Publications
Information about journal articles, updated at 24-08-2025, from platform CIÊNCIAVITAE.
A combination of ¿9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease
Sánchez-Fernández, Nuria; Gómez-Acero, Laura; Castañé, Anna; Adell, Albert; Campa, Leticia; Bonaventura, Jordi; Brito, Verónica; et al, Neurotherapeutics. 5. 21. 2024. https://doi.org/10.1016/j.neurot.2024.e00439 . 10.1016/j.neurot.2024.e00439 . Neurotherapeutics
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation
Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13040715 . 10.3390/biom13040715 . Biomolecules
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease
Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/8/6968 . 10.3390/ijms24086968 . International Journal of Molecular Sciences
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease
Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13081173 . 10.3390/biom13081173 . Biomolecules
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas
Cátia R. Lopes; Andreia Oliveira; Ingride Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al, Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/1/106 . 10.3390/biom13010106 . Biomolecules
CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity
Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Cunha, R.A., International Journal of Molecular Sciences. 12826 - 12826. 21. 23. 2022. http://dx.doi.org/10.3390/ijms232112826 . 10.3390/ijms232112826 . International Journal of Molecular Sciences
Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure
Lopes, C.R.; Amaral, I.M.; Pereira, M.F.; Lopes, J.P.; Madeira, D.; Canas, P.M.; Cunha, R.A.; Agostinho, P., Journal of Neurochemistry. 556 - 567. 5. 160. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124559190&partnerID=MN8TOARS . 10.1111/jnc.15575 . Journal of Neurochemistry
Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.
Valada P; Alçada-Morais S; Cunha RA; Lopes JP, International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/36142422 . 10.3390/ijms231810510 . International journal of molecular sciences
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.
Valada P; Hinz S; Vielmuth C; Lopes CR; Cunha RA; Müller CE; Lopes JP, Purinergic signalling. 2022. http://europepmc.org/abstract/med/36156760 . 10.1007/s11302-022-09899-7 . Purinergic signalling
l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory
Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al, The FASEB Journal. 8. 35. 2021. http://dx.doi.org/10.1096/fj.202100336r . 10.1096/fj.202100336r . The FASEB Journal
Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al, Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS . 10.1038/s41598-021-89964-0 . Scientific Reports
Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade
Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology
Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.
Lopes, João, Neurobiology of disease. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of disease
The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors
João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology
Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine
Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease
What is the extracellular calcium concentration within brain synapses?
João Pedro Lopes; Rodrigo A. Cunha, Journal of Neurochemistry. 435 - 437. 4. 149. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry
Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice
Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., Journal of Neurochemistry. 796 - 809. 6. 148. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS . 10.1111/jnc.14653 . Journal of Neurochemistry
Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al, Neurobiology of Disease. 72 - 81. 117. 2018. http://dx.doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease
The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.
Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P, 2016. http://europepmc.org/abstract/med/26497029 . 10.1007/s12035-015-9491-9 .
The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system
Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al, Journal of Neurochemistry. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS . 10.1111/jnc.13109 . Journal of Neurochemistry
Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease
Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A., PLoS ONE. 2. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS . 10.1371/journal.pone.0056870 . PLoS ONE
Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity
Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A., Brain and Behavior. 67 - 74. 2. 3. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS . 10.1002/brb3.118 . Brain and Behavior
Cdk5: Multitasking between physiological and pathological conditions
Lopes, J.P.; Agostinho, P., Progress in Neurobiology. 49 - 63. 1. 94. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.03.006 . Progress in Neurobiology
Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5
Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Aging Cell. 64 - 77. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS . 10.1111/j.1474-9726.2009.00536.x . Aging Cell
Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides
Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cell Cycle. 97 - 104. 1. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS . Cell Cycle
Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology
Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS . 10.3233/JAD-2009-0993 . Journal of Alzheimer's Disease
Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?
Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Current Alzheimer Research. 205 - 212. 3. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS . 10.2174/156720509788486590 . Current Alzheimer Research
Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides
Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula, Cell Cycle. 97 - 104. 1. 8. 2009. http://dx.doi.org/10.4161/cc.8.1.7506 . 10.4161/cc.8.1.7506 . Cell Cycle
Overactivation of calcineurin induced by amyloid-beta and prion proteins
Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R., Neurochemistry International. 1226 - 1233. 6. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS . 10.1016/j.neuint.2008.01.005 . Neurochemistry International
Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies
Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cellular and Molecular Neurobiology. 943 - 957. 7. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS . 10.1007/s10571-007-9224-3 . Cellular and Molecular Neurobiology
Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente
Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A., Revista Portuguesa de Pneumologia. 5. 9. 2003. http://dx.doi.org/10.1016/s0873-2159(15)30711-x . 10.1016/s0873-2159(15)30711-x . Revista Portuguesa de Pneumologia
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