; Gomes, Catarina A., 2014. Frontiers in Cellular Neuroscience. 8. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336831500002&KeyUID=WOS:000336831500002 . 10.3389/fnce1.2014.00153 . Frontiers in Cellular Neuroscience

Cellular prion protein (PrPC) modulates ethanol-induced behavioral adaptive changes in mice

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ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice

Carmo, Marta R. S.; Simoes, Ana Patricia; Fonteles, Analu A.; Souza, Carolina M.; Cunha, Rodrigo A.; Andrade, Geanne M., 2014. European Journal of Neuroscience. 614 - 622. 4. 39. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000331338500009&KeyUID=WOS:000331338500009 . European Journal of Neuroscience

Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices

Ribeiro, Patricia O.; Tome, Angelo R.; Silva, Henrique B.; Cunha, Rodrigo A.; Antunes, Luis M., 2014. Brain Research. 10 - 17. 1560. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335874700002&KeyUID=WOS:000335874700002 . 10.1016/j.brainres.2014.03.004 . Brain Research

Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease

Canas, P.M.; Simões, A.P.; Rodrigues, R.J.; Cunha, R.A., 2014. Neuropharmacology. 51 - 56. PART A. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.08.026 . Neuropharmacology

ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice.

Carmo MR; Simões AP; Fonteles AA; Souza CM; Cunha RA; Andrade GM, 2014. 2014. http://europepmc.org/abstract/med/24304101 . 10.1111/ejn.12435 .

Synaptic and Sub-Synaptic Localization of Amyloid-beta Protein Precursor in the Rat Hippocampus

Rodrigues, Diana I.; Gutierres, Jessie; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula, 2014. Journal of Alzheimers Disease. 981 - 992. 4. 40. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336262000016&KeyUID=WOS:000336262000016 . 10.3233/jad-132030 . Journal of Alzheimers Disease

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garcao, Pedro; Goncalves, Francisco Q.; Silva, Henrique B.; Tome, Angelo R.; et al, 2014. Plos One. 12. 9. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346907600046&KeyUID=WOS:000346907600046 . 10.1371/journal.pone.0114216 . Plos One

Role of Microglia Adenosine A(2A) Receptors in Retinal and Brain Neurodegenerative Diseases

Santiago, Ana R.; Baptista, Filipa I.; Santos, Paulo F.; Cristovao, Goncalo; Ambrosio, Antonio F.; Cunha, Rodrigo A.; Gomes, Catarina A., 2014. Mediators of Inflammation. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339788100001&KeyUID=WOS:000339788100001 . 10.1155/2014/465694 . Mediators of Inflammation

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

Cunha, Rodrigo, 2014. Neuropharmacology. 2014. 10.1016/j.neuropharm.2014.01.045 . Neuropharmacology

Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease

Canas, P.M.; Simões, A.P.; Rodrigues, Ricardo J.; Cunha, R.A., 2014. Neuropharmacology. 51 - 56. PART A. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.08.026 . published Neuropharmacology

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

Rial, Daniel; Pamplona, Fabricio A.; Moreira, Eduardo L. G.; Moreira, Karin M.; Hipolide, Debora; Rodrigues, Diana I.; Dombrowski, Patricia A.; et al, 2014. European Journal of Neuroscience. 2479 - 2486. 3. 40. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340502500002&KeyUID=WOS:000340502500002 . 10.1111/ejn.12600 . European Journal of Neuroscience

Activation of microglia bolsters synapse formation.

Cristovão G; Pinto MJ; Cunha RA; Almeida RD; Gomes CA, 2014. 2014. http://europepmc.org/abstract/med/24917790 . 10.3389/fncel.2014.00153 .

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Agostinho, Paula; Tome, Angelo R.; Chen, Jiayang; et al, 2014. Neuropharmacology. 488 - 497. 79. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333774200050&KeyUID=WOS:000333774200050 . 10.1016/j.neuropharm.2013.12.014 . Neuropharmacology

Nicotinic alpha 7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens

Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Chen, Jiayang; Padolecchia, Cristina; Pittaluga, Anna; Tome, Angelo R.; Cunha, Rodrigo A.; Marchi, Mario, 2014. Frontiers in Cellular Neuroscience. 8. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000344535000001&KeyUID=WOS:000344535000001 . 10.3389/fncel.2014.00332 . Frontiers in Cellular Neuroscience

Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia

Ribeiro, Patricia O.; Silva, Henrique B.; Tome, Angelo R.; Cunha, Rodrigo A.; Antunes, Luis M., 2014. Lab Animal. 343 - 347. 10. 43. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342719300019&KeyUID=WOS:000342719300019 . Lab Animal

Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum

Garcao, Pedro; Oliveira, Catarina R.; Cunha, Rodrigo A.; Agostinho, Paula, 2014. Neuroscience Letters. 106 - 110. 566. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335613800022&KeyUID=WOS:000335613800022 . 10.1016/j.neulet.2014.02.018 . Neuroscience Letters

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

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Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder

Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A., 2013. European Neuropsychopharmacology. 317 - 328. 4. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS . 10.1016/j.euroneuro.2012.04.011 . European Neuropsychopharmacology

Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum

Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology

A Single Neurotoxic Dose of Methamphetamine Induces a Long-Lasting Depressive-Like Behaviour in Mice.

Silva CD; Neves AF; Dias AI; Freitas HJ; Mendes SM; Pita I; Viana SD; et al, 2013. 2013. http://europepmc.org/abstract/med/24072398 . 10.1007/s12640-013-9423-2 .

Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum

Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology

Spatial memory impairments in a prediabetic rat model

Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, 2013. Neuroscience. 565 - 577. 250. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.07.055 . Neuroscience

Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.

Pandolfo P; Machado NJ; Köfalvi A; Takahashi RN; Cunha RA, 2013. 2013. http://europepmc.org/abstract/med/22561003 . 10.1016/j.euroneuro.2012.04.011 .

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

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Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice

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Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A., 2013. Brain Research Bulletin. 126 - 135. 97. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS . 10.1016/j.brainresbull.2013.06.007 . Brain Research Bulletin

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-a2 controlling glutamate uptake in astrocytes.

Matos M; Augusto E; Agostinho P; Cunha RA; Chen JF, 2013. 2013. http://europepmc.org/abstract/med/24259572 . 10.1523/jneurosci.1828-13.2013 .

Ecto-5'- nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions

Augusto, E.; Matos, M.; Sévigny, J.; El-Tayeb, A.; Bynoe, M.S.; Müller, C.E.; Cunha, R.A.; Chen, J.-F., 2013. Journal of Neuroscience. 11390 - 11399. 28. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880426005&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5817-12.2013 . Journal of Neuroscience

Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain

Wei, C.J.; Augusto, E.; Gomes, C.A.; Singer, P.; Wang, Y.; Boison, D.; Cunha, R.A.; Yee, B.K.; Chen, J.-F., 2013. Biological Psychiatry. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879384311&partnerID=MN8TOARS . 10.1016/j.biopsych.2013.05.003 . Biological Psychiatry

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

Gomes, C.; Ferreira, R.; George, J.; Sanches, R.; Rodrigues, D.I.; Gonçalves, N.; Cunha, R.A., 2013. Journal of Neuroinflammation. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021276&partnerID=MN8TOARS . 10.1186/1742-2094-10-16 . Journal of Neuroinflammation

Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

Gonçalves, N.; Simões, A.T.; Cunha, R.A.; De Almeida, L.P., 2013. Annals of Neurology. 655 - 666. 5. 73. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS . 10.1002/ana.23866 . Annals of Neurology

CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation

Joana M Marques; Rodrigues, Ricardo J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J., 2013. Journal of Neuroscience. 18298 - 18310. 46. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3136-13.2013 . published Journal of Neuroscience

Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia

Espinosa, J.; Rocha, A.; Nunes, F.; Costa, M.S.; Schein, V.; Kazlauckas, V.; Kalinine, E.; et al, 2013. Journal of Alzheimer's Disease. 509 - 518. 2. 34. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874311332&partnerID=MN8TOARS . 10.3233/JAD-111982 . Journal of Alzheimer's Disease

Adenosine A(2A) Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation

Shen, Hai-Ying; Canas, Paula M.; Garcia-Sanz, Patricia; Lan, Jing-Quan; Boison, Detlev; Moratalla, Rosario; Cunha, Rodrigo A.; Chen, Jiang-Fan, 2013. Plos One. 11. 8. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327657900015&KeyUID=WOS:000327657900015 . 10.1371/journal.pone.0080902 . Plos One

CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International

Metabotropic signaling by kainate receptors

Rodrigues, Ricardo J.; Lerma, J., 2012. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 399 - 410. 4. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877959298&partnerID=MN8TOARS . 10.1002/wmts.35 . published Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Blockade of adenosine A 2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A., 2012. Journal of Neuroinflammation. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS . 10.1186/1742-2094-9-204 . Journal of Neuroinflammation

Adenosine A 2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

Matos, M.; Augusto, E.; Santos-Rodrigues, A.D.; Schwarzschild, M.A.; Chen, J.-F.; Cunha, R.A.; Agostinho, P., 2012. GLIA. 702 - 716. 5. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862776724&partnerID=MN8TOARS . 10.1002/glia.22290 . GLIA

Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat

Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B., 2012. Neuropharmacology. 784 - 797. 5. 63. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS . 10.1016/j.neuropharm.2012.06.003 . Neuropharmacology

Astrocytic adenosine A 2A receptors control the amyloid-ß peptide-induced decrease of glutamate uptake

Matos, M.; Augusto, E.; MacHado, N.J.; Dos Santos-Rodrigues, A.; Cunha, R.A.; Agostinho, P., 2012. Journal of Alzheimer's Disease. 555 - 567. 3. 31. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865592766&partnerID=MN8TOARS . 10.3233/JAD-2012-120469 . Journal of Alzheimer's Disease

Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach

Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A., 2012. Journal of Neuroscience Methods. 366 - 373. 2. 204. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS . 10.1016/j.jneumeth.2011.11.028 . Journal of Neuroscience Methods

Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of nonczno10/ltj mice

Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A., 2012. PLoS ONE. 4. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS . 10.1371/journal.pone.0021899 . PLoS ONE

CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International

Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences

Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International

Pre-synaptic glycine GlyT1 transporter - NMDA receptor interaction: Relevance to NMDA autoreceptor activation in the presence of Mg 2+ ions

Musante, V.; Summa, M.; Cunha, R.A.; Raiteri, M.; Pittaluga, A., 2011. Journal of Neurochemistry. 516 - 527. 3. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953877316&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07223.x . Journal of Neurochemistry

Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, Ricardo J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . published European Journal of Neuroscience

Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging

De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology

Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.

Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia, 2011. Diabetologia. 458 - 458. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain

Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission

Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A., 2011. Journal of Neurochemistry. 100 - 111. 1. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07178.x . Journal of Neurochemistry

Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission

Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry

Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . European Journal of Neuroscience

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum

Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A., 2011. Biochimica et Biophysica Acta - Biomembranes. 1380 - 1399. 5. 1808. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS . 10.1016/j.bbamem.2010.12.001 . Biochimica et Biophysica Acta - Biomembranes

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum

Pandolfo, P.; Silveirinha, V.; Santos-Rodrigues, A.D.; Venance, L.; Ledent, C.; Takahashi, R.N.; Cunha, R.A.; Köfalvi, A., 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952535110&partnerID=MN8TOARS . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina

Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease

Agostinho, P.; Cunha, R.A.; Oliveira, C., 2010. Current Pharmaceutical Design. 2766 - 2778. 25. 16. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957970155&partnerID=MN8TOARS . Current Pharmaceutical Design

Conferenc Paper: Presynaptic A2A adenosine and CB1 cannabinoid receptors inhibit the function of one another at corticostriatal terminals.

Ferreira, Samira G.; Köfalvi, Attila; Cunha, Rodrigo A., 2010. Purinergic Signalling. 44 - 44. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling

Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

Cognato, G.P.; Agostinho, P.M.; Hockemeyer, J.; Müller, C.E.; Souza, D.O.; Cunha, R.A., 2010. Journal of Neurochemistry. 453 - 462. 2. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150168&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06465.x . Journal of Neurochemistry

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F., 2010. Neuroscience. 1589 - 1600. 4. 169. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.06.021 . Neuroscience

Conferenc Paper: Complex regulation of CB1-mediated effects by activation and blockade of striatal adenosine A2A receptors.

Tebano MT; Martire, A.; Köfalvi, Attila; Chiodi, V.; Ferrante A; Domenici MR; Ferreira, Samira G.; Cunha, Rodrigo A.; Popoli, P., 2010. Purinergic Signalling. 19 - 19. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling

Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders

Mendonça, A.; Cunha, R.A., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956222935&partnerID=MN8TOARS . 10.3233/JAD-2010-01420 . Journal of Alzheimer's Disease

Conferenc Paper: Blockade of synaptic adenosine A2A receptor prevents convulsion-induced damage.

Augusto, Elisabete; Paula M. Canas; Lisiane O. Porciúncula; Tiago M. Alfaro; Andrade GM; Köfalvi, Attila; Agostinho PM; Cunha, Rodrigo A., 2010. Purinergic Signalling. 108 - 108. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling

Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks.

de Mendonça, A.; Cunha, R.A., 2010. Journal of Alzheimer's disease : JAD. 20 Suppl 1. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956212740&partnerID=MN8TOARS . Journal of Alzheimer's disease : JAD

Conferenc Paper: Chronic caffeine treatment during adolescence improves behavioral flexibility in an animal model of attention deficit hyperactivity disorder.

Pandolfo, P.; Machado NM; Köfalvi, Attila; Takahashi RN; Cunha, Rodrigo A., 2010. Purinergic Signalling. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

Cunha, R.A.; Agostinho, P.M., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954537925&partnerID=MN8TOARS . 10.3233/JAD-2010-1408 . Journal of Alzheimer's Disease

Caffeine, adenosine receptors, and synaptic plasticity

Costenla, A.R.; Cunha, R.A.; De Mendonça, A., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956219897&partnerID=MN8TOARS . 10.3233/JAD-2010-091384 . Journal of Alzheimer's Disease

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by ß-amyloid peptides via p38 mitogen-activated protein kinase pathway

Canas, P.M.; Porciúncula, L.O.; Cunha, G.M.A.; Silva, C.G.; Machado, N.J.; Oliveira, J.M.A.; Oliveira, C.R.; Cunha, R.A., 2009. Journal of Neuroscience. 14741 - 14751. 47. 29. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449208698&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3728-09.2009 . Journal of Neuroscience

ATP (P2X1-3) AND alpha 3 beta 2 NICOTINIC ACETYLCHOLINE RECEPTORS INTERACT PHYSICALLY AND FUNCTIONALLY IN HIPPOCAMPAL TERMINALS

Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco, 2009. Journal of Physiological Sciences. 2009. https://publons.com/publon/8181593/ . Journal of Physiological Sciences

N-acyldopamines control striatal input terminals via novel ligand-gated cation channels

Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging

Conferenc Paper: When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis.

Köfalvi, Attila, 2009. Journal of Neurochemistry. 103 - 104. s1. 110. 2009. http://dx.doi.org/10.1111/j.1471-4159.2009.06064_27.x . 10.1111/j.1471-4159.2009.06064_27.x . Journal of Neurochemistry

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors

Gomes, C.A.R.V.; Simões, P.F.; Canas, P.M.; Quiroz, C.; Sebastião, A.M.; Ferré, S.; Cunha, R.A.; Ribeiro, J.A., 2009. Journal of Neurochemistry. 1208 - 1219. 5. 108. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449098460&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.05876.x . Journal of Neurochemistry

N-acyldopamines control striatal input terminals via novel ligand-gated cation channels

Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, Ricardo J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . published Neurobiology of Aging

Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway

Quiroz, C.; Luján, R.; Uchigashima, M.; Simoes, A.P.; Lerner, T.N.; Borycz, J.; Kachroo, A.; et al, 2009. TheScientificWorldJournal. 1321 - 1344. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949159248&partnerID=MN8TOARS . 10.1100/tsw.2009.143 . TheScientificWorldJournal

Spermine improves recognition memory deficit in a rodent model of Huntington's disease

Velloso, N.A.; Dalmolin, G.D.; Gomes, G.M.; Rubin, M.A.; Canas, P.M.; Cunha, R.A.; Mello, C.F., 2009. Neurobiology of Learning and Memory. 574 - 580. 4. 92. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949090346&partnerID=MN8TOARS . 10.1016/j.nlm.2009.07.006 . Neurobiology of Learning and Memory

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R., 2009. Journal of Neurochemistry. 368 - 379. 2. 111. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349338971&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06349.x . Journal of Neurochemistry

Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum

Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience

Conferenc Paper: Dual regulatory role of pre- and post-synaptic adenosine A2A receptors on CB1-mediated effects in the striatum.

Tebano MT; Martire A; Köfalvi, Attila; Chiodi, V.; Domenici MR; Pepponi R; Ferrante A; et al, 2009. Purinergic Signalling. 51 - 51. 1. 6. 2009. http://dx.doi.org/10.1007/s11302-009-9171-1 . 10.1007/s11302-009-9171-1 . Purinergic Signalling

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging

Caffeine, adenosine receptors, memory and Alzheimer's disease | Cafeína, receptores de adenosina, memoria y enfermedad de Alzheimer

Cunha, R.A., 2008. Medicina Clinica. 790 - 795. 20. 131. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549108150&partnerID=MN8TOARS . 10.1016/S0025-7753(08)75506-4 . Medicina Clinica

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx

Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . Cell Calcium

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells

Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . published Pancreas

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx

Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . published Cell Calcium

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats

Rodrigues, Ricardo J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . accepted Neurobiology of Aging

Potential therapeutic interest of adenosine A2A receptors in Psychiatric disorders

Cunha, R.A.; Ferré, S.; Vaugeois, J.-M.; Chen, J.-F., 2008. Current Pharmaceutical Design. 1512 - 1524. 15. 14. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349125085&partnerID=MN8TOARS . 10.2174/138161208784480090 . Current Pharmaceutical Design

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats

Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . Neurobiology of Aging

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

Rebola, N.; Lujan, R.; Cunha, R.A.; Mulle, C., 2008. Neuron. 121 - 134. 1. 57. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549021899&partnerID=MN8TOARS . 10.1016/j.neuron.2007.11.023 . Neuron

Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity

Cunha, R.A., 2008. Neurochemistry International. 65 - 72. 1. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849073199&partnerID=MN8TOARS . 10.1016/j.neuint.2007.06.026 . Neurochemistry International

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells

Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . Pancreas

Adenosine A2A receptor blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801

Cunha, G.M.A.; Canas, P.M.; Melo, C.S.; Hockemeyer, J.; Müller, C.E.; Oliveira, C.R.; Cunha, R.A., 2008. Experimental Neurology. 776 - 781. 2. 210. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136710&partnerID=MN8TOARS . 10.1016/j.expneurol.2007.11.013 . Experimental Neurology

An update on adenosine A2A-dopamine D2 receptor interactions: Implications for the function of G protein-coupled receptors

Ferré, S.; Quiroz, C.; Woods, A.S.; Cunha, R.; Popoli, P.; Ciruela, F.; Lluis, C.; et al, 2008. Current Pharmaceutical Design. 1468 - 1474. 15. 14. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349126631&partnerID=MN8TOARS . 10.2174/138161208784480108 . Current Pharmaceutical Design

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs

Shen, H.-Y.; Coelho, J.E.; Ohtsuka, N.; Canas, P.M.; Day, Y.-J.; Huang, Q.-Y.; Rebola, N.; et al, 2008. Journal of Neuroscience. 2970 - 2975. 12. 28. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136068&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5255-07.2008 . Journal of Neuroscience

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

Yu, L.; Shen, H.-Y.; Coelho, J.E.; Araújo, I.M.; Huang, Q.-Y.; Day, Y.-J.; Rebola, N.; et al, 2008. Annals of Neurology. 338 - 346. 3. 63. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849085227&partnerID=MN8TOARS . 10.1002/ana.21313 . Annals of Neurology

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, Ricardo J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . published Journal of Neurochemistry

Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Oses, J.P.; Rodrigues, Ricardo J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . published Neuroscience

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry

Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Conferenc Paper: CB1 cannabinoid receptors in the physiopathology of hippocampal glucose homeostasis.

Duarte, JMN; Nogueira, C.; Carvalho; Mackie, K.; Oliveira, CR; Cunha, Rodrigo A.; Köfalvi, Attila, 2007. Journal of Neurochemistry. 115 - 115. s1. 102. 2007. http://dx.doi.org/10.1111/j.0022-3042.2007.04727.x . 10.1111/j.0022-3042.2007.04727.x . Journal of Neurochemistry

Adenosine A2A receptors and basal ganglia physiology

Schiffmann, S.N.; Fisone, G.; Moresco, R.; Cunha, R.A.; Ferré, S., 2007. Progress in Neurobiology. 277 - 292. 5. 83. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36148983766&partnerID=MN8TOARS . 10.1016/j.pneurobio.2007.05.001 . Progress in Neurobiology

Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . Neuroscience

Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons

Silva, C.G.; Porciúncula, L.O.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2007. Neurobiology of Disease. 182 - 189. 2. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447634291&partnerID=MN8TOARS . 10.1016/j.nbd.2007.04.018 . Neurobiology of Disease

Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy

Duarte, J.M.N.; Cunha, R.A.; Carvalho, R.A., 2007. Neuroscience. 1305 - 1313. 4. 144. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846274201&partnerID=MN8TOARS . 10.1016/j.neuroscience.2006.11.027 . Neuroscience

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses

Rebola, N.; Sachidhanandam, S.; Perrais, D.; Cunha, R.A.; Mulle, C., 2007. Journal of Neuroscience. 3987 - 3993. 15. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247146060&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5182-06.2007 . Journal of Neuroscience

Caffeine and adenosine A2a receptor antagonists prevent ß-amyloid (25-35)-induced cognitive deficits in mice

Dall'Igna, O.P.; Fett, P.; Gomes, M.W.; Souza, D.O.; Cunha, R.A.; Lara, D.R., 2007. Experimental Neurology. 241 - 245. 1. 203. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751427701&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.08.008 . Experimental Neurology

Adenosine receptor heteromers and their integrative role in striatal function

Ferré, S.; Ciruela, F.; Quiroz, C.; Luján, R.; Popoli, P.; Cunha, R.A.; Agnati, L.F.; et al, 2007. TheScientificWorldJournal. 74 - 85. SUPPL. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249058539&partnerID=MN8TOARS . 10.1100/tsw.2007.211 . TheScientificWorldJournal

Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Oliveira, C.R.; Ambrósio, A.F.; Cunha, R.A., 2006. Neurochemistry International. 144 - 150. 2. 48. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450466&partnerID=MN8TOARS . 10.1016/j.neuint.2005.08.008 . Neurochemistry International

Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals

Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters

Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress

Cunha, G.M.A.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience. 1775 - 1781. 4. 141. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747160404&partnerID=MN8TOARS . 10.1016/j.neuroscience.2006.05.024 . Neuroscience

Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus

Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . Journal of Molecular Neuroscience

Hypoxia-induced desensitization and internalization of adenosine A 1 receptors in the rat hippocampus

Coelho, J.E.; Rebola, N.; Fragata, I.; Ribeiro, J.A.; De Mendonça, A.; Cunha, R.A., 2006. Neuroscience. 1195 - 1203. 4. 138. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644838682&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.12.012 . Neuroscience

TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . Journal of Neuroscience Research

Regulation of neurotransmitter release by presynaptic P2X receptors

Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology

Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals

Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters

Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))

Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Ciruela, F.; Casadó, V.; Rodrigues, Ricardo J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . published Journal of Neuroscience

Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . published Journal of Molecular Neuroscience

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, Ricardo J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . published Molecular Pharmacology

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology

TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

Pereira, D.B.; Rebola, N.; Rodrigues, Ricardo J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . published Journal of Neuroscience Research

Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin

Joana M Marques; Rodrigues, Ricardo J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T., 2006. Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS . 10.1074/jbc.M603753200 . published Journal of Biological Chemistry

Heterodimeric adenosine receptors: A device to regulate neurotransmitter release

Ciruela, F.; Ferré, S.; Casadó, V.; Cortés, A.; Cunha, R.A.; Lluis, C.; Franco, R., 2006. Cellular and Molecular Life Sciences. 2427 - 2431. 21. 63. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882222&partnerID=MN8TOARS . 10.1007/s00018-006-6216-2 . Cellular and Molecular Life Sciences

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . Journal of Neuroscience

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

Rebola, N.; Rodrigues, Ricardo J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . published Neuroscience

Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum

Rodrigues, Ricardo J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neurochemistry. 433 - 441. 3. 92. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244264871&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02887.x . published Journal of Neurochemistry

Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons

Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neurochemistry International. 317 - 325. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044454590&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.009 . published Neurochemistry International

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neuroscience. 6286 - 6295. 27. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844443354&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0628-05.2005 . published Journal of Neuroscience

Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses

Pinheiro, P.S.; Rodrigues, Ricardo J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., 2005. Neurochemistry International. 309 - 316. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.007 . published Neurochemistry International

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

Rebola, N.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 893 - 903. 4. 132. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344362097&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.014 . Neuroscience

Purinergic control of GABA release

Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA, 2005. Journal of Neurochemistry. 2005. https://publons.com/publon/27547643/ . Journal of Neurochemistry

Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia

Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis

Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis

Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . published Journal of Neuroscience

Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.

Rebola N; Porciúncula LO; Lopes LV; Oliveira CR; Soares-da-Silva P; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/15987272 . 10.1111/j.1528-1167.2005.01026.x .

Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.

Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/18404497 . 10.1007/s11302-005-0649-1 .

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.

Köfalvi A; Rodrigues RJ; Ledent C; Mackie K; Vizi ES; Cunha RA; Sperlágh B, 2005. 2005. http://europepmc.org/abstract/med/15772347 . 10.1523/JNEUROSCI.4232-04.2005 .

Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.

Ferré S; Borycz J; Goldberg SR; Hope BT; Morales M; Lluis C; Franco R; Ciruela F; Cunha R, 2005. 2005. http://europepmc.org/abstract/med/16385640 . 10.1142/S0219635205000987 .

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.

Rodrigues RJ; Almeida T; Richardson PJ; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/16000618 . 10.1523/JNEUROSCI.0628-05.2005 .

Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.

Pinto-Duarte A; Coelho JE; Cunha RA; Ribeiro JA; Sebastião AM, 2005. 2005. http://europepmc.org/abstract/med/15836618 . 10.1111/j.1471-4159.2005.03071.x .

Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.

Rodrigues RJ; Alfaro TM; Rebola N; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/15659214 . 10.1111/j.1471-4159.2004.02887.x .

Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.

Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/16011860 . 10.1016/j.neuint.2005.05.009 .

Long-term effect of convulsive behavior on the density of adenosine A 1 and A 2A receptors in the rat cerebral cortex

Rebola, N.; Porciúncula, L.O.; Lopes, L.V.; Oliveira, C.R.; Soares-Da-Silva, P.; Cunha, R.A., 2005. Epilepsia. 159 - 165. SUPPL. 5. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844450198&partnerID=MN8TOARS . Epilepsia

Adenosine and brain function.

Fredholm BB; Chen JF; Cunha RA; Svenningsson P; Vaugeois JM, 2005. 2005. http://europepmc.org/abstract/med/15797469 . 10.1016/S0074-7742(05)63007-3 .

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . Neuroscience

Effect of free radicals on adenosine A2A and dopamine D 2 receptors in the striatum of young adult and aged rats

Alfaro, T.M.; Vigia, E.; Oliveira, C.R.; Cunha, R.A., 2004. Neurochemistry International. 733 - 738. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042601106&partnerID=MN8TOARS . 10.1016/j.neuint.2004.02.003 . Neurochemistry International

Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid

Cunha, R.A.; Ribeiro, J.A.; Malva, J.O., 2004. Neurochemistry International. 371 - 379. 5. 44. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345304227&partnerID=MN8TOARS . 10.1016/S0197-0186(03)00167-0 . Neurochemistry International

Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: Evidence that CGS 21680 binds to A1 receptors in hippocampus

Halldner, L.; Lopes, L.V.; Daré, E.; Lindström, K.; Johansson, B.; Ledent, C.; Cunha, R.A.; Fredholm, B.B., 2004. Naunyn-Schmiedeberg's Archives of Pharmacology. 270 - 278. 4. 370. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244262300&partnerID=MN8TOARS . 10.1007/s00210-004-0970-1 . Naunyn-Schmiedeberg's Archives of Pharmacology

Release and neuromodulatory role of ATP in hippocampal synapses

Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181529/ . Fundamental & Clinical Pharmacology

P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices

Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics

Conferenc Paper: Ischemia induced up-regulation of P2X7 receptors on GABAergic neurons in corticoencephalic cell cultures.

Günther, A.; Köfalvi, Attila; Reinhardt, R.; Franke, F.; Madarász, E.; Vizi, E. Sylvester; Schneider, D.; et al, 2004. European Journal of Neurology. 58 - 58. s2. 11. 2004. http://dx.doi.org/10.1111/j.1468-1331.2004.00919.x . 10.1111/j.1468-1331.2004.00919.x . European Journal of Neurology

Binding of the prototypical adenosine A 2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A 1 and A 2A receptor knockout mice

Lopes, L.V.; Halldner, L.; Rebola, N.; Johansson, B.; Ledent, C.; Chen, J.F.; Fredholm, B.B.; Cunha, R.A., 2004. British Journal of Pharmacology. 1006 - 1014. 6. 141. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942472484&partnerID=MN8TOARS . 10.1038/sj.bjp.0705692 . British Journal of Pharmacology

Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum

Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181569/ . Fundamental & Clinical Pharmacology

Conferenc Paper: Regulation of transmitter release in the CNS by cannabinoid receptors.

Sperlágh, B.; Köfalvi, Attila; E. Sylvester Vizi, 2004. Pharmacology. 141 - 141. 2. 72. 2004. http://dx.doi.org/10.1159/000080185 . 10.1159/000080185 . Pharmacology

Conferenc Paper: The role of presynaptic P2X receptors in the regulation of tritiated NA release from rat hippocampal slices.

Papp, L.; Balázsa, T.; Köfalvi, Attila; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 37 - 37. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology

Conferenc Paper: Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the rodent striatum.

Köfalvi, Attila; Ricardo J. Rodrigues; Cunha, Rodrigo A.; Catherine Ledent; Vizi, E. Sylvester; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 57 - 57. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices

Almeida, T.; Rodrigues, Ricardo J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . published Neuroscience

Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action

Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience

Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors

Malva, J.O.; Silva, A.P.; Cunha, R.A., 2003. Neurochemical Research. 1501 - 1515. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS . 10.1023/A:1025618324593 . Neurochemical Research

Heteroexchange of purines in the hippocampus: Mixing-up or messing-up ATP and adenosine

Cunha, R.A., 2003. British Journal of Pharmacology. 473 - 474. 3. 139. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038002126&partnerID=MN8TOARS . British Journal of Pharmacology

Adenosine A3 receptors are located in neurons of the rat hippocampus

Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2003. NeuroReport. 1645 - 1648. 12. 14. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS . 10.1097/00001756-200308260-00021 . NeuroReport

Pharmacology of adenosine A2A receptors and therapeutic applications.

Fredholm, B.B.; Cunha, R.A.; Svenningsson, P., 2003. Current topics in medicinal chemistry. 413 - 426. 4. 3. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038143146&partnerID=MN8TOARS . Current topics in medicinal chemistry

Neuroprotection by caffeine and adenosine A 2A receptor blockade of ß-amyloid neurotoxicity

Dall'lgna, O.P.; Porciúncula, L.O.; Souza, D.O.; Cunha, R.A.; Lara, D.R., 2003. British Journal of Pharmacology. 1207 - 1209. 7. 138. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038415954&partnerID=MN8TOARS . 10.1038/sj.bjp.0705185 . British Journal of Pharmacology

ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve

Santos, D.A.; Salgado, A.I.; Cunha, R.A., 2003. Neuroscience Letters. 225 - 228. 3. 338. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422297&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01419-2 . Neuroscience Letters

Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices

Almeida, C.G.; De Mendonça, A.; Cunha, R.A.; Ribeiro, J.A., 2003. Neuroscience Letters. 127 - 130. 2. 339. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457352&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01478-7 . Neuroscience Letters

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . Neuroscience Letters

Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors

Lopes, L.V.; Rebola, N.; Costenla, A.R.; Halldner, L.; Jacobson, M.A.; Oliveira, C.R.; Richardson, P.J.; et al, 2003. Drug Development Research. 428 - 438. 4. 58. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038388748&partnerID=MN8TOARS . 10.1002/ddr.10188 . Drug Development Research

Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings

Magalhães-Cardoso, M.T.; Pereira, M.F.; Oliveira, L.; Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sá, P., 2003. Journal of Physiology. 399 - 408. 2. 549. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038511040&partnerID=MN8TOARS . Journal of Physiology

Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats

Rebola, N.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; Oliveira, C.R.; Soares-da-Silva, P.; De Mendonça, A.; Cunha, R.A., 2003. European Journal of Neuroscience. 820 - 828. 4. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042819806&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02815.x . European Journal of Neuroscience

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices

Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . Neuroscience

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . published Neuroscience Letters

Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus

Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A., 2003. Brain Research. 49 - 58. 1. 987. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS . 10.1016/S0006-8993(03)03247-5 . Brain Research

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats

Rebola, N.; Sebastião, A.M.; De Mendonca, A.; Oliveira, C.R.; Ribeiro, J.A.; Cunha, R.A., 2003. Journal of Neurophysiology. 1295 - 1303. 2. 90. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042817860&partnerID=MN8TOARS . 10.1152/jn.00896.2002 . Journal of Neurophysiology

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus

Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry

Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition

Lopes, L.V.; Cunha, R.A.; Kull, B.; Fredholm, B.B.; Ribeiro, J.A., 2002. Neuroscience. 319 - 329. 2. 112. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037129938&partnerID=MN8TOARS . 10.1016/S0306-4522(02)00080-5 . Neuroscience

Adenosine A 2A receptors in portal hypertension: Their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits

Villa de Brito, M.T.; Canto, A.; Duarte Correia, J.H.; Cunha, R.A.; Marques, M.C., 2002. British Journal of Pharmacology. 1324 - 1330. 5. 135. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036196797&partnerID=MN8TOARS . British Journal of Pharmacology

Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation

Díaz-Hernández, M.; Fátima Pereira, M.; Pintor, J.; Cunha, R.A.; Ribeiro, J.A.; Miras-Portugal, M.T., 2002. Journal of Pharmacology and Experimental Therapeutics. 441 - 450. 2. 301. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232217&partnerID=MN8TOARS . 10.1124/jpet.301.2.441 . Journal of Pharmacology and Experimental Therapeutics

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices

Cunha, R.A.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A., 2002. Pharmacology and Toxicology. 208 - 213. 4. 90. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251881&partnerID=MN8TOARS . 10.1034/j.1600-0773.2002.900407.x . Pharmacology and Toxicology

Transducing system operated by adenosine A2A receptors to facilitate acetylcholine release in the rat hippocampus

Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2002. European Journal of Pharmacology. 31 - 38. 1. 454. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036843638&partnerID=MN8TOARS . 10.1016/S0014-2999(02)02475-5 . European Journal of Pharmacology

Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors

Cunha, R.A., 2001. Neurochemistry International. 107 - 125. 2. 38. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255227&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00034-6 . Neurochemistry International

Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord

Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International

Age-dependent decrease in adenosine A 1 receptor binding sites in the rat brain: Effect of cis unsaturated free fatty acids

Cunha, R.A.; Dolores Constantino, M.; Fonseca, E.; Ribeiro, J.A., 2001. European Journal of Biochemistry. 2939 - 2947. 10. 268. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034830959&partnerID=MN8TOARS . 10.1046/j.1432-1327.2001.02183.x . European Journal of Biochemistry

Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals

Cunha, R.A., 2001. Neurochemical Research. 979 - 991. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034753234&partnerID=MN8TOARS . 10.1023/A:1012392719601 . Neurochemical Research

Conferenc Paper: ATP releases [3H]GABA from rat hippocampal slices via P2X7 receptor activation.

Köfalvi, Attila; Baranyi M; Vizi ES; Sperlagh, B., 2001. Fundamental and Clinical Pharmacology. 135 - 135. S1. 15. 2001. http://dx.doi.org/10.1046/j.1472-8206.2001.00113.x . 10.1046/j.1472-8206.2001.00113.x . Fundamental and Clinical Pharmacology

Bringing the brain into the test tube: An experiment illustrating the effect of ethanol on nerve terminal viability

Cunha, R.A., 2001. Biochemistry and Molecular Biology Education. 105 - 109. 3. 29. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899059&partnerID=MN8TOARS . 10.1016/S1470-8175(01)00035-2 . Biochemistry and Molecular Biology Education

Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine

Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P., 2001. Epilepsia. 600 - 608. 5. 42. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS . 10.1046/j.1528-1157.2001.43600.x . Epilepsia

Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats

Cunha, R.A.; Almeida, T.; Ribeiro, J.A., 2001. Journal of Neurochemistry. 372 - 382. 2. 76. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035140223&partnerID=MN8TOARS . 10.1046/j.1471-4159.2001.00095.x . Journal of Neurochemistry

Adenosine receptor interactions in the hippocampus

Ribeiro, J.A.; Cunha-Reis, D.; Lopes, L.V.; Coelho, J.E.; Costenla, A.R.; Correia-de-Sá, P.; Cunha, R.A.; De Mendonça, A.; Sebastiao, A.M., 2001. Drug Development Research. 337 - 345. 1-2. 52. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035028567&partnerID=MN8TOARS . 10.1002/ddr.1132 . Drug Development Research

Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens

Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research

Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation

Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics

Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals

Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A., 2000. Brain Research. 50 - 54. 1-2. 879. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02726-8 . Brain Research

Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress

Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R., 2000. Neurochemistry International. 255 - 265. 3. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00113-8 . Neurochemistry International

Cellular Neurophysiology

Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; E. Sylvester Vizi; Sperlagh, B., 2000. Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus. . suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.

GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus

Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience

Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R., 2000. Experimental Eye Research. 577 - 587. 5. 70. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS . 10.1006/exer.1999.0815 . Experimental Eye Research

Conference Paper: Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.

Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; Vizi ES; Sperlágh, B., 2000. The Journal of Physiology. 64 - 65. suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . The Journal of Physiology

Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus

Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A., 2000. Journal of Neurochemistry. 334 - 338. 1. 74. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS . 10.1046/j.1471-4159.2000.0740334.x . Journal of Neurochemistry

ATP as a presynaptic modulator

Cunha, R.A.; Ribeiro, J.A., 2000. Life Sciences. 119 - 137. 2. 68. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034554789&partnerID=MN8TOARS . Life Sciences

Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats

Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A., 2000. British Journal of Pharmacology. 1629 - 1634. 8. 131. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS . British Journal of Pharmacology

Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus

Cunha, R.A.; Almeida, T.; Ribeiro, J.A., 2000. Journal of Biological Chemistry. 37572 - 37581. 48. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS . 10.1074/jbc.M003011200 . Journal of Biological Chemistry

Meeting Report - Biochemical Education at the University Level, Lisbon, Portugal, October 30-31, 1999

Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P., 2000. Biochemistry and Molecular Biology Education. 234 - 237. 4. 28. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS . 10.1016/S1470-8175(00)00008-4 . Biochemistry and Molecular Biology Education

Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: Interaction with presynaptic nicotinic receptors

Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A., 2000. Brain Research. 245 - 250. 2. 877. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02679-2 . Brain Research

Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats

Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A., 2000. Neurochemistry International. 563 - 566. 7. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00164-3 . Neurochemistry International

Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation

Cunha, R.A.; Ribeiro, J.A., 2000. Neuroscience Letters. 127 - 130. 2. 289. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS . 10.1016/S0304-3940(00)01295-7 . Neuroscience Letters

Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release

A. Cunha, R.; Malva, J.O.; Ribeiro, J.A., 2000. FEBS Letters. 159 - 162. 2-3. 469. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS . 10.1016/S0014-5793(00)01272-2 . FEBS Letters

Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals

Cunha, R.A.; Ribeiro, J.A., 2000. Neuropharmacology. 1156 - 1167. 7. 39. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS . 10.1016/S0028-3908(99)00237-3 . Neuropharmacology

Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases

Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A., 1999. Progress in Brain Research. 183 - 192. 120. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS . Progress in Brain Research

Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes

Cunha, R.A.; Ribeiro, J.A., 1999. European Journal of Neuroscience. 2171 - 2174. 6. 11. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS . 10.1046/j.1460-9568.1999.00661.x . European Journal of Neuroscience

Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus

Cunha, R.A.; Malva, J.O.; Ribeiro, J.A., 1999. Molecular Pharmacology. 429 - 433. 2. 56. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS . Molecular Pharmacology

G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., 1999. Naunyn-Schmiedeberg's Archives of Pharmacology. 295 - 302. 4. 359. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS . 10.1007/PL00005355 . Naunyn-Schmiedeberg's Archives of Pharmacology

Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives

Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P., 1999. Journal of Medicinal Chemistry. 2582 - 2587. 14. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS . 10.1021/jm980627g . Journal of Medicinal Chemistry

Conference Paper: The Effect of Nicotine on GABA Release from Rat Hippocampal Slices is Mediated via alpha7-Type Homopentameric Neuronal Nicotinic Acetylcholine Receptors

Köfalvi, Attila; E. Sylvester Vizi; Beáta Sperlágh, 1999. Fundamental and Clinical Pharmacology. S1. 13. 1999. http://dx.doi.org/10.1111/j.1472-8206.1999.tb00383.x . 10.1111/j.1472-8206.1999.tb00383.x . Fundamental and Clinical Pharmacology

Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons

Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 1999. Journal of Neuroscience. 4544 - 4558. 11. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS . Journal of Neuroscience

Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A(2A) receptors in the limbic cortex, but not striatum, of aged rats

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., 1999. Journal of Neurochemistry. 1733 - 1738. 4. 73. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863555&partnerID=MN8TOARS . 10.1046/j.1471-4159.1999.731733.x . Journal of Neurochemistry

ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor responses

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., 1999. European Journal of Pharmacology. 395 - 398. 3. 383. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779092&partnerID=MN8TOARS . 10.1016/S0014-2999(99)00659-7 . European Journal of Pharmacology

Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus

Almeida, T.; Cunha, R.A.; Ribeiro, J.A., 1999. Brain Research. 104 - 111. 1. 826. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS . 10.1016/S0006-8993(99)01267-6 . Brain Research

Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., 1999. Journal of Neurophysiology. 3196 - 3203. 6. 82. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS . Journal of Neurophysiology

Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors

Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A., 1998. Journal of Neuroscience. 1987 - 1995. 6. 18. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS . Journal of Neuroscience

On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)

Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C., 1998. Trends in Neurosciences. 286 - 287. 7. 21. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS . Trends in Neurosciences

ZM241385 is an antagonist of the facilitatory responses produced by the A(2A) adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., 1997. British Journal of Pharmacology. 1279 - 1284. 7. 122. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030734490&partnerID=MN8TOARS . British Journal of Pharmacology

Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., 1997. European Journal of Pharmacology. 167 - 172. 2-3. 323. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030610655&partnerID=MN8TOARS . 10.1016/S0014-2999(97)00043-5 . European Journal of Pharmacology

Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes

Gonçalves, M.L.; Cunha, R.A.; Ribeiro, J.A., 1997. Neuroscience Letters. 73 - 77. 1-2. 238. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031283080&partnerID=MN8TOARS . 10.1016/S0304-3940(97)00803-3 . Neuroscience Letters

Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides

Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A., 1996. British Journal of Pharmacology. 253 - 260. 2. 119. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS . British Journal of Pharmacology

Purinergic regulation of acetylcholine release

Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M., 1996. Progress in Brain Research. 231 - 241. 109. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS . Progress in Brain Research

Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices

Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M., 1996. Journal of Neurochemistry. 2180 - 2187. 5. 67. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS . Journal of Neurochemistry

Purinoceptors and synaptic plasticity

Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M., 1996. Drug Development Research. 353 - 360. 3-4. 39. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS . Drug Development Research

Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors

Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B., 1996. Naunyn-Schmiedeberg's Archives of Pharmacology. 261 - 271. 3. 353. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS . Naunyn-Schmiedeberg's Archives of Pharmacology

A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion

Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M., 1995. Neuroscience Letters. 83 - 86. 2. 185. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS . 10.1016/0304-3940(94)11230-G . Neuroscience Letters

Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus

Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M., 1995. Neuroscience Letters. 41 - 44. 1-2. 196. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS . Neuroscience Letters

Modification of A1 and A(2a) adenosine receptor binding in aged striatum, hippocampus and cortex of the rat

Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A., 1995. NeuroReport. 1583 - 1588. 11. 6. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS . NeuroReport

Evidence for functionally important adenosine A2a receptors in the rat hippocampus

Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B., 1994. Brain Research. 208 - 216. 1-2. 649. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS . Brain Research

Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus

Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M., 1994. Journal of Neurochemistry. 207 - 214. 1. 63. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS . Journal of Neurochemistry

Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus and cerebral cortex of the rat: Role of the ectonucleotidases

Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M., 1994. European Journal of Neuroscience. 33 - 42. 1. 6. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS . 10.1111/j.1460-9568.1994.tb00245.x . European Journal of Neuroscience

Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog

Cunha, R.A.; Sebastiao, A.M., 1993. Pflugers Archiv European Journal of Physiology. 503 - 510. 5-6. 424. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS . Pflugers Archiv European Journal of Physiology

Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., 1992. Journal of Neurochemistry. 657 - 666. 2. 59. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS . 10.1111/j.1471-4159.1992.tb09420.x . Journal of Neurochemistry

Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., 1991. Nucleosides and Nucleotides. 1189 - 1190. 5. 10. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS . Nucleosides and Nucleotides

Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog

Cunha, R.A.; Sebastiao, A.M., 1991. European Journal of Pharmacology. 83 - 92. 1. 197. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829211&partnerID=MN8TOARS . European Journal of Pharmacology

Blockade of AMP degradation allows the quantification of adenine nucleotides released by nerve stimulation in the innervated frog sartorius muscle

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., 1990. European Journal of Pharmacology. 1684 - 1685. 5. 183. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025106547&partnerID=MN8TOARS . 10.1016/0014-2999(90)91979-L . European Journal of Pharmacology

Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography

Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A., 1989. Chromatographia. 610 - 612. 11-12. 28. 1989. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS . 10.1007/BF02260687 . Chromatographia

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