Caio Haddad Franco

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al, International Journal for Parasitology: Drugs and Drug Resistance. 107 - 120. 13. 2020. 10.1016/j.ijpddr.2020.06.001 . published International Journal for Parasitology: Drugs and Drug Resistance

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity

Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia, Planta Medica. 782 - 789. 11. 86. 2020. 10.1055/a-1179-1003 . published Planta Medica

Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

Cleber C. Melo-Filho; Rodolpho C. Braga; Eugene N. Muratov; Caio Haddad Franco; Carolina B. Moraes; Lucio H. Freitas-Junior; Carolina Horta Andrade, European Journal of Medicinal Chemistry. 649 - 659. 163. 2019. 10.1016/j.ejmech.2018.11.062 . published European Journal of Medicinal Chemistry

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics

Borsari, Chiara; Dolores Jimenez-Anton, Maria; Eick, Julia; Bifeld, Eugenia; Jose Torrado, Juan; Isabel Olias-Molero, Ana; Jesus Corral, Maria; et al, European Journal of Medicinal Chemistry. 2019. 10.1016/J.EJMECH.2019.111676 . published European Journal of Medicinal Chemistry

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Caio Haddad Franco; Laura Maria Alcântara; Eric Chatelain; Lucio Freitas-Junior; Carolina Borsoi Moraes, Tropical Medicine and Infectious Disease. 82 - 82. 2. 4. 2019. 10.3390/tropicalmed4020082 . published Tropical Medicine and Infectious Disease

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al, Bioorganic & Medicinal Chemistry. 22. 27. 2019. 10.1016/j.bmc.2019.115083 . published Bioorganic & Medicinal Chemistry

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Linciano, Pasquale; Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al, Journal of Medicinal Chemistry. 2019. 10.1021/ACS.JMEDCHEM.8B02021 . published Journal of Medicinal Chemistry

Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir

Rodrigues e Silva Tiago; Vaz dos Santos Neto Eugenio; Lucia Tasca Goiz Ruiz Ana; Ann Foglio Mary; Haddad Franco Caio; Borsoi Moraes Carolina; Maia de Oliveira Valéria, African Journal of Microbiology Research. 897 - 907. 37. 12. 2018. 10.5897/ajmr2018.8940 . published African Journal of Microbiology Research

Tetracycline@silver ions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration

Karim Bouchmella; Felipe Davi Campanaro; Gabriela Borba Mondo; Murilo Izidoro Santos; Caio Haddad Franco; Carolina Borsoi Moraes; Christine Biolley; Ahmad Mehdi; Mateus Borba Cardoso, Nanomedicine. 14. 13. 2018. 10.2217/nnm-2018-0027 . published Nanomedicine

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

Fabricio Castro Machado; Caio Haddad Franco; Jose Vitorino dos Santos Neto; Karina Luiza Dias-Teixeira; Carolina Borsoi Moraes; Ulisses Gazos Lopes; Bertal Huseyin Aktas; Sergio Schenkman, Scientific Reports. 1. 8. 2018. 10.1038/s41598-018-23259-9 . published Scientific Reports

Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities

Tiago R. Silva; Alysson W. F. Duarte; Michel R. Z. Passarini; Ana Lucia T. G. Ruiz; Caio Haddad Franco; Carolina Borsoi Moraes; Itamar Soares de Melo; et al, Polar Biology. 1505 - 1519. 7. 41. 2018. 10.1007/s00300-018-2300-y . published Polar Biology

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. 10.1016/j.ejmech.2018.01.043 . published European Journal of Medicinal Chemistry

Investigating the structure-activity relationships of N’-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds

Palace-Berl, F.; Pasqualoto, K.F.M.; Zingales, B.; Moraes, C.B.; Bury, M.; Franco, C.H.; da Silva Neto, A.L.; et al, European Journal of Medicinal Chemistry. 29 - 40. 144. 2018. 10.1016/j.ejmech.2017.12.011 . published European Journal of Medicinal Chemistry

A comparative study of warheads for design of cysteine protease inhibitors

Daniel G. Silva; Jean F.R. Ribeiro; Daniela De Vita; Lorenzo Cianni; Caio Haddad Franco; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; et al, Bioorganic & Medicinal Chemistry Letters. 5031 - 5035. 22. 27. 2017. 10.1016/j.bmcl.2017.10.002 . published Bioorganic & Medicinal Chemistry Letters

Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols

Balfour, M.N.; Franco, C.H.; Moraes, C.B.; Freitas-Junior, L.H.; Stefani, H.A., European Journal of Medicinal Chemistry. 202 - 212. 128. 2017. 10.1016/j.ejmech.2017.01.040 . published European Journal of Medicinal Chemistry

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

Chiara Borsari; Nuno Santarem; Juan Torrado; Ana Isabel Olías; María Jesús Corral; Catarina Baptista; Sheraz Gul; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. 10.1016/j.ejmech.2016.12.017 . published European Journal of Medicinal Chemistry

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

Silva, F.T.; Franco, C.H.; Favaro, D.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ferreira, E.I., European Journal of Medicinal Chemistry. 553 - 560. 121. 2016. 10.1016/j.ejmech.2016.04.065 . published European Journal of Medicinal Chemistry

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

Damien Bosc; Elisabeth Mouray; Sandrine Cojean; Caio Haddad Franco; Philippe M. Loiseau; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; Philippe Grellier; Joëlle Dubois, European Journal of Medicinal Chemistry. 173 - 186. 109. 2016. 10.1016/j.ejmech.2015.12.045 . published European Journal of Medicinal Chemistry

Novel drug discovery for Chagas disease

Carolina B. Moraes; Caio H. Franco, Expert Opinion on Drug Discovery. 447 - 455. 5. 11. 2016. 10.1517/17460441.2016.1160883 . published Expert Opinion on Drug Discovery

Mutagenic potential of lettuce grown from irradiated seeds

Caio Haddad Franco; Valter H.M. dos Santos; Luciana P. Silva; Valter Arthur; Regildo M.G. Silva, Scientia Horticulturae. 27 - 30. 182. 2015. 10.1016/j.scienta.2014.11.011 . published Scientia Horticulturae

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development

Moraes, C.B.; Giardini, M.A.; Kim, H.; Franco, C.H.; Araujo-Junior, A.M.; Schenkman, S.; Chatelain, E.; Freitas-Junior, L.H., Scientific Reports. 1 - 11. 4. 2014. 10.1038/srep04703 . published Scientific Reports

Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites

Laura M. Alcantara; Junwon Kim; Carolina B. Moraes; Caio H. Franco; Kathrin D. Franzoi; Sukjun Lee; Lucio H. Freitas-Junior; Lawrence S. Ayong, Experimental Parasitology. 235 - 243. 2. 134. 2013. 10.1016/j.exppara.2013.03.022 . published Experimental Parasitology