Rodrigo A. Cunha

Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, Glia. 2023. https://doi.org/10.1002/glia.24384 . 10.1002/glia.24384 . Glia

Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors

Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, Cellular and Molecular Life Sciences. 2023. https://doi.org/10.1007/s00018-023-04983-6 . 10.1007/s00018-023-04983-6 . Cellular and Molecular Life Sciences

The striatum drives the ergogenic effects of caffeine

Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al, Purinergic Signalling. 2023. https://doi.org/10.1007/s11302-023-09922-5 . 10.1007/s11302-023-09922-5 . Purinergic Signalling

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al, ACS Chemical Neuroscience. 1299 - 1309. 7. 14. 2023. http://dx.doi.org/10.1021/acschemneuro.2c00810 . 10.1021/acschemneuro.2c00810 . published ACS Chemical Neuroscience

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula

Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al, Nature Communications. 1. 14. 2023. http://dx.doi.org/10.1038/s41467-023-37601-x . 10.1038/s41467-023-37601-x . published Nature Communications

Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13040715 . 10.3390/biom13040715 . Biomolecules

Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals

Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R., Purinergic Signalling. 2023. http://dx.doi.org/10.1007/s11302-023-09937-y . 10.1007/s11302-023-09937-y . accepted Purinergic Signalling

Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices

Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R., Neuroscience Letters. 808. 2023. http://dx.doi.org/10.1016/j.neulet.2023.137292 . 10.1016/j.neulet.2023.137292 . published Neuroscience Letters

Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest

Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al, Frontiers in Behavioral Neuroscience. 17. 2023. http://dx.doi.org/10.3389/fnbeh.2023.1176382 . 10.3389/fnbeh.2023.1176382 . published Frontiers in Behavioral Neuroscience

Adenosine A2A receptors control generalization of contextual fear in rats

Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al, Translational Psychiatry. 1. 13. 2023. http://dx.doi.org/10.1038/s41398-023-02613-0 . 10.1038/s41398-023-02613-0 . published Translational Psychiatry

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al, International Journal of Molecular Sciences. 8. 24. 2023. http://dx.doi.org/10.3390/ijms24086968 . 10.3390/ijms24086968 . published International Journal of Molecular Sciences

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease

Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13081173 . 10.3390/biom13081173 . Biomolecules

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha, International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232112826 . 10.3390/ijms232112826 . International Journal of Molecular Sciences

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update

IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A., Pharmacological Reviews. 340 - 372. 2. 74. 2022. http://dx.doi.org/10.1124/pharmrev.121.000445 . 10.1124/pharmrev.121.000445 . published Pharmacological Reviews

Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease

Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A., Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.835885 . 10.3389/fnagi.2022.835885 . published Frontiers in Aging Neuroscience

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure

Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, Journal of Neurochemistry. 2022. https://doi.org/10.1111/jnc.15575 . 10.1111/jnc.15575 . Journal of Neurochemistry

The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine

Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al, Pharmaceuticals. 2022. https://doi.org/10.3390/ph15111323 . 10.3390/ph15111323 . Pharmaceuticals

Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes

Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho, Cellular and Molecular Life Sciences. 2022. https://doi.org/10.1007/s00018-022-04492-y . 10.1007/s00018-022-04492-y . Cellular and Molecular Life Sciences

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage

Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes, International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231810510 . 10.3390/ijms231810510 . International Journal of Molecular Sciences

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al, Molecular Neurobiology. 1659 - 1674. 3. 60. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . accepted Molecular Neurobiology

Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al, Journal of Clinical Investigation. 12. 132. 2022. http://dx.doi.org/10.1172/jci149371 . 10.1172/jci149371 . published Journal of Clinical Investigation

Adenosine A2A receptors control synaptic remodeling in the adult brain

Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al, Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports

Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al, Journal of Clinical Investigation. 22. 132. 2022. http://dx.doi.org/10.1172/jci152924 . 10.1172/jci152924 . published Journal of Clinical Investigation

Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes

Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas, Purinergic Signalling. 2022. https://doi.org/10.1007/s11302-022-09864-4 . 10.1007/s11302-022-09864-4 . Purinergic Signalling

Deletion of CD73 increases exercise power in mice

Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A., Purinergic Signalling. 393 - 397. 3. 17. 2021. http://dx.doi.org/10.1007/s11302-021-09797-4 . 10.1007/s11302-021-09797-4 . published Purinergic Signalling

l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al, The FASEB Journal. 8. 35. 2021. https://doi.org/10.1096/fj.202100336R . 10.1096/fj.202100336R . The FASEB Journal

Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides

Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-021-02538-z . 10.1007/s12035-021-02538-z . Molecular Neurobiology

Exercise decreases aberrant corticostriatal plasticity in an animal model of <scp>l</scp>-DOPA-induced dyskinesia

Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. R541 - R546. 4. 320. 2021. http://dx.doi.org/10.1152/ajpregu.00295.2020 . 10.1152/ajpregu.00295.2020 . published American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . Science

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A., Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.639322 . 10.3389/fncel.2021.639322 . published Frontiers in Cellular Neuroscience

Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape

Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa, Frontiers in Cellular and Infection Microbiology. 11. 2021. http://dx.doi.org/10.3389/fcimb.2021.678568 . 10.3389/fcimb.2021.678568 . Frontiers in Cellular and Infection Microbiology

Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al, Neurobiology of Disease. 157. 2021. http://dx.doi.org/10.1016/j.nbd.2021.105441 . 10.1016/j.nbd.2021.105441 . published Neurobiology of Disease

Use of knockout mice to explore CNS effects of adenosine

Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M., Biochemical Pharmacology. 187. 2021. http://dx.doi.org/10.1016/j.bcp.2020.114367 . 10.1016/j.bcp.2020.114367 . published Biochemical Pharmacology

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A. A.; Porciúncula, Lisiane O.; et al, Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-89964-0 . 10.1038/s41598-021-89964-0 . Scientific Reports

Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease

Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula, Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.666710 . 10.3389/fnins.2021.666710 . Frontiers in Neuroscience

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Binge-Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood

Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al, Alcoholism: Clinical and Experimental Research. 56 - 63. 1. 45. 2021. https://doi.org/10.1111/acer.14501 . 10.1111/acer.14501 . Alcoholism: Clinical and Experimental Research

Clustering of adenosine A_2Breceptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by<i>Leishmania amazonensis</i>

Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al, The FASEB Journal. 5. 35. 2021. http://dx.doi.org/10.1096/fj.202002396rr . 10.1096/fj.202002396rr . published The FASEB Journal

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation

Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al, Cerebral Cortex. 5652 - 5663. 12. 31. 2021. http://dx.doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral Cortex

Adenosine A2A Receptors as Biomarkers of Brain Diseases

Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A., Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.702581 . 10.3389/fnins.2021.702581 . Frontiers in Neuroscience

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi, European Journal of Neuroscience. 2020. https://doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience

The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease

Cunha, Rodrigo, Purinergic Signalling. 2020. http://dx.doi.org/10.1007/s11302-020-09694-2 . 10.1007/s11302-020-09694-2 . Purinergic Signalling

Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities

Cunha, Rodrigo, European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . European Journal of Neuroscience

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Neurobiology of Disease. 105137 - 105137. 146. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of Disease

Control of glutamate release by complexes of adenosine and cannabinoid receptors

Cunha, Rodrigo, BMC Biology. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology

Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder

de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly, Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo, Neuroscience. 140 - 148. 448. 2020. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030 . 10.1016/j.neuroscience.2020.09.030 . published Neuroscience

Purinergic signaling orchestrating neuron-glia communication

Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M., Pharmacological Research. 162. 2020. http://dx.doi.org/10.1016/j.phrs.2020.105253 . 10.1016/j.phrs.2020.105253 . published Pharmacological Research

Control of NMDA Receptor-Mediated Currents by Adenosine A₁ and A_2A Receptors Within the Basolateral Amygdala

Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G., Journal of Caffeine and Adenosine Research. 61 - 70. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0024 . 10.1089/caff.2019.0024 . published Journal of Caffeine and Adenosine Research

Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder

França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al, Molecular Neurobiology. 3902 - 3919. 9. 57. 2020. http://dx.doi.org/10.1007/s12035-020-02002-4 . 10.1007/s12035-020-02002-4 . published Molecular Neurobiology

ATP Signaling Controlling Dyskinesia Through P2X7 Receptors

Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M., Frontiers in Molecular Neuroscience. 13. 2020. http://dx.doi.org/10.3389/fnmol.2020.00111 . 10.3389/fnmol.2020.00111 . published Frontiers in Molecular Neuroscience

Role of Adenosine in Epilepsy and Seizures

Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha, Rodrigo A.; Ana M. Sebastião; Boison, Detlev, Journal of Caffeine and Adenosine Research. 45 - 60. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0022 . 10.1089/caff.2019.0022 . Journal of Caffeine and Adenosine Research

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . published Brain Research Bulletin

Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice

Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger; Fernandes, Pedro Augusto; et al, NeuroToxicology. 144 - 154. 80. 2020. http://dx.doi.org/10.1016/j.neuro.2020.07.008 . 10.1016/j.neuro.2020.07.008 . NeuroToxicology

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig, Astrid; Cunha, Rodrigo, Nutrients. 10. 12. 2020. http://dx.doi.org/10.3390/nu12103141 . 10.3390/nu12103141 . published Nutrients

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Cunha, Rodrigo, Glia. 2019. http://dx.doi.org/10.1002/glia.23476 . 10.1002/glia.23476 . Glia

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Cunha, Rodrigo, Frontiers in Neuroscience. 2019. http://dx.doi.org/10.3389/fnins.2018.01015 . 10.3389/fnins.2018.01015 . Frontiers in Neuroscience

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A. Cunha; Francisco Ciruela, Journal of Neurochemistry. 796 - 809. 6. 148. 2019. https://doi.org/10.1111/jnc.14653 . 10.1111/jnc.14653 . Journal of Neurochemistry

Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice

Cunha, Rodrigo, Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1278-3 . 10.1007/s12035-018-1278-3 . Molecular Neurobiology

Signaling by adenosine receptors—Homeostatic or allostatic control?

Rodrigo A. Cunha, PLOS Biology. e3000213 - e3000213. 4. 17. 2019. https://doi.org/10.1371/journal.pbio.3000213 . 10.1371/journal.pbio.3000213 . PLOS Biology

Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors

Cunha, Rodrigo, Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1296-1 . 10.1007/s12035-018-1296-1 . Molecular Neurobiology

What is the extracellular calcium concentration within brain synapses?

João Pedro Lopes; Rodrigo A. Cunha, Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry

G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum

Cunha, Rodrigo, Neural Regeneration Research. 2019. http://dx.doi.org/10.4103/1673-5374.259610 . 10.4103/1673-5374.259610 . Neural Regeneration Research

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve

Cunha, Rodrigo, Molecules. 2019. http://dx.doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease

Cunha, Rodrigo, British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14771 . 10.1111/bph.14771 . British Journal of Pharmacology

Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus

Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas, Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14816 . 10.1111/jnc.14816 . Journal of Neurochemistry

Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Rodrigo A Cunha, Brain. 2019. https://doi.org/10.1093/brain/awz335 . 10.1093/brain/awz335 . Brain

Purinergic signalling and brain development

Cunha, Rodrigo, Seminars in Cell & Developmental Biology. 2019. http://dx.doi.org/10.1016/j.semcdb.2018.12.001 . 10.1016/j.semcdb.2018.12.001 . Seminars in Cell & Developmental Biology

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Cunha, Rodrigo, Neurobiology of Disease. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder

Cunha, Rodrigo, European Journal of Neuroscience. 2019. http://dx.doi.org/10.1111/ejn.14348 . 10.1111/ejn.14348 . European Journal of Neuroscience

Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats

Cunha, Rodrigo, Frontiers in Neuroscience. 2018. http://dx.doi.org/10.3389/fnins.2018.00653 . 10.3389/fnins.2018.00653 . Frontiers in Neuroscience

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M. Canas; et al, Neurobiology of Disease. 72 - 81. 117. 2018. https://doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats

Cunha, Rodrigo, Behavioural Brain Research. 2018. http://dx.doi.org/10.1016/j.bbr.2018.05.007 . 10.1016/j.bbr.2018.05.007 . Behavioural Brain Research

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

Cunha, Rodrigo, Molecular Psychiatry. 2018. http://dx.doi.org/10.1038/s41380-018-0110-9 . 10.1038/s41380-018-0110-9 . Molecular Psychiatry

Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex

Cunha, Rodrigo, European Journal of Neuroscience. 2018. http://dx.doi.org/10.1111/ejn.13912 . 10.1111/ejn.13912 . European Journal of Neuroscience

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

Cunha, Rodrigo, Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2017.00899 . 10.3389/fphar.2017.00899 . Frontiers in Pharmacology

Chronic coffee consumption and respiratory disease: A systematic review

Cunha, Rodrigo, The Clinical Respiratory Journal. 2018. http://dx.doi.org/10.1111/crj.12662 . 10.1111/crj.12662 . The Clinical Respiratory Journal

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

Cunha, Rodrigo, Cell Death & Disease. 2018. http://dx.doi.org/10.1038/s41419-018-0351-1 . 10.1038/s41419-018-0351-1 . Cell Death & Disease

Distinct sensitivity to caffeine-induced insomnia related to age

Cunha, Rodrigo, Journal of Psychopharmacology. 2018. http://dx.doi.org/10.1177/0269881117722997 . 10.1177/0269881117722997 . Journal of Psychopharmacology

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Cunha, Rodrigo, Human Molecular Genetics. 2018. http://dx.doi.org/10.1093/hmg/ddy264 . 10.1093/hmg/ddy264 . Human Molecular Genetics

Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex

Cunha, Rodrigo, Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00133 . 10.3389/fphar.2018.00133 . Frontiers in Pharmacology

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Cunha, Rodrigo, eneuro. 2018. http://dx.doi.org/10.1523/eneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro

Elevated Pressure Changes the Purinergic System of Microglial Cells

Cunha, Rodrigo, Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00016 . 10.3389/fphar.2018.00016 . Frontiers in Pharmacology

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice

Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha, Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-29050-0 . 10.1038/s41598-018-29050-0 . Scientific Reports

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making

Cunha, Rodrigo, Frontiers in Molecular Neuroscience. 2018. http://dx.doi.org/10.3389/fnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience

Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice

Cunha, Rodrigo, Journal of Caffeine and Adenosine Research. 2018. http://dx.doi.org/10.1089/caff.2018.0016 . 10.1089/caff.2018.0016 . Journal of Caffeine and Adenosine Research

Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.

Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al, 2017. http://europepmc.org/abstract/med/26534909 . 10.1093/cercor/bhv268 .

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F, 2017. http://europepmc.org/abstract/med/28007645 . 10.1016/j.neulet.2016.12.040 .

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2017. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L, 2017. http://europepmc.org/abstract/med/28032667 . 10.1002/ana.24867 .

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al, 2017. http://europepmc.org/abstract/med/26860412 . 10.1007/s12035-016-9774-9 .

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aß1-40) administration in mice.

Santos VV; Stark R; Rial D; Silva HB; Bayliss JA; Lemus MB; Davies JS; et al, 2017. http://europepmc.org/abstract/med/28380673 . 10.1111/jne.12476 .

Brain Membrane Fractionation: An <em>Ex Vivo </em>Approach to Assess Subsynaptic Protein Localization

Cunha, Rodrigo, Journal of Visualized Experiments. 2017. http://dx.doi.org/10.3791/55661 . 10.3791/55661 . Journal of Visualized Experiments

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al, Molecular Psychiatry. 1035 - 1043. 7. 22. 2017. https://doi.org/10.1038/mp.2016.173 . 10.1038/mp.2016.173 . Molecular Psychiatry

Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages

Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro, Pulmonary Pharmacology & Therapeutics. 90 - 94. 45. 2017. https://doi.org/10.1016/j.pupt.2017.04.009 . 10.1016/j.pupt.2017.04.009 . Pulmonary Pharmacology & Therapeutics

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Cunha, Rodrigo, Journal of Controlled Release. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.07.007 . 10.1016/j.jconrel.2017.07.007 . Journal of Controlled Release

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease

Cunha, Rodrigo, Journal of Alzheimer's Disease. 2017. http://doi.org/10.3233/JAD-170356 . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

Cunha, Rodrigo, Scientific Reports. 2017. http://dx.doi.org/10.1038/s41598-017-10147-x . 10.1038/s41598-017-10147-x . Scientific Reports

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

Cunha, Rodrigo, Cell Death & Disease. 2017. http://dx.doi.org/10.1038/cddis.2017.451 . 10.1038/cddis.2017.451 . Cell Death & Disease

Age-Related Changes in the Synaptic Density of Amyloid-ß Protein Precursor and Secretases in the Human Cerebral Cortex.

Pliássova A; Canas PM; Xavier AC; da Silva BS; Cunha RA; Agostinho P, 2016. http://europepmc.org/abstract/med/27104908 . 10.3233/jad-160213 .

Selective A(2A) receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury

Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrosio, Antonio Francisco; Santiago, Ana Raquel, Translational Research. 112 - 128. 169. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370392700010&KeyUID=WOS:000370392700010 . 10.1016/j.trsl.2015.11.005 . Translational Research

HIGH SUCROSE CONSUMPTION INDUCES MEMORY IMPAIRMENT IN RATS ASSOCIATED WITH ELECTROPHYSIOLOGICAL MODIFICATIONS BUT NOT WITH METABOLIC CHANGES IN THE HIPPOCAMPUS

Lemos, C.; Rial, D.; Goncalves, F. Q.; Pires, J.; Silva, H. B.; Matheus, F. C.; Da Silva, A. C.; et al, Neuroscience. 196 - 205. 315. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368312700015&KeyUID=WOS:000368312700015 . 10.1016/j.neuroscience.2015.12.018 . Neuroscience

Depression as a Glial-Based Synaptic Dysfunction

Rial, Daniel; Lemos, Cristina; Pinheiro, Helena; Duarte, Joana M.; Goncalves, Francisco Q.; Real, Joana I.; Prediger, Rui D.; et al, Frontiers in Cellular Neuroscience. 9. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368534000001&KeyUID=WOS:000368534000001 . 10.3389/fncel.2015.00521 . Frontiers in Cellular Neuroscience

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats

Matheus, Filipe C.; Rial, Daniel; Real, Joana I.; Lemos, Cristina; Ben, Juliana; Guaita, Gisele O.; Pita, Ines R.; et al, Behavioural Brain Research. 43 - 54. 301. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370108600006&KeyUID=WOS:000370108600006 . 10.1016/j.bbr.2015.12.011 . Behavioural Brain Research

Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

Ardais, Ana Paula; Rocha, Andreia S.; Borges, Mauricio Felisberto; Fioreze, Gabriela T.; Sallaberry, Cassia; Mioranzza, Sabrina; Nunes, Fernanda; et al, Behavioural Brain Research. 76 - 84. 303. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372688900010&KeyUID=CCC:000372688900010 . Behavioural Brain Research

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

Viana da Silva S; Haberl MG; Zhang P; Bethge P; Lemos C; Gonçalves N; Gorlewicz A; et al, 2016. http://europepmc.org/abstract/med/27312972 . 10.1038/ncomms11915 .

Characterization of extracellular nucleotide metabolism in Candida albicans.

Rodrigues L; Russo-Abrahão T; Cunha RA; Gonçalves T; Meyer-Fernandes JR, 2016. http://europepmc.org/abstract/med/26538575 . 10.1093/femsle/fnv212 .

Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices

João M. N. Duarte; Rodrigo A. Cunha; Rui A. Carvalho, Journal of Neurochemistry. 947 - 957. 5. 136. 2016. https://doi.org/10.1111%2Fjnc.13512 . 10.1111/jnc.13512 . Journal of Neurochemistry

Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.

Ardais AP; Rocha AS; Borges MF; Fioreze GT; Sallaberry C; Mioranzza S; Nunes F; et al, 2016. http://europepmc.org/abstract/med/26774980 . 10.1016/j.bbr.2016.01.026 .

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.

George J; Cunha RA; Mulle C; Amédée T, 2016. http://europepmc.org/abstract/med/27199162 . 10.1111/ejn.13191 .

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.

Moidunny S; Matos M; Wesseling E; Banerjee S; Volsky DJ; Cunha RA; Agostinho P; Boddeke HW; Roy S, 2016. http://europepmc.org/abstract/med/27287400 . 10.1186/s12974-016-0613-8 .

Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

Rodrigues RJ; Almeida T; Díaz-Hernández M; Marques JM; Franco R; Solsona C; Miras-Portugal MT; Ciruela F; Cunha RA, 2016. http://europepmc.org/abstract/med/26801076 . 10.1016/j.neuropharm.2016.01.022 .

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Pinheiro BS; Lemos C; Neutzling Kaufmann F; Marques JM; da Silva-Santos CS; Carvalho E; Mackie K; et al, 2016. http://europepmc.org/abstract/med/27208730 . 10.1016/j.brainresbull.2016.05.009 .

Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.

Matheus FC; Rial D; Real JI; Lemos C; Takahashi RN; Bertoglio LJ; Cunha RA; Prediger RD, 2016. http://europepmc.org/abstract/med/26164273 . 10.1007/s12035-015-9330-z .

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP, 2016. http://europepmc.org/abstract/med/27848069 .

Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.

Harmatz ES; Stone L; Lim SH; Lee G; McGrath A; Gisabella B; Peng X; et al, 2016. http://europepmc.org/abstract/med/28010876 . 10.1016/j.biopsych.2016.11.009 .

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Köfalvi A; Lemos C; Martín-Moreno AM; Pinheiro BS; García-García L; Pozo MA; Valério-Fernandes Â; et al, 2016. http://europepmc.org/abstract/med/26976670 . 10.1016/j.neuropharm.2016.03.015 .

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

Ana Patrícia Simões; Nuno J Machado; Nélio Gonçalves; Manuella P Kaster; Ana T Simões; Ana Nunes; Luís Pereira de Almeida; et al, Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. https://doi.org/10.1038/npp.2016.98 . 10.1038/npp.2016.98 . Neuropsychopharmacology

How does adenosine control neuronal dysfunction and neurodegeneration?

Rodrigo A. Cunha, Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13724 . 10.1111/jnc.13724 . Journal of Neurochemistry

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.

Rodrigues L; Miranda IM; Andrade GM; Mota M; Cortes L; Rodrigues AG; Cunha RA; Gonçalves T, 2016. http://europepmc.org/abstract/med/27590517 . 10.18632/oncotarget.11760 .

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system

Lopes, Joao P.; Morato, Xavier; Souza, Carolina; Pinhal, Cindy; Machado, Nuno J.; Canas, Paula M.; Silva, Henrique B.; et al, Journal of Neurochemistry. 135 - 146. 1. 134. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356368800014&KeyUID=WOS:000356368800014 . 10.1111/jnc.13109 . Journal of Neurochemistry

The Effects of Different Concentrations of the alpha(2)-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice

Ribeiro, Patricia O.; Antunes, Luis M.; Nunes, Catarina S.; Silva, Henrique B.; Cunha, Rodrigo A.; Tome, Angelo R., Anesthesia and Analgesia. 1130 - 1137. 5. 120. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353342800031&KeyUID=WOS:000353342800031 . 10.1213/ane.0000000000000636 . Anesthesia and Analgesia

ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J.; Tome, AngeloR; Cunha, Rodrigo A., Frontiers in Neuroscience. 9. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353649000001&KeyUID=WOS:000353649000001 . 10.3389/fnins.2015.00148 . Frontiers in Neuroscience

Optogenetic activation of intracellular adenosine A(2A) receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Li, P.; Rial, D.; Canas, P. M.; Yoo, J. H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363465300009&KeyUID=WOS:000363465300009 . 10.1038/mp.2014.182 . Molecular Psychiatry

Localization and Trafficking of Amyloid-beta Protein Precursor and Secretases: Impact on Alzheimer's Disease

Agostinho, Paula; Pliassova, Anna; Oliveira, Catarina R.; Cunha, Rodrigo A., Journal of Alzheimers Disease. 329 - 347. 2. 45. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351583900002&KeyUID=WOS:000351583900002 . 10.3233/jad-142730 . Journal of Alzheimers Disease

Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents

Bitencourt, Rafael M.; Alpar, Alan; Cinquina, Valentina; Ferreira, Samira G.; Pinheiro, Barbara S.; Lemos, Cristina; Ledent, Catherine; et al, Neurochemistry International. 72 - 84. 90. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365366600009&KeyUID=WOS:000365366600009 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G., Nmr in Biomedicine. 1111 - 1116. 9. 28. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006 . 10.1002/nbm.3355 . Nmr in Biomedicine

Inactivation of adenosine A(2A) receptors reverses working memory deficits at early stages of Huntington's disease models

Li, Wei; Silva, Henrique B.; Real, Joana; Wang, Yu-Mei; Rial, Daniel; Li, Ping; Payen, Marie-Pierce; et al, Neurobiology of Disease. 70 - 80. 79. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356110700007&KeyUID=WOS:000356110700007 . 10.1016/j.nbd.2015.03.030 . Neurobiology of Disease

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.

Li P; Rial D; Canas PM; Yoo JH; Li W; Zhou X; Wang Y; et al, 2015. http://europepmc.org/abstract/med/25802981 . 10.1038/mp.2015.43 .

Deletion of Adenosine A(2A) Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Matos, Marco; Shen, Hai-Ying; Augusto, Elisabete; Wang, Yumei; Wei, Catherine J.; Wang, Yu Tian; Agostinho, Paula; et al, Biological Psychiatry. 763 - 774. 11. 78. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365046200008&KeyUID=WOS:000365046200008 . 10.1016/j.biopsych.2015.02.026 . Biological Psychiatry

Adenosine A(2b) receptors control A(1) receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Goncalves, Francisco Q.; Pires, Johny; Pliassova, Anna; Beleza, Rui; Lemos, Cristina; Marques, Joana M.; Rodrigues, Ricardo J.; et al, European Journal of Neuroscience. 876 - 886. 7. 41. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352540800002&KeyUID=WOS:000352540800002 . 10.1111/ejn.12851 . European Journal of Neuroscience

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

George, Jimmy; Goncalves, Francisco Q.; Cristovao, Goncalo; Rodrigues, Lisa; Meyer Fernandes, Jose Roberto; Goncalves, Teresa; Cunha, Rodrigo A.; Gomes, Catarina A., Glia. 1636 - 1645. 9. 63. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357958100011&KeyUID=WOS:000357958100011 . 10.1002/glia.22833 . Glia

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-beta Levels in Patients with Alzheimer's Disease?

Travassos, Maria; Santana, Isabel; Baldeiras, Ines; Tsolaki, Magda; Gkatzima, Olymbia; Genc, Sermin; Yener, Gorsev G.; et al, Journal of Alzheimers Disease. 1069 - 1078. 4. 47. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360931300024&KeyUID=WOS:000360931300024 . 10.3233/jad-150374 . Journal of Alzheimers Disease

Hyperactivation of D1 and A(2A) receptors contributes to cognitive dysfunction in Huntington's disease

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Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice

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Adenosine A3 receptors are located in neurons of the rat hippocampus

Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., NeuroReport. 1645 - 1648. 12. 14. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS . 10.1097/00001756-200308260-00021 . NeuroReport

Pharmacology of adenosine A2A receptors and therapeutic applications.

Fredholm, B.B.; Cunha, R.A.; Svenningsson, P., Current topics in medicinal chemistry. 413 - 426. 4. 3. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038143146&partnerID=MN8TOARS . Current topics in medicinal chemistry

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats

Rebola, N.; Sebastião, A.M.; De Mendonca, A.; Oliveira, C.R.; Ribeiro, J.A.; Cunha, R.A., Journal of Neurophysiology. 1295 - 1303. 2. 90. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042817860&partnerID=MN8TOARS . 10.1152/jn.00896.2002 . Journal of Neurophysiology

Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings

Magalhães-Cardoso, M.T.; Pereira, M.F.; Oliveira, L.; Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sá, P., Journal of Physiology. 399 - 408. 2. 549. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038511040&partnerID=MN8TOARS . Journal of Physiology

Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors

Malva, J.O.; Silva, A.P.; Cunha, R.A., Neurochemical Research. 1501 - 1515. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS . 10.1023/A:1025618324593 . Neurochemical Research

Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors

Lopes, L.V.; Rebola, N.; Costenla, A.R.; Halldner, L.; Jacobson, M.A.; Oliveira, C.R.; Richardson, P.J.; et al, Drug Development Research. 428 - 438. 4. 58. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038388748&partnerID=MN8TOARS . 10.1002/ddr.10188 . Drug Development Research

ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve

Santos, D.A.; Salgado, A.I.; Cunha, R.A., Neuroscience Letters. 225 - 228. 3. 338. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422297&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01419-2 . Neuroscience Letters

Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices

Almeida, C.G.; De Mendonça, A.; Cunha, R.A.; Ribeiro, J.A., Neuroscience Letters. 127 - 130. 2. 339. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457352&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01478-7 . Neuroscience Letters

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . Neuroscience Letters

Neuroprotection by caffeine and adenosine A 2A receptor blockade of ß-amyloid neurotoxicity

Dall'lgna, O.P.; Porciúncula, L.O.; Souza, D.O.; Cunha, R.A.; Lara, D.R., British Journal of Pharmacology. 1207 - 1209. 7. 138. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038415954&partnerID=MN8TOARS . 10.1038/sj.bjp.0705185 . British Journal of Pharmacology

Transducing system operated by adenosine A2A receptors to facilitate acetylcholine release in the rat hippocampus

Rebola, N.; Oliveira, C.R.; Cunha, R.A., European Journal of Pharmacology. 31 - 38. 1. 454. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036843638&partnerID=MN8TOARS . 10.1016/S0014-2999(02)02475-5 . European Journal of Pharmacology

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices

Cunha, R.A.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A., Pharmacology and Toxicology. 208 - 213. 4. 90. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251881&partnerID=MN8TOARS . 10.1034/j.1600-0773.2002.900407.x . Pharmacology and Toxicology

Adenosine A 2A receptors in portal hypertension: Their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits

Villa de Brito, M.T.; Canto, A.; Duarte Correia, J.H.; Cunha, R.A.; Marques, M.C., British Journal of Pharmacology. 1324 - 1330. 5. 135. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036196797&partnerID=MN8TOARS . British Journal of Pharmacology

Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation

Díaz-Hernández, M.; Fátima Pereira, M.; Pintor, J.; Cunha, R.A.; Ribeiro, J.A.; Miras-Portugal, M.T., Journal of Pharmacology and Experimental Therapeutics. 441 - 450. 2. 301. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232217&partnerID=MN8TOARS . 10.1124/jpet.301.2.441 . Journal of Pharmacology and Experimental Therapeutics

Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition

Lopes, L.V.; Cunha, R.A.; Kull, B.; Fredholm, B.B.; Ribeiro, J.A., Neuroscience. 319 - 329. 2. 112. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037129938&partnerID=MN8TOARS . 10.1016/S0306-4522(02)00080-5 . Neuroscience

Age-dependent decrease in adenosine A 1 receptor binding sites in the rat brain: Effect of cis unsaturated free fatty acids

Cunha, R.A.; Dolores Constantino, M.; Fonseca, E.; Ribeiro, J.A., European Journal of Biochemistry. 2939 - 2947. 10. 268. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034830959&partnerID=MN8TOARS . 10.1046/j.1432-1327.2001.02183.x . European Journal of Biochemistry

Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals

Cunha, R.A., Neurochemical Research. 979 - 991. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034753234&partnerID=MN8TOARS . 10.1023/A:1012392719601 . Neurochemical Research

Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine

Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P., Epilepsia. 600 - 608. 5. 42. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS . 10.1046/j.1528-1157.2001.43600.x . Epilepsia

Bringing the brain into the test tube: An experiment illustrating the effect of ethanol on nerve terminal viability

Cunha, R.A., Biochemistry and Molecular Biology Education. 105 - 109. 3. 29. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899059&partnerID=MN8TOARS . 10.1016/S1470-8175(01)00035-2 . Biochemistry and Molecular Biology Education

Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats

Cunha, R.A.; Almeida, T.; Ribeiro, J.A., Journal of Neurochemistry. 372 - 382. 2. 76. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035140223&partnerID=MN8TOARS . 10.1046/j.1471-4159.2001.00095.x . Journal of Neurochemistry

Adenosine receptor interactions in the hippocampus

Ribeiro, J.A.; Cunha-Reis, D.; Lopes, L.V.; Coelho, J.E.; Costenla, A.R.; Correia-de-Sá, P.; Cunha, R.A.; De Mendonça, A.; Sebastiao, A.M., Drug Development Research. 337 - 345. 1-2. 52. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035028567&partnerID=MN8TOARS . 10.1002/ddr.1132 . Drug Development Research

Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors

Cunha, R.A., Neurochemistry International. 107 - 125. 2. 38. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255227&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00034-6 . Neurochemistry International

Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus

Cunha, R.A.; Almeida, T.; Ribeiro, J.A., Journal of Biological Chemistry. 37572 - 37581. 48. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS . 10.1074/jbc.M003011200 . Journal of Biological Chemistry

Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation

Cunha, R.A.; Ribeiro, J.A., Neuroscience Letters. 127 - 130. 2. 289. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS . 10.1016/S0304-3940(00)01295-7 . Neuroscience Letters

Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats

Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A., British Journal of Pharmacology. 1629 - 1634. 8. 131. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS . British Journal of Pharmacology

Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress

Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R., Neurochemistry International. 255 - 265. 3. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00113-8 . Neurochemistry International

Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus

Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A., Journal of Neurochemistry. 334 - 338. 1. 74. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS . 10.1046/j.1471-4159.2000.0740334.x . Journal of Neurochemistry

Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals

Cunha, R.A.; Ribeiro, J.A., Neuropharmacology. 1156 - 1167. 7. 39. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS . 10.1016/S0028-3908(99)00237-3 . Neuropharmacology

Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release

A. Cunha, R.; Malva, J.O.; Ribeiro, J.A., FEBS Letters. 159 - 162. 2-3. 469. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS . 10.1016/S0014-5793(00)01272-2 . FEBS Letters

ATP as a presynaptic modulator

Cunha, R.A.; Ribeiro, J.A., Life Sciences. 119 - 137. 2. 68. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034554789&partnerID=MN8TOARS . Life Sciences

Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats

Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A., Neurochemistry International. 563 - 566. 7. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00164-3 . Neurochemistry International

Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: Interaction with presynaptic nicotinic receptors

Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A., Brain Research. 245 - 250. 2. 877. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02679-2 . Brain Research

Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R., Experimental Eye Research. 577 - 587. 5. 70. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS . 10.1006/exer.1999.0815 . Experimental Eye Research

Meeting Report - Biochemical Education at the University Level, Lisbon, Portugal, October 30-31, 1999

Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P., Biochemistry and Molecular Biology Education. 234 - 237. 4. 28. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS . 10.1016/S1470-8175(00)00008-4 . Biochemistry and Molecular Biology Education

Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals

Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A., Brain Research. 50 - 54. 1-2. 879. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02726-8 . Brain Research

Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases

Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A., Progress in Brain Research. 183 - 192. 120. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS . Progress in Brain Research

Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A(2A) receptors in the limbic cortex, but not striatum, of aged rats

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., Journal of Neurochemistry. 1733 - 1738. 4. 73. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863555&partnerID=MN8TOARS . 10.1046/j.1471-4159.1999.731733.x . Journal of Neurochemistry

Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., Journal of Neurophysiology. 3196 - 3203. 6. 82. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS . Journal of Neurophysiology

ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor responses

Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., European Journal of Pharmacology. 395 - 398. 3. 383. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779092&partnerID=MN8TOARS . 10.1016/S0014-2999(99)00659-7 . European Journal of Pharmacology

Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes

Cunha, R.A.; Ribeiro, J.A., European Journal of Neuroscience. 2171 - 2174. 6. 11. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS . 10.1046/j.1460-9568.1999.00661.x . European Journal of Neuroscience

Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives

Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P., Journal of Medicinal Chemistry. 2582 - 2587. 14. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS . 10.1021/jm980627g . Journal of Medicinal Chemistry

Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus

Cunha, R.A.; Malva, J.O.; Ribeiro, J.A., Molecular Pharmacology. 429 - 433. 2. 56. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS . Molecular Pharmacology

G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., Naunyn-Schmiedeberg's Archives of Pharmacology. 295 - 302. 4. 359. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS . 10.1007/PL00005355 . Naunyn-Schmiedeberg's Archives of Pharmacology

Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus

Almeida, T.; Cunha, R.A.; Ribeiro, J.A., Brain Research. 104 - 111. 1. 826. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS . 10.1016/S0006-8993(99)01267-6 . Brain Research

Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors

Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A., Journal of Neuroscience. 1987 - 1995. 6. 18. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032521330&partnerID=MN8TOARS . Journal of Neuroscience

On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)

Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C., Trends in Neurosciences. 286 - 287. 7. 21. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS . Trends in Neurosciences

Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes

Gonçalves, M.L.; Cunha, R.A.; Ribeiro, J.A., Neuroscience Letters. 73 - 77. 1-2. 238. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031283080&partnerID=MN8TOARS . 10.1016/S0304-3940(97)00803-3 . Neuroscience Letters

ZM241385 is an antagonist of the facilitatory responses produced by the A(2A) adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., British Journal of Pharmacology. 1279 - 1284. 7. 122. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030734490&partnerID=MN8TOARS . British Journal of Pharmacology

Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes

Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., European Journal of Pharmacology. 167 - 172. 2-3. 323. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030610655&partnerID=MN8TOARS . 10.1016/S0014-2999(97)00043-5 . European Journal of Pharmacology

Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors

Cunha, R.A.; Johansson, B.; Constantino, M.D.; Sebastião, A.M.; Fredholm, B.B., Naunyn-Schmiedeberg's Archives of Pharmacology. 261 - 271. 3. 353. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670460&partnerID=MN8TOARS . Naunyn-Schmiedeberg's Archives of Pharmacology

Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices

Cunha, R.A.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M., Journal of Neurochemistry. 2180 - 2187. 5. 67. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029819083&partnerID=MN8TOARS . Journal of Neurochemistry

Purinoceptors and synaptic plasticity

Ribeiro, J.A.; De Mendonça, A.; Correia-de-Sá, P.; Cunha, R.A.; Sebastião, A.M., Drug Development Research. 353 - 360. 3-4. 39. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030435849&partnerID=MN8TOARS . Drug Development Research

Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides

Cunha, R.A.; Correia-de-Sá, P.; Sebastião, A.M.; Ribeiro, J.A., British Journal of Pharmacology. 253 - 260. 2. 119. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029844019&partnerID=MN8TOARS . British Journal of Pharmacology

Purinergic regulation of acetylcholine release

Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sa, P.; Sebastiao, A.M., Progress in Brain Research. 231 - 241. 109. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030474316&partnerID=MN8TOARS . Progress in Brain Research

A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion

Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M., Neuroscience Letters. 83 - 86. 2. 185. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS . 10.1016/0304-3940(94)11230-G . Neuroscience Letters

Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus

Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Alexandre Ribeiro, J.; Sebastião, A.M., Neuroscience Letters. 41 - 44. 1-2. 196. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028984662&partnerID=MN8TOARS . Neuroscience Letters

Modification of A1 and A(2a) adenosine receptor binding in aged striatum, hippocampus and cortex of the rat

Cunha, R.A.; Constantino, M.D.; Sebastiao, A.M.; Ribeiro, J.A., NeuroReport. 1583 - 1588. 11. 6. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028983106&partnerID=MN8TOARS . NeuroReport

Purinergic modulation of the evoked release of [3H]Acetylcholine from the hippocampus and cerebral cortex of the rat: Role of the ectonucleotidases

Cunha, R.A.; Ribeiro, J.A.; Sebastiao, A.M., European Journal of Neuroscience. 33 - 42. 1. 6. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028031731&partnerID=MN8TOARS . 10.1111/j.1460-9568.1994.tb00245.x . European Journal of Neuroscience

Evidence for functionally important adenosine A2a receptors in the rat hippocampus

Cunha, R.A.; Johansson, B.; van der Ploeg, I.; Sebastião, A.M.; Alexandre Ribeiro, J.; Fredholm, B.B., Brain Research. 208 - 216. 1-2. 649. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028342730&partnerID=MN8TOARS . Brain Research

Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus

Cunha, R.A.; Milusheva, E.; Vizi, E.S.; Ribeiro, J.A.; Sebastião, A.M., Journal of Neurochemistry. 207 - 214. 1. 63. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241057&partnerID=MN8TOARS . Journal of Neurochemistry

Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog

Cunha, R.A.; Sebastiao, A.M., Pflugers Archiv European Journal of Physiology. 503 - 510. 5-6. 424. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027250345&partnerID=MN8TOARS . Pflugers Archiv European Journal of Physiology

Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., Journal of Neurochemistry. 657 - 666. 2. 59. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026660013&partnerID=MN8TOARS . 10.1111/j.1471-4159.1992.tb09420.x . Journal of Neurochemistry

Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., Nucleosides and Nucleotides. 1189 - 1190. 5. 10. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070005&partnerID=MN8TOARS . Nucleosides and Nucleotides

Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog

Cunha, R.A.; Sebastiao, A.M., European Journal of Pharmacology. 83 - 92. 1. 197. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829211&partnerID=MN8TOARS . European Journal of Pharmacology

Blockade of AMP degradation allows the quantification of adenine nucleotides released by nerve stimulation in the innervated frog sartorius muscle

Cunha, R.A.; Sebastiao, A.M.; Ribeiro, J.A., European Journal of Pharmacology. 1684 - 1685. 5. 183. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025106547&partnerID=MN8TOARS . 10.1016/0014-2999(90)91979-L . European Journal of Pharmacology

Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography

Cunha, R.A.; Sebastião, A.M.; Ribeiro, J.A., Chromatographia. 610 - 612. 11-12. 28. 1989. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001249211&partnerID=MN8TOARS . 10.1007/BF02260687 . Chromatographia