Publications
Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease
Nobre, Rui Jorge; Miranda C; Paiva VH; Duarte JV; Castelhano J; Petrella L; Sereno J; et al, Acta Neuropathologica communications . 2022. https://www.doi.org/10.1186/s40478-022-01329-4 . in press Acta Neuropathologica communications
Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening
Aguiar, Sandra Isabel; Dias, Joana N. R.; André, Ana Santos; Silva, Marta Lisete; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; et al, Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101598 . 10.3390/pharmaceutics13101598 . Pharmaceutics
MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3
Nobre, Rui Jorge; Lobo, Diana D.; Henriques, Carina; Duarte, Sonia P.; Lopes, Sara M.; Silva, Ana C.; Lopes, Miguel M.; et al, Nucleic Acid Therapeutics. 2021. http://dx.doi.org/10.1089/nat.2021.0020 . 10.1089/nat.2021.0020 . Nucleic Acid Therapeutics
Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway and a target for therapy
Marcelo, Adriana; Rosa, Ana; Alves-Cruzeiro, João; Ferreira, Benedita; Reis, Ricardo; Afonso, Inês; Henriques, Carina; et al, 2021. under revision
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples
Nobre, Rui Jorge; Duarte Lobo, Diana; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís, Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-00955-0 . 10.1186/s40478-020-00955-0 . Acta Neuropathologica Communications
Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research
Gaspar, Laetitia S.; Santana, Magda M.; Henriques, Carina; Pinto, Maria M.; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luís, Molecular Therapy - Methods & Clinical Development. 723 - 737. 18. 2020. http://dx.doi.org/10.1016/j.omtm.2020.07.012 . 10.1016/j.omtm.2020.07.012 . Molecular Therapy - Methods & Clinical Development
Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies
Lopes, Sara Monteiro; Faro, Rosário; Lopes, Miguel Monteiro; Onofre, Isabel; Mendonça, Nuno; Ribeiro, Joana; Januário, Cristina; Nobre, Rui Jorge; Pereira de Almeida, Luís, The Journal of Molecular Diagnostics. 2020. http://dx.doi.org/10.1016/j.jmoldx.2020.03.003 . 10.1016/j.jmoldx.2020.03.003 . published The Journal of Molecular Diagnostics
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-020-02302-2 . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease
Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al, Molecular Therapy. 2131 - 2151. 9. 26. 2018. http://dx.doi.org/10.1016/j.ymthe.2018.07.007 . 10.1016/j.ymthe.2018.07.007 . published Molecular Therapy
Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line
Marques, Ana Patrícia; Rosmaninho-Salgado, Joana; Estrada, Marta; Cortez, Vera; Nobre, Rui Jorge; Cavadas, Cláudia, Biochimica et Biophysica Acta (BBA) - General Subjects. 673 - 682. 3. 1861. 2017. http://dx.doi.org/10.1016/j.bbagen.2016.12.005 . 10.1016/j.bbagen.2016.12.005 . published Biochimica et Biophysica Acta (BBA) - General Subjects
Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment
Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira, Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep28220 . 10.1038/srep28220 . published Scientific Reports
Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death
Costa, João T.; Mele, Miranda; Baptista, Márcio S.; Gomes, João R.; Ruscher, Karsten; Nobre, Rui J.; de Almeida, Luís Pereira; Wieloch, Tadeusz; Duarte, Carlos B., Molecular Neurobiology. 3513 - 3527. 6. 53. 2015. http://dx.doi.org/10.1007/s12035-015-9283-2 . 10.1007/s12035-015-9283-2 . published Molecular Neurobiology
Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5
Santos, Ana I.; Carreira, Bruno P.; Nobre, Rui J.; Carvalho, Caetana M.; Araújo, Inês M., Stem Cells International. 1 - 13. 2014. 2014. http://dx.doi.org/10.1155/2014/878397 . 10.1155/2014/878397 . published Stem Cells International
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado–Joseph disease
Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luís, Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://dx.doi.org/10.1093/hmg/ddu209 . 10.1093/hmg/ddu209 . published Human Molecular Genetics
Gene Therapy for Parkinsons and Alzheimers Diseases: from the Bench to Clinical Trials
Jorge Nobre, Rui; Pereira de Almeida, Luis, Current Pharmaceutical Design. 3434 - 3445. 31. 17. 2011. http://dx.doi.org/10.2174/138161211798072472 . 10.2174/138161211798072472 . published Current Pharmaceutical Design
Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing
Nobre, Rui Jorge; Cruz, Eugénia; Real, Odete; de Almeida, Luís Pereira; Martins, Teresa C., Journal of Medical Virology. 1024 - 1032. 6. 82. 2010. http://dx.doi.org/10.1002/jmv.21756 . 10.1002/jmv.21756 . published Journal of Medical Virology
E7 Oncoprotein of Novel Human Papillomavirus Type 108 Lacking the E6 Gene Induces Dysplasia in Organotypic Keratinocyte Cultures
Nobre, R. J.; Herraez-Hernandez, E.; Fei, J.-W.; Langbein, L.; Kaden, S.; Grone, H.-J.; de Villiers, E.-M., Journal of Virology. 2907 - 2916. 7. 83. 2009. http://dx.doi.org/10.1128/jvi.02490-08 . 10.1128/jvi.02490-08 . published Journal of Virology
Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm
Nobre, Rui Jorge; de Almeida, Luís Pereira; Martins, Teresa C., Journal of Clinical Virology. 13 - 21. 1. 42. 2008. http://dx.doi.org/10.1016/j.jcv.2007.11.021 . 10.1016/j.jcv.2007.11.021 . published Journal of Clinical Virology
5 18 out of 18 Publications
All projects
Information of exclusive responsibility of the researcher 19-03-2023 , from platform CIÊNCIAVITAE.
2020/06/01 - 2020/11/30
Expedited validation and large-scale manufacture of a blowing device for collection with inactivation of samples for detection of SARS-CoV-2
269_596884125
Principal investigator
ViraVector-Unidade de Produção de vetores virais para a transferência de genes; Infogene; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2020/11/01 - 2025/10/31
Accelerating research & development for advanced therapies
945473
Researcher
Innovative Health Initiative
Funders: European Commission; European Federation of Pharmaceutical Industries and Associations
2019/02 - 2019/09
Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
.
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: uniQure NV
2018/04 -
Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
.
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Wave Life Sciences
2018/07/01 -
Bloqueio da neurodegenerescência por dispersão de silenciadores génicos
PTDC/BTM-SAL/29716/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2018/09 - 2019/06
Exosomes as gene delivery vectors for the treatment of Machado-Joseph disease/Spinocerebellar ataxia type 3
21163
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: AFM-Téléthon
2017/09/01 - 2018/09/05
BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Centro 2020
2017 -
Tackling CANcer STEM CELIs: a chanllenge anda n opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2016/04/01 -
Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2016/06/01 -
Visualização da terapia génica do sistema nervoso central
PTDC/BBB-NAN/0932/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2013/03 - 2014/04
Silencing Machado-Joseph Disease through the systemic route
125367
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2012 - 2016
Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells
116512
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Associação para a Inovação e Desenvolvimento da FCT
2010 - 2017/08/31
Silencing Machado-Joseph disease trough the systemic route
SFRH/BPD/66705/2009
Post-doc Fellow
Funders: Associação para a Inovação e Desenvolvimento da FCT
2010/04 - 2010/09
HPV home-kit – self-collection kit for HPV detection and other STD agents
.
Principal investigator
Infogene
Funders: Quadro de Referência Estratégica Nacional - QREN; Fundo Europeu de Desenvolvimento Regional
2008/10 - 2010/03
Desenvolvimento e validação clínica de um Kit de auto-colheita de células do colo do útero para rastreio do Papilomavírus Humano – HPV
.
Other
Funders: Banco Espírito Santo e Comercial de Lisboa
2005/01 - 2006/03
Análise de Alterações Moleculares Relevantes para a Carcinogénese e Tratamento dos Tumores do Estroma Gastrointestinal
.
Researcher
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra
Funders: Novartis Oncology
2005/01 - 2006/03
Análise de Alterações Moleculares Relevantes para a Carcinogénese e Tratamento dos Tumores do Estroma Gastrointestinal
.
Researcher
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra
Funders: Novartis Oncology
2004 - 2008
Unravelling the role of human papillomavirus in the development of cervical cancer: new phylogenetic perspective and new pathogenic concepts
SFRH/BD/19165/2004
PhD Student Fellow
Funders: Associação para a Inovação e Desenvolvimento da FCT
5 18 out of 18 projects
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