Aging
Hypothalamus
Biological Clocks
Autofagia
Inflammation
Neuroendocrine axis and aging
Hypothalamus: a target to delay aging and age-related disorders
New drugs to target hallmarks of aging and age-related diseases
Circadian Rhythms in aging and age-related diseases
The Mission of Neuroendocrinology and Aging Group is to contribute to develop new knowledge in the aging field, namely to demonstrate that neuroendocrine system and related mechanisms can be targeted in experimental models to delay, stop, and in some examples, reverse manifestations of aging and age-related disorders.
The knowledge generated by our group has been contributing to the hypothesis that aging and age-related disorders could be controlled by using neuroendocrine strategies. These strategies are based on targeting the main brain area involved in the neuroendocrine system - the hypothalamus -, its main functions (circadian rhythm, sleep, food intake, metabolism), and also the hypothalamus-periphery axis.
The group members have complementary expertise: establishment of cellular and animal models of aging and age-related disorders (progeria, neurodegenerative disorders, OSA, OA, insomnia, metabolic dysfunction and obesity), evaluation of physiology, cellular and molecular aging markers (namely autophagy, senescence, inflammation), gene transfer approaches, circadian rhythm analysis, medicinal chemistry and histopathological methodologies. Moreover, the group has expertise to organize pre-clinical studies and public engagement activities.
Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A
PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.
Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2021. Aging. 2021. accepted Aging
Skin senescence: mechanisms and impact on whole-body aging
Ana Catarina Franco; Célia Aveleira; Cláudia Cavadas, 2022. Trends in Molecular Medicine. 2022. https://doi.org/10.1016/j.molmed.2021.12.003 . 10.1016/j.molmed.2021.12.003 . Trends in Molecular Medicine
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway
Cunha-Santos, J.; Duarte-Neves, J.; Carmona, V.; Guarente, L.; De Almeida, L.P.; Cavadas, C., 2016. Nature Communications. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968928647&partnerID=MN8TOARS . 10.1038/ncomms11445 . Nature Communications
Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.
Leptin enhances progerin clearance and ameliorates the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells (under submission))
Real, AC; Ferreira-Marques, M (EA15-6C9F-F15E); Cortes, Luisa; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2022. 2022. submitted
Skin senescence: mechanisms and impact on whole-body aging
Ana Catarina Franco; Aveleira C; Cavadas, Claudia, 2022. Trends Molecular Medicine. 97 - 109. 2. 28. 2022. published Trends Molecular Medicine
Cellular senescence mechanisms in the context of current biomarkers and senotherapies (under submission)
Vasco Lucas; Claudia Cavadas; Aveleira C, 2022. Pharmacological Reviews. 2022. submitted Pharmacological Reviews
Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases
Cátia Sousa; Alexandrina Ferreira Mendes, 2022. Biomolecules. 2022. https://doi.org/10.3390/biom12070921 . 10.3390/biom12070921 . Biomolecules
Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun scaffold fabrication
Semitela, Ângela; Ramalho, Gonçalo; Capitão, Ana; Sousa, Cátia; Mendes, Alexandrina F; AAP Marques, Paula; Completo, António, 2022. Journal of Tissue Engineering. 13. 2022. http://dx.doi.org/10.1177/20417314211069342 . 10.1177/20417314211069342 . Journal of Tissue Engineering
SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway.
Leal H; Cardoso J; Valério P; Quatorze M; Carmona V; Cunha-Santos J; Pereira de Almeida L; et al, 2022. International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/35743232 . 10.3390/ijms23126790 . International journal of molecular sciences
Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases
Brás, João; Henriques, Daniel; Moreira, Ricardo; Santana, Magda M.; Silva-Pedrosa, Rita; Adão, Diana; Braz, Sandra; et al, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-16369-y . 10.1038/s41598-022-16369-y . Scientific Reports
PET Imaging of the Neuropeptide Y System: A Systematic Review.
Fonseca ICF; Castelo-Branco M; Cavadas C; Abrunhosa AJ, 2022. Molecules (Basel, Switzerland). 2022. http://europepmc.org/abstract/med/35744852 . 10.3390/molecules27123726 . Molecules (Basel, Switzerland)
A look on food intake and satiety: from humans to rodent models
2022. Nutrition Reviews. 2022. http://dx.doi.org/10.1093/nutrit/nuac010 . 10.1093/nutrit/nuac010 . Nutrition Reviews
Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis.
Gaspar LS; Santos-Carvalho A; Santos B; Carvalhas-Almeida C; Barros-Viegas AT; Oliveiros B; Donato H; et al, 2022. Sleep medicine reviews. 2022. http://europepmc.org/abstract/med/35753150 . 10.1016/j.smrv.2022.101659 . Sleep medicine reviews
Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis
Gaspar, Laetitia S.; Santos-Carvalho, Ana; Santos, Bárbara; Carvalhas-Almeida, Catarina; Barros-Viegas, Ana Teresa; Oliveiros, Bárbara; Donato, Helena; et al, 2022. Sleep Medicine Reviews. 64. 2022. http://dx.doi.org/10.1016/j.smrv.2022.101659 . 10.1016/j.smrv.2022.101659 . Sleep Medicine Reviews
Enhancing ghrelin signaling alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (under submission).
Ferreira-Marques, M (EA15-6C9F-F15E); Carvalho, A; Franco, Ana Catarina; Leal, A; Botelho, M; Carmo-Silva, Sara; Águas, R; et al, 2022. 2022. submitted
Ataxin-2 in the hypothalamus at the crossroads between metabolism & circadian rhythm (under revision)
Carmo-Silva, Sara; Ferreira-Marques, M (EA15-6C9F-F15E); Nóbrega, Clévio David Rodrigues ; Botelho M; Costa, D; Aveleira C; Pulst, Stefan; Almeida, Luís Pereira de; Cavadas, Claudia, 2022. Journal of Molecular Endocrinology. 2022. under revision Journal of Molecular Endocrinology
Skin senescence: mechanisms and impact on whole-body aging
Ana Catarina Franco; Célia Aveleira; Cláudia Cavadas, 2022. Trends in Molecular Medicine. 2022. https://doi.org/10.1016/j.molmed.2021.12.003 . 10.1016/j.molmed.2021.12.003 . Trends in Molecular Medicine
The NutriClock Study Protocol - Assessing the Impact of a Chrononutrition Intervention in Patients With Cardiometabolic Disturbances
Lages, Marlene; Gaspar, Laetitia; Carmo-Silva, Sara; Frontini, Roberta; Álvaro, Ana; Cavadas, Cláudia; Fonseca, Rui; et al, 2021. Current Developments in Nutrition. 468 - 468. Supplement. 5. 2021. http://dx.doi.org/10.1093/cdn/nzab039_004 . 10.1093/cdn/nzab039_004 . Current Developments in Nutrition
Copper impair autophagy on zebrafish (Danio rerio) gill epithelium
Luzio, A.; Parra, S.; Costa, B.; Santos, D.; Álvaro, A.R.; Monteiro, S.M., 2021. Environmental Toxicology and Pharmacology. 86. 2021. http://dx.doi.org/10.1016/j.etap.2021.103674 . 10.1016/j.etap.2021.103674 . published Environmental Toxicology and Pharmacology
Effects of short-term exposure to genistein and overfeeding diet on the neural and retinal progenitor competence of adult zebrafish (Danio rerio)
Luzio, A.; Figueiredo, M.; Matos, M.M.; Coimbra, A.M.; Álvaro, A.R.; Monteiro, S.M., 2021. Neurotoxicology and Teratology. 88. 2021. http://dx.doi.org/10.1016/j.ntt.2021.107030 . 10.1016/j.ntt.2021.107030 . published Neurotoxicology and Teratology
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Gaspar, Laetitia S.; Sousa, Cátia; Álvaro, Ana Rita; Cavadas, Cláudia; Mendes, Alexandrina Ferreira, 2021. Pharmacological Research. 164. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research
Long-term Continuous Positive Airway Pressure Treatment Ameliorates Biological Clock Disruptions in Obstructive Sleep Apnea
C014-4DE9-206C; Janina Hesse; Müge Yalçin; 0F1A-8AFD-63A0; Catarina Carvalhas-Almeida; Mafalda Ferreira; B01F-45DC-F6D7; et al, 2021. Ebiomedicine. 2021. in press Ebiomedicine
PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.
Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2021. Aging. 2021. accepted Aging
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky D J; Abdel-Aziz A K; ...; Aveleira C; Chun-Kit Tong, 2021. Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . published Autophagy
PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons
Cavadas, Claudia, 2021. Aging. 2021. https://doi.org/10.18632/aging.202805 . 10.18632/aging.202805 . Aging
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease.
Cavadas, Claudia, 2021. Scientific reports. 2021. https://europepmc.org/articles/PMC7870889 . 10.1038/s41598-021-82339-5 . Scientific reports
Multi-layered electrospinning and electrospraying approach: Effect of polymeric supplements on chondrocyte suspension
Semitela, Ângela; Leal Pereira, Andreia; Sousa, Cátia; Mendes, Alexandrina F.; Marques, Paula A.A.P.; Completo, António, 2021. Journal of Biomaterials Applications. 2021. http://dx.doi.org/10.1177/08853282211064403 . 10.1177/08853282211064403 . Journal of Biomaterials Applications
Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line
Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes, 2021. Biomedicines. 777 - 777. 7. 9. 2021. https://doi.org/10.3390/biomedicines9070777 . 10.3390/biomedicines9070777 . Biomedicines
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.
Cavadas, Claudia, 2021. Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Laetitia S. Gaspar; Cátia Sousa; Ana Rita Álvaro; Cláudia Cavadas; Alexandrina Ferreira Mendes, 2021. Pharmacological Research. 105369 - 105369. 2021. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research
Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and rescues hepatic mitochondrial bioenergetics
Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Matos, P.; et al, 2021. Nutrients. 12. 13. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119606449&partnerID=MN8TOARS . 10.3390/nu13124192 . Nutrients
Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases
Ribeiro, R.F.N.; Cavadas, C.; Silva, M.M.C., 2021. Drug Discovery Today. 1620 - 1641. 7. 26. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104421181&partnerID=MN8TOARS . 10.1016/j.drudis.2021.03.015 . Drug Discovery Today
Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea (EBioMedicine)
Laetitia S. Gaspar; Janina Hesse; Müge Yalçin; Bárbara Santos; Catarina Carvalhas-Almeida; Mafalda Ferreira; Joaquim Moita; et al, 2021. EBioMedicine. 2021. https://doi.org/10.1016/j.ebiom.2021.103248 . 10.1016/j.ebiom.2021.103248 . in press EBioMedicine
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Cavadas, Claudia, 2020. Pharmacological research. 2020. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological research
Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity
Mendes, Alexandrina Ferreira , 2020. Scientific Reports. 10. 2020. https://rdcu.be/b3Rts . published Scientific Reports
Expression and function of the nonclassical estrogen receptor, GPR30, in human cartilage and chondrocytes
Madalena Ribeiro; Cátia Sousa; Ana T. Rufino; Fernando Judas; Alexandrina F. Mendes, 2020. Journal of Cellular Physiology. 2020. https://doi.org/10.1002/jcp.29691 . 10.1002/jcp.29691 . Journal of Cellular Physiology
The Superpowers of Our Sleep
Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . Frontiers for Young Minds
Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar rats
Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Figueirinha, A.; et al, 2020. Pharmaceutics. 1 - 29. 11. 12. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096072381&partnerID=MN8TOARS . 10.3390/pharmaceutics12111094 . Pharmaceutics
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells
Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 1073 - 1078. 6. 75. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models
Santana, M.M.; Paixão, S.; Cunha-Santos, J.; Silva, T.P.; Trevino-Garcia, A.; Gaspar, L.S.; Nóbrega, C.; et al, 2020. Journal of Translational Medicine. 1. 18. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083210032&partnerID=MN8TOARS . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine
The Superpowers of Our Sleep
Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . published Frontiers for Young Minds
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A
Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases
Cavadas, Claudia, 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences
The importance of determining circadian parameters in pharmacological studies
Mendes, Alexandrina, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology
The importance of determining circadian parameters in pharmacological studies
Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2827 - 2847. 16. 176. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology
The importance of determining circadian parameters in pharmacological studies
Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology
Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases
Mendes, Alexandrina Ferreira , 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences
Editorial: The Physiology of Inflammation—The Final Common Pathway to Disease
Mendes, Alexandrina, 2018. Frontiers in Physiology. 2018. 10.3389/fphys.2018.01741 . Frontiers in Physiology
Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice
Marques, A.P.; Cunha-Santos, J.; Leal, H.; Sousa-Ferreira, L.; Pereira de Almeida, L.; Cavadas, C.; Rosmaninho-Salgado, J., 2018. Biochimica et Biophysica Acta - General Subjects. 403 - 413. 3. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037668547&partnerID=MN8TOARS . 10.1016/j.bbagen.2017.11.012 . Biochimica et Biophysica Acta - General Subjects
Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.
Pólvora-Brandão D; Joaquim M; Godinho I; Aprile D; Álvaro AR; Onofre I; Raposo AC; et al, 2018. Human molecular genetics. 2018. http://europepmc.org/abstract/med/30102380 . 10.1093/hmg/ddy274 . Human molecular genetics
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress
Spadari, R.C.; Cavadas, C.; de Carvalho, A.E.T.S.; Ortolani, D.; de Moura, A.L.; Vassalo, P.F., 2018. Cellular and Molecular Neurobiology. 109 - 120. 1. 38. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032021647&partnerID=MN8TOARS . 10.1007/s10571-017-0557-2 . Cellular and Molecular Neurobiology
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Exercise-Induced Immune Response
Mendes, Alexandrina, 2018. Journal of Functional Morphology and Kinesiology. 2018. http://www.mdpi.com/2411-5142/3/3/42 . 10.3390/jfmk3030042 . Journal of Functional Morphology and Kinesiology
In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components
Costa, S.; Cavadas, C.; Cavaleiro, C.; Salgueiro, L.; do Céu Sousa, M., 2018. Experimental Parasitology. 34 - 40. 190. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047422613&partnerID=MN8TOARS . 10.1016/j.exppara.2018.05.002 . Experimental Parasitology
Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation
Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., 2017. Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . published Mediators of Inflammation
Obstructive Sleep Apnea and Hallmarks of Aging
Gaspar, Laetitia S.; Álvaro, Ana Rita; Moita, Joaquim; Cavadas, Cláudia, 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://dx.doi.org/10.1016/j.molmed.2017.06.006 . 10.1016/j.molmed.2017.06.006 . published Trends in Molecular Medicine
The NAD<sup>+</sup>-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes
Lemos, V.; de Oliveira, R.M.; Naia, L.; Szegö, E.; Ramos, E.; Pinho, S.; Magro, F.; et al, 2017. Human Molecular Genetics. 4105 - 4117. 21. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034211658&partnerID=MN8TOARS . 10.1093/hmg/ddx298 . Human Molecular Genetics
Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line
Ana Patrícia Marques; Joana Rosmaninho-Salgado; Marta Estrada; Vera Cortez; Rui Jorge Nobre; Cláudia Cavadas, 2017. Biochimica et Biophysica Acta (BBA) - General Subjects. 673 - 682. 3. 1861. 2017. https://doi.org/10.1016/j.bbagen.2016.12.005 . 10.1016/j.bbagen.2016.12.005 . Biochimica et Biophysica Acta (BBA) - General Subjects
Obstructive Sleep Apnea and Hallmarks of Aging
Gaspar, L.S.; Álvaro, A.R.; Moita, J.; Cavadas, C., 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025131167&partnerID=MN8TOARS . 10.1016/j.molmed.2017.06.006 . Trends in Molecular Medicine
Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes
Rufino, Ana; Ribeiro, Madalena; Pinto Ferreira, João; Judas, Fernando; Mendes, Alexandrina, 2017. Journal of Functional Morphology and Kinesiology. 2. 2. 2017. http://dx.doi.org/10.3390/jfmk2020015 . 10.3390/jfmk2020015 . Journal of Functional Morphology and Kinesiology
Unraveling the Role of Ataxin-2 in Metabolism
Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C., 2017. Trends in Endocrinology and Metabolism. 309 - 318. 4. 28. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS . 10.1016/j.tem.2016.12.006 . Trends in Endocrinology and Metabolism
Assessment of cell line competence for studies of pharmacological GPR30 modulation
Sousa, Cátia; Ribeiro, Madalena; Rufino, Ana Teresa; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira, 2016. Journal of Receptors and Signal Transduction. 181 - 188. 2. 37. 2016. http://dx.doi.org/10.1080/10799893.2016.1203943 . 10.1080/10799893.2016.1203943 . Journal of Receptors and Signal Transduction
The Adenosinergic System in Diabetic Retinopathy
Vindeirinho, J.; Santiago, A. R.; Cavadas, C.; Ambrósio, A. F.; Santos, P. F., 2016. Journal of Diabetes Research. 1 - 8. 2016. 2016. http://dx.doi.org/10.1155/2016/4270301 . 10.1155/2016/4270301 . published Journal of Diabetes Research
Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.
Ferreira-Marques M; Aveleira CA; Carmo-Silva S; Botelho M; Pereira de Almeida L; Cavadas C; Ferreira-Marques, Marisa; et al, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://europepmc.org/abstract/med/27441412 . 10.18632/aging.100996 . Aging
Antileishmanial activity of antiretroviral drugs combined with miltefosine
Costa, Sonya; Machado, Marisa; Cavadas, Cláudia; do Céu Sousa, Maria, 2016. Parasitology Research. 3881 - 3887. 10. 115. 2016. http://dx.doi.org/10.1007/s00436-016-5153-8 . 10.1007/s00436-016-5153-8 . published Parasitology Research
The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing
Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . Nature Reviews Endocrinology
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Articular Cartilage Tissue Engineering and Mechanical Stimulation
Mendes, Alexandrina, 2016. Journal of Functional Morphology and Kinesiology. 2016. http://www.mdpi.com/2411-5142/1/2/162 . 10.3390/jfmk1020162 . Journal of Functional Morphology and Kinesiology
Corrigendum to "Intracellular mechanisms coupled to NPY Y<inf>2</inf> and Y<inf>5</inf> receptor activation and lipid accumulation in murine adipocytes" [neuropeptides 46/6 (2012) 359-366]
Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., 2016. Neuropeptides. 101 - 101. 57. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950130030&partnerID=MN8TOARS . 10.1016/j.npep.2015.11.089 . Neuropeptides
Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation
Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, Cláudia, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://dx.doi.org/10.18632/aging.100996 . 10.18632/aging.100996 . published Aging
The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing
Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . published Nature Reviews Endocrinology
Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases
Joana Duarte-Neves; Luís Pereira de Almeida; Cláudia Cavadas, 2016. Neurobiology of Disease. 210 - 224. 95. 2016. https://doi.org/10.1016%2Fj.nbd.2016.07.022 . 10.1016/j.nbd.2016.07.022 . Neurobiology of Disease
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway
Cunha-Santos, J.; Duarte-Neves, J.; Carmona, V.; Guarente, L.; De Almeida, L.P.; Cavadas, C., 2016. Nature Communications. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968928647&partnerID=MN8TOARS . 10.1038/ncomms11445 . Nature Communications
Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation
Ribeiro, M.; López de Figueroa, P.; Nogueira-Recalde, U.; Centeno, A.; Mendes, A.F.; Blanco, F.J.; Caramés, B., 2016. Osteoarthritis and Cartilage. 2116 - 2125. 12. 24. 2016. http://dx.doi.org/10.1016/j.joca.2016.06.019 . 10.1016/j.joca.2016.06.019 . Osteoarthritis and Cartilage
Insulin decreases autophagy and leads to cartilage degradation
Ribeiro, M.; López de Figueroa, P.; Blanco, F.J.; Mendes, A.F.; Caramés, B., 2016. Osteoarthritis and Cartilage. 731 - 739. 4. 24. 2016. http://dx.doi.org/10.1016/j.joca.2015.10.017 . 10.1016/j.joca.2015.10.017 . Osteoarthritis and Cartilage
Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53
Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R., 2016. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 138 - 146. 185-186. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS . 10.1016/j.cbpc.2016.03.010 . Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction
Alexandrina F Mendes; Susana C Rosa; Ana T Rufino; Madalena Ribeiro; Fernando Judas, 2015. BMC Musculoskeletal Disorders. S1. 16. 2015. https://doi.org/10.1186%2F1471-2474-16-s1-s1 . 10.1186/1471-2474-16-s1-s1 . BMC Musculoskeletal Disorders
Hypothalamic involvement in premature aging laminopathies.
Cavadas C, 2015. 2015. http://europepmc.org/abstract/PMC/PMC4652511 .
Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases
Rufino, Ana T.; Ferreira, Isabel; Judas, Fernando; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina F., 2015. Pharmaceutical Biology. 1220 - 1230. 8. 53. 2015. http://dx.doi.org/10.3109/13880209.2014.970701 . 10.3109/13880209.2014.970701 . Pharmaceutical Biology
Neuropeptide Y: An Anti-Aging Player?
Botelho, Mariana; Cavadas, Cláudia, 2015. Trends in Neurosciences. 701 - 711. 11. 38. 2015. http://dx.doi.org/10.1016/j.tins.2015.08.012 . 10.1016/j.tins.2015.08.012 . published Trends in Neurosciences
Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells
Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., 2015. Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . published Neuroscience Letters
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?
Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . Autophagy
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
Tissue Engineered Cartilage in Unconfined Compression: Biomechanical Analysis
Cátia Bandeiras; António Completo; António Ramos; Ana Teresa Rufino; Madalena Ribeiro; João Pinto Ferreira; Alexandrina Ferreira Mendes, 2015. Materials Today: Proceedings. 355 - 364. 1. 2. 2015. https://doi.org/10.1016%2Fj.matpr.2015.04.032 . 10.1016/j.matpr.2015.04.032 . Materials Today: Proceedings
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, Magda M.; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico C.; Kaster, Manuella P.; Aveleira, Célia A.; Ferreira, Marisa; Álvaro, Ana Rita; Cavadas, Cláudia, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://dx.doi.org/10.1016/j.euroneuro.2015.06.013 . 10.1016/j.euroneuro.2015.06.013 . published European Neuropsychopharmacology
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; Álvaro, A.R.; Cavadas, C., 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology
Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis
Mendes, Alexandrina; Rufino, A.T.; Ribeiro, M.; Sousa, C.; Judas, F.; Salgueiro, L.; Cavaleiro, C.; Mendes, A.F., 2015. European Journal of Pharmacology. 141 - 150. 750. 2015. http://www.sciencedirect.com/science/article/pii/S0014299915000412 . http://dx.doi.org/10.1016/j.ejphar.2015.01.018 . European Journal of Pharmacology
Hypothalamic involvement in premature aging laminopathies
Cavadas, Claudia, 2015. Orphanet Journal of Rare Diseases. Suppl 2. 10. 2015. http://dx.doi.org/10.1186/1750-1172-10-s2-o6 . 10.1186/1750-1172-10-s2-o6 . published Orphanet Journal of Rare Diseases
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
Gomes, Pedro; Fleming Outeiro, Tiago; Cavadas, Cláudia, 2015. Trends in Pharmacological Sciences. 756 - 768. 11. 36. 2015. http://dx.doi.org/10.1016/j.tips.2015.08.001 . 10.1016/j.tips.2015.08.001 . published Trends in Pharmacological Sciences
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; et al, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology
Neuropeptide Y system in the retina: From localization to function
Santos-Carvalho, Ana; Ambrósio, António Francisco; Cavadas, Cláudia, 2015. Progress in Retinal and Eye Research. 19 - 37. 47. 2015. http://dx.doi.org/10.1016/j.preteyeres.2015.03.001 . 10.1016/j.preteyeres.2015.03.001 . published Progress in Retinal and Eye Research
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease
Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa; den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Cavadas, Cláudia; Pereira de Almeida, Luís, 2015. Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://dx.doi.org/10.1093/hmg/ddv271 . 10.1093/hmg/ddv271 . published Human Molecular Genetics
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?
Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . published Autophagy
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective ActionsIn Vitro
Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; et al, 2015. ASN Neuro. 4. 7. 2015. http://dx.doi.org/10.1177/1759091415598292 . 10.1177/1759091415598292 . published ASN Neuro
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
Anti-inflammatory and Chondroprotective Activity of (+)-a-Pinene: Structural and Enantiomeric Selectivity
Mendes, Alexandrina, 2014. Journal of Natural Products. 2014. 10.1021/np400828x . Journal of Natural Products
Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach
Mendes, Alexandrina, 2014. PlosOne. 2014. 10.1371/journal.pone.0109048 . PlosOne
Role of hypothalamic neurogenesis in feeding regulation
Sousa-Ferreira, L.; Almeida, L.P.D.; Cavadas, C., 2014. Trends in Endocrinology and Metabolism. 80 - 88. 2. 25. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892986633&partnerID=MN8TOARS . 10.1016/j.tem.2013.10.005 . Trends in Endocrinology and Metabolism
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia, 2014. Progress in Neurobiology. 70 - 79. Jan. 112. 2014. 10.1016/j.pneurobio.2013.10.002 . published Progress in Neurobiology
Sousa-Ferreira L, Aveleira C, Botelho M, Alvaro AR, Pereira de Almeida L, Cavadas C. Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.
Cavadas, Claudia, 2014. PLoS One. 2014 Mar 5;9(3):e88917... 2014. PLoS One. 2014 Mar 5;9(3):e88917..
Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro
Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE
Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress
Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901323540&partnerID=MN8TOARS . 10.1016/j.neuroscience.2014.04.042 . Neuroscience
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
Santos-Carvalho, A.; Álvaro, A.R.; Martins, J.; Ambrósio, A.F.; Cavadas, C., 2014. Progress in Neurobiology. 70 - 79. 112. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890802011&partnerID=MN8TOARS . 10.1016/j.pneurobio.2013.10.002 . Progress in Neurobiology
Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress
Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://dx.doi.org/10.1016/j.neuroscience.2014.04.042 . 10.1016/j.neuroscience.2014.04.042 . published Neuroscience
Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro
Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro
Sousa-Ferreira, L; Aveleira, C.; Botelho, M; Álvaro, Ana Rita Costa Silva; de Almeida, P.L.; Cavadas, C., 2014. PLoS One. eCollection2014 - eCollection2014. 3. 9. 2014. 10.1371/journal.pone.0088917 . published PLoS One
Neuropeptide y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate
Santos-Carvalho, A.; Elvas, F.; Álvaro, A.R.; Ambrósio, A.F.; Cavadas, C., 2013. Cell Death and Disease. 5. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879394627&partnerID=MN8TOARS . 10.1038/cddis.2013.160 . Cell Death and Disease
Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: Possible role in glucose sensing
Rufino, A.T.; Rosa, S.C.; Judas, F.; Mobasheri, A.; Lopes, M.C.; Mendes, A.F., 2013. Journal of Cellular Biochemistry. 1879 - 1889. 8. 114. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879133940&partnerID=MN8TOARS . 10.1002/jcb.24532 . Journal of Cellular Biochemistry
Neuropeptide Y receptors Y1 and Y2 are present in neurons and glial cells in rat retinal cells in culture
Santos-Carvalho, A.; Aveleira, C.A.; Elvas, F.; Ambrósio, A.F.; Cavadas, C., 2013. Investigative Ophthalmology and Visual Science. 429 - 443. 1. 54. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874719907&partnerID=MN8TOARS . 10.1167/iovs.12-10776 . Investigative Ophthalmology and Visual Science
Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System
Vindeirinho, J.; Costa, G.N.; Correia, M.B.; Cavadas, C.; Santos, P.F., 2013. PLoS ONE. 6. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879548830&partnerID=MN8TOARS . 10.1371/journal.pone.0067499 . PLoS ONE
Progenitor cells in chromospheres: In response to Arthur S. Tischler
Santana, M.M.; Ehrhart-Bornstein, M.; Cavadas, C., 2013. Stem Cells Translational Medicine. 1020 - 1021. 12. 2. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888415377&partnerID=MN8TOARS . 10.5966/sctm.2013-0062 . Stem Cells Translational Medicine
Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate
Santos-Carvalho, A; Elvas, F; ¿?lvaro, A R; Ambrósio, A F; Cavadas, C., 2013. Cell Death and Disease. e636 - e636. 5. 4. 2013. 10.1038/cddis.2013.160 . published Cell Death and Disease
Physiology and pathophysiology of musculoskeletal aging: current research trends and future priorities
Mobasheri, Ali; Mendes, Alexandrina F.; Mobasheri, A.; Mendes, A.F., 2013. Frontiers in Physiology. 4. 2013. http://dx.doi.org/10.3389/fphys.2013.00073 . 10.3389/fphys.2013.00073 . Frontiers in Physiology
Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture
Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, 2013. Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . published Investigative Opthalmology & Visual Science
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease
Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís, 2013. Brain. 2173 - 2188. 7. 136. 2013. http://dx.doi.org/10.1093/brain/awt144 . 10.1093/brain/awt144 . published Brain
Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity
Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., 2012. PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . published PLoS ONE
Dipeptidyl-peptidase-IV by cleaving neuropeptide y induces lipid accumulation and PPAR-¿ expression
Cavadas, Claudia, 2012. BBA. 49 - 54. 1. 37. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865246554&partnerID=MN8TOARS . 10.1016/j.peptides.2012.06.014 . BBA
Potassium channels in articular chondrocytes
Mobasheri, A.; Lewis, R.; Ferreira-Mendes, A.; Rufino, A.; Dart, C.; Barrett-Jolley, R., 2012. Channels. 416 - 425. 6. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871438042&partnerID=MN8TOARS . 10.4161/chan.22340 . Channels
Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla
Santana, M.M.; Chung, K.-F.; Vukicevic, V.; Rosmaninho-Salgado, J.; Kanczkowski, W.; Cortez, V.; Hackmann, K.; et al, 2012. Stem Cells Translational Medicine. 783 - 791. 11. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873024306&partnerID=MN8TOARS . 10.5966/sctm.2012-0022 . Stem Cells Translational Medicine
Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes
Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., 2012. Neuropeptides. 359 - 366. 6. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869870468&partnerID=MN8TOARS . 10.1016/j.npep.2012.08.006 . Neuropeptides
Regulation of catecholamine release in human adrenal chromaffin cells by ß-adrenoceptors
Cortez, V.; Santana, M.; Marques, A.P.; Mota, A.; Rosmaninho-Salgado, J.; Cavadas, C., 2012. Neurochemistry International. 387 - 393. 4. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857026869&partnerID=MN8TOARS . 10.1016/j.neuint.2011.12.018 . Neurochemistry International
Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose
Costa, G.N.; Vindeirinho, J.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F., 2012. Molecular and Cellular Neuroscience. 113 - 123. 1. 50. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860624256&partnerID=MN8TOARS . 10.1016/j.mcn.2012.04.003 . Molecular and Cellular Neuroscience
Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 19745 - 19745. 5. 6. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21589937 . 10.1371/journal.pone.0019745 . published PLoS ONE
Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 5. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0019745 . 10.1371/journal.pone.0019745 . published PLoS ONE
Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and orexin-a and differentiate to functional neurons
Sousa-Ferreira, L.; Álvaro, A.R.; Aveleira, C.; Santana, M.; Brandão, I.; Kügler, S.; de Almeida, L.P.; Cavadas, C., 2011. PLoS ONE. 5. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955917559&partnerID=MN8TOARS . 10.1371/journal.pone.0019745 . PLoS ONE
Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats
Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE
Cortical strut allografting in reconstructive orthopaedic surgery
Judas, F.; Saavedra, M.J.; Mendes, A.F.; Dias, R., 2011. Acta Reumatologica Portuguesa. 24 - 28. 1. 36. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955647442&partnerID=MN8TOARS . Acta Reumatologica Portuguesa
Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat
Martins, J.; Castelo-Branco, M.; Batista, A.; Oliveiros, B.; Santiago, A.R.; Galvão, J.; Fernandes, E.; et al, 2011. PLoS ONE. 12. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84455161646&partnerID=MN8TOARS . 10.1371/journal.pone.0029583 . PLoS ONE
Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats
Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE
Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin
Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Osteoarthritis and Cartilage. 719 - 727. 6. 19. 2011. 10.1016/j.joca.2011.02.004 . published Osteoarthritis and Cartilage
Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes
Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Journal of Cellular Biochemistry. 2813 - 2824. 10. 112. 2011. 10.1002/jcb.23196 . published Journal of Cellular Biochemistry
TNF- Signals Through PKCz /NF- kB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., 2010. Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . published Diabetes
High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism
Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, 2010. Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . published Cytokine
Screening of Five Essential Oils for Identification of Potential Inhibitors of IL-1-induced Nf-¿B Activation and NO Production in Human Chondrocytes: Characterization of the Inhibitory Activity of a -Pinene
Neves, Ângela; Rosa, Susana C.; Gonçalves, Juliana; Rufino, Ana T.; Judas, Fernando M.; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina Ferreira, 2010. Planta Medica. 303 - 308. 03. 76. 2010. 10.1055/s-0029-1186085 . published Planta Medica
Neuropeptide Y inhibits [Ca 2+]i changes in rat retinal neurons through NPY Y1 , Y4 and Y5 receptors
Álvaro, Ana Rita ; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19344373 . 10.1111/j.1471-4159.2009.06079.x . published Journal of Neurochemistry
Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Osteoarthritis and Cartilage. 1657 - 1661. 12. 17. 2009. 10.1016/j.joca.2009.08.016 . published Osteoarthritis and Cartilage
Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Ali Mobasheri; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Arthritis Research & Therapy. 1 - 11. R80. 11. 2009. http://arthritis-research.com/content/11/3/R80 . 10.1186/ar2713 . published Arthritis Research & Therapy
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: role of neuropeptide Y and nitric oxide
Rosmaninho-Salgado, Joana; Araújo, Inês M.; ¿?lvaro, Ana Rita; Mendes, Alexandrina Ferreira; Ferreira, Lígia; Grouzmann, Eric; Mota, Alfredo; Duarte, Emília. P.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry
Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide y in noradrenergic neurons
Ruohonen, S.T.; Savontaus, E.; Rinne, P.; Rosmaninho-Salgado, J.; Cavadas, C.; Ruskoaho, H.; Koulu, M.; Pesonen, U., 2009. Neuroendocrinology. 351 - 360. 3. 89. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349122908&partnerID=MN8TOARS . 10.1159/000188602 . Neuroendocrinology
Neuropeptide y inhibits [Ca2+]i changes in rat retinal neurons through NPY Y1, Y4, and Y5 receptors
Álvaro, A.R.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549153628&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06079.x . Journal of Neurochemistry
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide
Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; Duarte, E.P.; Cavadas, C., 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . Journal of Neurochemistry
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide
Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; et al, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry
High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., 2009. Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . published Experimental Eye Research
Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A. R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18249070 . 10.1016/j.neuroscience.2007.12.027 . published Neuroscience
Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide
¿?lvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18331583 . 10.1111/j.1471-4159.2008.05334.x . published Journal of Neurochemistry
Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines.
Mobasheri, A.; Bondy, C.A.; Moley, K.; Mendes, A.F.; Rosa, S.C.; Richardson, S.M.; Hoyland, J.A.; Barrett-Jolley, R.; Shakibaei, M., 2008. Advances in anatomy, embryology, and cell biology. 200. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149170369&partnerID=MN8TOARS . Advances in anatomy, embryology, and cell biology
Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: A role for microglia
Xapelli, S.; Bernardino, L.; Ferreira, R.; Grade, S.; Silva, A.P.; Salgado, J.R.; Cavadas, C.; et al, 2008. European Journal of Neuroscience. 2089 - 2102. 8. 27. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049112780&partnerID=MN8TOARS . 10.1111/j.1460-9568.2008.06172.x . European Journal of Neuroscience
Neuropeptide Y stimulates retinal neural cell proliferation - Involvement of nitric oxide
Álvaro, A.R.; Martins, J.; Araújo, I.M.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649189136&partnerID=MN8TOARS . 10.1111/j.1471-4159.2008.05334.x . Journal of Neurochemistry
Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., 2008. Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . published Ocular Immunology and Inflammation
Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39649105016&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.12.027 . Neuroscience
Nitric oxide synthase isoforms and NF-¿B activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide
Rosa, Susana C.; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2008. Nitric Oxide. 276 - 283. 3. 19. 2008. 10.1016/j.niox.2008.07.005 . published Nitric Oxide
Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells
Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Duarte, E.P.; Cavadas, C.; Álvaro, A.R., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . published Journal of Neurochemistry
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells
Rosmaninho-Salgado, J.; Álvaro, A.R.; Grouzmann, E.; Duarte, E.P.; Cavadas, C., 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846606438&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.015 . Peptides
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17353067 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells
Rosmaninho-Salgado, Joana; ¿?lvaro, Ana Rita; Grouzmann, Eric; Duarte, Emilia P.; Cavadas, Cláudia, 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17207896 . 10.1016/j.peptides.2006.11.015 . published Peptides
NPY Y<inf>1</inf> receptor is not involved in the hemodynamic response to an acute cold pressor test in mice
Cavadas, C.; Waeber, B.; Pedrazzini, T.; Grand, D.; Aubert, J.-F.; Buclin, T.; Grouzmann, E., 2007. Peptides. 315 - 319. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846574363&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.022 . Peptides
Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts: Effect of Cryoprotective Agents
Judas, Fernando M.; Rosa, Susana C.; TEIXEIRA, L; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2007. Transplantation Proceedings. 2531 - 2534. 8. 39. 2007. 10.1016/j.transproceed.2007.07.028 . published Transplantation Proceedings
Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells
Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Duarte, E.P.; Cavadas, C., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . Journal of Neurochemistry
Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization
Moreno, António J.; Oliveira, Paulo J.; Nova, Carlos D.; ¿?lvaro, Ana R.; Moreira, Renata A.; Santos, Sandra M. D.; Macedo, Tice, 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17427176 . 10.1002/jbt.20159 . published Journal of Biochemical and Molecular Toxicology
Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion
Cavadas, C.; Céfai, D.; Rosmaninho-Salgado, J.; Vieira-Coelho, M.A.; Moura, E.; Busso, N.; Pedrazzini, T.; et al, 2006. Proceedings of the National Academy of Sciences of the United States of America. 10497 - 10502. 27. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745899338&partnerID=MN8TOARS . 10.1073/pnas.0600913103 . Proceedings of the National Academy of Sciences of the United States of America
The putative neuroprotective role of neuropeptide Y in the central nervous system
Silva, A.P.; Xapelli, S.; Grouzmann, E.; Cavadas, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 331 - 347. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144457255&partnerID=MN8TOARS . 10.2174/1568007054546153 . Current Drug Targets: CNS and Neurological Disorders
Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats
Silva, A.P.; Xapelli, S.; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; et al, 2005. Journal of Neurochemistry. 163 - 170. 1. 93. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144388681&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.03005.x . Journal of Neurochemistry
Neuropeptide Y expression, localization and cellular transducing effects in HUVEC
Silva, A.P.; Kaufmann, J.E.; Vivancos, C.; Fakan, S.; Cavadas, C.; Shaw, P.; Brunner, H.R.; Vischer, U.; Grouzmann, E., 2005. Biology of the Cell. 457 - 467. 6. 97. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21044442442&partnerID=MN8TOARS . 10.1042/BC20040102 . Biology of the Cell
Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice
Grouzmann, E.; Cavadas, C.; Grand, D.; Moratel, M.; Aubert, J.-F.; Brunner, H.R.; Mazzolai, L., 2003. Pflugers Archiv European Journal of Physiology. 254 - 258. 2. 447. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842265696&partnerID=MN8TOARS . 10.1007/s00424-003-1140-x . Pflugers Archiv European Journal of Physiology
Dexamethasone prevents interleukin-1ß-induced nuclear factor-¿B activation by upregulating I¿B-a synthesis, in lymphoblastic cells
Castro-caldas, M.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 37 - 46. 1. 12. 2003. 10.1080/0962935031000096953 . published Mediators of Inflammation
Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK
Castro-caldas, M.; Mendes, Alexandrina Ferreira; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 329 - 337. 6. 12. 2003. 10.1080/09629350310001633351 . published Mediators of Inflammation
Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular chondrocytes: Implications for the regulation of iNOS expression
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Cell Biology and Toxicology. 203 - 214. 4. 19. 2003. 10.1023/B:CBTO.0000003730.21261.fa . published Cell Biology and Toxicology
Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT<inf>1</inf>receptor
Cavadas, C.; Grand, D.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., 2003. Regulatory Peptides. 61 - 65. 1-3. 111. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037471366&partnerID=MN8TOARS . 10.1016/S0167-0115(02)00253-7 . Regulatory Peptides
Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Journal of Cellular Biochemistry. 783 - 793. 4. 88. 2003. 10.1002/jcb.10428 . published Journal of Cellular Biochemistry
NPY, NPY receptors, and DPP IV activity are modulated by LPS, TNF-a and IFN-¿ in HUVEC
Silva, Antonio P; Cavadas, Claudia; Bai¨sse-Agushi, Bénédicte; Spertini, Olivier; Brunner, Hans R; Grouzmann, Eric, 2003. Regulatory Peptides. 71 - 79. 1-3. 116. 2003. http://dx.doi.org/10.1016/s0167-0115(03)00191-5 . 10.1016/s0167-0115(03)00191-5 . published Regulatory Peptides
NPY, NPY receptors, and DPP IV activity are modulated by LPS, TNF-a and IFN-¿ in HUVEC
Silva, A.P.; Cavadas, C.; Baïsse-Agushi, B.; Spertini, O.; Brunner, H.R.; Grouzmann, E., 2003. Regulatory Peptides. 71 - 79. 1-3. 116. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242329827&partnerID=MN8TOARS . 10.1016/S0167-0115(03)00191-5 . Regulatory Peptides
Neuropeptide Y and its receptors as potential therapeutic drug targets
Silva, A.P.; Cavadas, C.; Grouzmann, E., 2002. Clinica Chimica Acta. 3 - 25. 1-2. 326. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036889596&partnerID=MN8TOARS . 10.1016/S0009-8981(02)00301-7 . Clinica Chimica Acta
Dibasic cleavage site is required for sorting to the regulated secretory pathway for both pro- and neuropeptide Y
Brakch, N.; Allemandou, F.; Cavadas, C.; Grouzmann, E.; Brunner, H.R., 2002. Journal of Neurochemistry. 1166 - 1175. 6. 81. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036316744&partnerID=MN8TOARS . 10.1046/j.1471-4159.2002.00919.x . Journal of Neurochemistry
Diacerhein and Rhein Prevent Interleukin-1beta-Induced Nuclear Factor-kappaB Activation by Inhibiting the Degradation of Inhibitor kappaB-alpha
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Pharmacology and Toxicology. 22 - 28. 1. 91. 2002. 10.1034/j.1600-0773.2002.910104.x . published Pharmacology and Toxicology
Differential secretion of catecholamine and neuropeptide Y in response to KCl from mice chromaffin cells.
Cavadas C; Silva AP; Cotrim MD; Ribeiro CA; Brunner HR; Grouzmann E, 2002. 2002. http://europepmc.org/abstract/med/12438145 . 10.1111/j.1749-6632.2002.tb04489.x .
Catecholamine and neuropeptide Y secretion from human adrenal chromaffin cells: effect of nicotine and KCl.
Cavadas C; Ribeiro CA; Cotrim Md; Mosimann F; Brunner HR; Grouzmann E, 2002. 2002. http://europepmc.org/abstract/med/12438144 . 10.1111/j.1749-6632.2002.tb04488.x .
Role of nitric oxide in the activation of NF-¿B, AP-1 and NOS II expression in articular chondrocytes
Mendes, A.F.; Carvalho, A.P.; Caramona, M.M.; Lopes, M.C.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2002. Inflammation Research. 369 - 375. 7. 51. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036019462&partnerID=MN8TOARS . 10.1007/PL00000317 . published Inflammation Research
Loss of dipeptidylpeptidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P in the nasal mucosa.
Grouzmann, E.; Monod, M.; Landis, B.; Wilk, S.; Brakch, N.; Nicoucar, K.; Giger, R.; et al, 2002. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1132 - 1134. 9. 16. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036634815&partnerID=MN8TOARS . published The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Role of Mitogen-Activated Protein Kinases and Tyrosine Kinases on IL-1-Induced NF-¿B Activation and iNOS Expression in Bovine Articular Chondrocytes
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Nitric Oxide. 35 - 44. 1. 6. 2002. 10.1006/niox.2001.0378 . published Nitric Oxide
NPY regulates catecholamine secretion from human adrenal chromaffin cells
Cavadas, C.; Silva, A.P.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., 2001. Journal of Clinical Endocrinology and Metabolism. 5956 - 5963. 12. 86. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035217710&partnerID=MN8TOARS . 10.1210/jc.86.12.5956 . Journal of Clinical Endocrinology and Metabolism
Cardiovascular effects of fentanyl in conscious rats
Baechtold, F.; Cavadas, C.; Gasser, D.; Markert, M.; Grouzmann, E.; Peterson, K.L.; Waeber, B.; Feihl, F., 2001. Pflugers Archiv European Journal of Physiology. 155 - 162. 1. 443. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035161078&partnerID=MN8TOARS . 10.1007/s004240100693 . Pflugers Archiv European Journal of Physiology
Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y
Bergonzelli, G.E.; Pralong, F.P.; Glauser, M.; Cavadas, C.; Grouzmann, E.; Gaillard, R.C.; Bergonzelli GE; et al, 2001. Diabetes. 2666 - 2672. 12. 50. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035656192&partnerID=MN8TOARS . 10.2337/diabetes.50.12.2666 . Diabetes
Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma
Grouzmann, E.; Fathi, M.; Gillet, M.; De Torrenté, A.; Cavadas, C.; Brunner, H.; Buclin, T.; et al, 2001. Clinical Chemistry. 1075 - 1082. 6 I. 47. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035010093&partnerID=MN8TOARS . Clinical Chemistry
Erratum: Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma (Clinical Chemistry (2001) 47 (1075-82))
Grouzmann, E.; Fathi, M.; Gillet, M.; De Torrenté, A.; Cavadas, C.; Brunner, H.; Buclin, T., 2001. Clinical Chemistry. 9. 47. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034866571&partnerID=MN8TOARS . Clinical Chemistry
Diphenyleneiodonium inhibits NF-¿B activation and iNOS expression induced by IL-1ß: involvement of reactive oxygen species
Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2001. Mediators of Inflammation. 209 - 215. 4. 10. 2001. 10.1080/09629350120080401 . published Mediators of Inflammation
In vitro study of the interaction of Tilia europeae L. aqueous extract with GABA(A) receptors in rat brain
Cavadas, C.; Fontes Ribeiro, C.A.; Santos, M.S.; Cunha, A.P.; Macedo, T.; Caramona, M.M.; Cotrim, M.D., 1997. Phytotherapy Research. 17 - 21. 1. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031051651&partnerID=MN8TOARS . 10.1002/(SICI)1099-1573(199702)11:1<17::AID-PTR948>3.0.CO;2-6 . Phytotherapy Research
Changes in the subcellular distribution of the rat uterus oestrogen receptor as induced by oestradiol, tamoxifen and ZD 182, 780
Ferreira Mendes, A.; Caramona, M.M.; Celeste Lopes, M., 1996. Journal of Pharmacy and Pharmacology. 302 - 305. 3. 48. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029891372&partnerID=MN8TOARS . Journal of Pharmacy and Pharmacology
In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABA(A) receptor in rat brain
Cavadas, C.; Araujo, I.; Cotrim, M.D.; Amaral, T.; Cunha, A.P.; Macedo, T.; Fontes Ribeiro, C., 1995. Arzneimittel-Forschung/Drug Research. 753 - 755. 7. 45. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063620&partnerID=MN8TOARS . Arzneimittel-Forschung/Drug Research
5 187 out of 187 Publications
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