Metabolism, Aging and Disease

MitoXT – Mitochondrial Toxicology and Experimental Therapeutics

Mitochondria

Oxidative stress

Aging

Lifestyle-related diseases


Research lines

Role of bioenergetic failure in the initiation and progression of cardiovascular, hepatic, and neurodegenerative diseases, as well as on osteoporosis

Modulation of energy metabolism function and cross-tolerance against cardiac injury afforded by exercise and diet

Fetal programming of cardiac mitochondrial fitness and relevance for adulthood pathologies

Mitochondrial alterations during stem cell differentiation and carcinogenesis

Use of mitochondria-directed natural and synthetic compounds as anti-cancer and anti-oxidant agents

Overview

The MitoXT group focuses on the role of mitochondria in lifestyles and aging-related diseases. Our objective is to understand the mechanisms underlying mitochondrial failure, to develop effective therapies. Among different topics, we study the a) failure of energy metabolism on drug and stress-induced cardiovascular injury, b) role of bioenergetic failure in the initiation and progression of cardiovascular, hepatic, and neurodegenerative diseases, as well as on osteoporosis, c) modulation of energy metabolism function and cross-tolerance against cardiac injury afforded by exercise and diet, d) fetal programming of cardiac mitochondrial fitness and relevance for adulthood pathologies, e) mitochondrial alterations during stem cell differentiation and carcinogenesis, and f) use of mitochondria-directed natural and synthetic compounds as anticancer and antioxidant agents. The group is located at the UC-Biotech building, Biocant Park, Cantanhede. In its laboratory space, the group has available several pieces of hardware, including a thermocycler and qRT-PCR system, fluorescent/UV-visible/luminescence multi-plate readers, Clark-type oxygen electrodes and oxygraphs, Western Blotting apparatus and imaging system, a multi-cuvette spectrophotometer, an epifluorescent microscope, a gTOXX Analyzer and a MIRA device, a Seahorse XFe96 Extracellular Flux Analyzer, as well as different centrifuges. Besides, the group has access to CNC/Biotech UC core equipment and facilities, including cell culture rooms, animal care facilities, epifluorescence, confocal microscopy, and flow cytometry, among others. The group has a robust internationalization, confirmed by the number of collaborations, secondments of foreign students, and activity of their Ph.D. members in international committees and Societies, and invited talks in several international events.

Publications

Show less

Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations

Teresa Cunha-Oliveira; Daniela Franco Silva; Luis Segura; Inês Baldeiras; Ricardo Marques; Tatiana Rosenstock; Paulo J. Oliveira; Filomena S. G. Silva, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13798 . 10.1111/eci.13798 . European Journal of Clinical Investigation

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Cláudia M. Deus; José Teixeira; Nuno Raimundo; Paolo Tucci; Fernanda Borges; Luciano Saso; Paulo J. Oliveira, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13820 . 10.1111/eci.13820 . European Journal of Clinical Investigation

Mitochondrial and metabolic remodelling in human skin fibroblasts in response to glucose availability

Sónia A. Pinho; Cláudio F. Costa; Cláudia M. Deus; Sonia L. C. Pinho; Inês Miranda-Santos; Gonçalo Afonso; Olivia Bagshaw; et al, 2022. The FEBS Journal. 2022. https://doi.org/10.1111/febs.16413 . 10.1111/febs.16413 . The FEBS Journal

Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant Molecule on Bovine Sperm Function and Embryo Production

João Campos Santos; Carla Cruz Marques; Maria Conceição Baptista; Jorge Pimenta; José Carlos Santos Teixeira; Liliana Montezinho; Fernando Cagide; et al, 2022. Animals. 2022. https://www.mdpi.com/2076-2615/12/7/804 . 10.3390/ani12070804 . Animals

The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to Therapeutics

Catarina Melim; Maria R. Lauro; Isabel M. Pires; Paulo J. Oliveira; Célia Cabral, 2022. Pharmaceutics. 2022. https://doi.org/10.3390/pharmaceutics14010190 . 10.3390/pharmaceutics14010190 . Pharmaceutics

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Anabela Marisa Azul; Martin Winter; Daniel Silva; Liljana Georgievska; Paulo J. Oliveira, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13749 . 10.1111/eci.13749 . European Journal of Clinical Investigation

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Paulo J Oliveira, 2022. European Heart Journal. 2022. https://doi.org/10.1093/eurheartj/ehab399 . 10.1093/eurheartj/ehab399 . European Heart Journal

Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics

Rui F. Simões; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2022. International Journal of Molecular Sciences. 3009 - 3009. 6. 23. 2022. https://doi.org/10.3390/ijms23063009 . 10.3390/ijms23063009 . International Journal of Molecular Sciences

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology

Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 Cardiomyoblasts

Bruno M. Moukette; José P. Castelão-Baptista; Luciana Ferreira; Ana M. Silva; Rui F. Simões; Célia Cabral; Constant A. Pieme; et al, 2021. Evidence-Based Complementary and Alternative Medicine. 2021. https://doi.org/10.1155/2021/8858165 . 10.1155/2021/8858165 . Evidence-Based Complementary and Alternative Medicine

H9c2(2-1)-based sulforhodamine B assay as a possible alternative in vitro platform to investigate effluent and metals toxicity on fish

Elsa T. Rodrigues; Miguel A. Pardal; Eduarda Pereira; Joana F. Monteiro; Ana C. Certal; Paulo J. Oliveira, 2021. Chemosphere. 2021. https://doi.org/10.1016/j.chemosphere.2021.130009 . 10.1016/j.chemosphere.2021.130009 . Chemosphere

Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation

Henrique J. Cardoso; Marília I. Figueira; Cátia V. Vaz; Tiago M. A. Carvalho; Luís A. Brás; Patrícia A. Madureira; Paulo J. Oliveira; Vilma A. Sardão; Sílvia Socorro, 2021. Cellular Oncology. 2021. https://doi.org/10.1007/s13402-020-00575-9 . 10.1007/s13402-020-00575-9 . Cellular Oncology

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; et al, 2021. Redox Biology. 102037 - 102037. 45. 2021. https://doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . Redox Biology

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Daniel Chavarria; Ophelie DA SILVA; Sofia Benfeito; Sandra Barreiro; Jorge Garrido; Cagide-Fagín; Pedro Soares; et al, 2021. Antioxidants. 2021. https://www.mdpi.com/2076-3921/10/2/329 . 10.3390/antiox10020329 . Antioxidants

Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

Rui F. Simões; Rute Pino; Maurício Moreira-Soares; Jaromira Kovarova; Jiri Neuzil; Rui Travasso; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2021. The FASEB Journal. 12. 35. 2021. https://doi.org/10.1096/fj.202100899R . 10.1096/fj.202100899R . The FASEB Journal

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Carlos Fernandes; Afonso J. C. Videira; Caroline D. Veloso; Sofia Benfeito; Pedro Soares; João D. Martins; Beatriz Gonçalves; et al, 2021. Biomolecules. 1605 - 1605. 11. 11. 2021. https://doi.org/10.3390/biom11111605 . 10.3390/biom11111605 . Biomolecules

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Luís F. Grilo; Carolina Tocantins; Mariana S. Diniz; Rodrigo Mello Gomes; Paulo J. Oliveira; Paulo Matafome; Susana P. Pereira, 2021. European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13625 . 10.1111/eci.13625 . European Journal of Clinical Investigation

Doxorubicin persistently rewires cardiac circadian homeostasis in mice

Luciana L. Ferreira; Marlene Cervantes; Hugo J. C. Froufe; Conceição Egas; Teresa Cunha-Oliveira; Paolo Sassone-Corsi; Paulo J. Oliveira, 2020. Archives of Toxicology. 257 - 271. 1. 94. 2020. https://doi.org/10.1007/s00204-019-02626-z . 10.1007/s00204-019-02626-z . Archives of Toxicology

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy

Kendall B. Wallace; Vilma A. Sardão; Paulo J. Oliveira, 2020. Circulation Research. 926 - 941. 7. 126. 2020. https://doi.org/10.1161/CIRCRESAHA.119.314681 . 10.1161/CIRCRESAHA.119.314681 . Circulation Research

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Guida Bento; Aygul K. Shafigullina; Albert A. Rizvanov; Vilma A. Sardão; Maria Paula Macedo; Paulo J. Oliveira, 2020. Cells. 573 - 573. 3. 9. 2020. https://doi.org/10.3390/cells9030573 . 10.3390/cells9030573 . Cells

Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

Susana Ponte; Lara Carvalho; Maria Gagliardi; Isabel Campos; Paulo J. Oliveira; António Jacinto, 2020. Biology Open. 2020. https://doi.org/10.1242/bio.048629 . 10.1242/bio.048629 . Biology Open

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Teresa Cunha-Oliveira; Liliana Montezinho; Catarina Mendes; Omidreza Firuzi; Luciano Saso; Paulo J. Oliveira; Filomena S. G. Silva; Jos L. Quiles, 2020. Oxidative Medicine and Cellular Longevity. 2020. https://doi.org/10.1155/2020/5021694 . 10.1155/2020/5021694 . Oxidative Medicine and Cellular Longevity

Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection

Ana R. Coelho; Paulo J. Oliveira, 2020. European Journal of Clinical Investigation. 2020. https://doi.org/10.1111/eci.13366 . 10.1111/eci.13366 . European Journal of Clinical Investigation

Publicly stressing the role of mitochondria in NAFLD with(in) a sports event

Mireia Alemany-Pagès; Rui Tavares; Sara Varela Amaral; Ana Teresa Barros-Viegas; Paulo J. Oliveira; João Ramalho-Santos; Anabela Marisa Azul, 2020. European Journal of Clinical Investigation. 2020. https://doi.org/10.1111/eci.13234 . 10.1111/eci.13234 . European Journal of Clinical Investigation

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

Ines C. M. Simoes; Agnieszka Karkucinska-Wieckowska; Justyna Janikiewicz; Sylwia Szymanska; Maciej Pronicki; Pawel Dobrzyn; Michal Dabrowski; et al, 2020. Antioxidants. 995 - 995. 10. 9. 2020. https://doi.org/10.3390/antiox9100995 . 10.3390/antiox9100995 . Antioxidants

A Mitochondrial Approach to Cardiovascular Risk and Disease

Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís Filipe Fragoso Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, 2019. Current Protein & Peptide Science. 2019. https://doi.org/10.2174/1389203720666190830163735 . 10.2174/1389203720666190830163735 . Current Protein & Peptide Science

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Adriana Fontes; Mireia Alemany-Pagès; Paulo J. Oliveira; João Ramalho-Santos; Hans Zischka; Anabela Marisa Azul, 2019. International Journal of Molecular Sciences. 3987 - 3987. 16. 20. 2019. https://doi.org/10.3390/ijms20163987 . 10.3390/ijms20163987 . International Journal of Molecular Sciences

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

Luciana L. Ferreira; Teresa Cunha-Oliveira; Caroline D. Veloso; Cláudio F. Costa; Kendall B. Wallace; Paulo J. Oliveira, 2019. Food and Chemical Toxicology. 450 - 461. 124. 2019. https://doi.org/10.1016/j.fct.2018.12.017 . 10.1016/j.fct.2018.12.017 . Food and Chemical Toxicology

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Ignazio Grattagliano; Liliana P. Montezinho; Paulo J. Oliveira; Gema Frühbeck; Javier Gómez-Ambrosi; Fabrizio Montecucco; Federico Carbone; et al, 2019. Biochemical Pharmacology. 34 - 45. 160. 2019. https://doi.org/10.1016/j.bcp.2018.11.020 . 10.1016/j.bcp.2018.11.020 . Biochemical Pharmacology

Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides

Elsa T. Rodrigues; Ana T. Varela; Miguel A. Pardal; Paulo J. Oliveira, 2019. Environmental Pollution. 476 - 482. 252. 2019. https://doi.org/10.1016/j.envpol.2019.05.033 . 10.1016/j.envpol.2019.05.033 . Environmental Pollution

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

Daniel Chavarria; Carlos Fernandes; Tiago Silva; Jorge Garrido; Fernando Remião; Paulo J. Oliveira; Fernanda Borges, 2019. Organic & Biomolecular Chemistry. 2019. https://doi.org/10.1039/C9OB01875A . 10.1039/C9OB01875A . Organic & Biomolecular Chemistry

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues

Daniel Chavarria; Carlos Fernandes; Brandon Aguiar; Tiago Silva; Jorge Garrido; Fernando Remiao; Paulo J. Oliveira; Eugenio Uriarte; Borges Fernanda, 2019. Molecules. 2019. https://www.mdpi.com/1420-3049/24/23/4405 . 10.3390/molecules24234405 . Molecules

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Cunha-Oliveira T; Ferreira LL; Coelho AR; Deus CM; Oliveira PJ, 2018. Toxicology and applied pharmacology. 2018. http://europepmc.org/abstract/med/29653124 . 10.1016/j.taap.2018.04.009 . Toxicology and applied pharmacology

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate.

Jarak I; Barosa C; Martins FO; Silva JCP; Santos C; Belew GD; Rito J; et al, 2018. Magnetic resonance in medicine. 2018. http://europepmc.org/abstract/med/30058123 . 10.1002/mrm.27378 . Magnetic resonance in medicine

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants.

Teixeira J; Deus CM; Borges F; Oliveira PJ, 2018. The international journal of biochemistry & cell biology. 2018. http://europepmc.org/abstract/med/29454114 . 10.1016/j.biocel.2018.02.007 . The international journal of biochemistry & cell biology

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity.

Pereira SP; Deus CM; Serafim TL; Cunha-Oliveira T; Oliveira PJ, 2018. Toxicological sciences : an official journal of the Society of Toxicology. 2018. http://europepmc.org/abstract/med/29945227 . 10.1093/toxsci/kfy068 . Toxicological sciences : an official journal of the Society of Toxicology

SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application.

Correia-da-Silva M; Rocha V; Marques C; Deus CM; Marques-Carvalho A; Oliveira PJ; Palmeira A; et al, 2018. Journal of molecular endocrinology. 2018. http://europepmc.org/abstract/med/29588426 . 10.1530/jme-18-0031 . Journal of molecular endocrinology

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

Carlos Fernandes; Sofia Benfeito; Ricardo Amorim; José Teixeira; Paulo J. Oliveira; Fernando Remião; Fernanda Borges, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.8b00383 . 10.1021/acs.bioconjchem.8b00383 . Bioconjugate Chemistry

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.

Oliveira C; Cagide F; Teixeira J; Amorim R; Sequeira L; Mesiti F; Silva T; et al, 2018. Frontiers in chemistry. 2018. http://europepmc.org/abstract/med/29740575 . 10.3389/fchem.2018.00126 . Frontiers in chemistry

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

Reis J; Cagide F; Valencia ME; Teixeira J; Bagetta D; Pérez C; Uriarte E; et al, 2018. European journal of medicinal chemistry. 2018. http://europepmc.org/abstract/med/30245401 . 10.1016/j.ejmech.2018.07.056 . European journal of medicinal chemistry

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.

Marques-Aleixo I; Santos-Alves E; Oliveira PJ; Moreira PI; Magalhães J; Ascensão A, 2018. Biochimica et biophysica acta. Reviews on cancer. 2018. http://europepmc.org/abstract/med/29408395 . 10.1016/j.bbcan.2018.01.002 . Biochimica et biophysica acta. Reviews on cancer

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M; Kovarova J; Coelho AR; Boukalova S; Oh S; Rohlenova K; Svec D; et al, 2018. Cell metabolism. 2018. http://europepmc.org/abstract/med/30449682 . 10.1016/j.cmet.2018.10.014 . Cell metabolism

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

Giorgi C; Marchi S; Simoes ICM; Ren Z; Morciano G; Perrone M; Patalas-Krawczyk P; et al, 2018. International review of cell and molecular biology. 2018. http://europepmc.org/abstract/med/30072092 . 10.1016/bs.ircmb.2018.05.006 . International review of cell and molecular biology

Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains

Filipa S. Carvalho; Catarina M. Morais; Jon Holy; Dmytro Krasutsky; Sergiy V. Yemets; Pavel A. Krasutsky; Amália S. Jurado; Paulo J. Oliveira; Teresa L. Serafim, 2018. Chemico-Biological Interactions. 198 - 210. 296. 2018. https://doi.org/10.1016/j.cbi.2018.10.002 . 10.1016/j.cbi.2018.10.002 . Chemico-Biological Interactions

TRAP1 regulates autophagy in lung cancer cells.

Barbosa IA; Vega-Naredo I; Loureiro R; Branco AF; Garcia R; Scott PM; Oliveira PJ, 2018. European journal of clinical investigation. 2018. http://europepmc.org/abstract/med/29383696 . 10.1111/eci.12900 . European journal of clinical investigation

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

José Teixeira; Catarina Oliveira; Fernando Cagide; Ricardo Amorim; Jorge Garrido; Fernanda Borges; Paulo J. Oliveira, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 567 - 576. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1442831 . 10.1080/14756366.2018.1442831 . Journal of Enzyme Inhibition and Medicinal Chemistry

Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells.

Silva AM; Oliveira PJ, 2018. Methods in molecular biology (Clifton, N.J.). 2018. http://europepmc.org/abstract/med/29850992 . 10.1007/978-1-4939-7831-1_2 . Methods in molecular biology (Clifton, N.J.)

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.

Fernandes C; Pinto M; Martins C; Gomes MJ; Sarmento B; Oliveira PJ; Remião F; Borges F, 2018. Bioconjugate chemistry. 2018. http://europepmc.org/abstract/med/29635917 . 10.1021/acs.bioconjchem.8b00151 . Bioconjugate chemistry

Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity.

Ribeiro JA; Benfeito S; Cagide F; Teixeira J; Oliveira PJ; Borges F; Silva AF; Pereira CM, 2018. Analytical chemistry. 2018. http://europepmc.org/abstract/med/29863846 . 10.1021/acs.analchem.8b00787 . Analytical chemistry

Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells

Deus, C. M.; Serafim, T. L.; Magalhães-Novais, S.; Vilaça, A.; Moreira, A. C.; Sardão, V. A.; Cardoso, S. M.; Oliveira, P. J., 2017. Arch Toxicol. 1261 - 1278. 3. 91. 2017. https://www.ncbi.nlm.nih.gov/pubmed/27358235 . 10.1007/s00204-016-1784-x . Arch Toxicol

Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients

Lassed, Somia; Deus, Claudia M.; Djebbari, Radja; Zama, Djamila; Oliveira, Paulo J.; Rizvanov, Albert A.; Dahdouh, Abderrezak; Benayache, Fadila; Benayache, Samir, 2017. Evidence-Based Complementary and Alternative Medicine. 91568 - 91568. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392530400001&KeyUID=WOS:000392530400001 . 10.1155/2017/1691568 . Evidence-Based Complementary and Alternative Medicine

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease

Teixeira, J.; Chavarria, D.; Borges, F.; Wojtczak, L.; Wieckowski, M. R.; Karkucinska-Wieckowska, A.; Oliveira, P. J., 2017. Curr Med Chem. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28554320 . 10.2174/0929867324666170529101810 . Curr Med Chem

The pathophysiological role of cholecystokinin-1 receptor in mouse cholelithogenesis

Carbone, Federico; Oliveira, Paulo J.; Bonaventura, Aldo; Montecucco, Fabrizio, 2017. European Journal of Clinical Investigation. 195 - 196. 2. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393880500011&KeyUID=WOS:000393880500011 . 10.1111/eci.12713 . European Journal of Clinical Investigation

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.

Teixeira J; Amorim R; Santos K; Soares P; Datta S; Cortopassi GA; Serafim TL; et al, 2017. Toxicology. 2017. http://europepmc.org/abstract/med/29141199 . 10.1016/j.tox.2017.11.014 . Toxicology

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity.

Ferreira A; Cunha-Oliveira T; Simões RF; Carvalho FS; Burgeiro A; Nordgren K; Wallace KB; Oliveira PJ, 2017. Toxicology. 2017. http://europepmc.org/abstract/med/28865727 . 10.1016/j.tox.2017.08.011 . Toxicology

Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling

Marques-Aleixo, I.; Santos-Alves, E.; Torrella, J. R.; Oliveira, P. J.; Magalhães, J.; Ascensão, A., 2017. Cardiovasc Toxicol. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28536949 . 10.1007/s12012-017-9412-4 . Cardiovasc Toxicol

Carvedilol and antioxidant proteins in a type I diabetes animal model

Diogo, Catia V.; Deus, Claudia M.; Lebiedzinska-Arciszewska, Magdalena; Wojtala, Aleksandra; Wieckowski, Mariusz R.; Oliveira, Paulo J., 2017. European Journal of Clinical Investigation. 19 - 29. 1. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393880700002&KeyUID=WOS:000393880700002 . 10.1111/eci.12696 . European Journal of Clinical Investigation

Evaluation of biological properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity

Kochel, Krzysztof; Tomczyk, Mateusz D.; Simoes, Rui F.; Fraczek, Tomasz; Sobon, Adrian; Oliveira, Paulo J.; Walczak, Krzysztof Z.; et al, 2017. Bioorganic & Medicinal Chemistry Letters. 427 - 431. 3. 27. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392900600010&KeyUID=WOS:000392900600010 . 10.1016/j.bmc1.2016.12.055 . Bioorganic & Medicinal Chemistry Letters

The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression.

Vecchione G; Grasselli E; Cioffi F; Baldini F; Oliveira PJ; Sardão VA; Cortese K; et al, 2017. Frontiers in nutrition. 2017. http://europepmc.org/abstract/med/28971098 . 10.3389/fnut.2017.00042 . Frontiers in nutrition

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

Gouveia, P. J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H. V.; Monteiro, L.; Nunes, J.; et al, 2017. Biomaterials. 213 - 228. 139. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

Teixeira, Jose; Cagide, Fernando; Benfeito, Sofia; Soares, Pedro; Garrido, Jorge; Baldeiras, Ines; Ribeiro, Jose A.; et al, 2017. Journal of Medicinal Chemistry. 7084 - 7098. 16. 60. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408598500017&KeyUID=WOS:000408598500017 . 10.1021/acs.jmedchem.7b00741 . Journal of Medicinal Chemistry

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Dong, L. F.; Kovarova, J.; Bajzikova, M.; Bezawork-Geleta, A.; Svec, D.; Endaya, B.; Sachaphibulkij, K.; et al, 2017. Elife. 6. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28195532 . 10.7554/eLife.22187 . Elife

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts.

Coelho AR; Martins TR; Couto R; Deus C; Pereira CV; Simões RF; Rizvanov AA; et al, 2017. Biochimica et biophysica acta. Molecular basis of disease. 2017. http://europepmc.org/abstract/med/28760703 . 10.1016/j.bbadis.2017.07.030 . Biochimica et biophysica acta. Molecular basis of disease

Mitochondrial biology in cancer stem cells.

Loureiro R; Mesquita KA; Magalhães-Novais S; Oliveira PJ; Vega-Naredo I, 2017. Seminars in cancer biology. 2017. http://europepmc.org/abstract/med/28673608 . 10.1016/j.semcancer.2017.06.012 . Seminars in cancer biology

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Teixeira, Jose; Oliveira, Catarina; Amorim, Ricardo; Cagide, Fernando; Garrido, Jorge; Ribeiro, Jose A.; Pereira, Carlos M.; et al, 2017. Scientific Reports. 7. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406610000093&KeyUID=WOS:000406610000093 . 10.1038/s41598-017-07272-y . Scientific Reports

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.

Teixeira J; Basit F; Swarts HG; Forkink M; Oliveira PJ; Willems PHGM; Koopman WJH, 2017. Redox biology. 2017. http://europepmc.org/abstract/med/29331741 . 10.1016/j.redox.2017.12.018 . Redox biology

Determination of Metabolic Viability and Cell Mass Using a Tandem Resazurin/Sulforhodamine B Assay.

Silva FS; Starostina IG; Ivanova VV; Rizvanov AA; Oliveira PJ; Pereira SP, 2016. Current protocols in toxicology. 2016. http://europepmc.org/abstract/med/27145111 . 10.1002/cptx.1 . Current protocols in toxicology

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, Ana Marta; Barbosa, Ines A.; Seabra, Catia; Beltrao, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; Cunha-Oliveira, Teresa, 2016. Food and Chemical Toxicology. 148 - 158. 94. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380414900016&KeyUID=WOS:000380414900016 . 10.1016/j.fct.2016.06.001 . Food and Chemical Toxicology

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Lassed, Somia; Deus, Claudia M.; Lourenco, Nuno; Dahdouh, Abderrezak; Rizvanov, Albert A.; Oliveira, Paulo J.; Zama, Djamila, 2016. Biomed Research International. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000387239100001&KeyUID=WOS:000387239100001 . 10.1155/2016/5730569 . Biomed Research International

Establishing a new model for toxicological evaluation combining Sulforhodamine B and resazurin in human cells

Silva, F. S. G.; Starostina, I. G.; Ivanova, V. V.; Rizvanov, A. A.; Oliveira, P. J.; Pereira, S. P., 2016. European Journal of Clinical Investigation. 66 - 66. 46. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375378000155&KeyUID=WOS:000375378000155 . European Journal of Clinical Investigation

Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

Pereira, Goncalo C.; Pereira, Susana P.; Tavares, Ludgero C.; Carvalho, Filipa S.; Magalhaes-Novais, Silvia; Barbosa, Ines A.; Santos, Maria S.; et al, 2016. Mitochondrion. 95 - 104. 30. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384037300011&KeyUID=WOS:000384037300011 . 10.1016/j.mito.2016.07.005 . Mitochondrion

Targeting Mitochondria in Cardiovascular Diseases

Silva, Filomena S. G.; Simoes, Rui F.; Couto, Renata; Oliveira, Paulo J., 2016. Current Pharmaceutical Design. 5698 - 5717. 37. 22. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388519800006&KeyUID=WOS:000388519800006 . 10.2174/1381612822666160822150243 . Current Pharmaceutical Design

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

Silva, Filomena S. G.; Oliveira, Paulo J.; Duarte, Maria F., 2016. Journal of Agricultural and Food Chemistry. 2991 - 3008. 15. 64. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000374812700001&KeyUID=WOS:000374812700001 . 10.1021/acs.jafc.5b06021 . Journal of Agricultural and Food Chemistry

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

Marques-Aleixo, I; Santos-Alves, E.; Balca, M. M.; Moreira; Oliveira, P. J.; Magalhaes, J.; Ascensao, A., 2016. Mitochondrion. 43 - 57. 26. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370768100006&KeyUID=WOS:000370768100006 . 10.1016/j.mito.2015.12.002 . Mitochondrion

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease

Bernardo, T. C.; Marques-Aleixo, I.; Beleza, J.; Oliveira, P. J.; Ascensao, A.; Magalhaes, J., 2016. Brain Pathology. 648 - 663. 5. 26. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384678400008&KeyUID=WOS:000384678400008 . 10.1111/bpa.12403 . Brain Pathology

Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications.

Rizvanov AA; Persson J; Sahin F; Bellusci S; Oliveira PJ, 2016. Stem cells international. 2016. http://europepmc.org/abstract/med/27999598 . 10.1155/2016/3157365 . Stem cells international

Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis

Goncalves, Ines O.; Passos, Emanuel; Diogo, Catia V.; Rocha-Rodrigues, Silvia; Santos-Alves, Estela; Oliveira, Paulo J.; Ascensao, Antonio; Magalhaes, Jose, 2016. Applied Physiology Nutrition and Metabolism. 298 - 306. 3. 41. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375441400010&KeyUID=WOS:000375441400010 . 10.1139/apnm-2015-0470 . Applied Physiology Nutrition and Metabolism

Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress.

Marques-Aleixo I; Santos-Alves E; Mariani D; Rizo-Roca D; Padrão AI; Rocha-Rodrigues S; Viscor G; et al, 2015. 2015. http://europepmc.org/abstract/med/25446396 . 10.1016/j.mito.2014.10.008 .

Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype.

Branco AF; Pereira SP; Gonzalez S; Gusev O; Rizvanov AA; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/26121149 . 10.1371/journal.pone.0129303 .

Analysis of pro-apoptotic protein trafficking to and from mitochondria.

Vega-Naredo I; Cunha-Oliveira T; Serafim TL; Sardao VA; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25308496 . 10.1007/978-1-4939-1875-1_14 .

Effects of Moderate Global Maternal Nutrient Reduction on Fetal Baboon Renal Mitochondrial Gene Expression at 0.9 Gestation.

Pereira SP; Oliveira PJ; Tavares LC; Moreno AJ; Cox LA; Nathanielsz PW; Nijland MJ, 2015. 2015. http://europepmc.org/abstract/med/25761880 . 10.1152/ajprenal.00419.2014 .

Comment on 'mycophenolic acid attenuates the tumour necrosis factor-a-mediated proinflammatory response in endothelial cells by blocking the MAPK/NF-¿B and ROS pathways' by Olejarz et al.

Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25413447 . 10.1111/eci.12382 .

Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.

Teixeira J; Soares P; Benfeito S; Murphy MP; Oliveira PJ; Borges F, 2015. 2015. http://europepmc.org/abstract/med/25634268 . 10.1007/978-1-4939-2288-8_6 .

Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies.

Tavares LC; Jarak I; Nogueira FN; Oliveira PJ; Carvalho RA, 2015. 2015. http://europepmc.org/abstract/med/25524585 . 10.1111/eci.12358 .

Measuring p66Shc Signaling Pathway Activation and Mitochondrial Translocation in Cultured Cells.

Wieckowski MR; Deus CM; Couto R; Oparka M; Lebiedzinska-Arciszewska M; Duszynski J; Oliveira PJ, 2015. Current protocols in toxicology. 2015. http://europepmc.org/abstract/med/26523473 . 10.1002/0471140856.tx2506s66 . Current protocols in toxicology

Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts.

Deus CM; Zehowski C; Nordgren K; Wallace KB; Skildum A; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25997894 . 10.1016/j.tox.2015.05.001 .

Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-targeting Molecules.

Deus CM; Santos GL; Loureiro R; Vega-Naredo I; Faneca H; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25666790 .

Bisphenol A as epigenetic modulator: setting the stage for carcinogenesis?

Ferreira LL; Couto R; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25524584 . 10.1111/eci.12362 .

Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling.

Santos-Alves E; Marques-Aleixo I; Rizo-Roca D; Torrella JR; Oliveira PJ; Magalhães J; Ascensão A, 2015. 2015. http://europepmc.org/abstract/med/26135624 . 10.1016/j.lfs.2015.06.007 .

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers.

Marques-Aleixo I; Santos-Alves E; Balça MM; Rizo-Roca D; Moreira PI; Oliveira PJ; Magalhães J; Ascensão A, 2015. 2015. http://europepmc.org/abstract/med/26116519 . 10.1016/j.neuroscience.2015.06.027 .

Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin.

Rodrigues ET; Pardal MÂ; Laizé V; Cancela ML; Oliveira PJ; Serafim TL, 2015. 2015. http://europepmc.org/abstract/med/26319055 . 10.1016/j.envpol.2015.08.026 .

p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts.

Sampaio SF; Branco AF; Wojtala A; Vega-Naredo I; Wieckowski MR; Oliveira PJ; Sampaio, Susana F.; et al, 2015. Archives of Toxicology. 1669 - 1684. 7. 90. 2015. http://europepmc.org/abstract/med/26318906 . 10.1007/s00204-015-1583-9 . Archives of Toxicology

Measuring Mitochondrial Membrane Potential with a Tetraphenylphosphonium-Selective Electrode.

Moreno AJ; Santos DL; Magalhães-Novais S; Oliveira PJ, 2015. Current protocols in toxicology. 2015. http://europepmc.org/abstract/med/26250398 . 10.1002/0471140856.tx2505s65 . Current protocols in toxicology

Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells.

Loureiro R; Magalhães-Novais S; Mesquita KA; Baldeiras I; Sousa IS; Tavares LC; Barbosa IA; Oliveira PJ; Vega-Naredo I, 2015. 2015. http://europepmc.org/abstract/med/26025920 .

Protective role of necrostatin-1 in acute myocardial infarction.

Carbone F; Oliveira PJ; Montecucco F, 2015. European journal of clinical investigation. 2015. http://europepmc.org/abstract/med/26584011 . 10.1111/eci.12568 . European journal of clinical investigation

Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.

Jiménez-Chillarón JC; Nijland MJ; Ascensão AA; Sardão VA; Magalhães J; Hitchler MJ; Domann FE; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25774863 . 10.1080/15592294.2015.1020267 .

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J., 2014. Medicinal Research Reviews. 106 - 135. 1. 34. 2014. 10.1002/med.21280 . Medicinal Research Reviews

Modulation of cardiac mitochondrial permeability transition and apoptotic signaling by endurance training and intermittent hypobaric hypoxia

Magalhães, J.; Gonçalves, I. O.; Lumini-Oliveira, J.; Marques-Aleixo, I.; Passos, E.; Rocha-Rodrigues, S.; Machado, N. G.; et al, 2014. Int J Cardiol. 2014. 10.1016/j.ijcard.2014.02.011 . Int J Cardiol

Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity.

Ivanova VV; Khaiboullina SF; Cherenkova EE; Martynova EV; Nevzorova TA; Kunst MA; Sibgatullin TB; et al, 2014. 2014. http://europepmc.org/abstract/med/25562166 . 10.1159/000369663 .

ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco AF; Moreira AC; Cunha-Oliveira T; Couto R; Sardao VA; Rizvanov AA; Palotas A; Oliveira PJ, 2014. Current drug targets. 2014. http://europepmc.org/abstract/med/25182471 . 10.2174/1389450115666140902124230 . Current drug targets

Carriers for metal complexes on tumour cells: the effect of cyclodextrins vs CNTs on the model guest phenanthroline-5,6-dione trithiacyclononane ruthenium(II) chloride

Braga, S. S.; Marques, J.; Heister, E.; Diogo, C. V.; Oliveira, P. J.; Paz, F. A.; Santos, T. M.; Marques, M. P., 2014. Biometals. 2014. 10.1007/s10534-014-9725-8 . Biometals

Mitochondrial membrane lipids in life and death and their molecular modulation by diet: tuning the furnace.

Monteiro JP; Morais CM; Oliveira PJ; Jurado AS, 2014. Current drug targets. 2014. http://europepmc.org/abstract/med/24953065 . 10.2174/1389450115666140623115315 . Current drug targets

Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments.

Gonçalves IO; Passos E; Rocha-Rodrigues S; Diogo CV; Torrella JR; Rizo D; Viscor G; et al, 2014. 2014. http://europepmc.org/abstract/med/24727595 . 10.1016/j.mito.2014.03.012 .

Vital imaging of multicellular spheroids

Oliveira, P. J.; Perkins, E. L.; Holy, J., 2014. Methods Mol Biol. 227 - 41. 1075. 2014. 10.1007/978-1-60761-847-8_11 . Methods Mol Biol

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells.

Vega-Naredo I; Loureiro R; Mesquita KA; Barbosa IA; Tavares LC; Branco AF; Erickson JR; et al, 2014. 2014. http://europepmc.org/abstract/med/24832466 . 10.1038/cdd.2014.66 .

Exercise mitigates diclofenac-induced liver mitochondrial dysfunction.

Santos-Alves E; Marques-Aleixo I; Coxito P; Balça MM; Rizo-Roca D; Rocha-Rodrigues S; Martins S; et al, 2014. 2014. http://europepmc.org/abstract/med/24889192 . 10.1111/eci.12285 .

Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis.

Gonçalves IO; Maciel E; Passos E; Torrella JR; Rizo D; Viscor G; Rocha-Rodrigues S; et al, 2014. 2014. http://europepmc.org/abstract/med/25063232 . 10.1016/j.biocel.2014.07.011 .

New derivatives of lupane triterpenoids disturb breast cancer mitochondria and induce cell death.

Serafim TL; Carvalho FS; Bernardo TC; Pereira GC; Perkins E; Holy J; Krasutsky DA; et al, 2014. 2014. http://europepmc.org/abstract/med/25245673 . 10.1016/j.bmc.2014.08.013 .

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

Moreira AC; Branco AF; Sampaio SF; Cunha-Oliveira T; Martins TR; Holy J; Oliveira PJ; Sardão VA, 2014. 2014. http://europepmc.org/abstract/med/25283819 . 10.1016/j.bbadis.2014.09.015 .

Targeting mitochondrial function for the treatment of breast cancer.

Deus CM; Coelho AR; Serafim TL; Oliveira PJ, 2014. 2014. http://europepmc.org/abstract/med/25365234 . 10.4155/fmc.14.100 .

Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics.

Monteiro JP; Pereira CV; Silva AM; Maciel E; Baldeiras I; Peixoto F; Domingues MR; Jurado AS; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23636270 . 10.1007/s00204-013-1068-7 .

Breath tests with novel 13c-substrates for clinical studies of liver mitochondrial function in health and disease.

Grattagliano I; Bonfrate L; Oliveira PJ; Castorani L; Ruggiero V; Valenzano AT; Ascensão A; Buzoianu A; Portincasa P, 2013. 2013. http://europepmc.org/abstract/med/24443072 .

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition.

Bernardo TC; Cunha-Oliveira T; Serafim TL; Holy J; Krasutsky D; Kolomitsyna O; Krasutsky P; Moreno AM; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/24156937 . 10.1016/j.bmc.2013.09.066 .

Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology

Rocha-Rodrigues, Silvia; Santos-Alves, Estela; Coxito, Pedro M.; Marques-Aleixo, Ines; Passos, Emanuel; Guimaraes, Joao T.; Martins, Maria J.; et al, 2013. Life Sciences. 329 - 337. 8. 93. 2013. 10.1016/j.lfs.2013.07.004 . Life Sciences

Modulation of hepatic redox status and mitochondrial metabolism by exercise: therapeutic strategy for liver diseases.

Ascensão A; Martins MJ; Santos-Alves E; Gonçalves IO; Portincasa P; Oliveira PJ; Magalhães J, 2013. 2013. http://europepmc.org/abstract/med/23880173 . 10.1016/j.mito.2013.07.002 .

Cardiac mitochondrial dysfunction during hyperglycemia - The role of oxidative stress and p66Shc signaling

Diogo, C.V., 2013. International Journal of Biochemistry and Cell Biology. 114 - 122. 1. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870696911&partnerID=MN8TOARS . 10.1016/j.biocel.2012.07.004 . International Journal of Biochemistry and Cell Biology

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.

Pereira SL; Grãos M; Rodrigues AS; Anjo SI; Carvalho RA; Oliveira PJ; Arenas E; Ramalho-Santos J, 2013. 2013. http://europepmc.org/abstract/med/24312632 . 10.1371/journal.pone.0082095 .

Eccentric exercise transiently affects mice skeletal muscle mitochondrial function

Magalhaes, Jose; Fraga, Marta; Lumini-Oliveira, Jose; Goncalves, Ines; Costa, Manoel; Ferreira, Rita; Oliveira, Paulo J.; Ascensao, Antonio, 2013. Applied Physiology Nutrition and Metabolism-Physiologie Appliquee Nutrition Et Metabolisme. 401 - 409. 4. 38. 2013. 10.1139/apnm-2012-0226 . Applied Physiology Nutrition and Metabolism-Physiologie Appliquee Nutrition Et Metabolisme

Disrupted ATP synthase activity and mitochondrial hyperpolarisation- dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients

Lebiedzinska, M., 2013. International Journal of Biochemistry and Cell Biology. 141 - 150. 1. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870685606&partnerID=MN8TOARS . 10.1016/j.biocel.2012.07.020 . International Journal of Biochemistry and Cell Biology

Rapid human melanoma cell death induced by sanguinarine through oxidative stress

Burgeiro, A., 2013. European Journal of Pharmacology. 109 - 118. 1-3. 705. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875293604&partnerID=MN8TOARS . 10.1016/j.ejphar.2013.02.035 . European Journal of Pharmacology

Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats

Pereira, Susana P.; Pereira, Goncalo C.; Pereira, Claudia V.; Carvalho, Filipa S.; Cordeiro, Marilia H.; Mota, Paula C.; Ramalho-Santos, Joao; Moreno, Antonio J.; Oliveira, Paulo J., 2013. Environmental Pollution. 281 - 290. 180. 2013. 10.1016/j.envpol.2013.05.049 . Environmental Pollution

Mitochondria in cancer stem cells: a target for therapy.

Loureiro R; Mesquita KA; Oliveira PJ; Vega-Naredo I, 2013. 2013. http://europepmc.org/abstract/med/23360288 . 10.2174/18722148113079990006 .

Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity.

Monteiro JP; Silva AM; Jurado AS; Oliveira PJ, 2013. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013. http://europepmc.org/abstract/med/23933359 . 10.1016/j.fct.2013.07.073 . Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition

Burgeiro, Ana; Pereira, Claudia V.; Carvalho, Filipa S.; Pereira, Goncalo C.; Mollinedo, Faustino; Oliveira, Paulo J., 2013. Mitochondrion. 25 - 35. 1. 13. 2013. 10.1016/j.mito.2012.11.003 . Mitochondrion

Biological insight, high-throughput datasets and the nature of neuro-degenerative disorders.

Valente AX; Oliveira PJ; Khaiboullina SF; Palotás A; Rizvanov AA, 2013. 2013. http://europepmc.org/abstract/med/23937175 . 10.2174/13892002113149990100 .

A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects

Monteiro, Joao P.; Martins, Andre F.; Nunes, Claudia; Morais, Catarina M.; Lucio, Marlene; Reis, Salette; Pinheiro, Teresa J. T.; et al, 2013. Biochimica Et Biophysica Acta-Biomembranes. 1899 - 1908. 8. 1828. 2013. 10.1016/j.bbamem.2013.04.006 . Biochimica Et Biophysica Acta-Biomembranes

Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis.

Gonçalves IO; Oliveira PJ; Ascensão A; Magalhães J, 2013. European journal of clinical investigation. 2013. http://europepmc.org/abstract/med/24033085 . 10.1111/eci.12146 . European journal of clinical investigation

Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling.

Magalhães J; Falcão-Pires I; Gonçalves IO; Lumini-Oliveira J; Marques-Aleixo I; Dos Passos E; Rocha-Rodrigues S; et al, 2013. 2013. http://europepmc.org/abstract/med/24012275 . 10.1016/j.ijcard.2013.08.001 .

Ipilimumab and vemurafenib: two different routes for targeting melanoma.

Burgeiro A; Mollinedo F; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23862981 . 10.2174/15680096113139990080 .

Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: differential activation of stress and survival pathways.

Branco AF; Sampaio SF; Wieckowski MR; Sardão VA; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23958426 . 10.1016/j.biocel.2013.08.006 .

Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions.

Monteiro JP; Oliveira PJ; Jurado AS, 2013. 2013. http://europepmc.org/abstract/med/23827885 . 10.1016/j.plipres.2013.06.002 .

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

Grattagliano, Ignazio; Diogo, Catia V.; Mastrodonato, Maria; de Bari, Ornella; Persichella, Michele; Wang, David Q. H.; Liquori, Adriana; et al, 2013. World Journal of Gastroenterology. 3007 - 3017. 20. 19. 2013. 10.3748/wjg.v19.i20.3007 . World Journal of Gastroenterology

Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies

Barbosa, I.A., 2012. Biochimica et Biophysica Acta - Reviews on Cancer. 238 - 254. 1. 1826. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860808557&partnerID=MN8TOARS . 10.1016/j.bbcan.2012.04.005 . Biochimica et Biophysica Acta - Reviews on Cancer

Erratum: Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution (Journal of Cardiovascular Pharmacology (2012) 59 (151-157))

Alves, M.G., 2012. Journal of Cardiovascular Pharmacology. 2. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865613134&partnerID=MN8TOARS . 10.1097/FJC.0b013e31825cce63 . Journal of Cardiovascular Pharmacology

Epigenetic engineering to reverse the Parkinson's expression state

Valente, A.X.C.N., 2012. Parkinsonism and Related Disorders. 717 - 721. 6. 18. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS . 10.1016/j.parkreldis.2012.04.018 . Parkinsonism and Related Disorders

Endurance training and chronic intermittent hypoxia modulate in vitro salicylate-induced hepatic mitochondrial dysfunction

Ascensão, A., 2012. Mitochondrion. 607 - 616. 6. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869082628&partnerID=MN8TOARS . 10.1016/j.mito.2012.10.007 . Mitochondrion

Differentiation-dependent doxorubicin toxicity on h9c2 cardiomyoblasts

Branco, A.F., 2012. Cardiovascular Toxicology. 326 - 340. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870546889&partnerID=MN8TOARS . 10.1007/s12012-012-9177-8 . Cardiovascular Toxicology

Regulation and protection of mitochondrial physiology by sirtuins

Pereira, C.V., 2012. Mitochondrion. 66 - 76. 1. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856527254&partnerID=MN8TOARS . 10.1016/j.mito.2011.07.003 . Mitochondrion

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

Pereira, C.V., 2012. Toxicology and Applied Pharmacology. 167 - 181. 2. 264. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866878955&partnerID=MN8TOARS . 10.1016/j.taap.2012.07.030 . Toxicology and Applied Pharmacology

Mitochondrionopathy phenotype in doxorubicin-treated wistar rats depends on treatment protocol and is cardiac-specific

Pereira, G.C., 2012. PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862661781&partnerID=MN8TOARS . 10.1371/journal.pone.0038867 . PLoS ONE

Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity

Vega-Naredo, I., 2012. Journal of Pineal Research. 80 - 92. 1. 52. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555174326&partnerID=MN8TOARS . 10.1111/j.1600-079X.2011.00922.x . Journal of Pineal Research

Evaluation of respiration with clark type electrode in Isolated mitochondria and permeabilized animal cells

Silva, A.M., 2012. Methods in Molecular Biology. 7 - 24. 810. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355193801&partnerID=MN8TOARS . 10.1007/978-1-61779-382-0_2 . Methods in Molecular Biology

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

Pereira, C.V., 2012. Expert Opinion on Drug Metabolism and Toxicology. 219 - 237. 2. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856086570&partnerID=MN8TOARS . 10.1517/17425255.2012.645536 . Expert Opinion on Drug Metabolism and Toxicology

Exercise as a beneficial adjunct therapy during Doxorubicin treatment-Role of mitochondria in cardioprotection

Ascensão, A., 2012. International Journal of Cardiology. 4 - 10. 1. 156. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858070585&partnerID=MN8TOARS . 10.1016/j.ijcard.2011.05.060 . International Journal of Cardiology

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

Oliveira PJ; Carvalho RA; Portincasa P; Bonfrate L; Sardao VA, 2012. 2012. http://europepmc.org/abstract/med/22496981 . 10.1155/2012/365798 .

Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation

Grattagliano, I., 2012. Clinical Biochemistry. 610 - 618. 9. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861230299&partnerID=MN8TOARS . 10.1016/j.clinbiochem.2012.03.024 . Clinical Biochemistry

Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution

Alves, M.G., 2012. Journal of Cardiovascular Pharmacology. 151 - 157. 2. 59. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857063384&partnerID=MN8TOARS . 10.1097/FJC.0b013e3182391d17 . Journal of Cardiovascular Pharmacology

Toxicity evaluation of some traditional African spices on breast cancer cells and isolated rat hepatic mitochondria

Choumessi, A.T., 2012. Food and Chemical Toxicology. 4199 - 4208. 11. 50. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866522308&partnerID=MN8TOARS . 10.1016/j.fct.2012.08.008 . Food and Chemical Toxicology

In vitro salicylate does not further impair aging-induced brain mitochondrial dysfunction

Marques-Aleixo, I., 2012. Toxicology. 51 - 59. 1. 302. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866002199&partnerID=MN8TOARS . 10.1016/j.tox.2012.07.018 . Toxicology

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

Marques-Aleixo, I., 2012. Progress in Neurobiology. 149 - 162. 2. 99. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867896217&partnerID=MN8TOARS . 10.1016/j.pneurobio.2012.08.002 . Progress in Neurobiology

Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition

Cuenca-Lopez, M.D., 2012. Pharmacological Research. 120 - 128. 1. 65. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855986971&partnerID=MN8TOARS . 10.1016/j.phrs.2011.08.007 . Pharmacological Research

Erratum: Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line (Cardiovascular Toxicology DOI: 10.1007/s12012-011-9111-5)

Branco, A.F., 2011. Cardiovascular Toxicology. 3. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054890288&partnerID=MN8TOARS . 10.1007/s12012-011-9131-1 . Cardiovascular Toxicology

Differential effects of p,p'-DDE on testis and liver mitochondria:Implications for reproductive toxicology

Mota, P.C., 2011. Reproductive Toxicology. 80 - 85. 1. 31. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551613557&partnerID=MN8TOARS . 10.1016/j.reprotox.2010.09.010 . Reproductive Toxicology

Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia

Lumini-Oliveira, J., 2011. Mitochondrion. 54 - 63. 1. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650035561&partnerID=MN8TOARS . 10.1016/j.mito.2010.07.005 . Mitochondrion

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells

Burgeiro, A., 2011. Anti-Cancer Drugs. 507 - 518. 6. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958289658&partnerID=MN8TOARS . 10.1097/CAD.0b013e32834438f6 . Anti-Cancer Drugs

Drug-induced cardiac mitochondrial toxicity and protection: From doxorubicin to carvedilol

Pereira, G.C., 2011. Current Pharmaceutical Design. 2113 - 2129. 20. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052226370&partnerID=MN8TOARS . 10.2174/138161211796904812 . Current Pharmaceutical Design

Berberine as a promising safe anti-cancer agent - is there a role for mitochondria?

Diogo, C.V., 2011. Current Drug Targets. 850 - 859. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955619830&partnerID=MN8TOARS . 10.2174/138945011795528930 . Current Drug Targets

Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: A biophysical approach with relevance to mitochondrial uncoupling

Monteiro, J.P., 2011. Journal of Bioenergetics and Biomembranes. 287 - 298. 3. 43. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959768623&partnerID=MN8TOARS . 10.1007/s10863-011-9359-2 . Journal of Bioenergetics and Biomembranes

Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells

Serafim, T.L., 2011. Chemical Research in Toxicology. 763 - 774. 5. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956157475&partnerID=MN8TOARS . 10.1021/tx200126r . Chemical Research in Toxicology

Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity?

Monteiro, J.P., 2011. Toxicology in Vitro. 1215 - 1223. 6. 25. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960964709&partnerID=MN8TOARS . 10.1016/j.tiv.2011.05.014 . Toxicology in Vitro

Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion

Alves, M.G., 2011. Journal of Cellular Biochemistry. 3872 - 3881. 12. 112. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055000219&partnerID=MN8TOARS . 10.1002/jcb.23320 . Journal of Cellular Biochemistry

Sodium hydrosulfide improves the protective potential of the cardioplegic histidine buffer solution

Alves, M.G., 2011. European Journal of Pharmacology. 60 - 67. 1. 654. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78951491593&partnerID=MN8TOARS . 10.1016/j.ejphar.2010.12.010 . European Journal of Pharmacology

Mitochondrial tolerance to drugs and toxic agents in ageing and disease

Suski, J., 2011. Current Drug Targets. 827 - 849. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955592779&partnerID=MN8TOARS . 10.2174/138945011795529029 . Current Drug Targets

Mitochondria in chronic liver disease

Grattagliano, I., 2011. Current Drug Targets. 879 - 893. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955606583&partnerID=MN8TOARS . 10.2174/138945011795528877 . Current Drug Targets

Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen

Moreira, P.I., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology

Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats

Ascensão, A., 2011. Clinical Science. 37 - 49. 1. 120. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650871083&partnerID=MN8TOARS . 10.1042/CS20100254 . Clinical Science

Mitochondria as a target for exercise-induced cardioprotection

Ascensão, A., 2011. Current Drug Targets. 860 - 871. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955608557&partnerID=MN8TOARS . 10.2174/138945011795529001 . Current Drug Targets

Mitochondria as a drug target in health and disease

Oliveira, P.J., 2011. Current Drug Targets. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955623985&partnerID=MN8TOARS . 10.2174/138945011795528912 . Current Drug Targets

Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies

Pereira, S.L., 2011. Cardiovascular Toxicology. 180 - 190. 2. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958056642&partnerID=MN8TOARS . 10.1007/s12012-011-9112-4 . Cardiovascular Toxicology

Substrate selection in hearts subjected to ischemia/reperfusion: Role of cardioplegic solutions and gender

Alves, M.G., 2011. NMR in Biomedicine. 1029 - 1037. 9. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054064346&partnerID=MN8TOARS . 10.1002/nbm.1640 . NMR in Biomedicine

Re-wiring the circuit: Mitochondria as a pharmacological target in liver disease

Diogo, C.V., 2011. Current Medicinal Chemistry. 5448 - 5465. 35. 18. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255173714&partnerID=MN8TOARS . 10.2174/092986711798194432 . Current Medicinal Chemistry

Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line

Branco, A.F., 2011. Cardiovascular Toxicology. 191 - 203. 3. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054914028&partnerID=MN8TOARS . 10.1007/s12012-011-9111-5 . Cardiovascular Toxicology

Dimethylaminopyridine derivatives of lupane triterpenoids are potent disruptors of mitochondrial structure and function

Holy, J., 2010. Bioorganic and Medicinal Chemistry. 6080 - 6088. 16. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955472585&partnerID=MN8TOARS . 10.1016/j.bmc.2010.06.075 . Bioorganic and Medicinal Chemistry

Sub-chronic administration of doxorubicin to Wistar rats results in oxidative stress and unaltered apoptotic signaling in the lung

Machado, N.G., 2010. Chemico-Biological Interactions. 478 - 486. 3. 188. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149466319&partnerID=MN8TOARS . 10.1016/j.cbi.2010.09.027 . Chemico-Biological Interactions

Biapigenin modulates the activity of the adenine nucleotide translocator in isolated rat brain mitochondria

Silva, B.A., 2010. Neurotoxicity Research. 75 - 90. 1. 17. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77449110345&partnerID=MN8TOARS . 10.1007/s12640-009-9082-5 . Neurotoxicity Research

Electrochemical oxidation of sanguinarine and of its oxidation products at a glassy carbon electrode - relevance to intracellular effects

Diculescu, V.C., 2010. Electroanalysis. 113 - 120. 1. 22. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-72649099240&partnerID=MN8TOARS . 10.1002/elan.200900367 . Electroanalysis

Nitrogen compounds prevent h9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death.

Silva JP; Sardão VA; Coutinho OP; Oliveira PJ; Olveira PJ, 2010. 2010. http://europepmc.org/abstract/med/20119745 . 10.1007/s12012-010-9062-2 .

Long-term hyperglycaemia decreases gastrocnemius susceptibility to permeability transition

Lumini-Oliveira, J., 2010. European Journal of Clinical Investigation. 319 - 329. 4. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949664613&partnerID=MN8TOARS . 10.1111/j.1365-2362.2010.02267.x . European Journal of Clinical Investigation

Erratum: Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death (Cardiovascular Toxicology (2010) 10 (51-65) DOI:10.1007/s12012-010-9062-2)

Silva, J.P., 2010. Cardiovascular Toxicology. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956395509&partnerID=MN8TOARS . 10.1007/s12012-010-9067-x . Cardiovascular Toxicology

Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?

Pereira, S.P.; Pereira SP; Pereira GC; Moreno AJ; Oliveira PJ, 2009. ATLA Alternatives to Laboratory Animals. 355 - 365. 4. 37. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449604749&partnerID=MN8TOARS . ATLA Alternatives to Laboratory Animals

Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets

Sardão, V.A., 2009. Cell Biology and Toxicology. 227 - 243. 3. 25. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349167673&partnerID=MN8TOARS . 10.1007/s10565-008-9070-1 . Cell Biology and Toxicology

Parabens in male infertility-Is there a mitochondrial connection?

Tavares, R.S., 2009. Reproductive Toxicology. 1 - 7. 1. 27. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749116602&partnerID=MN8TOARS . 10.1016/j.reprotox.2008.10.002 . Reproductive Toxicology

Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats

Amaral, S., 2009. Mitochondrion. 41 - 50. 1. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60249101037&partnerID=MN8TOARS . 10.1016/j.mito.2008.11.005 . Mitochondrion

Electrochemical oxidation of berberine and of its oxidation products at a glassy carbon electrode

Diculescu, V.C., 2009. Electroanalysis. 1027 - 1034. 9. 21. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66649083195&partnerID=MN8TOARS . 10.1002/elan.200804516 . Electroanalysis

Doxorubicin: The good, the bad and the ugly effect

Carvalho, C., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety?

Pereira, C.V., 2009. Current Drug Safety. 34 - 54. 1. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-63249131066&partnerID=MN8TOARS . 10.2174/157488609787354440 . Current Drug Safety

Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts

Sardão, V.A., 2009. Cancer Chemotherapy and Pharmacology. 811 - 827. 4. 64. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169047&partnerID=MN8TOARS . 10.1007/s00280-009-0932-x . Cancer Chemotherapy and Pharmacology

Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-A model for endangered species

Mota, P., 2009. Reproductive Toxicology. 111 - 116. 2. 27. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549148154&partnerID=MN8TOARS . 10.1016/j.reprotox.2009.01.008 . Reproductive Toxicology

Mitochondrial preservation in celsior versus histidine buffer solution during cardiac Ischemia and reperfusion

Alves, M.G., 2009. Cardiovascular Toxicology. 185 - 193. 4. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-71949090655&partnerID=MN8TOARS . 10.1007/s12012-009-9052-4 . Cardiovascular Toxicology

Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin - Relevance for possible anti-cancer application

Diogo, C.V., 2009. Toxicology in Vitro. 772 - 779. 5. 23. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649401716&partnerID=MN8TOARS . 10.1016/j.tiv.2009.04.002 . Toxicology in Vitro

Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box?

Machado NG; Alves MG; Carvalho RA; Oliveira PJ, 2009. 2009. http://europepmc.org/abstract/med/19855945 . 10.1007/s12012-009-9055-1 .

Endurance training improves gastrocnemius mitochondrial function despite increased susceptibility to permeability transition

Lumini-Oliveira, J., 2009. Mitochondrion. 454 - 462. 6. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449133441&partnerID=MN8TOARS . 10.1016/j.mito.2009.08.005 . Mitochondrion

Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury.

Sardão VA; Pereira SL; Oliveira PJ, 2008. 2008. http://europepmc.org/abstract/med/18324876 . 10.1517/14740338.7.2.129 .

Inhibition of the adenine nucleotide translocator by N-acetyl perfluorooctane sulfonamides in vitro

O'Brien, T.M., 2008. Toxicology and Applied Pharmacology. 184 - 195. 2. 227. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949127988&partnerID=MN8TOARS . 10.1016/j.taap.2007.10.016 . Toxicology and Applied Pharmacology

Mechanisms of berberine (Natural Yellow 18) - Induced mitochondrial dysfunction: Interaction with the adenine nucleotide translocator

Pereira, C.V., 2008. Toxicological Sciences. 408 - 417. 2. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849122083&partnerID=MN8TOARS . 10.1093/toxsci/kfn131 . Toxicological Sciences

Quercetin, kaempferol and biapigenin from hypericum perforatum are neuroprotective against excitotoxic insults

Silva, B., 2008. Neurotoxicity Research. 265 - 279. 3-4. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55249095521&partnerID=MN8TOARS . 10.1007/BF03033510 . Neurotoxicity Research

Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells-Nuclear vs. mitochondrial effects

Serafim, T.L., 2008. Biochemical Pharmacology. 1459 - 1475. 11. 76. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949119796&partnerID=MN8TOARS . 10.1016/j.bcp.2008.07.013 . Biochemical Pharmacology

Diabetes and the impairment of reproductive function: Possible role of mitochondria and reactive oxygen species

Amaral, S., 2008. Current Diabetes Reviews. 46 - 54. 1. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949101210&partnerID=MN8TOARS . 10.2174/157339908783502398 . Current Diabetes Reviews

Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus

Lumini, J.A., 2008. Sports Medicine. 735 - 750. 9. 38. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49949103399&partnerID=MN8TOARS . 10.2165/00007256-200838090-00003 . Sports Medicine

Complex formation between heptakis(2,6-di-O-methyl)-ß-cyclodextrin and cyclopentadienyl molybdenum(II) dicarbonyl complexes: Structural studies and cytotoxicity evaluations

Pereira, C.C.L., 2008. Organometallics. 4948 - 4956. 19. 27. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249115357&partnerID=MN8TOARS . 10.1021/om800413w . Organometallics

Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line

Serafim, T.L., 2008. Cancer Chemotherapy and Pharmacology. 1007 - 1018. 6. 61. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41049098849&partnerID=MN8TOARS . 10.1007/s00280-007-0558-9 . Cancer Chemotherapy and Pharmacology

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, S., 2008. Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.08.008 . Free Radical Biology and Medicine

Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene - relevance for toxicological assessment.

Monteiro JP; Oliveira PJ; Moreno AJ; Jurado AS, 2008. 2008. http://europepmc.org/abstract/med/18511104 . 10.1016/j.chemosphere.2008.04.024 .

Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

Amaral, S., 2008. FEBS Letters. 4191 - 4196. 30. 582. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649108974&partnerID=MN8TOARS . 10.1016/j.febslet.2008.11.020 . FEBS Letters

Mitochondria as targets for neuronal protection against excitotoxicity: A role for phenolic compounds?

Silva, B.A., 2007. Central Nervous System Agents in Medicinal Chemistry. 205 - 222. 3. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548408654&partnerID=MN8TOARS . 10.2174/187152407781669152 . Central Nervous System Agents in Medicinal Chemistry

Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations - Relevance for carbaryl toxicity mechanisms

Moreno, A.J.M., 2007. Chemosphere. 404 - 411. 3. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751232011&partnerID=MN8TOARS . 10.1016/j.chemosphere.2006.06.030 . Chemosphere

Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle

Magalhães, J., 2007. Clinical Science. 459 - 466. 11-12. 113. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849067904&partnerID=MN8TOARS . 10.1042/CS20070075 . Clinical Science

Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide - Characterization of morphological features of cell death

Sardão, V.A., 2007. BMC Cell Biology. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947598915&partnerID=MN8TOARS . 10.1186/1471-2121-8-11 . BMC Cell Biology

Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in Wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization

Moreno, A.J., 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247399590&partnerID=MN8TOARS . 10.1002/jbt.20159 . Journal of Biochemical and Molecular Toxicology

Response [2]

Oliveira, P.J., 2007. Journal of Biochemical and Molecular Toxicology. 6. 21. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749085079&partnerID=MN8TOARS . 10:1002/jbt . Journal of Biochemical and Molecular Toxicology

Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: Comparison with direct effects on isolated mitochondrial fractions

Pereira, G.C., 2007. Journal of Pharmacology and Experimental Therapeutics. 636 - 649. 2. 323. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548974344&partnerID=MN8TOARS . 10.1124/jpet.107.128017 . Journal of Pharmacology and Experimental Therapeutics

Esterification prevents induction of the mitochondrial permeability transition by N-acetyl perfluorooctane sulfonamides

O'Brien, T.M., 2006. Chemical Research in Toxicology. 1305 - 1312. 10. 19. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209492&partnerID=MN8TOARS . 10.1021/tx060132r . Chemical Research in Toxicology

Effects of endurance training and acute doxorubicin treatment on rat heart mitochondrial alterations induced by in vitro anoxia-reoxygenation

Ascensão, A.; Ascensão A; Ferreira R; Oliveira PJ; Magalhães J, 2006. Cardiovascular Toxicology. 159 - 171. 3-4. 6. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947101036&partnerID=MN8TOARS . 10.1385/ct:6:3:159 . Cardiovascular Toxicology

Pt(II) vs Pd(II) polyamine complexes as new anticancer drugs: A structure-activity study

Fiuza, S.M., 2006. Letters in Drug Design and Discovery. 149 - 151. 3. 3. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645876182&partnerID=MN8TOARS . 10.2174/157018006776286989 . Letters in Drug Design and Discovery

Endurance training limits the functional alterations of heart rat mitochondria submitted to in vitro anoxia-reoxygenation

Ascensão, A., 2006. International Journal of Cardiology. 169 - 178. 2. 109. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646109584&partnerID=MN8TOARS . 10.1016/j.ijcard.2005.06.003 . International Journal of Cardiology

Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats - Relevance for mitochondrial dysfunction

Oliveira, P.J., 2006. Toxicology. 160 - 168. 2-3. 220. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33244492919&partnerID=MN8TOARS . 10.1016/j.tox.2005.12.009 . Toxicology

Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis

Teodoro, J., 2006. FEBS Letters. 2153 - 2157. 8. 580. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645241135&partnerID=MN8TOARS . 10.1016/j.febslet.2006.02.078 . FEBS Letters

Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration

Oliveira, P.J., 2006. Biochemistry (Moscow). 194 - 199. 2. 71. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645277082&partnerID=MN8TOARS . 10.1134/S000629790602012X . Biochemistry (Moscow)

Cardiac mitochondrial alterations observed in hyperglycaemic rats--what can we learn from cell biology?

Oliveira PJ; Oliveira, P.J., 2005. Current diabetes reviews. 11 - 21. 1. 1. 2005. http://europepmc.org/abstract/med/18220578 . 10.2174/1573399052952578 . Current diabetes reviews

Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction

Berthiaume, J.M., 2005. Cardiovascular Toxicology. 257 - 267. 3. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144450968&partnerID=MN8TOARS . 10.1385/CT:5:3:257 . Cardiovascular Toxicology

Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?

Ferreira M; Coxito PM; Sardão VA; Palmeira CM; Oliveira PJ; Ferreira, M., 2005. Cardiovascular toxicology. 63 - 73. 1. 5. 2005. http://europepmc.org/abstract/med/15738586 . 10.1385/ct:5:1:063 . Cardiovascular toxicology

Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria?

Oliveira, P.J., 2005. Current Vascular Pharmacology. 147 - 158. 2. 3. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144430946&partnerID=MN8TOARS . 10.2174/1570161053586903 . Current Vascular Pharmacology

Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis

Ascensão, A., 2005. American Journal of Physiology - Heart and Circulatory Physiology. 2 58-2. 289. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744489541&partnerID=MN8TOARS . 10.1152/ajpheart.01249.2004 . American Journal of Physiology - Heart and Circulatory Physiology

Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity

Oliveira, P.J., 2004. Toxicology and Applied Pharmacology. 159 - 168. 2. 200. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-5144227343&partnerID=MN8TOARS . 10.1016/j.taap.2004.04.005 . Toxicology and Applied Pharmacology

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats

Oliveira, P.J., 2004. Mitochondrion. 337 - 345. 6. 3. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484378&partnerID=MN8TOARS . 10.1016/j.mito.2004.02.005 . Mitochondrion

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.

Oliveira PJ; Rolo AP; Sardão VA; Monteiro P; Gonçalves L; Providência LA; Palmeira CM; Moreno AJ; Oliveira, P.J., 2004. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 1291 - 1298. 10. 23. 2004. http://europepmc.org/abstract/med/15641294 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Carvedilol Inhibits the Mitochondrial Permeability Transition by an Antioxidant Mechanism

Oliveira, P.J., 2004. Cardiovascular Toxicology. 11 - 20. 1. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942486470&partnerID=MN8TOARS . 10.1385/CT:4:1:11 . Cardiovascular Toxicology

Calcium-dependent mitochondrial permeability transition is augmented in the kidney of Goto-Kakizaki diabetic rat

Oliveira, P.J., 2004. Diabetes/Metabolism Research and Reviews. 131 - 136. 2. 20. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842853998&partnerID=MN8TOARS . 10.1002/dmrr.423 . Diabetes/Metabolism Research and Reviews

Diabetes induces metabolic adaptations in rat liver mitochondria: Role of coenzyme Q and cardiolipin contents

Ferreira, F.M., 2003. Biochimica et Biophysica Acta - Molecular Basis of Disease. 113 - 120. 2. 1639. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0642345079&partnerID=MN8TOARS . 10.1016/j.bbadis.2003.08.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease? | Colestase crónica e funçá~o mitocondrial cardíaca em ratos wistar: Um modelo para alterações cardiovasculares no contexto de doenças hepáticas crónicas?

Oliveira, P.J., 2003. Revista Portuguesa de Cardiologia. 67 - 75. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chenodexycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: Protective role of carvedilol

Rolo, A.P., 2003. Mitochondrion. 305 - 311. 4. 2. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037347309&partnerID=MN8TOARS . 10.1016/S1567-7249(03)00007-2 . Mitochondrion

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats

Oliveira, P.J., 2003. FEBS Letters. 511 - 514. 3. 554. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242541631&partnerID=MN8TOARS . 10.1016/S0014-5793(03)01233-X . FEBS Letters

Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC

Rolo, A.P., 2003. Hepatology Research. 217 - 224. 3. 26. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042167601&partnerID=MN8TOARS . 10.1016/S1386-6346(03)00108-6 . Hepatology Research

Reduction in cardiac mitochondrial calcium loading capacity is observable during a-naphthylisothiocyanate-induced acute cholestasis: A clue for hepatic-derived cardiomyopathies?

Oliveira, P.J., 2003. Biochimica et Biophysica Acta - Molecular Basis of Disease. 39 - 45. 1. 1637. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037454702&partnerID=MN8TOARS . 10.1016/S0925-4439(02)00212-0 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondria: Role in ischemia, reperfusion and cell death | Mitocôndrias: Que papel na isquémia, reperfusão e morte celular?

Monteiro, P., 2003. Revista Portuguesa de Cardiologia. 233 - 254. 2. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037732545&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with a-naphthyl-isothiocyanate (ANIT)

Palmeira, C.M., 2003. Toxicology. 185 - 196. 3. 190. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042133192&partnerID=MN8TOARS . 10.1016/S0300-483X(03)00163-X . Toxicology

Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats

Oliveira, P.J.; Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. Journal of Investigative Medicine. 86 - 94. 2. 51. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037338705&partnerID=MN8TOARS . Journal of Investigative Medicine

Pharmacological modulation of mitochondrial function during ischemia and reperfusion | Modulação farmacológica da função mitocondrial no contexto da isquemia e reperfusão

Monteiro, P., 2003. Revista Portuguesa de Cardiologia. 407 - 429. 3. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038795126&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12712811 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition | Carvedilol: Relação entre a actividade antioxidante e inibição da transição de permeabilidade mitocondrial

Oliveira, P.J., 2003. Revista Portuguesa de Cardiologia. 55 - 62. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Carvedilol: relation between antioxidant activity and inhibition of the mitochondrial permeability transition.

Oliveira PJ; Esteves T; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12712810 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Mitochondria: role in ischemia, reperfusion and cell death.

Monteiro P; Oliveira PJ; Gonçalves L; Providência LA, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12769003 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.

Ferreira FM; Oliveira PJ; Rolo AP; Santos MS; Moreno AJ; da Cunha MF; Seiça R; Palmeira CM; Ferreira, F.M., 2003. Archives of Toxicology. 194 - 200. 4. 77. 2003. http://europepmc.org/abstract/med/12698234 . Archives of Toxicology

Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: Relevance for caffeine toxicity

Sardão, V.A., 2002. Toxicology and Applied Pharmacology. 50 - 56. 1. 179. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037082662&partnerID=MN8TOARS . 10.1006/taap.2001.9334 . Toxicology and Applied Pharmacology

Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis

Rolo, A.P.; Rolo AP; Oliveira PJ; Seiça R; Santos MS; Moreno AJ; Palmeira CM, 2002. Journal of Investigative Medicine. 193 - 200. 3. 50. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS . Journal of Investigative Medicine

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion? | Impacto do carvedilol sobre o dano mitocondrial induzido por hipoxantina/xantina oxidase - Que papel na isquemia e reperfusão do miocárdio?

Oliveira, P.J., 2002. Revista Portuguesa de Cardiologia. 1447 - 1455. 12. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Impact of diabetes on induction of the mitochondrial permeability transition.

Oliveira PJ; Rolo AP; Seiça R; Sardão V; Monteiro P; Gonçalves L; Providência L; et al, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 759 - 766. 6. 21. 2002. http://europepmc.org/abstract/med/12194377 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of a-naphthylisothiocyanate

Rolo, A.P., 2002. Toxicology and Applied Pharmacology. 20 - 26. 1. 182. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036070550&partnerID=MN8TOARS . 10.1006/taap.2002.9434 . Toxicology and Applied Pharmacology

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase--what role in myocardial ischemia and reperfusion?

Oliveira PJ; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2002. http://europepmc.org/abstract/med/12621918 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Study of carvedilol by combined Raman spectroscopy and ab initio MO calculations

Marques, M.P.M., 2002. Journal of Raman Spectroscopy. 778 - 783. 10. 33. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036773098&partnerID=MN8TOARS . 10.1002/jrs.916 . Journal of Raman Spectroscopy

Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore

Rolo, A.P., 2001. Biochemical Pharmacology. 1449 - 1454. 11. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00620-7 . Biochemical Pharmacology

Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?

Oliveira, P.J., 2001. Life Sciences. 123 - 132. 2. 69. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS . 10.1016/S0024-3205(01)01109-2 . Life Sciences

Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore

Oliveira, P.J., 2001. European Journal of Pharmacology. 231 - 237. 3. 412. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS . 10.1016/S0014-2999(01)00745-2 . European Journal of Pharmacology

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate

Oliveira, P.J.; Oliveira PJ; Rolo AP; Seiça R; Palmeira CM; Santos MS; Moreno AJ, 2001. Bioscience Reports. 45 - 53. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034905572&partnerID=MN8TOARS . 10.1023/a:1010482017540 . Bioscience Reports

Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

Rolo, A.P., 2001. Bioscience Reports. 73 - 80. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS . 10.1023/A:1010438202519 . Bioscience Reports

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury

Oliveira, P.J., 2001. Cardiovascular Toxicology. 205 - 213. 3. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS . 10.1385/CT:1:3:205 . Cardiovascular Toxicology

Carvedilol inhibits the exogenous NADH dehydrogenase in rat heart mitochondria

Oliveira, P.J., 2000. Archives of Biochemistry and Biophysics. 279 - 285. 2. 374. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034652094&partnerID=MN8TOARS . 10.1006/abbi.1999.1624 . Archives of Biochemistry and Biophysics

Effects of carvedilol on isolated heart mitochondria: Evidence for a protonophoretic mechanism

Oliveira, P.J., 2000. Biochemical and Biophysical Research Communications. 82 - 87. 1. 276. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034675219&partnerID=MN8TOARS . 10.1006/bbrc.2000.3374 . Biochemical and Biophysical Research Communications

Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2000. 2000. http://europepmc.org/abstract/med/10966524 . 10.1093/toxsci/57.1.177 .

Awards

2004

Best Young Researcher (Portuguese Cardiology Society)

2018

FLAD Healthcare 2020 (FLAD) Over 25 poster or Presentation

2010-2020

Awards from multiple societies

2020

President’s Presenter’s Award (Society for Reproductive Investigation)

We use cookies to improve your visit to our website.