Neuroscience and Disease

Neuromodulation

Adenosine receptors

Ageing

Brain Diseases

Caffeine

Neuroprotection


Research lines

Coffee, caffeine and adenosine receptors controlling synaptic plasticity in brain diseases | Rodrigo A. Cunha & Ângelo R. Tomé

Adenosine A2A receptors as biomarker and triggers of ageing | Rodrigo A. Cunha

Impact of purines on astrocyte-neuron communication and memory | Paula Agostinho

Adenosine receptors in psychiatric disorders and neurodegenerative diseases | Paula Canas & Samira Ferreira

Role of adenosine A2A receptors in fear memory extinction | Ana P. Simões & Paula Canas

Overview

Adequate brain function depends on a balanced excitatory and inhibitory transmission fine-tuned by modulation systems. Inspired by the impact of coffee, which bolsters attention, normalizes mood and increases healthspan on ageing with a striking ability to prevent the onset of different neurodegenerative disorders (Alzheimer’s, Parkinson’s diseases), the aim of the group is to study modulation systems operated by purines (adenosine and ATP), known to be targeted by caffeine, to interfere with the evolution of neurodegenerative diseases. We have identified adenosine A2A receptors (A2AR) as the main targets of caffeine to control of brain disorders, using a combination of pharmacological, genetic and opto-genetic tools. We have established that A2AR are necessary and sufficient to trigger symptoms in different animal models of Alzheimer’s or Parkinson’s diseases, depression, epilepsy or diabetic encephalopathy, through a combined ability to restore synaptic plasticity, control neuroinflammation and bolster the metabolic support by astrocytes.

We have in-house different transgenic mice and pharmacologically-induced models of brain disease, as well as a toolbox to interfere with A2AR (cell-specific transgenic mice and viral mediated systems to bolster or decrease A2AR function) and access to human brain tissue. We follow an holistic approach to scientific questions, integrating our expertise in: i) behavior studies assessing learning and memory, motor performance, mood alterations and fear processing; ii) stereotaxic brain surgery; iii) ex-vivo (brain slices) electrophysiological studies to assess the function of brain circuits (extracellular recordings) and ionic currents (patch-clamp); iv) imaging of functional (live cell Ca2+), morphological (histochemistry) and neurochemical alterations (receptor expression binding and trafficking), combining PCR, radioligands, FRET, proximity ligation assay and Western-blot techniques); v) subcellular fractionation of synaptosomes and gliosomes and use of cell cultures (neurons and astrocytes) to study neurotransmitters release and uptake.
The group has a track record of over 250 publications in high-impact factor journals with more than 12,000 citations and an h-factor of 62, based on numerous worldwide collaborations. The group has a large experience in post-graduate training (over 15 post-doc, 40 PhD and 25 Master students), with research funds obtained from American and European agencies and private corporations and pharma.

Publications

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Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Margarida Beatriz; Rodrigues, Ricardo J.; Rita Vilaça; Conceição Egas; Paulo S. Pinheiro; George Q. Daley; Thorsten M. Schlaeger; et al, 2023. Theranostics. 3707 - 3724. 11. 13. 2023. http://dx.doi.org/10.7150/thno.81981 . 10.7150/thno.81981 . published Theranostics

Targeting corticostriatal transmission for the treatment of cannabinoid use disorder

Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis, 2023. Trends in Pharmacological Sciences. 495 - 506. 8. 44. 2023. http://dx.doi.org/10.1016/j.tips.2023.05.003 . 10.1016/j.tips.2023.05.003 . Trends in Pharmacological Sciences

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Rodrigues, Ricardo J.; Jean-Pierre Oses; et al, 2022. Molecular Neurobiology. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . Molecular Neurobiology

P2Y1 Receptor as a Catalyst of Brain Neurodegeneration

Rodrigues, Ricardo J.; Ana S. Figueira; Joana M. Marques, 2022. NeuroSci. 604 - 615. 3. 2022. https://doi.org/10.3390/neurosci3040043 . 10.3390/neurosci3040043 . published NeuroSci

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

Lígia Fão; Patrícia Coelho; Rodrigues, Ricardo J.; A. Cristina Rego, 2022. Cells. 2022. https://doi.org/10.3390/cells11193063 . 10.3390/cells11193063 . Cells

Adenosine A2A receptors control synaptic remodeling in the adult brain

Rodrigues, Ricardo J.; Joana M Marques, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, 2021. Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . published Science

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.

Rodrigues, Ricardo J.; Joana M Marques, 2021. Cerebral cortex (New York, N.Y. : 1991). 5652 - 5663. 12. 31. 2021. https://doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral cortex (New York, N.Y. : 1991)

Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.

Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology

Control of glutamate release by complexes of adenosine and cannabinoid receptors

Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology

The Yin and Yang of Adenosine Receptors: A Piquant Story

Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain

Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology

Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Rodrigues, Ricardo J.; Sara Xapelli, 2019. Journal of Caffeine and Adenosine Research. 129 - 144. 4. 9. 2019. https://doi.org/10.1089%2Fcaff.2019.0010 . 10.1089/caff.2019.0010 . published Journal of Caffeine and Adenosine Research

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease

Purinergic signalling and brain development.

Rodrigues, Ricardo J.; Joana M Marques; Cunha RA, 2018. Seminars in cell & developmental biology. 34 - 41. 95. 2018. http://europepmc.org/abstract/med/30529149 . 10.1016/j.semcdb.2018.12.001 . published Seminars in cell & developmental biology

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making

Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al, 2018. Cell Death and Disease. 3. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS . 10.1038/s41419-018-0351-1 . published Cell Death and Disease

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro

Boosting brain glucose metabolism to fight neurodegeneration?

de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .

P2 receptors control the migration of medial ganglionic eminence-derived interneurons

Ferreira, S.; Joana M Marques; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, Ricardo J., 2017. Journal of Neurochemistry. 2017. https://publons.com/publon/33584030/ . Journal of Neurochemistry

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al, 2017. Journal of Controlled Release. 58 - 71. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025167046&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.007 . published Journal of Controlled Release

Cannabis: A Treasure Trove or Pandora's Box?

Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS . 10.1016/j.brainresbull.2016.05.009 . published Brain Research Bulletin

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus

Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al, 2016. Neuroscience. 196 - 205. 315. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS . 10.1016/j.neuroscience.2015.12.018 . published Neuroscience

Stimulation of brain glucose uptake by cannabinoid CB<inf>2</inf> receptors and its therapeutic potential in Alzheimer's disease

Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.03.015 . published Neuropharmacology

Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Díaz-Hernández, M.; Joana M Marques; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A., 2016. Neuropharmacology. 241 - 257. 105. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.01.022 . published Neuropharmacology

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. https://doi.org/10.1016/j.neuropharm.2016.03.015 . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. https://doi.org/10.1016/j.brainresbull.2016.05.009 . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2016. 2016. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al, 2016. Molecular Neurobiology. 1552 - 1563. 2. 54. 2016. https://doi.org/10.1007%2Fs12035-016-9774-9 . 10.1007/s12035-016-9774-9 . Molecular Neurobiology

ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J.; Tomé, A.R.; Cunha, R.A., 2015. Frontiers in Neuroscience. APR. 9. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS . 10.3389/fnins.2015.00148 . published Frontiers in Neuroscience

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones, 2015. NMR Biomed.. 1111 - 1116. 9. 28. 2015. http://dx.doi.org/10.1002/nbm.3355 . 10.1002/nbm.3355 . NMR Biomed.

Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology

Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience

Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://dx.doi.org/10.1007/s11302-015-9474-3 . 10.1007/s11302-015-9474-3 . Purinergic Signalling

Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents

Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al, 2015. Neurochemistry International. 2015. http://dx.doi.org/10.1016/j.neuint.2015.07.014 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International

Adenosine A<inf>2b</inf> receptors control A<inf>1</inf> receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Joana M Marques; Rodrigues, Ricardo J.; et al, 2015. European Journal of Neuroscience. 876 - 886. 7. 41. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS . 10.1111/ejn.12851 . published European Journal of Neuroscience

Adenosine A<inf>2B</inf> receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Joana M Marques; Rodrigues, Ricardo J.; Cunha, R.A.; Rial, D.; Köfalvi, A., 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS . 10.1007/s11302-015-9474-3 . published Purinergic Signalling

Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Gonc¸alves, F.Q.; Joana M Marques; Tomé, Â.R.; Rodrigues, Ricardo J.; Nunes-Correia, I.; Ledent, C.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . published British Journal of Pharmacology

Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al, 2014. PLoS ONE. 12. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0114216 . 10.1371/journal.pone.0114216 . PLoS ONE

Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease

Canas, P.M.; Simões, A.P.; Rodrigues, Ricardo J.; Cunha, R.A., 2014. Neuropharmacology. 51 - 56. PART A. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.08.026 . published Neuropharmacology

Synaptic and glia involvement in the purinergic control of neurodegenerative diseases

Canas, Paula M.; Rial, Daniel; Simoes, Ana Patricia; Lopes, Joao Pedro; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al, 2014. Purinergic Signalling. 2014. https://publons.com/publon/8181585/ . Purinergic Signalling

Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum

Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology

Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A., 2013. Brain Research Bulletin. 126 - 135. 97. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS . 10.1016/j.brainresbull.2013.06.007 . Brain Research Bulletin

Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder

Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A., 2013. European Neuropsychopharmacology. 317 - 328. 4. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS . 10.1016/j.euroneuro.2012.04.011 . European Neuropsychopharmacology

CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation

Joana M Marques; Rodrigues, Ricardo J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J., 2013. Journal of Neuroscience. 18298 - 18310. 46. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3136-13.2013 . published Journal of Neuroscience

CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International

Metabotropic signaling by kainate receptors

Rodrigues, Ricardo J.; Lerma, J., 2012. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 399 - 410. 4. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877959298&partnerID=MN8TOARS . 10.1002/wmts.35 . published Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach

Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A., 2012. Journal of Neuroscience Methods. 366 - 373. 2. 204. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS . 10.1016/j.jneumeth.2011.11.028 . Journal of Neuroscience Methods

Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences

Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International

Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat

Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B., 2012. Neuropharmacology. 784 - 797. 5. 63. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS . 10.1016/j.neuropharm.2012.06.003 . Neuropharmacology

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum

Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology

Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission

Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina

Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research

Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging

De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain

Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, Ricardo J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . published European Journal of Neuroscience

ATP (P2X1-3) AND alpha 3 beta 2 NICOTINIC ACETYLCHOLINE RECEPTORS INTERACT PHYSICALLY AND FUNCTIONALLY IN HIPPOCAMPAL TERMINALS

Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco, 2009. Journal of Physiological Sciences. 2009. https://publons.com/publon/8181593/ . Journal of Physiological Sciences

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, Ricardo J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . published Neurobiology of Aging

N-acyldopamines control striatal input terminals via novel ligand-gated cation channels

Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging

Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum

Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats

Rodrigues, Ricardo J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . accepted Neurobiology of Aging

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx

Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . published Cell Calcium

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells

Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . published Pancreas

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, Ricardo J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . published Journal of Neurochemistry

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry

Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology

Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Oses, J.P.; Rodrigues, Ricardo J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . published Neuroscience

Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))

Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Ciruela, F.; Casadó, V.; Rodrigues, Ricardo J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . published Journal of Neuroscience

Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals

Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters

Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . published Journal of Molecular Neuroscience

Regulation of neurotransmitter release by presynaptic P2X receptors

Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, Ricardo J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . published Molecular Pharmacology

TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

Pereira, D.B.; Rebola, N.; Rodrigues, Ricardo J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . published Journal of Neuroscience Research

Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin

Joana M Marques; Rodrigues, Ricardo J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T., 2006. Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS . 10.1074/jbc.M603753200 . published Journal of Biological Chemistry

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neuroscience. 6286 - 6295. 27. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844443354&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0628-05.2005 . published Journal of Neuroscience

Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons

Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neurochemistry International. 317 - 325. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044454590&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.009 . published Neurochemistry International

Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia

Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis

Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis

Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . published Journal of Neuroscience

Purinergic control of GABA release

Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA, 2005. Journal of Neurochemistry. 2005. https://publons.com/publon/27547643/ . Journal of Neurochemistry

Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses

Pinheiro, P.S.; Rodrigues, Ricardo J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., 2005. Neurochemistry International. 309 - 316. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.007 . published Neurochemistry International

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

Rebola, N.; Rodrigues, Ricardo J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . published Neuroscience

Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum

Rodrigues, Ricardo J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neurochemistry. 433 - 441. 3. 92. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244264871&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02887.x . published Journal of Neurochemistry

Release and neuromodulatory role of ATP in hippocampal synapses

Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181529/ . Fundamental & Clinical Pharmacology

P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices

Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics

Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum

Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181569/ . Fundamental & Clinical Pharmacology

Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action

Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices

Almeida, T.; Rodrigues, Ricardo J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . published Neuroscience

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . published Neuroscience Letters

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus

Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry

Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord

Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International

Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens

Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research

Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation

Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics

GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus

Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience

Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons

Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 1999. Journal of Neuroscience. 4544 - 4558. 11. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS . Journal of Neuroscience

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