Metabolismo, Envelhecimento e Doença

A investigação na área do Metabolismo, Envelhecimento e Doenças debruça-se no estudo de doenças relacionadas com o envelhecimento e estilo de vida de um ponto de vista metabólico com foco na descoberta de mecanismos, biomarcadores e terapias

Sobre a Área de Metabolismo, Envelhecimento e Doença 

Visão Geral

A investigação na área de Metabolismo, Envelhecimento e Doença foca-se em estudos de alterações do metabolismo celular, particularmente nas vias de produção de energia, que resultam frequentemente na aceleração do processo de envelhecimento ou no desenvolvimento de doenças como diabetes, fígado gordo, doenças cardiovasculares, infertilidade e cancro.

Objetivos

To understand the lifestyle/diet impact in cell aging, focusing on whether overnutrition/undernutrition or physical activity modulates the signaling pathways commonly associated with aging metabolic alterations;
To understand mitochondrial functionality and how it can be regulated for biomedical purposes;
To identify impairments quality control processes in aging and lifestyle-related diseases;
To investigate the epigenetic regulation of metabolic capacity, namely whether metabolic capacity in the different tissues can be programmed in utero, and transmitted transgenerationally, resulting in predisposition to disease or accelerated aging in the adult;
To identify key serum markers or hormonal/metabolic alterations which anticipate the onset of frailty, focusing on early metabolic alterations that result in later loss of bone or muscle mass;
To understand the metabolic adaptations that are common to stem cell differentiation and tumorigenesis, in order to provide a basis for novel strategies to control stem cell differentiation and tumorigenesis;
To elucidate the molecular mechanisms behind human infertility and to develop new clinical tools;
To investigate the role of metabolism in inflammation and the immune response in chronic diseases.

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