Biotechnology

Tumor Microenvironment and Targeted Therapies

Drug Delivery

Tumor Microenvironment

Solid Tumors

Experimental Therapeutics


Research lines

Identify pathways for drug delivery to solid tumors (and beyond the liver)

Engineering strategies to temporal and special delivery of drug combinations targeting different components of the tumor microenvironment

Delivery of macromolecules to solid tumors

Novel anticancer targeted strategies to boost intratumoral immune system

Overview

Scientific activity has been focused on the design of targeted entities, namely lipid-based nanosystems for drug and nucleic acid delivery, addressing the impact on the tumor microenvironment and cancer cells, both at the cellular and molecular level. Scientific competences include formulation and characterization of lipid nanovesicles, in vitro and in vivo mechanistic studies, in vitro cytotoxicity, biodistribution, and therapeutic testing in animal models of cancer.

The goals of the group also point towards the identification and validation of target proteins overexpressed in tumors associated with clear unmet medical needs.  This aims at identifying novel pathways for drug delivery to solid tumors (and beyond the liver), combined with the demonstration of their importance for the tumorigenic process. We believe that this strategy will enable to establish the mechanism of action of the targeted strategies the members of the group have been working on, either with single or drug combinations. It will ultimately overcome the challenges posed by drug resistance and metastasis, thus leading to decrease of overall tumor burden and relapse as well, clearly benefiting cancer patients.

To further support the achievement of the referred scientific goals, and increase the translational potential of the generated knowledge, the involvement of researchers from hospitals and clinicians will be fostered at the early stages of the projects. This will be crucial to support the identified target proteins as markers for drug targeting, namely in patients-derived samples and validate the proposed targeting strategies. 

Publications

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Information about journal articles, updated at 25-07-2021, from platform CIÊNCIAVITAE.

Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy

Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A.; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F.; Malaguti, Fabiana; et al, 2021. Journal of Experimental & Clinical Cancer Research. 1. 40. 2021. http://dx.doi.org/10.1186/s13046-021-01993-9 . 10.1186/s13046-021-01993-9 . Journal of Experimental & Clinical Cancer Research

Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin

Rui Lopes; Kevin Shi; Nuno A. Fonseca; Adelina Gama; José S. Ramalho; Luís Almeida; Vera Moura; et al, 2021. Drug Delivery and Translational Research. 2021. https://doi.org/10.1007/s13346-021-00972-z . 10.1007/s13346-021-00972-z . Drug Delivery and Translational Research

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

Cláudia Pina Costa; João Nuno Moreira; José Manuel Sousa Lobo; Ana Catarina Silva, 2021. Acta Pharmaceutica Sinica B. 2021. https://doi.org/10.1016/j.apsb.2021.02.012 . 10.1016/j.apsb.2021.02.012 . Acta Pharmaceutica Sinica B

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Simões, Sérgio; Moreira, João Nuno, 2021. Nano Today. 37. 2021. http://dx.doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis

Carvalho, Laura Sofia; Gonçalves, Nélio; Fonseca, Nuno André; Moreira, João Nuno, 2021. Pharmaceuticals. 1. 14. 2021. http://dx.doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals

Application of the Quality-by-Design (QbD) Approach to Improve the Nose-to-Brain Delivery of Diazepam-Loaded Nanostructured Lipid Carriers (NLCs)

Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana Catarina, 2020. Proceedings. 1. 78. 2020. http://dx.doi.org/10.3390/iecp2020-08658 . 10.3390/iecp2020-08658 . Proceedings

Current challenges and emerging opportunities of CAR-T cell therapies

Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno (EF1B-FA3D-0787), 2020. Journal of Controlled Release. 246 - 261. 319. 2020. http://dx.doi.org/10.1016/j.jconrel.2019.12.047 . 10.1016/j.jconrel.2019.12.047 . Journal of Controlled Release

Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review

Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C., 2020. Nanomedicine: Nanotechnology, Biology and Medicine. 2020. http://dx.doi.org/10.1016/j.nano.2020.102206 . 10.1016/j.nano.2020.102206 . in press Nanomedicine: Nanotechnology, Biology and Medicine

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

Romano, Sofia; Fonseca, Nuno; Simões, Sérgio; Gonçalves, João; Moreira, João Nuno, 2019. Drug Discovery Today. 1985 - 2001. 10. 24. 2019. http://dx.doi.org/10.1016/j.drudis.2019.06.018 . 10.1016/j.drudis.2019.06.018 . published Drug Discovery Today

Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis

Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C., 2019. Journal of Controlled Release. 187 - 200. 295. 2019. http://dx.doi.org/10.1016/j.jconrel.2018.12.049 . 10.1016/j.jconrel.2018.12.049 . published Journal of Controlled Release

Meeting the needs of breast cancer: A nucleolin's perspective

Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2018. Critical Reviews in Oncology/Hematology. 89 - 101. 125. 2018. http://dx.doi.org/10.1016/j.critrevonc.2018.03.008 . 10.1016/j.critrevonc.2018.03.008 . Critical Reviews in Oncology/Hematology

Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles

Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno, 2018. Current Pharmaceutical Design. 6563 - 6572. 43. 23. 2018. http://dx.doi.org/10.2174/1381612823666171115105252 . 10.2174/1381612823666171115105252 . Current Pharmaceutical Design

Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity

Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno, 2018. Experimental Cell Research. 68 - 77. 1. 370. 2018. http://dx.doi.org/10.1016/j.yexcr.2018.06.005 . 10.1016/j.yexcr.2018.06.005 . published Experimental Cell Research

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

Zupancic, Eva; Curato, Caterina; Kim, Jung-Seok; Yeini, Eilam; Porat, Ziv; Viana, Ana S.; Globerson-Levin, Anat; et al, 2018. Nanomedicine: Nanotechnology, Biology and Medicine. 835 - 847. 3. 14. 2018. http://dx.doi.org/10.1016/j.nano.2017.12.011 . 10.1016/j.nano.2017.12.011 . Nanomedicine: Nanotechnology, Biology and Medicine

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João, 2018. Scientific Reports. 1. 8. 2018. http://dx.doi.org/10.1038/s41598-018-25816-8 . 10.1038/s41598-018-25816-8 . Scientific Reports

The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors

Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2017. Critical Reviews in Oncology/Hematology. 111 - 121. 113. 2017. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016 . 10.1016/j.critrevonc.2017.03.016 . Critical Reviews in Oncology/Hematology

Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming

Zupancic, Eva; Curato, Caterina; Paisana, Maria; Rodrigues, Catarina; Porat, Ziv; Viana, Ana S.; Moreira, João N.; et al, 2017. Journal of Controlled Release. 182 - 195. 258. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.05.014 . 10.1016/j.jconrel.2017.05.014 . Journal of Controlled Release

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer

Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório; et al, 2017. Pathology & Oncology Research. 701 - 716. 4. 24. 2017. http://dx.doi.org/10.1007/s12253-017-0307-2 . 10.1007/s12253-017-0307-2 . Pathology & Oncology Research

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2016. PLOS ONE. 11. 11. 2016. http://dx.doi.org/10.1371/journal.pone.0165817 . 10.1371/journal.pone.0165817 . PLOS ONE

Development of e-learning platform about biologic drugs with focus on monoclonal antibodies

J. Goncalves; L. Graça; Moreira, João Nuno; I. V. Figueiredo; F. Scappaticci; J. Eurico Fonseca; F. Magro; et al, 2016. International Journal of Clinical Pharmacy. 519 - 520. 2. 38. 2016. published International Journal of Clinical Pharmacy

Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome

Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al, 2016. RSC Advances. 114599 - 114612. 115. 6. 2016. https://doi.org/10.1039/C6RA21623D . 10.1039/C6RA21623D . RSC Advances

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Data in Brief. 700 - 705. 6. 2016. http://dx.doi.org/10.1016/j.dib.2016.01.017 . 10.1016/j.dib.2016.01.017 . Data in Brief

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Biomaterials. 124 - 137. 82. 2016. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021 . 10.1016/j.biomaterials.2015.12.021 . published Biomaterials

Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin

Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2015. Acta Biomaterialia. 196 - 205. 18. 2015. http://dx.doi.org/10.1016/j.actbio.2015.02.018 . 10.1016/j.actbio.2015.02.018 . Acta Biomaterialia

Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination

Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João Nuno, 2015. Biomaterials. 76 - 88. 69. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007 . 10.1016/j.biomaterials.2015.08.007 . published Biomaterials

Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines

Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena, 2015. Current Topics in Medicinal Chemistry. 291 - 313. 3. 16. 2015. http://dx.doi.org/10.2174/1568026615666150701115508 . 10.2174/1568026615666150701115508 . Current Topics in Medicinal Chemistry

Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination

Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2014. Journal of Controlled Release. 122 - 131. 196. 2014. http://dx.doi.org/10.1016/j.jconrel.2014.09.024 . 10.1016/j.jconrel.2014.09.024 . Journal of Controlled Release

Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering

Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. Biomater. Sci.. 1195 - 1209. 9. 2. 2014. http://dx.doi.org/10.1039/c4bm00069b . 10.1039/c4bm00069b . published Biomater. Sci.

Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering

Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. ACS Nano. 8082 - 8094. 8. 8. 2014. http://dx.doi.org/10.1021/nn5021049 . 10.1021/nn5021049 . published ACS Nano

Development of a Novel Nanoparticle-based Therapeutic Vaccine for Breast Cancer Immunotherapy

Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F., 2014. Procedia in Vaccinology. 62 - 67. 8. 2014. http://dx.doi.org/10.1016/j.provac.2014.07.011 . 10.1016/j.provac.2014.07.011 . published Procedia in Vaccinology

Bridging cancer biology and the patients' needs with nanotechnology-based approaches

Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N., 2014. Cancer Treatment Reviews. 626 - 635. 5. 40. 2014. http://dx.doi.org/10.1016/j.ctrv.2014.02.002 . 10.1016/j.ctrv.2014.02.002 . published Cancer Treatment Reviews

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões, Sérgio; Moreira, João N, 2013. Nanomedicine. 1397 - 1413. 9. 8. 2013. http://dx.doi.org/10.2217/nnm.12.174 . 10.2217/nnm.12.174 . published Nanomedicine

Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment

Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N; Pereira de Almeida, Luís; Pedroso de Lima, Maria C, 2013. Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 . 10.1038/mtna.2013.30 . published Molecular Therapy - Nucleic Acids

MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent

Figueiredo, S.; Cutrin, J.C.; Rizzitelli, S.; De Luca, E.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2013. Molecular Imaging and Biology. 307 - 315. 3. 15. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727777&partnerID=MN8TOARS . 10.1007/s11307-012-0603-x . Molecular Imaging and Biology

Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells

Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2013. European Journal of Pharmaceutics and Biopharmaceutics. 356 - 364. 3. 85. 2013. http://dx.doi.org/10.1016/j.ejpb.2013.04.007 . 10.1016/j.ejpb.2013.04.007 . published European Journal of Pharmaceutics and Biopharmaceutics

On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human mesenchymal stem cells

Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.; Moreira, João Nuno, 2013. Journal of Tissue Engineering and Regenerative Medicine. 1056 - 1066. 9. 9. 2013. http://dx.doi.org/10.1002/term.1817 . 10.1002/term.1817 . published Journal of Tissue Engineering and Regenerative Medicine

Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin

Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N., 2013. Current Gene Therapy. 189 - 201. 3. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS . 10.2174/1566523211313030004 . Current Gene Therapy

Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N., 2013. Cellular and Molecular Life Sciences. 1417 - 1438. 8. 71. 2013. http://dx.doi.org/10.1007/s00018-013-1502-2 . 10.1007/s00018-013-1502-2 . published Cellular and Molecular Life Sciences

Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations

Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2012. Journal of Nanoscience and Nanotechnology. 2891 - 2900. 3. 12. 2012. http://dx.doi.org/10.1166/jnn.2012.5703 . 10.1166/jnn.2012.5703 . Journal of Nanoscience and Nanotechnology

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. International Journal of Pharmaceutics. 9 - 19. 1-2. 434. 2012. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018 . 10.1016/j.ijpharm.2012.05.018 . published International Journal of Pharmaceutics

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. Accounts of Chemical Research. 1163 - 1171. 7. 45. 2012. http://dx.doi.org/10.1021/ar300048p . 10.1021/ar300048p . published Accounts of Chemical Research

Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes

Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2011. Bioorganic and Medicinal Chemistry. 1131 - 1135. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS . 10.1016/j.bmc.2010.07.057 . Bioorganic and Medicinal Chemistry

[Visualization of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]

Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E., 2011. Revista Portuguesa de Pneumologia (English Edition). 5. 17. 2011. http://dx.doi.org/10.1016/j.rppnen.2011.09.002 . 10.1016/j.rppnen.2011.09.002 . Revista Portuguesa de Pneumologia (English Edition)

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2011. Breast Cancer Research and Treatment. 61 - 73. 1. 133. 2011. http://dx.doi.org/10.1007/s10549-011-1688-7 . 10.1007/s10549-011-1688-7 . published Breast Cancer Research and Treatment

Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging

Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo, 2011. Chemical Communications. 38. 47. 2011. http://dx.doi.org/10.1039/c1cc14019a . 10.1039/c1cc14019a . published Chemical Communications

Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR

Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2011. Journal of Medicinal Chemistry. 6375 - 6393. 18. 54. 2011. http://dx.doi.org/10.1021/jm200803d . 10.1021/jm200803d . Journal of Medicinal Chemistry

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2010. Cancer Chemotherapy and Pharmacology. 275 - 284. 2. 67. 2010. http://dx.doi.org/10.1007/s00280-010-1315-z . 10.1007/s00280-010-1315-z . published Cancer Chemotherapy and Pharmacology

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability

Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N., 2010. Brazilian Journal of Medical and Biological Research. 1001 - 1009. 10. 43. 2010. http://dx.doi.org/10.1590/s0100-879x2010007500099 . 10.1590/s0100-879x2010007500099 . published Brazilian Journal of Medical and Biological Research

Design of peptide-targeted liposomes containing nucleic acids

Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2010. Biochimica et Biophysica Acta (BBA) - Biomembranes. 433 - 441. 3. 1798. 2010. http://dx.doi.org/10.1016/j.bbamem.2009.12.001 . 10.1016/j.bbamem.2009.12.001 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

Liposomal imatinib-mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer

Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2010. The Prostate. 81 - 90. 1. 71. 2010. http://dx.doi.org/10.1002/pros.21224 . 10.1002/pros.21224 . The Prostate

Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment

Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio, 2010. Bioconjugate Chemistry. 157 - 168. 1. 21. 2010. http://dx.doi.org/10.1021/bc9004365 . 10.1021/bc9004365 . published Bioconjugate Chemistry

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio, 2010. Biotechnology and Bioengineering. 884 - 893. 5. 107. 2010. http://dx.doi.org/10.1002/bit.22858 . 10.1002/bit.22858 . published Biotechnology and Bioengineering

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P., 2010. Bioorganic and Medicinal Chemistry. 4385 - 4396. 12. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS . 10.1016/j.bmc.2010.04.085 . Bioorganic and Medicinal Chemistry

Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis

Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2010. Journal of Medicinal Chemistry. 7632 - 7638. 21. 53. 2010. http://dx.doi.org/10.1021/jm1007769 . 10.1021/jm1007769 . published Journal of Medicinal Chemistry

Targeted Lipoplexes for siRNA Delivery

Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso, 2009. Methods in Enzymology. 267 - 287. 2009. http://dx.doi.org/10.1016/s0076-6879(09)65014-x . 10.1016/s0076-6879(09)65014-x . Methods in Enzymology

Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols

Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2009. Journal of Medicinal Chemistry. 4007 - 4019. 13. 52. 2009. http://dx.doi.org/10.1021/jm9003973 . 10.1021/jm9003973 . published Journal of Medicinal Chemistry

Non-viral lipid-based nanoparticles for cancer systemic gene silencing

João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al, 2008. Journal of Nanoscience and Nanotechnology. 2187 - 2204 . 5. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS . 10.1166/jnn.2008.319 . published Journal of Nanoscience and Nanotechnology

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer

Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N., 2008. Cytometry Part A. 1165 - 1172. 12. 73A. 2008. http://dx.doi.org/10.1002/cyto.a.20634 . 10.1002/cyto.a.20634 . published Cytometry Part A

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner

Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2008. Cancer Chemotherapy and Pharmacology. 445 - 454. 3. 64. 2008. http://dx.doi.org/10.1007/s00280-008-0892-6 . 10.1007/s00280-008-0892-6 . published Cancer Chemotherapy and Pharmacology

Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality

Moreira, João Nuno; Santos, Adriana; Simões, Sérgio, 2006. Reviews on Recent Clinical Trials. 217 - 235. 3. 1. 2006. http://dx.doi.org/10.2174/157488706778250050 . 10.2174/157488706778250050 . published Reviews on Recent Clinical Trials

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S, 2005. European Journal of Pharmaceutics and Biopharmaceutics. 359 - 366. 2. 59. 2005. http://dx.doi.org/10.1016/j.ejpb.2004.08.012 . 10.1016/j.ejpb.2004.08.012 . published European Journal of Pharmaceutics and Biopharmaceutics

On the formulation of pH-sensitive liposomes with long circulation times

Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima, 2004. Advanced Drug Delivery Reviews. 947 - 965. 7. 56. 2004. http://dx.doi.org/10.1016/j.addr.2003.10.038 . 10.1016/j.addr.2003.10.038 . Advanced Drug Delivery Reviews

Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer

Moreira, J.N.; Gaspar, R., 2004. Brazilian Journal of Medical and Biological Research. 1185 - 1192. 8. 37. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS . 10.1590/s0100-879x2004000800008 . published Brazilian Journal of Medical and Biological Research

Technology evaluation: LErafAON, NeoPharm

Moreira, J.N.; Simões, S., 2003. Current Opinion in Molecular Therapeutics. 547 - 552. 5. 5. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS . published Current Opinion in Molecular Therapeutics

Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity

Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M., 2002. Pharmaceutical Research. 265 - 269. 3. 19. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS . 10.1023/A:1014434732752 . published Pharmaceutical Research

Adventures in targeting

Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D., 2002. Journal of Liposome Research. 5 - 12. 1-2. 12. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS . 10.1081/LPR-120004771 . Journal of Liposome Research

Targeting Stealth liposomes in a murine model of human small cell lung cancer

Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M., 2001. Biochimica et Biophysica Acta (BBA) - Biomembranes. 167 - 176. 2. 1515. 2001. http://dx.doi.org/10.1016/s0005-2736(01)00411-4 . 10.1016/s0005-2736(01)00411-4 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer

Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M., 2001. Biochimica et Biophysica Acta - Biomembranes. 303 - 317. 2. 1514. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS . 10.1016/S0005-2736(01)00386-8 . published Biochimica et Biophysica Acta - Biomembranes

Carboplatin liposomes coated with O-palmitoylpullulan: In vitro characterization

Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L., 1997. International Journal of Pharmaceutics. 153 - 164. 2. 147. 1997. http://dx.doi.org/10.1016/s0378-5173(96)04808-9 . 10.1016/s0378-5173(96)04808-9 . published International Journal of Pharmaceutics

Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)

Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L., 1996. Journal of Materials Science: Materials in Medicine. 301 - 303. 5. 7. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS . 10.1007/bf00058571 . published Journal of Materials Science: Materials in Medicine

Characterization of the in vitro dissolution of some commercial sustained release theophylline dosage forms

Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A., 1994. Drug Development and Industrial Pharmacy. 1471 - 1483. 8. 20. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS . Drug Development and Industrial Pharmacy

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