Laura Maria Alcântara

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PostDoc Researcher

Overview

Laura Maria Alcântara completed the Ph.D from Universidade Estadual de Campinas, UNICAMP, in 2017. The main research developed by L. M. Alcântara is in the fields of Microbiology and Parasitology. Her main activities have been focused on the establishment of in vitro infection models based on high-content assays, performing large-scale screenings with libraries of compounds/natural products and performing drug combination/repurposing assays. L. M. Alcântara is currently working as a MSCA Postdoctoral researcher (Marie Sklodowska-Curie fellowship), at the RNA & Infection laboratory (CNC/CIBB, University of Coimbra), under the supervision of Dr. Ana Eulalio. Her studies are focused on functional screening and host-pathogen interactions, particularly in infection with Staphylococcus aureus.

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth

Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Souza-Melo, Normanda; Alcântara, Laura Maria; Bittencourt-Cunha, Paula; Moraes, Carolina Borsoi; Jha, Bijay Kumar; et al, Cellular Microbiology. e13295. 2020. http://dx.doi.org/10.1111/cmi.13295 . 10.1111/cmi.13295 . published Cellular Microbiology

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

Alcântara, Laura M.; Ferreira, Thalita C. S.; Fontana, Vanessa; Chatelain, Eric; Moraes, Carolina B.; Freitas-Junior, Lucio H., Molecules. 11. 25. 2020. http://dx.doi.org/10.3390/molecules25112551 . 10.3390/molecules25112551 . published Molecules

Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes

Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al, International Journal of Molecular Sciences. 10. 21. 2020. http://dx.doi.org/10.3390/ijms21103659 . 10.3390/ijms21103659 . published International Journal of Molecular Sciences

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Caio Haddad Franco; Laura Maria Alcântara; eric; Lucio Freitas-Junior; Carolina Borsoi Moraes, Tropical Medicine and Infectious Disease. 2019. 10.3390/tropicalmed4020082 . Tropical Medicine and Infectious Disease

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. 10.1016/j.ejmech.2018.01.043 . European Journal of Medicinal Chemistry

Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis

Alcântara, L.M.; Ferreira, T.C.S.; Gadelha, F.R.; Miguel, D.C., International Journal for Parasitology: Drugs and Drug Resistance. 430 - 439. 3. 8. 2018. 10.1016/j.ijpddr.2018.09.006 . International Journal for Parasitology: Drugs and Drug Resistance

Exploiting the 2-Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery

Linciano, P.; Dawson, A.; Pöhner, I.; Costa, D.M.; Sa, M.S.; Cordeiro-Da-Silva, A.; Luciani, R.; et al, ACS Omega. 5666 - 5683. 9. 2. 2017. 10.1021/acsomega.7b00473 . ACS Omega

Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity

Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; et al, Molecules. 3. 22. 2017. 10.3390/molecules22030426 . Molecules

Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum

Gomes, M.N.; Alcântara, L.M.; Neves, B.J.; Melo-Filho, C.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ma, R.; et al, Bioorganic and Medicinal Chemistry Letters. 2459 - 2464. 11. 27. 2017. 10.1016/j.bmcl.2017.04.010 . Bioorganic and Medicinal Chemistry Letters

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

Borsari, C.; Santarem, N.; Torrado, J.; Olías, A.I.; Corral, M.J.; Baptista, C.; Gul, S.; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. 10.1016/j.ejmech.2016.12.017 . European Journal of Medicinal Chemistry

N-[4-[Benzyloxy] benzyl]-benzenemethaneamines with High Biological Activity against Intracellular Trypanosoma cruzi and Leishmania infantum Amastigotes.

Gabrielle Frizzo Souza; Simon Bernhard Cämmerer; Caio Haddad Franco; Alcântara, Laura; Carolina Borsoi Moraes; Lucio Freitas-Junior, International Journal of Chemistry and Pharmaceutical Sciences.. 570 - 578. 11. 4. 2016. published International Journal of Chemistry and Pharmaceutical Sciences.

Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites

Alcantara, L.M.; Kim, J.; Moraes, C.B.; Franco, C.H.; Franzoi, K.D.; Lee, S.; Freitas-Junior, L.H.; Ayong, L.S., Experimental Parasitology. 235 - 243. 2. 134. 2013. 10.1016/j.exppara.2013.03.022 . Experimental Parasitology

All projects

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2020/10 -

Functional high-throughput analysis of the role of microRNAs in regulating Staphylococcus aureus infection (miRs4Staph).

Marie Sklodowska-Curie fellowship 893942

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions

2019/04 - 2020/09

New therapies for Chagas Disease: repurposing of drugs with synergistic effect with Benznidazole to counteract Trypanosoma cruzi infection

CAPES/FCT - 28/2017

Post-doc Fellow

Instituto do Coração do Hospital das Clínicas da FMUSP - Incor

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação para a Ciência e a Tecnologia

2017/11 - 2019/03

Development of secondary in vitro assays for Chagas disease and leishmaniasis early drug discovery.

VPPIS-003-PPE-15-2-6

Post-doc Fellow

Universidade de São Paulo

Funders: Drugs for Neglected Diseases initiative

2017 - 2018

Identification of starting points for drug discovery and target identification against major neglected diseases

MMV2016

Post-doc Fellow

Universidade de São Paulo

Funders: Medicines for Malaria Venture

2014 - 2017

NMTrypl - New Drugs for Trypanosomatidic Infections

603240

PhD Student Fellow

Centro Nacional de Pesquisa em Energia e Materiais

Funders: European Commission Seventh Framework Programme for Research and Technological Development

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