Neuroscience and Disease

Neurotrophin Signaling and Synaptic (Dys)Function

Neurotrophins

Learning & Memory

Brain Ischemia

Epilepsy

Fear


Research lines

Regulation of glutamatergic synapses by BDNF in synaptic plasticity and in disease

NT3-TrkC signaling in the regulation of fear memories

New molecular players in Rett syndrome (RTT) pathophysiology

Molecular mechanisms of epileptogenesis: the role of GABAergic synapses

Excitotoxic injury in brain ischemia: the role dysregulation of the ubiquitin-proteasome system

Overview

The activity of neuronal circuits under physiological conditions is tightly regulated, by mechanisms acting at pre- and post-synaptic levels. Changes in neuronal connectivity, either strengthening or weakening the interaction between neurons, are associated with many disorders of the nervous system. Research in this unit focuses on 1) the mechanisms of regulation of the synaptic function by neurotrophins, which account for their role in long-term synaptic plasticity and in learning and memory formation, and how dysregulation of these processes contribute to several diseases of the nervous system; 2) the alterations in proteostasis coupled neuronal death in brain ischemia; 3) how dysregulation of GABAergic synapses contribute to the increased neuronal excitability in epilepsy; and 4) the new molecular players underlying neuronal architecture changes in intellectual disability, such as Rett syndrome. The group uses standard biochemistry, cellular and molecular biology, electrophysiology and behavioural approaches, complemented with in vitro (neuronal cultures) and in vivo models of disease, to address these questions.

Publications

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Information about journal articles, updated at 25-07-2021, from platform CIÊNCIAVITAE.

Response of the cerebral vasculature to systemic carbon monoxide administration: Regional differences and sexual dimorphism

Oliveira, Sara R.; Castelhano, João; Sereno, José; Vieira, Helena L. A.; Duarte, Carlos B.; Castelo-Branco, Miguel, 2020. European Journal of Neuroscience. 2771 - 2780. 1. 52. 2020. http://dx.doi.org/10.1111/ejn.14725 . 10.1111/ejn.14725 . European Journal of Neuroscience

Polyamide 6.6 thin films with distinct ratios of the main chemical groups: Influence in the primary neuronal cell culture

Piedade, Ana P.; Veneza, Cátia; Duarte, Carlos B., 2019. Applied Surface Science. 30 - 37. 490. 2019. http://dx.doi.org/10.1016/j.apsusc.2019.06.066 . 10.1016/j.apsusc.2019.06.066 . Applied Surface Science

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte, 2019. Science Signaling. eaav3577 - eaav3577. 586. 12. 2019. https://doi.org/10.1126/scisignal.aav3577 . 10.1126/scisignal.aav3577 . Science Signaling

BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo

Singer, W.; Manthey, M.; Panford-Walsh, R.; Matt, L.; Geisler, H.-S.; Passeri, E.; Baj, G.; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054809235&partnerID=MN8TOARS . 10.3389/fnmol.2018.00325 . Frontiers in Molecular Neuroscience

P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study

Oliveira, S.R.; Figueiredo-Pereira, C.; Duarte, C.B.; Vieira, H.L.A., 2018. Molecular Neurobiology. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052053347&partnerID=MN8TOARS . 10.1007/s12035-018-1302-7 . Molecular Neurobiology

The RNA-binding protein hnRNP K mediates the effect of BDNF on dendritic mRNA metabolism and regulates synaptic NMDA receptors in hippocampal neurons

Leal, G.; Comprido, D.; de Luca, P.; Morais, E.; Rodrigues, L.; Mele, M.; Santos, A.R.; et al, 2017. eNeuro. 6. 4. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85039718465&partnerID=MN8TOARS . 10.1523/ENEURO.0268-17.2017 . eNeuro

Downregulation of GABA<inf>A</inf>Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia

Mele, M.; Aspromonte, M.C.; Duarte, C.B., 2017. Molecular Neurobiology. 45 - 57. 1. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953293603&partnerID=MN8TOARS . 10.1007/s12035-015-9661-9 . Molecular Neurobiology

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, 2016. Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

The role of proteases in hippocampal synaptic plasticity: Putting together small pieces of a complex puzzle

Salazar, I.L.; Caldeira, M.V.; Curcio, M.; Duarte, C.B., 2016. Neurochemical Research. 156 - 182. 1-2. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946811163&partnerID=MN8TOARS . 10.1007/s11064-015-1752-5 . Neurochemical Research

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

Mollereau, B.; Rzechorzek, N.M.; Roussel, B.D.; Sedru, M.; Van den Brink, D.M.; Bailly-Maitre, B.; Palladino, F.; et al, 2016. Brain Research. 603 - 616. 1648. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960193866&partnerID=MN8TOARS . 10.1016/j.brainres.2016.02.033 . Brain Research

Erratum to “Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury” (Progress in Neurobiology (2016) 147 (20) (S0301008216300090) (10.1016/j.pneurobio.2016.06.001))

Curcio, M.; Salazar, I.L.; Mele, M.; Canzoniero, L.M.T.; Duarte, C.B., 2016. Progress in Neurobiology. 147. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997683943&partnerID=MN8TOARS . 10.1016/j.pneurobio.2016.08.004 . Progress in Neurobiology

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABA<inf>A</inf>Receptor Clustering and Contributes to Neuronal Death

Costa, J.T.; Mele, M.; Baptista, M.S.; Gomes, J.R.; Ruscher, K.; Nobre, R.J.; de Almeida, L.P.; Wieloch, T.; Duarte, C.B., 2016. Molecular Neurobiology. 3513 - 3527. 6. 53. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931863889&partnerID=MN8TOARS . 10.1007/s12035-015-9283-2 . Molecular Neurobiology

Role of GABAA receptor trafficking in the plasticity of inhibitory synapses

Mele, M.; Leal, G.; Duarte, C.B., 2016. Journal of Neurochemistry. 997 - 1018. 6. 139. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990020943&partnerID=MN8TOARS . 10.1111/jnc.13742 . Journal of Neurochemistry

7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’

Duarte, C.B.; Carvalho, A.L., 2016. Journal of Neurochemistry. 918 - 920. 6. 139. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002680853&partnerID=MN8TOARS . 10.1111/jnc.13839 . Journal of Neurochemistry

Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury

Michele Curcio; Ivan L. Salazar; Miranda Mele; Lorella M.T. Canzoniero; Carlos B. Duarte, 2016. Progress in Neurobiology. 1 - 35. 143. 2016. http://dx.doi.org/10.1016/j.pneurobio.2016.06.001 . 10.1016/j.pneurobio.2016.06.001 . Progress in Neurobiology

Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons

Curcio, M.; Salazar, I.L.; Inácio, A.R.; Duarte, E.P.; Canzoniero, L.M.T.; Duarte, C.B., 2015. Cell Death and Disease. 2. 6. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927597988&partnerID=MN8TOARS . 10.1038/cddis.2014.578 . Cell Death and Disease

Effect of carbon monoxide on gene expression in cerebrocortical astrocytes: Validation of reference genes for quantitative real-time PCR

Oliveira, S.R.; Vieira, H.L.A.; Duarte, C.B., 2015. Nitric Oxide - Biology and Chemistry. 80 - 89. 49. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938365745&partnerID=MN8TOARS . 10.1016/j.niox.2015.07.003 . Nitric Oxide - Biology and Chemistry

Regulation of hippocampal synaptic plasticity by BDNF

Leal, G.; Afonso, P.M.; Salazar, I.L.; Duarte, C.B., 2015. Brain Research. 82 - 101. 1621. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941585404&partnerID=MN8TOARS . 10.1016/j.brainres.2014.10.019 . Brain Research

Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP

Santos, A.R.; Mele, M.; Vaz, S.H.; Kellermayer, B.; Grimaldi, M.; Colino-Oliveira, M.; Rombo, D.M.; et al, 2015. Journal of Neuroscience. 3319 - 3329. 8. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923356181&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4521-14.2015 . Journal of Neuroscience

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

BDNF-induced local protein synthesis and synaptic plasticity

Leal, G.; Comprido, D.; Duarte, C.B., 2014. Neuropharmacology. 639 - 656. PART C. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890442031&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.04.005 . Neuropharmacology

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, 2014. Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?

Caldeira, M.V.; Salazar, I.L.; Curcio, M.; Canzoniero, L.M.T.; Duarte, C.B., 2014. Progress in Neurobiology. 50 - 69. 112. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890805926&partnerID=MN8TOARS . 10.1016/j.pneurobio.2013.10.003 . Progress in Neurobiology

Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons

Leal, G.; Afonso, P.M.; Duarte, C.B., 2014. PLoS ONE. 10. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907698379&partnerID=MN8TOARS . 10.1371/journal.pone.0108175 . PLoS ONE

GABA<inf>A</inf>receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia

Mele, M.; Ribeiro, L.; Inácio, A.R.; Wieloch, T.; Duarte, C.B., 2014. Neurobiology of Disease. 220 - 232. 65. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896313006&partnerID=MN8TOARS . 10.1016/j.nbd.2014.01.019 . Neurobiology of Disease

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease

Simões, A.T.; Gonçalves, N.; Nobre, R.J.; Duarte, C.B.; Pereira de Almeida, L., 2014. Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS . 10.1093/hmg/ddu209 . Human Molecular Genetics

Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons

Melo, C.V.; Okumoto, S.; Gomes, J.R.; Baptista, M.S.; Bahr, B.A.; Frommer, W.B.; Duarte, C.B., 2013. Neuroscience. 66 - 86. 237. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874734906&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.01.054 . Neuroscience

BDNF Regulates the Expression and Distribution of Vesicular Glutamate Transporters in Cultured Hippocampal Neurons

Melo, C.V.; Mele, M.; Curcio, M.; Comprido, D.; Silva, C.G.; Duarte, C.B., 2013. PLoS ONE. 1. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872222727&partnerID=MN8TOARS . 10.1371/journal.pone.0053793 . PLoS ONE

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Curcio, M.; Leal, G.; Salazar, I.L.; Mele, M.; Santos, A.R.A.; Melo, C.V.; et al, 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 263 - 274. 1. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868560715&partnerID=MN8TOARS . 10.1016/j.bbadis.2012.10.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors

Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L., 2012. Journal of Biological Chemistry. 6868 - 6877. 9. 287. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS . 10.1074/jbc.M111.322909 . Journal of Biological Chemistry

Role of the ubiquitin-proteasome system in nervous system function and disease: Using C. elegans as a dissecting tool

Baptista, M.S.; Duarte, C.B.; Maciel, P., 2012. Cellular and Molecular Life Sciences. 2691 - 2715. 16. 69. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864276502&partnerID=MN8TOARS . 10.1007/s00018-012-0946-0 . Cellular and Molecular Life Sciences

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

Simões, A.T.; Gonçalves, N.; Koeppen, A.; Déglon, N.; Kügler, S.; Duarte, C.B.; Pereira De Almeida, L., 2012. Brain. 2428 - 2439. 8. 135. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864658791&partnerID=MN8TOARS . 10.1093/brain/aws177 . Brain

Neuroprotection by GDNF in the ischemic brain

Duarte, E.P.; Curcio, M.; Canzoniero, L.M.; Duarte, C.B., 2012. Growth Factors. 242 - 257. 4. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866129833&partnerID=MN8TOARS . 10.3109/08977194.2012.691478 . Growth Factors

Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons

Gomes, J.R.; Costa, J.T.; Melo, C.V.; Felizzi, F.; Monteiro, P.; Pinto, M.J.; Inácio, A.R.; et al, 2012. Journal of Neuroscience. 4610 - 4622. 13. 32. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859013000&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0374-12.2012 . Journal of Neuroscience

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, 2011. Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.; Cruz, M.T., 2011. Toxicology and Applied Pharmacology. 87 - 95. 2. 250. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650559757&partnerID=MN8TOARS . 10.1016/j.taap.2010.10.003 . Toxicology and Applied Pharmacology

Proteomics-Based technologies in the discovery of biomarkers for multiple sclerosis in the cerebrospinal fluid

Lourenço, A.S.T.; Baldeiras, I.; Grãos, M.; Duarte, C.B., 2011. Current Molecular Medicine. 326 - 349. 4. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958096423&partnerID=MN8TOARS . Current Molecular Medicine

Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites

Gomes, J.R.; Lobo, A.C.; Melo, C.V.; Inácio, A.R.; Takano, J.; Iwata, N.; Saido, T.C.; et al, 2011. Journal of Neuroscience. 4622 - 4635. 12. 31. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953008096&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3541-10.2011 . Journal of Neuroscience

Excitotoxicity through Ca<sup>2+</sup>-permeable AMPA receptors requires Ca<sup>2+</sup>-dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2010. Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells

Simões-Wüst, A.P.; Grãos, M.; Duarte, C.B.; Brenneisen, R.; Hamburger, M.; Mennet, M.; Ramos, M.H.; et al, 2010. Phytomedicine. 980 - 986. 12. 17. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956619629&partnerID=MN8TOARS . 10.1016/j.phymed.2010.03.005 . Phytomedicine

Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: Relevance of different signalling pathways

Francisco, V.; Neves, B.M.; Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2010. Archives of Dermatological Research. 271 - 282. 4. 302. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952180893&partnerID=MN8TOARS . 10.1007/s00403-009-0993-z . Archives of Dermatological Research

Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons

Baptista, M.S.; Melo, C.V.; Armelão, M.; Herrmann, D.; Pimentel, D.O.; Leal, G.; Caldeira, M.V.; et al, 2010. PLoS ONE. 4. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956333111&partnerID=MN8TOARS . 10.1371/journal.pone.0010139 . PLoS ONE

Regulation of local translation at the synapse by BDNF

Santos, A.R.; Comprido, D.; Duarte, C.B., 2010. Progress in Neurobiology. 505 - 516. 4. 92. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664066&partnerID=MN8TOARS . 10.1016/j.pneurobio.2010.08.004 . Progress in Neurobiology

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Regulation of AMPA receptors and synaptic plasticity

Santos, S.D.; Carvalho, A.L.; Caldeira, M.V.; Duarte, C.B., 2009. Neuroscience. 105 - 125. 1. 158. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149467917&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.02.037 . Neuroscience

Differential roles of PI3-Kinase, MAPKs and NF-¿B on the manipulation of dendritic cell T<inf>h</inf>1/T<inf>h</inf>2 cytokine/chemokine polarizing profile

Neves, B.M.; Cruz, M.T.; Francisco, V.; Garcia-Rodriguez, C.; Silvestre, R.; Cordeiro-da-Silva, A.; Dinis, A.M.; et al, 2009. Molecular Immunology. 2481 - 2492. 13. 46. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650397827&partnerID=MN8TOARS . 10.1016/j.molimm.2009.05.021 . Molecular Immunology

BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: Protein levels and dendritic mRNA

Manadas, B.; Santos, A.R.; Szabadfi, K.; Gomes, J.R.; Garbis, S.D.; Fountoulakis, M.; Duarte, C.B., 2009. Journal of Proteome Research. 4536 - 4552. 10. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349976976&partnerID=MN8TOARS . 10.1021/pr900366x . Journal of Proteome Research

Role of the brain-derived neurotrophic factor at glutamatergic synapses

Carvalho, A.L.; Caldeira, M.V.; Santos, S.D.; Duarte, C.B., 2008. British Journal of Pharmacology. SUPPL. 1. 153. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349114504&partnerID=MN8TOARS . 10.1038/sj.bjp.0707509 . British Journal of Pharmacology

In vitro behavior and surface morphology of modified 316L stainless steel stents

Nunes, J.; Piedade, A.P.; Duarte, C.B.; Vieira, M.T., 2008. Microscopy and Microanalysis. 35 - 36. SUPPL. 3. 14. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349102289&partnerID=MN8TOARS . 10.1017/S1431927608089307 . Microscopy and Microanalysis

Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors

Gomes, A.R.; Ferreira, J.S.; Paternain, A.V.; Lerma, J.; Duarte, C.B.; Carvalho, A.L., 2008. Molecular and Cellular Neuroscience. 323 - 334. 2. 37. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749131588&partnerID=MN8TOARS . 10.1016/j.mcn.2007.10.008 . Molecular and Cellular Neuroscience

Validation of internal control genes for expression studies: Effects of the neurotrophin BDNF on hippocampal neurons

Santos, A.R.A.; Duarte, C.B., 2008. Journal of Neuroscience Research. 3684 - 3692. 16. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-59349102710&partnerID=MN8TOARS . 10.1002/jnr.21796 . Journal of Neuroscience Research

Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line

Neves, B.M.; Cruz, M.T.; Francisco, V.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2008. Toxicology Letters. 74 - 82. 1. 177. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39549123001&partnerID=MN8TOARS . 10.1016/j.toxlet.2007.12.006 . Toxicology Letters

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 12619 - 12628. 17. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250329980&partnerID=MN8TOARS . 10.1074/jbc.M700607200 . Journal of Biological Chemistry

Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: Role of different immunosuppressive drugs

Cruz, M.T.; Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2007. Immunopharmacology and Immunotoxicology. 225 - 241. 2. 29. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548553284&partnerID=MN8TOARS . 10.1080/08923970701512304 . Immunopharmacology and Immunotoxicology

Erratum: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons (Journal of Biological Chemistry (2007) 282, (12619-12628))

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 37. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848900818&partnerID=MN8TOARS . Journal of Biological Chemistry

BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.F.; Carvalho, A.L.; Duarte, C.B., 2007. Molecular and Cellular Neuroscience. 208 - 219. 2. 35. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249712975&partnerID=MN8TOARS . 10.1016/j.mcn.2007.02.019 . Molecular and Cellular Neuroscience

PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression

Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L., 2007. Traffic. 259 - 269. 3. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS . 10.1111/j.1600-0854.2006.00521.x . Traffic

Effects of mood stabilizers on the inhibition of adenylate cyclase via dopamine D<inf>2</inf>-like receptors

Montezinho, L.P.; Mørk, A.; Duarte, C.B.; Penschuck, S.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2007. Bipolar Disorders. 290 - 297. 3. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147106555&partnerID=MN8TOARS . 10.1111/j.1399-5618.2007.00354.x . Bipolar Disorders

Sample sonication after trichloroacetic acid precipitation increases protein recovery from cultured hippocampal neurons, and improves resolution and reproducibility in two-dimensional gel electrophoresis

Manadas, B.J.; Vougas, K.; Fountoulakis, M.; Duarte, C.B., 2006. Electrophoresis. 1825 - 1831. 9. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646590654&partnerID=MN8TOARS . 10.1002/elps.200500757 . Electrophoresis

TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . Journal of Neuroscience Research

Excitotoxicity mediated by Ca<sup>2+</sup>-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., 2006. Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

The interaction between dopamine D<inf>2</inf>-like and beta-adrenergic receptors in the prefrontal cortex is altered by mood-stabilizing agents

Montezinho, L.P.; Castro, M.M.C.A.; Duarte, C.B.; Penschuck, S.; Geraldes, C.F.G.C.; Mørk, A., 2006. Journal of Neurochemistry. 1336 - 1348. 5. 96. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645101243&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03654.x . Journal of Neurochemistry

DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells

Matos, T.J.; Duarte, C.B.; Gonçalo, M.; Lopes, M.C., 2005. Journal of Dermatological Science. 113 - 123. 2. 39. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044493875&partnerID=MN8TOARS . 10.1016/j.jdermsci.2005.03.011 . Journal of Dermatological Science

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

Almeida, R.D.; Manadas, B.J.; Melo, C.V.; Gomes, J.R.; Mendes, C.S.; Grãos, M.M.; Carvalho, R.F.; Carvalho, A.P.; Duarte, C.B., 2005. Cell Death and Differentiation. 1329 - 1343. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144508812&partnerID=MN8TOARS . 10.1038/sj.cdd.4401662 . Cell Death and Differentiation

Release of IL-1ß via IL-1ß-converting enzyme in a skin dendritic cell line exposed to 2,4-dinitrofluorobenzene

Matos, T.J.; Jaleco, S.P.; Gonçalo, M.; Duarte, C.B.; Lopes, M.C., 2005. Mediators of Inflammation. 131 - 138. 3. 2005. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-25644454243&partnerID=MN8TOARS . 10.1155/MI.2005.131 . Mediators of Inflammation

Contact sensitizers downregulate the expression of the chemokine receptors CCR6 and CXCR4 in a skin dendritic cell line

Cruz, M.T.; Gonçalo, M.; Paiva, A.; Morgado, J.M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2005. Archives of Dermatological Research. 43 - 47. 1. 297. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-25644435637&partnerID=MN8TOARS . 10.1007/s00403-005-0574-8 . Archives of Dermatological Research

The sensitizers nickel sulfate and 2,4-dinitrofluorobenzene increase CD40 and IL-12 receptor expression in a fetal skin dendritic cell line

Vital, A.L.; Gonçalo, M.; Cruz, M.T.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2005. Bioscience Reports. 191 - 202. 3. 24. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944504971&partnerID=MN8TOARS . 10.1007/s10540-005-2580-7 . Bioscience Reports

Role of oxidative stress in ERK and p38 MAPK activation induced by the chemical sensitizer DNFB in a fetal skin dendritic cell line

Matos, T.J.; Duarte, C.B.; Gonçalo, M.; Lopes, M.C., 2005. Immunology and Cell Biology. 607 - 614. 6. 83. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-30544454184&partnerID=MN8TOARS . 10.1111/j.1440-1711.2005.01378.x . Immunology and Cell Biology

Calpains are activated by photodynamic therapy but do not contribute to apoptotic tumor cell death

Almeida, R.D.; Gomes, E.R.; Carvalho, A.P.; Duarte, C.B., 2004. Cancer Letters. 183 - 189. 2. 216. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7744231977&partnerID=MN8TOARS . 10.1016/j.canlet.2004.07.006 . Cancer Letters

Intracellular signaling mechanisms in photodynamic therapy

Almeida, R.D.; Manadas, B.J.; Carvalho, A.P.; Duarte, C.B., 2004. Biochimica et Biophysica Acta - Reviews on Cancer. 59 - 86. 2. 1704. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444265338&partnerID=MN8TOARS . 10.1016/j.bbcan.2004.05.003 . Biochimica et Biophysica Acta - Reviews on Cancer

Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression

Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B., 2004. Journal of Neurochemistry. 673 - 682. 3. 90. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02519.x . Journal of Neurochemistry

Intracellular lithium and cyclic AMP levels are mutually regulated in neuronal cells

Montezinho, L.P.; Duarte, C.B.; Fonseca, C.P.; Glinka, Y.; Layden, B.; Mota De Freitas, D.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2004. Journal of Neurochemistry. 920 - 930. 4. 90. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4143076854&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02551.x . Journal of Neurochemistry

Contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line

Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Duarte, C.B.; Lopes, M.C., 2004. Experimental Dermatology. 18 - 26. 1. 13. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842308107&partnerID=MN8TOARS . 10.1111/j.0906-6705.2004.00105.x . Experimental Dermatology

Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: Evidence for the involvement of cAMP and p38 MAPK

Castro-Caldas, M.; Mendes, A.F.; Duarte, C.B.; Lopes, M.C.F., 2003. Mediators of Inflammation. 329 - 337. 6. 12. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742286852&partnerID=MN8TOARS . 10.1080/09629350310001633351 . Mediators of Inflammation

Dexamethasone prevents interleukin-1ß-induced nuclear factor-¿B activation by upregulating I¿B-a synthesis, in lymphoblastic cells

Castro-Caldas, M.; Mendes, A.F.; Carvalho, A.P.; Duarte, C.B.; Lopes, M.C., 2003. Mediators of Inflammation. 37 - 46. 1. 12. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037657851&partnerID=MN8TOARS . 10.1080/0962935031000096953 . Mediators of Inflammation

Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-¿B activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line

Vital, A.L.; Gonçalo, M.; Cruz, M.T.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2003. Mediators of Inflammation. 71 - 78. 2. 12. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038466135&partnerID=MN8TOARS . 10.1080/0962935031000097673 . Mediators of Inflammation

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in Rat Dentate Gyrus by the Tyrosine Kinase Ihibitor, Genistein

Pereira, D.B.; Duarte, C.B., 2003. Hippocampus. 978 - 979. 8. 13. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346505474&partnerID=MN8TOARS . 10.1002/hipo.10148 . Hippocampus

The sensitizer 2,4-dinitrofluorobenzene activates caspase-3 and induces cell death in a skin dendritic cell line

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C., 2003. International Journal of Toxicology. 43 - 48. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037236021&partnerID=MN8TOARS . 10.1080/10915810305069 . International Journal of Toxicology

Regulation of AMPA receptor activity, synaptic targeting and recycling: Role in synaptic plasticity

Gomes, A.R.; Correia, S.S.; Carvalho, A.L.; Duarte, C.B., 2003. Neurochemical Research. 1459 - 1473. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705374&partnerID=MN8TOARS . 10.1023/A:1025610122776 . Neurochemical Research

Protein kinase C¿ associates directly with the GluR4 a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit: Effect on receptor phosphorylation

Santos Correia, S.; Bandeira Duarte, C.; Faro, C.J.; Vieira Pires, E.; Carvalho, A.L., 2003. Journal of Biological Chemistry. 6307 - 6313. 8. 278. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037458663&partnerID=MN8TOARS . 10.1074/jbc.M205587200 . Journal of Biological Chemistry

Genistein inhibits Ca<sup>2+</sup>influx and glutamate release from hippocampal synaptosomes: Putative non-specific effects

Pereira, D.B.; Carvalho, A.P.; Duarte, C.B., 2003. Neurochemistry International. 179 - 188. 2. 42. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037207465&partnerID=MN8TOARS . 10.1016/S0197-0186(02)00071-2 . Neurochemistry International

Dexamethasone induces the secretion of annexin I in immature lymphoblastic cells by a calcium-dependent mechanism

Castro-Caldas, M.; Duarte, C.B.; Carvalho, A.P.; Fernandes Lopes, M.C., 2002. Molecular and Cellular Biochemistry. 31 - 38. 1-2. 237. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036686832&partnerID=MN8TOARS . 10.1023/A:1016502120139 . Molecular and Cellular Biochemistry

Nitric oxide modulates tumor cell death induced by photodynamic therapy through a cGMP-dependent mechanism

Gomes, E.R.; Almeida, R.D.; Carvalho, A.P.; Duarte, C.B., 2002. Photochemistry and Photobiology. 423 - 430. 4. 76. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036782294&partnerID=MN8TOARS . 10.1562/0031-8655(2002)076&lt;0423:NOMTCD&gt;2.0.CO;2 . Photochemistry and Photobiology

Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line in response to the strong sensitizer 2,4-dinitrofluorobenzene

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C., 2002. Archives of Dermatological Research. 419 - 425. 9. 294. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036458129&partnerID=MN8TOARS . Archives of Dermatological Research

Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons

Carvalho, A.L.; Correia, S.; Faro, C.J.; Duarte, C.B.; Carvalho, A.P.; Pires, E.M.V., 2002. European Journal of Neuroscience. 465 - 474. 3. 15. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036456320&partnerID=MN8TOARS . 10.1046/j.0953-816x.2001.01881.x . European Journal of Neuroscience

Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes

Pereira, D.B.; Carvalho, A.P.; Duarte, C.B., 2002. Neuropharmacology. 9 - 19. 1. 42. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036142796&partnerID=MN8TOARS . 10.1016/S0028-3908(01)00162-9 . Neuropharmacology

LPS induction of I¿B-a degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, tyrphostin B42

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.C., 2001. Nitric Oxide - Biology and Chemistry. 53 - 61. 1. 5. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035708551&partnerID=MN8TOARS . 10.1006/niox.2000.0320 . Nitric Oxide - Biology and Chemistry

Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C., 2001. Immunology and Cell Biology. 590 - 596. 6. 79. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035176476&partnerID=MN8TOARS . 10.1046/j.1440-1711.2001.01041.x . Immunology and Cell Biology

17ß-Estradiol promotes the synthesis and the secretion of annexin I in the CCRF-CEM human cell line

Castro-Caldas, M.; Duarte, C.B.; Carvalho, A.P.; Celeste Lopes, M., 2001. Mediators of Inflammation. 245 - 251. 5. 10. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034747177&partnerID=MN8TOARS . 10.1080/09629350120093713 . Mediators of Inflammation

Regulation of AMPA Receptors by Phosphorylation

Carvalho, A.L.; Duarte, C.B.; Carvalho, A.P., 2000. Neurochemical Research. 1245 - 1255. 9-10. 25. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034304035&partnerID=MN8TOARS . 10.1023/A:1007644128886 . Neurochemical Research

Adenosine A<inf>1</inf> receptors inhibit Ca<sup>2+</sup> channels coupled to the release of ACh, but not of GABA, in cultured retina cells

Santos, P.F.; Caramelo, O.L.; Carvalho, A.P.; Duarte, C.B., 2000. Brain Research. 10 - 15. 1. 852. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033621543&partnerID=MN8TOARS . 10.1016/S0006-8993(99)02155-1 . Brain Research

Corelease of two functionally opposite neurotransmitters by retinal amacrine cells: Experimental evidence and functional significance

Duarte, C.B.; Santos, P.F.; Carvalho, A.P., 1999. Journal of Neuroscience Research. 475 - 479. 4. 58. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571086&partnerID=MN8TOARS . 10.1002/(SICI)1097-4547(19991115)58:4&lt;475::AID-JNR1&gt;3.0.CO;2-O . Journal of Neuroscience Research

Characterization of ATP release from cultures enriched in cholinergic amacrine-like neurons

Santos, P.F.; Caramelo, O.L.; Carvalho, A.P.; Duarte, C.B., 1999. Journal of Neurobiology. 340 - 348. 3. 41. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571302&partnerID=MN8TOARS . 10.1002/(SICI)1097-4695(19991115)41:3&lt;340::AID-NEU3&gt;3.0.CO;2-8 . Journal of Neurobiology

Photosensitization of lymphoblastoid cells with phthalocyanines at different saturating incubation times

Gomes, E.R.; Cruz, T.; Lopes, C.F.; Carvalho, A.P.; Duarte, C.B., 1999. Cell Biology and Toxicology. 249 - 260. 4. 15. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033367925&partnerID=MN8TOARS . 10.1023/A:1007615813184 . Cell Biology and Toxicology

Metabotropic glutamate receptors modulate [<sup>3</sup>H]acetylcholine release from cultured amacrine-like neurons

Caramelo, O.L.; Santos, P.F.; Carvalho, A.P.; Duarte, C.B., 1999. Journal of Neuroscience Research. 505 - 514. 4. 58. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571139&partnerID=MN8TOARS . 10.1002/(SICI)1097-4547(19991115)58:4&lt;505::AID-JNR4&gt;3.0.CO;2-J . Journal of Neuroscience Research

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.G., 1999. American Journal of Physiology - Cell Physiology. 6 46-6. 277. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033373205&partnerID=MN8TOARS . American Journal of Physiology - Cell Physiology

[<sup>3</sup>H]Acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A<inf>1</inf>receptor activation

Santos, P.F.; Caramelo, O.L.; Carvalho, A.P.; Duarte, C.B., 1998. NeuroReport. 3693 - 3698. 16. 9. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032538658&partnerID=MN8TOARS . NeuroReport

Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors

Ferreira, I.L.; Duarte, C.B.; Carvalho, A.P., 1998. NeuroReport. 3471 - 3475. 15. 9. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032569601&partnerID=MN8TOARS . 10.1097/00001756-199810260-00025 . NeuroReport

Nitric oxide differentially affects the exocytotic and the carrier-mediated release of [<sup>3</sup>H]¿-aminobutyric acid in rat hippocampal synaptosomes

Sequeira, S.M.; Duarte, C.B.; Carvalho, A.P.; Carvalho, C.M., 1998. Molecular Brain Research. 337 - 340. 2. 55. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032052170&partnerID=MN8TOARS . 10.1016/S0169-328X(98)00021-7 . Molecular Brain Research

Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells

Carvalho, A.L.; Duarte, C.B.; Faro, C.J.; Carvalho, A.P.; Pires, E.V., 1998. Journal of Neurochemistry. 2112 - 2119. 5. 70. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031980737&partnerID=MN8TOARS . Journal of Neurochemistry

Modulation of [<sup>3</sup>H]acetylcholine release from cultured amacrine-like neurons by adenosine A<inf>1</inf>receptors

Santos, P.F.; Santos, M.S.; Carvalho, A.P.; Duarte, C.B., 1998. Journal of Neurochemistry. 1086 - 1094. 3. 71. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031595164&partnerID=MN8TOARS . Journal of Neurochemistry

Differential acetylcholine and GABA release from cultured chick retina cells

Santos, P.F.; Carvalho, A.L.; Carvalho, A.P.; Duarte, C.B., 1998. European Journal of Neuroscience. 2723 - 2730. 8. 10. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031927252&partnerID=MN8TOARS . 10.1046/j.1460-9568.1998.00281.x . European Journal of Neuroscience

Glutamate in life and death of retinal amacrine cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Carvalho, A.L.; Agostinho, P.M.; Carvalho, A.P., 1998. General Pharmacology. 289 - 295. 3. 30. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032033584&partnerID=MN8TOARS . 10.1016/S0306-3623(97)00360-1 . General Pharmacology

Culture medium components modulate retina cell damage induced by glutamate, kainate or 'chemical ischemia'

Ferreira, I.L.; Duarte, C.B.; Neves, A.R.; Carvalho, A.P., 1998. Neurochemistry International. 387 - 396. 4. 32. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032053747&partnerID=MN8TOARS . 10.1016/S0197-0186(97)00099-5 . Neurochemistry International

Oxidative stress affects the selective ion permeability of voltage-sensitive Ca<sup>2+</sup> channels in cultured retinal cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., 1997. Neuroscience Research. 323 - 334. 4. 27. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030951140&partnerID=MN8TOARS . 10.1016/S0168-0102(96)01165-0 . Neuroscience Research

Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: Effect of antioxidants

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., 1997. FASEB Journal. 154 - 163. 2. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031027249&partnerID=MN8TOARS . FASEB Journal

'Chemical ischemia' in cultured retina cells: The role of excitatory amino acid receptors and of energy levels on cell death

Ferreira, I.L.; Duarte, C.B.; Carvalho, A.P., 1997. Brain Research. 157 - 166. 1-2. 768. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030756369&partnerID=MN8TOARS . 10.1016/S0006-8993(97)00634-3 . Brain Research

Ca<sup>2+</sup>influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death

Ferreira, I.L.; Duarte, C.B.; Carvalho, A.P., 1996. European Journal of Pharmacology. 153 - 162. 1-3. 302. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029658975&partnerID=MN8TOARS . 10.1016/0014-2999(96)00044-1 . European Journal of Pharmacology

Ca2+ influx through glutamate receptorassociated channels in retina cells correlates with neuronal cell death

Ferreira, I.L.; Duarte, C.B.; Carvalho, A.P., 1996. Biochemical Society Transactions. 4. 24. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749180144&partnerID=MN8TOARS . Biochemical Society Transactions

Glutamate receptor agonists evoked Ca<sup>2+</sup>-dependent and Ca<sup>2+</sup>-independent release of [<sup>3</sup>H]D-aspartate from cultured chick retina cells

Santos, P.F.; Duarte, C.B.; Carvalho, A.P., 1996. Neurochemical Research. 361 - 368. 3. 21. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030006280&partnerID=MN8TOARS . 10.1007/BF02531653 . Neurochemical Research

Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: Modulation by arachidonic acid

Duarte, C.B.; Santos, P.F.; Sánchez-Prieto, J.; Carvalho, A.P., 1996. Journal of Neuroscience Research. 363 - 373. 4. 44. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029923724&partnerID=MN8TOARS . 10.1002/(SICI)1097-4547(19960515)44:4&lt;363::AID-JNR8&gt;3.0.CO;2-A . Journal of Neuroscience Research

Intracellular free Na<sup>+</sup>concentration increases in cultured retinal cells under oxidative stress conditions

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., 1996. Neuroscience Research. 343 - 351. 4. 25. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029770633&partnerID=MN8TOARS . 10.1016/S0168-0102(96)01058-9 . Neuroscience Research

Release of glutamate by chick retina cells in culture: Role of Ca<sup>2+</sup> and arachidonic acid

Carvalho, A.; Santos, P.; Ferreira, I.; Duarte, C., 1996. Investigative Ophthalmology and Visual Science. 3. 37. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750149373&partnerID=MN8TOARS . Investigative Ophthalmology and Visual Science

Voltage-sensitive Ca<sup>2+</sup> channels in rat striatal synaptosomes: Role on the [Ca<sup>2+</sup>]<inf>i</inf> responses to membrane depolarization

Duarte, C.B.; Cristóvão, A.J.; Carvalho, A.P.; Carvalho, C.M., 1996. Neurochemistry International. 67 - 75. 1. 28. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029656264&partnerID=MN8TOARS . 10.1016/0197-0186(95)00056-E . Neurochemistry International

[Ca<sup>2+</sup>]<inf>i</inf>regulation by glutamate receptor agonists in cultured chick retina cells

Duarte, C.B.; Santos, P.F.; Carvalho, A.P., 1996. Vision Research. 1091 - 1102. 8. 36. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029670184&partnerID=MN8TOARS . 10.1016/0042-6989(95)00208-1 . Vision Research

Activity of ionotropic glutamate receptors in retinal cells: Effect of ascorbate/Fe<sup>2+</sup>-induced oxidative stress

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., 1996. Journal of Neurochemistry. 1153 - 1163. 3. 67. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029801193&partnerID=MN8TOARS . Journal of Neurochemistry

On-line detection of glutamate release from cultured chick retinospheroids

Duarte, C.B.; Santos, P.F.; Sánchez-Prieto, J.; Carvalho, A.P., 1996. Vision Research. 1867 - 1872. 13. 36. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030008951&partnerID=MN8TOARS . 10.1016/0042-6989(95)00309-6 . Vision Research

Characterization of Voltage-Sensitive Ca<sup>2+</sup>Channels Activated by Presynaptic Glutamate Receptor Stimulation in Hippocampus

CARVALHO, C.M.; MALVA, J.O.; DUARTE, C.B.; CARVALHO, A.P., 1995. Annals of the New York Academy of Sciences. 457 - 459. 757. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029129986&partnerID=MN8TOARS . 10.1111/j.1749-6632.1995.tb17505.x . accepted Annals of the New York Academy of Sciences

Glutamate Receptor Modulation of [<sup>3</sup>H]GABA Release and Intracellular Calcium in Chick Retina Cells

CARVALHO, A.P.; FERREIRA, I.L.; CARVALHO, A.L.; DUARTE, C.B., 1995. Annals of the New York Academy of Sciences. 439 - 456. 757. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029100401&partnerID=MN8TOARS . 10.1111/j.1749-6632.1995.tb17504.x . accepted Annals of the New York Academy of Sciences

Influence of oxidative stress on membrane potential and on K<sup>+</sup>channels in neuronal cells

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., 1995. Bioelectrochemistry and Bioenergetics. 297 - 305. 2. 38. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343743141&partnerID=MN8TOARS . 10.1016/0302-4598(95)01850-E . Bioelectrochemistry and Bioenergetics

Modulation of N-methyl-d-aspartate receptor activity by oxidative stress conditions in chick retinal cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., 1995. Neuroscience Letters. 193 - 196. 3. 198. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028973020&partnerID=MN8TOARS . 10.1016/0304-3940(95)11996-A . Neuroscience Letters

Relation of [Ca<sup>2+</sup>]<inf>i</inf>to dopamine release in striatal synaptosomes: role of Ca<sup>2+</sup>channels

Carvalho, C.M.; Ferreira, I.L.; Duarte, C.B.; Malva, J.O.; Tretter, L.; Adam-Vizi, V.; Carvalho, A.P., 1995. Brain Research. 234 - 244. 2. 669. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028839020&partnerID=MN8TOARS . 10.1016/0006-8993(94)01252-D . Brain Research

Involvement of class A calcium channels in the KCl induced Ca<sup>2+</sup> influx in hippocampal synaptosomes

Malva, J.O.; Ambrósio, A.F.; Carvalho, A.P.; Duarte, C.B.; Carvalho, C.M., 1995. Brain Research. 242 - 245. 1-2. 696. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028860747&partnerID=MN8TOARS . 10.1016/0006-8993(95)00816-9 . Brain Research

Effect of oxidative stress on the release of [<sup>3</sup>H]GABA in cultured chick retina cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., 1994. Brain Research. 213 - 221. 1-2. 655. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027931845&partnerID=MN8TOARS . 10.1016/0006-8993(94)91616-0 . Brain Research

Domoic acid induced release of [<sup>3</sup>H]GABA in cultured chick retina cells

Alfonso, M.; Duran, R.; Duarte, C.B.; Ferreira, I.L.; Carvalho, A.P., 1994. Neurochemistry International. 267 - 274. 3. 24. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028218977&partnerID=MN8TOARS . 10.1016/0197-0186(94)90084-1 . Neurochemistry International

Release of [<sup>3</sup>H]GABA evoked by glutamate receptor agonists in cultured chick retina cells: effect of Ca<sup>2+</sup>

Ferreira, I.L.; Duarte, C.B.; Santos, P.F.; Carvalho, C.M.; Carvalho, A.P., 1994. Brain Research. 252 - 256. 1-2. 664. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028172872&partnerID=MN8TOARS . 10.1016/0006-8993(94)91981-X . Brain Research

Reactive Oxygen Species on GABA Release: GABA RELEASE

OLIVEIRA, C.R.; AGOSTINHO, P.; CASEIRO, P.; DUARTE, C.B.; CARVALHO, A.P., 1994. Annals of the New York Academy of Sciences. 130 - 140. 738. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028609848&partnerID=MN8TOARS . 10.1111/j.1749-6632.1994.tb21798.x . accepted Annals of the New York Academy of Sciences

Relation of exocytotic release of ¿-aminobutyric acid to Ca<sup>2+</sup> entry through Ca<sup>2+</sup> channels or by reversal of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger in synaptosomes

Duarte, C.B.; Ferreira, I.L.; Carvalho, A.P.; Carvalho, C.M., 1993. Pflügers Archiv European Journal of Physiology. 314 - 323. 3-4. 423. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027263283&partnerID=MN8TOARS . 10.1007/BF00374411 . Pflügers Archiv European Journal of Physiology

Glutamate increases the [Ca<sup>2+</sup>]<inf>i</inf> but stimulates Ca<sup>2+</sup>-independent release of [<sup>3</sup>H]GABA in cultured chick retina cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Oliveira, C.R.; Carvalho, A.P., 1993. Brain Research. 130 - 138. 1. 611. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027335488&partnerID=MN8TOARS . 10.1016/0006-8993(93)91784-P . Brain Research

Neomycin blocks dihydropyridine-insensitive Ca<sup>2+</sup>influx in bovine adrenal chromaffin cells

Duarte, C.B.; Tome, A.R.; Forsberg, E.; Carvalho, C.A.M.; Carvalho, A.P.; Santos, R.M.; Rosario, L.M., 1993. European Journal of Pharmacology: Molecular Pharmacology. 259 - 267. 3. 244. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027536487&partnerID=MN8TOARS . 10.1016/0922-4106(93)90151-X . European Journal of Pharmacology: Molecular Pharmacology

A Toxin Fraction (FTX) from the Funnel-Web Spider Poison Inhibits Dihydropyridine-Insensitive Ca<sup>2+</sup>Channels Coupled to Catecholamine Release in Bovine Adrenal Chromaffin Cells

Duarte, C.B.; Rosario, L.M.; Sena, C.M.; Carvalho, A.P., 1993. Journal of Neurochemistry. 908 - 913. 3. 60. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027477686&partnerID=MN8TOARS . 10.1111/j.1471-4159.1993.tb03236.x . Journal of Neurochemistry

Ca<sup>2+</sup>-dependent release of [<sup>3</sup>H]GABA in cultured chick retina cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Oliveira, C.R.; Carvalho, A.P., 1992. Brain Research. 27 - 32. 1. 591. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026668073&partnerID=MN8TOARS . 10.1016/0006-8993(92)90974-E . Brain Research

Regulation of carrier-mediated and exocytotic release of [<sup>3</sup>H]GABA in rat brain synaptosomes

Carvalho, C.M.; Bandeira-Duarte, C.; Ferreira, I.L.; Carvalho, A.P., 1991. Neurochemical Research. 763 - 772. 7. 16. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025820698&partnerID=MN8TOARS . 10.1007/BF00965685 . Neurochemical Research

Synaptosomal [Ca<sup>2+</sup>]<inf>i</inf> as influenced by Na<sup>+</sup> Ca<sup>2+</sup> exchange and K<sup>+</sup> depolarization

Duarte, C.B.; Carvalho, C.A.M.; Ferreira, I.L.; Carvalho, A.P., 1991. Cell Calcium. 623 - 633. 9. 12. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025917963&partnerID=MN8TOARS . 10.1016/0143-4160(91)90059-N . Cell Calcium

Sodium-calcium exchange in nerve terminals: Influence on internal Ca2+ and neurosecretion

Carvalho, A.P.; Bandeira-Duarte, C.; Ferreira, I.L.; Coutinho, O.P.; Carvalho, C.M., 1991. Annals of the New York Academy of Sciences. 300 - 311. 639. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026377475&partnerID=MN8TOARS . Annals of the New York Academy of Sciences

Influence of isolation media on synaptosomal properties: Intracellular pH, pCa, and Ca<sup>2+</sup>uptake

Bandeira-Duarte, C.; Carvalho, C.A.M.; Cragoe Jr., E.J.; Carvalho, A.P., 1990. Neurochemical Research. 313 - 320. 3. 15. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025240818&partnerID=MN8TOARS . 10.1007/BF00968678 . Neurochemical Research

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