Overview
Adequate brain function depends on a balanced excitatory and inhibitory transmission fine-tuned by modulation systems. Inspired by the impact of coffee, which bolsters attention, normalizes mood and increases healthspan on ageing with a striking ability to prevent the onset of different neurodegenerative disorders (Alzheimer’s, Parkinson’s diseases), the aim of the group is to study modulation systems operated by purines (adenosine and ATP), known to be targeted by caffeine, to interfere with the evolution of neurodegenerative diseases. We have identified adenosine A2A receptors (A2AR) as the main targets of caffeine to control of brain disorders, using a combination of pharmacological, genetic and opto-genetic tools. We have established that A2AR are necessary and sufficient to trigger symptoms in different animal models of Alzheimer’s or Parkinson’s diseases, depression, epilepsy or diabetic encephalopathy, through a combined ability to restore synaptic plasticity, control neuroinflammation and bolster the metabolic support by astrocytes.
We have in-house different transgenic mice and pharmacologically-induced models of brain disease, as well as a toolbox to interfere with A2AR (cell-specific transgenic mice and viral mediated systems to bolster or decrease A2AR function) and access to human brain tissue. We follow an holistic approach to scientific questions, integrating our expertise in: i) behavior studies assessing learning and memory, motor performance, mood alterations and fear processing; ii) stereotaxic brain surgery; iii) ex-vivo (brain slices) electrophysiological studies to assess the function of brain circuits (extracellular recordings) and ionic currents (patch-clamp); iv) imaging of functional (live cell Ca2+), morphological (histochemistry) and neurochemical alterations (receptor expression binding and trafficking), combining PCR, radioligands, FRET, proximity ligation assay and Western-blot techniques); v) subcellular fractionation of synaptosomes and gliosomes and use of cell cultures (neurons and astrocytes) to study neurotransmitters release and uptake.
The group has a track record of over 250 publications in high-impact factor journals with more than 12,000 citations and an h-factor of 62, based on numerous worldwide collaborations. The group has a large experience in post-graduate training (over 15 post-doc, 40 PhD and 25 Master students), with research funds obtained from American and European agencies and private corporations and pharma.
Publications
Information about journal articles, updated at 25-07-2021, from platform CIÊNCIAVITAE.
Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.
Rodrigues, Ricardo J., 2021. Cerebral cortex (New York, N.Y. : 1991). 2021. https://doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . Cerebral cortex (New York, N.Y. : 1991)
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 Diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology
The Yin and Yang of Adenosine Receptors: A Piquant Story
Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism
Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology
Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders
Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Ricardo J. Rodrigues; Sara Xapelli, 2019. Journal of Caffeine and Adenosine Research. 129 - 144. 4. 9. 2019. https://doi.org/10.1089%2Fcaff.2019.0010 . 10.1089/caff.2019.0010 . Journal of Caffeine and Adenosine Research
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation
Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al, 2018. Cell Death and Disease. 3. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS . 10.1038/s41419-018-0351-1 . Cell Death and Disease
Purinergic signalling and brain development.
Rodrigues RJ; Marques JM; Cunha RA, 2018. Seminars in cell & developmental biology. 2018. http://europepmc.org/abstract/med/30529149 . 10.1016/j.semcdb.2018.12.001 . Seminars in cell & developmental biology
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro
Cannabis: A Treasure Trove or Pandora's Box?
Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry
Boosting brain glucose metabolism to fight neurodegeneration?
de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential
Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al, 2017. Journal of Controlled Release. 58 - 71. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025167046&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.007 . Journal of Controlled Release
P2 receptors control the migration of medial ganglionic eminence-derived interneurons
Ferreira, S.; Marques, J. M.; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, R. J., 2017. Journal of Neurochemistry. 2017. https://publons.com/publon/33584030/ . Journal of Neurochemistry
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin
High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus
Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al, 2016. Neuroscience. 196 - 205. 315. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS . 10.1016/j.neuroscience.2015.12.018 . Neuroscience
Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses
Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al, 2016. Molecular Neurobiology. 1552 - 1563. 2. 54. 2016. https://doi.org/10.1007%2Fs12035-016-9774-9 . 10.1007/s12035-016-9774-9 . Molecular Neurobiology
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2016. 2016. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .
Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus
Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A., 2016. Neuropharmacology. 241 - 257. 105. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.01.022 . Neuropharmacology
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. https://doi.org/10.1016/j.brainresbull.2016.05.009 . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease
Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. https://doi.org/10.1016/j.neuropharm.2016.03.015 . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology
Stimulation of brain glucose uptake by cannabinoid CB<inf>2</inf> receptors and its therapeutic potential in Alzheimer's disease
Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology
Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain
Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://dx.doi.org/10.1007/s11302-015-9474-3 . 10.1007/s11302-015-9474-3 . Purinergic Signalling
Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus
Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience
Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology
Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents
Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al, 2015. Neurochemistry International. 2015. http://dx.doi.org/10.1016/j.neuint.2015.07.014 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International
ATP as a multi-target danger signal in the brain
Rodrigues, R.J.; Tomé, A.R.; Cunha, R.A., 2015. Frontiers in Neuroscience. APR. 9. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS . 10.3389/fnins.2015.00148 . Frontiers in Neuroscience
Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Ferreira, S.G.; Gonc¸alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology
Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices
Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones, 2015. NMR Biomed.. 1111 - 1116. 9. 28. 2015. http://dx.doi.org/10.1002/nbm.3355 . 10.1002/nbm.3355 . NMR Biomed.
Adenosine A<inf>2b</inf> receptors control A<inf>1</inf> receptor-mediated inhibition of synaptic transmission in the mouse hippocampus
Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 876 - 886. 7. 41. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience
Adenosine A<inf>2B</inf> receptor activation stimulates glucose uptake in the mouse forebrain
Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Marques, J.M.; Rodrigues, R.J.; Cunha, R.A.; Rial, D.; Köfalvi, A., 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS . 10.1007/s11302-015-9474-3 . Purinergic Signalling
Synaptic and glia involvement in the purinergic control of neurodegenerative diseases
Canas, Paula M.; Rial, Daniel; Simoes, Ana Patricia; Lopes, Joao Pedro; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al, 2014. Purinergic Signalling. 2014. https://publons.com/publon/8181585/ . Purinergic Signalling
Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease
Canas, P.M.; Simões, A.P.; Rodrigues, R.J.; Cunha, R.A., 2014. Neuropharmacology. 51 - 56. PART A. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.08.026 . Neuropharmacology
Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al, 2014. PLoS ONE. 12. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0114216 . 10.1371/journal.pone.0114216 . PLoS ONE
Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder
Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A., 2013. European Neuropsychopharmacology. 317 - 328. 4. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS . 10.1016/j.euroneuro.2012.04.011 . European Neuropsychopharmacology
Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum
Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology
Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain
Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A., 2013. Brain Research Bulletin. 126 - 135. 97. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS . 10.1016/j.brainresbull.2013.06.007 . Brain Research Bulletin
CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation
Marques, J.M.; Rodrigues, R.J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J., 2013. Journal of Neuroscience. 18298 - 18310. 46. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3136-13.2013 . Journal of Neuroscience
Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat
Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B., 2012. Neuropharmacology. 784 - 797. 5. 63. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS . 10.1016/j.neuropharm.2012.06.003 . Neuropharmacology
Metabotropic signaling by kainate receptors
Rodrigues, R.J.; Lerma, J., 2012. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 399 - 410. 4. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877959298&partnerID=MN8TOARS . 10.1002/wmts.35 . Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences
Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International
Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach
Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A., 2012. Journal of Neuroscience Methods. 366 - 373. 2. 204. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS . 10.1016/j.jneumeth.2011.11.028 . Journal of Neuroscience Methods
CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus
Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International
Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology
Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry
Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing
Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . European Journal of Neuroscience
Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina
Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain
Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging
De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum
Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience
ATP (P2X1-3) AND alpha 3 beta 2 NICOTINIC ACETYLCHOLINE RECEPTORS INTERACT PHYSICALLY AND FUNCTIONALLY IN HIPPOCAMPAL TERMINALS
Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco, 2009. Journal of Physiological Sciences. 2009. https://publons.com/publon/8181593/ . Journal of Physiological Sciences
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats
Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . Neurobiology of Aging
Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells
Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . Pancreas
GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx
Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . Cell Calcium
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . Neuroscience
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . Journal of Neuroscience
Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus
Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . Journal of Molecular Neuroscience
Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience
TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus
Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . Journal of Neuroscience Research
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters
Regulation of neurotransmitter release by presynaptic P2X receptors
Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology
Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin
Marques, J.M.; Rodrigues, R.J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T., 2006. Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS . 10.1074/jbc.M603753200 . Journal of Biological Chemistry
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
Purinergic control of GABA release
Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA, 2005. Journal of Neurochemistry. 2005. https://publons.com/publon/27547643/ . Journal of Neurochemistry
Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
Rodrigues, R.J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neurochemistry. 433 - 441. 3. 92. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244264871&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02887.x . Journal of Neurochemistry
Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons
Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neurochemistry International. 317 - 325. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044454590&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.009 . Neurochemistry International
Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia
Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience
Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus
Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . Neuroscience
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience
Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses
Pinheiro, P.S.; Rodrigues, R.J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., 2005. Neurochemistry International. 309 - 316. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.007 . Neurochemistry International
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus
Rodrigues, R.J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neuroscience. 6286 - 6295. 27. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844443354&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0628-05.2005 . Journal of Neuroscience
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices
Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics
Release and neuromodulatory role of ATP in hippocampal synapses
Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181529/ . Fundamental & Clinical Pharmacology
Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum
Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181569/ . Fundamental & Clinical Pharmacology
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices
Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . Neuroscience
Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus
Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . Neuroscience Letters
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action
Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry
Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens
Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research
Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord
Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International
Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation
Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 1999. Journal of Neuroscience. 4544 - 4558. 11. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS . Journal of Neuroscience
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