Ana Luisa Carvalho

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E-mail
alc@cnc.uc.pt

Overview

Ana Luisa Carvalho is Associate Professor and group leader at the CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She has 20 years of experience working as a Neuroscientist. The aim of her research is to uncover cellular and molecular mechanisms at the basis of neuronal excitability and synaptic function, and how they are impaired in brain diseases. She has made important contributions to the identification of receptor associated proteins and metabolic hormones that regulate synaptic function and plasticity, and to understanding synaptic dysfunction in neurodevelopmental disorders. She has published over 65 papers (H index= 36; >4300 citations) in high impact journals such as PNAS, Molecular Psychiatry, Neuron, Nature Communications and J Cell Biology. Ana Luisa has mentored 19 PhD and 20 MSc students and presently coordinates the H2020-MSCA-ITN European Training Network Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders. She has coordinated 12 research grants funded by FCT, the EU or private foundations, and participated in 20 other grants. She was a member of the Scientific Research Council for FCT (2013-16) and is ad hoc reviewer for over 20 international research funding agencies.

Affiliation

Department of Life Sciences, University of Coimbra

Publications

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Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al, Molecular Psychiatry. 2022. http://dx.doi.org/10.1038/s41380-022-01487-w . 10.1038/s41380-022-01487-w . Molecular Psychiatry

Interplay between NMDA receptor dynamics and the synaptic proteasome

Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc, European Journal of Neuroscience. 6000 - 6011. 6. 54. 2021. https://doi.org/10.1111/ejn.15427 . 10.1111/ejn.15427 . European Journal of Neuroscience

It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Ana Luisa Carvalho; Dominique Fernandes, PLOS Biology. 2021. https://doi.org/10.1371/journal.pbio.3001448 . 10.1371/journal.pbio.3001448 . PLOS Biology

Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . Science Signaling

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al, Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al, Cerebral Cortex. 2019. https://doi.org/10.1093/cercor/bhz032 . 10.1093/cercor/bhz032 . Cerebral Cortex

The role of ghrelin in regulating synaptic function and plasticity of feeding-associated circuits

Serrenho, D.; Santos, S.D.; Carvalho, A.L., Frontiers in Cellular Neuroscience. 13. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068476880&partnerID=MN8TOARS . 10.3389/fncel.2019.00205 . Frontiers in Cellular Neuroscience

New insights on synaptic dysfunction in neuropsychiatric disorders

Lima Caldeira, G.; Peça, J.; Carvalho, A.L., Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al, Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. https://doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses

Louros, S.R.; Caldeira, G.L.; Carvalho, A.L., Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054810796&partnerID=MN8TOARS . 10.3389/fnmol.2018.00328 . Frontiers in Molecular Neuroscience

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses

Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al, Neuron. 106 - 119.e7. 1. 100. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS . 10.1016/j.neuron.2018.09.012 . Neuron

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Morató, X.; Luján, R.; Gonçalves, N.; Watanabe, M.; Altafaj, X.; Carvalho, A.L.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., Human Molecular Genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . Human Molecular Genetics

Mechanisms of homeostatic plasticity in the excitatory synapse

Dominique Fernandes; Ana Luísa Carvalho, Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13687 . 10.1111/jnc.13687 . Journal of Neurochemistry

7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’

Carlos B. Duarte; Ana Luisa Carvalho, Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13839 . 10.1111/jnc.13839 . Journal of Neurochemistry

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons

Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos, BIO-PROTOCOL. 10. 6. 2016. http://dx.doi.org/10.21769/bioprotoc.1807 . 10.21769/bioprotoc.1807 . BIO-PROTOCOL

GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome

Ferreira, J.S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K.W.; Smit, A.B.; Craig, A.M.; Carvalho, A.L., Journal of Neuroscience. 8462 - 8479. 22. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930427217&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3567-14.2015 . Journal of Neuroscience

Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97

Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 1950 - 1959. 9. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.06.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

A role for stargazin in experience-dependent plasticity

Louros, S.; Hooks, B.; Litvina, L.; Carvalho, A.; Chen, C., Cell Reports. 1614 - 1625. 5. 7. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902344846&partnerID=MN8TOARS . 10.1016/j.celrep.2014.04.054 . Cell Reports

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway

Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., Experimental Neurology. 698 - 709. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.07.023 . Experimental Neurology

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., Molecular Vision. 894 - 907. 20. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903118075&partnerID=MN8TOARS . Molecular Vision

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L., Proceedings of the National Academy of Sciences of the United States of America. 1. 111. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS . 10.1073/pnas.1313798111 . Proceedings of the National Academy of Sciences of the United States of America

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

Regulation of synapse composition by protein acetylation: The role of acetylated cortactin

Catarino, T.; Ribeiro, L.; Santos, S.D.; Carvalho, A.L., Journal of Cell Science. 149 - 162. 1. 126. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875621271&partnerID=MN8TOARS . 10.1242/jcs.110742 . Journal of Cell Science

Glutamate Binding to the GluN2B Subunit Controls Surface Trafficking of N-Methyl-D-aspartate (NMDA) Receptors

She, Kevin; Ferreira, Joana S.; Carvalho, Ana Luisa; Craig, Ann Marie, Journal of Biological Chemistry. 27432 - 27445. 33. 287. 2012. 10.1074/jbc.M112.345108 . Journal of Biological Chemistry

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., Neuroscience. 23 - 32. 219. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors

Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L., Journal of Biological Chemistry. 6868 - 6877. 9. 287. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS . 10.1074/jbc.M111.322909 . Journal of Biological Chemistry

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease

Matos, C.A.; de Macedo-Ribeiro, S.; Carvalho, A.L., Progress in Neurobiology. 26 - 48. 1. 95. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960668226&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.06.007 . Progress in Neurobiology

Activity and protein kinase C regulate synaptic accumulation of N-Methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant

Ferreira, J.S.; Rooyakkers, A.; She, K.; Ribeiro, L.; Carvalho, A.L.; Craig, A.M., Journal of Biological Chemistry. 28331 - 28342. 32. 286. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051515440&partnerID=MN8TOARS . 10.1074/jbc.M111.222539 . Journal of Biological Chemistry

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Leptin regulates AMPA receptor trafficking via PTEN inhibition

Moult, P.R.; Cross, A.; Santos, S.D.; Carvalho, A.-L.; Lindsay, Y.; Connolly, C.N.; Irving, A.J.; Leslie, N.R.; Harvey, J., Journal of Neuroscience. 4088 - 4101. 11. 30. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949725839&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3614-09.2010 . Journal of Neuroscience

Regulation of AMPA receptors and synaptic plasticity

Santos, S.D.; Carvalho, A.L.; Caldeira, M.V.; Duarte, C.B., Neuroscience. 105 - 125. 1. 158. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149467917&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.02.037 . Neuroscience

Nucleocytoplasmic shuttling activity of ataxin-3

Macedo-Ribeiro, S.; Cortes, L.; Maciel, P.; Carvalho, A.L., PLoS ONE. 6. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149129949&partnerID=MN8TOARS . 10.1371/journal.pone.0005834 . PLoS ONE

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection

Nunes-Correia, I.; Rodríguez, J.M.; Eulálio, A.; Carvalho, A.L.; Citovsky, V.; Simões, S.; Faro, C.; Salas, M.L.; Pedroso de Lima, M.C., Veterinary Microbiology. 47 - 59. 1-2. 130. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549086170&partnerID=MN8TOARS . 10.1016/j.vetmic.2007.12.010 . Veterinary Microbiology

Role of the brain-derived neurotrophic factor at glutamatergic synapses

Carvalho, A.L.; Caldeira, M.V.; Santos, S.D.; Duarte, C.B., British Journal of Pharmacology. SUPPL. 1. 153. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349114504&partnerID=MN8TOARS . 10.1038/sj.bjp.0707509 . British Journal of Pharmacology

Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors

Gomes, A.R.; Ferreira, J.S.; Paternain, A.V.; Lerma, J.; Duarte, C.B.; Carvalho, A.L., Molecular and Cellular Neuroscience. 323 - 334. 2. 37. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749131588&partnerID=MN8TOARS . 10.1016/j.mcn.2007.10.008 . Molecular and Cellular Neuroscience

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Alves, S.; Régulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A.L.; et al, Human Molecular Genetics. 2071 - 2083. 14. 17. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249122383&partnerID=MN8TOARS . 10.1093/hmg/ddn106 . Human Molecular Genetics

PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression

Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L., Traffic. 259 - 269. 3. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS . 10.1111/j.1600-0854.2006.00521.x . Traffic

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

NEDD8: A new ataxin-3 interactor

Ferro, A.; Carvalho, A.L.; Teixeira-Castro, A.; Almeida, C.; Tomé, R.J.; Cortes, L.; Rodrigues, A.-J.; et al, Biochimica et Biophysica Acta - Molecular Cell Research. 1619 - 1627. 11. 1773. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548938484&partnerID=MN8TOARS . 10.1016/j.bbamcr.2007.07.012 . Biochimica et Biophysica Acta - Molecular Cell Research

BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.F.; Carvalho, A.L.; Duarte, C.B., Molecular and Cellular Neuroscience. 208 - 219. 2. 35. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249712975&partnerID=MN8TOARS . 10.1016/j.mcn.2007.02.019 . Molecular and Cellular Neuroscience

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., Journal of Biological Chemistry. 12619 - 12628. 17. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250329980&partnerID=MN8TOARS . 10.1074/jbc.M700607200 . Journal of Biological Chemistry

Erratum: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons (Journal of Biological Chemistry (2007) 282, (12619-12628))

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., Journal of Biological Chemistry. 37. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848900818&partnerID=MN8TOARS . Journal of Biological Chemistry

Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides

Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P., Journal of Allergy and Clinical Immunology. 878 - 884. 4. 118. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS . 10.1016/j.jaci.2006.05.029 . Journal of Allergy and Clinical Immunology

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C., Journal of Virology. 1393 - 1404. 3. 80. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS . 10.1128/JVI.80.3.1393-1404.2006 . Journal of Virology

Downregulation of retinal GLUT1 in diabetes by ubiquitinylation

Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C., Molecular Vision. 618 - 628. 10. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-16544391719&partnerID=MN8TOARS . Molecular Vision

Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression

Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B., Journal of Neurochemistry. 673 - 682. 3. 90. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02519.x . Journal of Neurochemistry

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P., Journal of Virology. 9731 - 9739. 18. 78. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS . 10.1128/JVI.78.18.9731-9739.2004 . Journal of Virology

Regulation of AMPA receptor activity, synaptic targeting and recycling: Role in synaptic plasticity

Gomes, A.R.; Correia, S.S.; Carvalho, A.L.; Duarte, C.B., Neurochemical Research. 1459 - 1473. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705374&partnerID=MN8TOARS . 10.1023/A:1025610122776 . Neurochemical Research

Protein kinase C¿ associates directly with the GluR4 a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit: Effect on receptor phosphorylation

Santos Correia, S.; Bandeira Duarte, C.; Faro, C.J.; Vieira Pires, E.; Carvalho, A.L., Journal of Biological Chemistry. 6307 - 6313. 8. 278. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037458663&partnerID=MN8TOARS . 10.1074/jbc.M205587200 . Journal of Biological Chemistry

Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons

Carvalho, A.L.; Correia, S.; Faro, C.J.; Duarte, C.B.; Carvalho, A.P.; Pires, E.M.V., European Journal of Neuroscience. 465 - 474. 3. 15. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036456320&partnerID=MN8TOARS . 10.1046/j.0953-816x.2001.01881.x . European Journal of Neuroscience

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons

Santos, A.E.; Carvalho, A.L.; Lopes, M.C.; Carvalho, A.P., Journal of Neuroscience Research. 643 - 655. 4. 66. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889524&partnerID=MN8TOARS . 10.1002/jnr.10036 . Journal of Neuroscience Research

Regulation of AMPA Receptors by Phosphorylation

Carvalho, A.L.; Duarte, C.B.; Carvalho, A.P., Neurochemical Research. 1245 - 1255. 9-10. 25. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034304035&partnerID=MN8TOARS . Neurochemical Research

Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors

Carvalho, A.L.; Kameyama, K.; Huganir, R.L., Journal of Neuroscience. 4748 - 4754. 12. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033564041&partnerID=MN8TOARS . Journal of Neuroscience

Differential acetylcholine and GABA release from cultured chick retina cells

Santos, P.F.; Carvalho, A.L.; Carvalho, A.P.; Duarte, C.B., European Journal of Neuroscience. 2723 - 2730. 8. 10. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031927252&partnerID=MN8TOARS . 10.1046/j.1460-9568.1998.00281.x . European Journal of Neuroscience

Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells

Carvalho, A.L.; Duarte, C.B.; Faro, C.J.; Carvalho, A.P.; Pires, E.V., Journal of Neurochemistry. 2112 - 2119. 5. 70. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031980737&partnerID=MN8TOARS . Journal of Neurochemistry

Glutamate in life and death of retinal amacrine cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Carvalho, A.L.; Agostinho, P.M.; Carvalho, A.P., General Pharmacology. 289 - 295. 3. 30. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032033584&partnerID=MN8TOARS . 10.1016/S0306-3623(97)00360-1 . General Pharmacology

Photoacoustic measurements of porphyrin triplet-state quantum yields and singlet-oxygen efficiencies

Pineiro, M.; Carvalho, A.L.; Pereira, M.M.; Rocha Gonsalves, A.M.D'A.; Arnaut, L.G.; Formosinho, S.J.; Pineiro, M; et al, Chemistry - A European Journal. 2299 - 2307. 11. 4. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031742441&partnerID=MN8TOARS . 10.1002/(SICI)1521-3765(19981102)4:11<2299::AID-CHEM2299>3.0.CO;2-H . Chemistry - A European Journal

In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent

Osborne, N.N.; Cazevieille, C.; Carvalho, A.L.; Larsen, A.K.; Desantis, L.; Larson, A., Brain Research. 113 - 123. 1. 751. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030894739&partnerID=MN8TOARS . 10.1016/S0006-8993(96)01393-5 . Brain Research

All projects

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Information of exclusive responsibility of the researcher 17-12-2023 , from platform CIÊNCIAVITAE.

2023/03/01 - 2024/08/31

MicroRNAs And Cognition in Longcovid: Exploratory Study

2022.04018.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/03/01 - 2024/08/31

A New TransSynaptic Bridge: Functional characterization of the NMDA receptor-Neurexin interaction

2022.05386.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/04/01 - 2026/03/31

Homeostatic plasticity defects in autism: insight from human mutations in the CNTNAP2 gene

202202-30-31

Co-Principal Investigator (Co-PI)

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundació la Marató de TV3

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2021 - 2024

Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization

PTDC/BIA-CEL/2286/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/12/01 - 2024/11/30

microSTRESS: Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p

HR21-01077

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT

2021/01/01 - 2025/12/31

DYNABrain - DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders

952422

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission

2020/12/01 - 2024/11/30

MStar - Potassium channel dysfunction in models of neurodevelopmental disorders

HR20-00904

Principal investigator

Funders: Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT

2019/03 - 2023/08

Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders

H2020-MSCA-ITN-2018 (813986)

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2018/06 - 2021/05

Understanding the pathogenesis in CASPR2-antibody autoimmune synaptic encephalitis

PTDC/MED-NEU/29452/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

Molecular tools for Machado-Joseph disease: chaperoning toxic protein conformers in polyglutamine-containing proteins

PTDC/BIA-BFS/31173/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07 - 2021/06

COGNITIVE DISORDERS AS DEFECTS IN SYNAPTIC FUNCTION: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE

PTDC/MED-NEU/28541/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction

PTDC/BIA-CEL/29451/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2020

BrainHealth2020 - Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders

CENTRO-01-0145-FEDER-000008

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Regional Development Fund

2017 - 2020

BrainHealth2020

CENTRO-01-0145-FEDER-000008:BrainHealth 2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Regional Development Fund

2016 - 2018

A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity

PTDC/NEU-NMC/4888/2014

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016 - 2018

BEHAVIOR ANALYSES OF MICE EXPRESSING A CACNG2 MUTATION ASSOCIATED WITH INTELLECTUAL DISABILITY

1530

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fondation Jérôme Lejeune

2015 - 2018

StrokeTherapy - Plataformas terapêuticas para acidentes vasculares cerebrais

3386

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Development Fund

2015 - 2018

Schizophrenia as a disruption of developmental homeostatic plasticity: a role for stargazin

23151

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Brain and Behavior Research Foundation

2014/04/01 - 2015/09/30

A sabedoria do faminto: modulação por ghrelina da neurogénese e da sua relação com a memória

EXPL/NEU-SCC/1193/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2014/03/01 - 2015/09/30

Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo

EIT-KIC/IVE/0043/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Administração Regional de Saúde do Centro IP; Universidade de Coimbra Instituto de Investigação Interdisciplinar; Universidade de Coimbra; Universidade de Coimbra Faculdade de Medicina

Funders: Fundação para a Ciência e a Tecnologia

2014/04 - 2015/09

Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory

Provided by PTCRIS: 134218

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2014/03 - 2015/09

Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing

Provided by PTCRIS: 135805

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013/07 - 2015/09

A Novel Model for Schizophrenia: Defects in Stargazin-Mediated Homeostatic Plasticity.

Provided by PTCRIS: 125355

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013/07 - 2015/11

Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission

Provided by PTCRIS: 125955

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/01/01 - 2012/12/31

Strategic Project - LA 1 - 2011-2012

PEst-C/SAU/LA0001/2011

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/01 - 2014/06

Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease

Provided by PTCRIS: 110602

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/04 - 2013/06

Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors

Provided by PTCRIS: 113738

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/09 - 2013/12

Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type

Provided by PTCRIS: 99440

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2009/01 - 2011/12

Implementation of a Nacional Facility for DNA Microarrays: Phase II

Provided by PTCRIS: 64745

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2008/04 - 2011/03

Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors

Provided by PTCRIS: 71789

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2008 - 2008

Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways

NA

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Biogen Portugal

2007/06 - 2010/12

Regulation of AMPA receptors by hyperglycemia in the retina

Provided by PTCRIS: 71228

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/04 - 2010/04

Cleavage of the vesicular glutamate (VGLUT) and GABA (VGAT) transporters under excitotoxic conditions: identification of the cleavage sites and functional implications

Provided by PTCRIS: 65846

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005/01 - 2007/12

Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors

Provided by PTCRIS: 58955

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005/06 - 2008/12

Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease

Provided by PTCRIS: 60156

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2003/03/01 - 2007

Regulation of the expression of ionotropic glutamate receptors by brain-derived neurotrophic factor (BDNF) in hippocampal neurons

info:eu-repo/grantAgreement/FCT/POCI/46466/PT

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2002 - 2004

Expression and functional characterization of naturally occuring truncated forms of AMPA-type glutamate receptor subunits

POCTI/MGI/43629/2001

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2000/11/01 - 2004

Protective effects of neurotrophins against glutamate toxicity in the hippocampus: intracellular signaling mechanisms

info:eu-repo/grantAgreement/FCT/POCI/32631/PT

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

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