João Pedro Oliveira da Silva Paulino Lopes

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Publications

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Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13040715 . 10.3390/biom13040715 . Biomolecules

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/8/6968 . 10.3390/ijms24086968 . International Journal of Molecular Sciences

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease

Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes, Biomolecules. 2023. https://doi.org/10.3390/biom13081173 . 10.3390/biom13081173 . Biomolecules

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

Cátia R. Lopes; Andreia Oliveira; Ingride Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al, Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/1/106 . 10.3390/biom13010106 . Biomolecules

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Cunha, R.A., International Journal of Molecular Sciences. 12826 - 12826. 21. 23. 2022. http://dx.doi.org/10.3390/ijms232112826 . 10.3390/ijms232112826 . International Journal of Molecular Sciences

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure

Lopes, C.R.; Amaral, I.M.; Pereira, M.F.; Lopes, J.P.; Madeira, D.; Canas, P.M.; Cunha, R.A.; Agostinho, P., Journal of Neurochemistry. 556 - 567. 5. 160. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124559190&partnerID=MN8TOARS . 10.1111/jnc.15575 . Journal of Neurochemistry

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.

Valada P; Alçada-Morais S; Cunha RA; Lopes JP, International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/36142422 . 10.3390/ijms231810510 . International journal of molecular sciences

The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.

Valada P; Hinz S; Vielmuth C; Lopes CR; Cunha RA; Müller CE; Lopes JP, Purinergic signalling. 2022. http://europepmc.org/abstract/med/36156760 . 10.1007/s11302-022-09899-7 . Purinergic signalling

l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al, The FASEB Journal. 8. 35. 2021. http://dx.doi.org/10.1096/fj.202100336r . 10.1096/fj.202100336r . The FASEB Journal

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al, Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS . 10.1038/s41598-021-89964-0 . Scientific Reports

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.

Lopes, João, Neurobiology of disease. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of disease

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

What is the extracellular calcium concentration within brain synapses?

João Pedro Lopes; Rodrigo A. Cunha, Journal of Neurochemistry. 435 - 437. 4. 149. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., Journal of Neurochemistry. 796 - 809. 6. 148. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS . 10.1111/jnc.14653 . Journal of Neurochemistry

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al, Neurobiology of Disease. 72 - 81. 117. 2018. http://dx.doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P, 2016. http://europepmc.org/abstract/med/26497029 . 10.1007/s12035-015-9491-9 .

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system

Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al, Journal of Neurochemistry. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS . 10.1111/jnc.13109 . Journal of Neurochemistry

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A., PLoS ONE. 2. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS . 10.1371/journal.pone.0056870 . PLoS ONE

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity

Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A., Brain and Behavior. 67 - 74. 2. 3. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS . 10.1002/brb3.118 . Brain and Behavior

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J.P.; Agostinho, P., Progress in Neurobiology. 49 - 63. 1. 94. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.03.006 . Progress in Neurobiology

Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Aging Cell. 64 - 77. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS . 10.1111/j.1474-9726.2009.00536.x . Aging Cell

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cell Cycle. 97 - 104. 1. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS . Cell Cycle

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology

Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS . 10.3233/JAD-2009-0993 . Journal of Alzheimer's Disease

Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Current Alzheimer Research. 205 - 212. 3. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS . 10.2174/156720509788486590 . Current Alzheimer Research

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula, Cell Cycle. 97 - 104. 1. 8. 2009. http://dx.doi.org/10.4161/cc.8.1.7506 . 10.4161/cc.8.1.7506 . Cell Cycle

Overactivation of calcineurin induced by amyloid-beta and prion proteins

Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R., Neurochemistry International. 1226 - 1233. 6. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS . 10.1016/j.neuint.2008.01.005 . Neurochemistry International

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cellular and Molecular Neurobiology. 943 - 957. 7. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS . 10.1007/s10571-007-9224-3 . Cellular and Molecular Neurobiology

Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente

Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A., Revista Portuguesa de Pneumologia. 5. 9. 2003. http://dx.doi.org/10.1016/s0873-2159(15)30711-x . 10.1016/s0873-2159(15)30711-x . Revista Portuguesa de Pneumologia

All projects

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Information of exclusive responsibility of the researcher 17-12-2023 , from platform CIÊNCIAVITAE.

2023/07/31 - 2029/07/30

Harnessing the potential of VNUT modulation against memory dysfunction in Alzheimer's Disease

2022.05689.CEECIND/CP1714/CT0015

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2019/02/05 - 2023/07/30

Impact of purinergic neuromodulation in neurodegenerative brain pathologies

DL 57/2016/CP1448/CT0001

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07 - 2021/06

Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica

Provided by PTCRIS: PTDC/MED-NEU/31274/2017

Funders: Fundação para a Ciência e a Tecnologia

2018/01/01 - 2019/06/30

Manipulation of A2A receptors to control symptoms of Angelman syndrome

---

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação Amélia de Melo

2018 -

Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress

Fundacion LaCaixa

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia; Fundación La Caixa

2018/05/01 - 2020/06/06

Strategies for healthy aging

CENTRO-01-0246-FEDER-000010

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

2017 -

Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs

-

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2017 -

Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs

-

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2019/07

Papel dos astrócitos no controlo da memória- foco nos recetores adenosina A2A

Provided by PTCRIS: PTDC/NEU-NMC/4154/2014

Funders: Fundação para a Ciência e a Tecnologia

2016/10 - 2017/09

Adenosine A2A Receptor Antagonism Affords Integrated Benefits for Neurological Symptoms of Neurofibromatosis Type I

W81XWH-18-1-0532

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Congressionally Directed Medical Research Programs

2015/01/01 - 2017/06/30

The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer's disease

Mantero-Bellard Award

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Santa Casa da Misericórdia de Lisboa

2013/01 - 2019/02

Tinkering with adenosine metabolism to manipulate adenosine neuromdulation and bolster neuroprotectin in brain disorders

Provided by PTCRIS: SFRH/BPD/85404/2012

Funders: Fundação para a Ciência e a Tecnologia

2012/05 - 2014/08

Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection

PTDC/SAU-TOX/122005/2010

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2011/08 - 2013/12

Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease

Provided by PTCRIS: 114810

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2008 -

Causas e consequências da reactivação do ciclo celular nos neurónios: implicações na doença de Alzheimer e nas encefalopatias por priões

GAPI 01/08

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2007 -

Neuroinflamação associada à doenca de Alzheimer

GAPI 04/07

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2006 -

Degeneração neuronal associada à doenca de Alzheimer e às encefalopatias causadas por priões

GAI 05/06

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2005 -

Disfunção colinérgica na doença de Alzheimer: avaliação da capacidade neuroprotectora de compostos com acção antioxidante e inibidora das colinesterases

GAI 14/05

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2005/01 - 2008/12

NEURODEGENERATION IN ALZHEIMER´S DISEASE AND PRION RELATED ENCEPHALOPATHIES: THE ROLE OF CYCLIN-DEPENDENT KINASE 5 AND CELL CYCLE REGULATORS

Provided by PTCRIS: SFRH/BD/16381/2004

Funders: Fundação para a Ciência e a Tecnologia

2004 -

O efeito de novos inibidores das colinesterases na neurotoxicidade do peptídeo beta amilóide. Potenciais agentes terapêuticos na doença de Alzheimer

GAI 05/04

Master Student Fellow

Universidade de Coimbra Faculdade de Medicina

2003/09/01 - 2004/12/31

A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies

POCTI/36101/NSE/1999

Master Student Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

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