Biotechnology

Vacinas & Adjuvantes: Imunomodeladores de Nanopartículas

Nanotechnology

Chitosan

Glucan

Hepatitis B

Vaccine Adjuvants

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Leader

Olga Borges

Researcher


Research lines

Polysaccharide and Polyester based particulate vaccine adjuvants

Immunotoxicologycal non-desired aspects of the nanoparticles (polymeric nanoparticles as drug delivery systems and environmental particles)

Overview

About 3 million people die each year from vaccine-preventable diseases, mostly concentrated in poor countries. Developing vaccines for poor countries is the main mission of this research group. More stable and needle-free, self-administrable, oral and intranasal vaccines would help, not only to increase the vaccine coverage, but also to decrease the infections associated with bad clinical practices during the administration of injectables. The group have been working on the re-designing of the hepatitis B vaccine with the aim of helping WHO achieve one of the 2030 elimination targets.

To achieve its Mission, this research group has established the following objectives:

  • To design a therapeutic hepatitis B vaccine
  • To develop adjuvants for intranasal vaccines to protect against respiratory infections including the new SARS-COV-2
  • To design vaccine adjuvants for the oral route of administration.
  • To design adjuvants for the more stable genetic (DNA and RNA) vaccines.

The nanotechnology is the facilitating tool to obtain ‘pathogen-like’ particulate adjuvants. Our research group assumed that combining on same nanoparticle several immunopotentiators, the resultant adjuvant would have predictable immunomodulatory properties for an intended vaccine. Therefore, the main objective has been to design and develop the methods for obtaining polymeric nanoparticles with pathogen-mimicking characteristics.

Techniques and Expertise

Preparation methods to obtain antigen and/or immunopotentiator loaded polymeric nanoparticles; Physicochemical characterization of the nanoparticles using standardized methods and protocols; Interaction studies of the nanoparticles with biological membranes and with immune cells; immunotoxicological tests with nanoparticles; immunization studies and evaluation of the cellular and humoral immune response.

Publications

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Information about journal articles, updated at 25-07-2021, from platform CIÊNCIAVITAE.

Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-by-Design Concepts

Borchard, Gerrit; Som, Claudia; Zinn, Manfred; Ostafe, Vasile; Borges, Olga; Perale, Giuseppe; Wick, Peter, 2020. Frontiers in Bioengineering and Biotechnology. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.599950 . 10.3389/fbioe.2020.599950 . Frontiers in Bioengineering and Biotechnology

A Methodological Safe-by-Design Approach for the Development of Nanomedicines

Schmutz, Mélanie; Borges, Olga; Jesus, Sandra; Borchard, Gerrit; Perale, Giuseppe; Zinn, Manfred; Sips, Ädrienne A. J. A. M; et al, 2020. Frontiers in Bioengineering and Biotechnology. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00258 . 10.3389/fbioe.2020.00258 . Frontiers in Bioengineering and Biotechnology

Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation of efficacy and safety

Chatzitaki, Aikaterini-Theodora; Jesus, Sandra; Karavasili, Christina; Andreadis, Dimitrios; Fatouros, Dimitrios G.; Borges, Olga, 2020. International Journal of Pharmaceutics. 589. 2020. http://dx.doi.org/10.1016/j.ijpharm.2020.119776 . 10.1016/j.ijpharm.2020.119776 . published International Journal of Pharmaceutics

Photophysics and drug delivery behavior of methylene blue into Arabic-gum based hydrogel matrices

Vilsinski, Bruno H.; Souza, Paulo R.; de Oliveira, Ariel C.; Filho, César M.C.; Valente, Artur J.M.; Muniz, Edvani C.; Borges, Olga; et al, 2020. Materials Today Communications. 2020. http://dx.doi.org/10.1016/j.mtcomm.2020.101889 . 10.1016/j.mtcomm.2020.101889 . published Materials Today Communications

Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends

Sandra Jesus; Natalia Bernardi; Jessica da Silva; Mariana Colaço; João Panão Costa; Pedro Fonte; Olga Borges, 2020. Chemical Research in Toxicology. 2020. https://doi.org/10.1021/acs.chemrestox.0c00208 . 10.1021/acs.chemrestox.0c00208 . Chemical Research in Toxicology

A Methodological Safe-by-Design Approach for the Development of Nanomedicines

Schmutz, Mélanie; Borges, Olga; Jesus, Sandra; Borchard, Gerrit; Perale, Giuseppe; Zinn, Manfred; Sips, Ädrienne A. J. A. M; et al, 2020. Frontiers in Bioengineering and Biotechnology. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00258 . 10.3389/fbioe.2020.00258 . in press Frontiers in Bioengineering and Biotechnology

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Marques, Cíntia; Som, Claudia; Schmutz, Mélanie; Borges, Olga; Borchard, Gerrit, 2020. Frontiers in Bioengineering and Biotechnology. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00165 . 10.3389/fbioe.2020.00165 . published Frontiers in Bioengineering and Biotechnology

Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility

Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al, 2020. Frontiers in Bioengineering and Biotechnology. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00100 . 10.3389/fbioe.2020.00100 . published Frontiers in Bioengineering and Biotechnology

Airborne environmental fine particles induce intense inflammatory response regardless of the absence of heavy metal elements

Colaço, Mariana; Duarte, Alana; Zuzarte, Mónica; Costa, Benilde F.O.; Borges, Olga, 2020. Ecotoxicology and Environmental Safety. 195. 2020. http://dx.doi.org/10.1016/j.ecoenv.2020.110500 . 10.1016/j.ecoenv.2020.110500 . published Ecotoxicology and Environmental Safety

Safe-by-Design of Glucan Nanoparticles: Size Matters When Assessing the Immunotoxicity

Colaço, Mariana; Marques, Ana P.; Jesus, Sandra; Duarte, Alana; Borges, Olga, 2020. Chemical Research in Toxicology. 2020. http://dx.doi.org/10.1021/acs.chemrestox.9b00467 . 10.1021/acs.chemrestox.9b00467 . Chemical Research in Toxicology

Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant

Bento, Dulce; Jesus, Sandra; Lebre, Filipa; Gonçalves, Teresa; Borges, Olga, 2019. Pharmaceutics. 2. 11. 2019. http://dx.doi.org/10.3390/pharmaceutics11020072 . 10.3390/pharmaceutics11020072 . published Pharmaceutics

Biocompatible and high-magnetically responsive iron oxide nanoparticles for protein loading

Gaspar, André S.; Santos, Paulo H.C.; Borges, Olga; Costa, Benilde F.O.; Durães, Luisa, 2019. Journal of Physics and Chemistry of Solids. 273 - 285. 134. 2019. http://dx.doi.org/10.1016/j.jpcs.2019.06.016 . 10.1016/j.jpcs.2019.06.016 . published Journal of Physics and Chemistry of Solids

Early Interaction of Alternaria infectoria Conidia with Macrophages

M. C. Almeida; D. Antunes; B. M. A. Silva; L. Rodrigues; M. Mota; O. Borges; C. Fernandes; T. Gonçalves, 2019. Mycopathologia. 383 - 392. 3. 184. 2019. https://doi.org/10.1007/s11046-019-00339-6 . 10.1007/s11046-019-00339-6 . Mycopathologia

Polymeric nanoengineered HBsAg DNA vaccine designed in combination with ß-glucan

Edna Soares; Rosemeyre Cordeiro; Henrique Faneca; Olga Borges, 2019. International Journal of Biological Macromolecules. 930 - 939. 122. 2019. https://doi.org/10.1016/j.ijbiomac.2018.11.024 . 10.1016/j.ijbiomac.2018.11.024 . International Journal of Biological Macromolecules

Glucan Particles Are a Powerful Adjuvant for the HBsAg, Favoring Antiviral Immunity

Edna Soares; Zwier M.A. Groothuismink; André Boonstra; Olga Borges, 2019. Molecular Pharmaceutics. 2019. https://doi.org/10.1021/acs.molpharmaceut.8b01322 . 10.1021/acs.molpharmaceut.8b01322 . Molecular Pharmaceutics

Optimization of Chitosan-a-casein Nanoparticles for Improved Gene Delivery: Characterization, Stability, and Transfection Efficiency

Panão Costa, João; Carvalho, Sofia; Jesus, Sandra; Soares, Edna; Marques, Ana Patrícia; Borges, Olga, 2019. AAPS PharmSciTech. 3. 20. 2019. http://dx.doi.org/10.1208/s12249-019-1342-y . 10.1208/s12249-019-1342-y . published AAPS PharmSciTech

Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases Its Immunotoxicity

Da Silva, Jessica; Jesus, Sandra; Bernardi, Natália; Colaço, Mariana; Borges, Olga, 2019. Frontiers in Bioengineering and Biotechnology. 7. 2019. http://dx.doi.org/10.3389/fbioe.2019.00137 . 10.3389/fbioe.2019.00137 . Frontiers in Bioengineering and Biotechnology

Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies

Filipa Lebre; Ed C. Lavelle; Olga Borges, 2019. Journal of Pharmacy and Pharmacology. 2019. https://doi.org/10.1111/jphp.13082 . 10.1111/jphp.13082 . Journal of Pharmacy and Pharmacology

Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far

Jesus, Sandra; Schmutz, Mélanie; Som, Claudia; Borchard, Gerrit; Wick, Peter; Borges, Olga, 2019. Frontiers in Bioengineering and Biotechnology. 7. 2019. http://dx.doi.org/10.3389/fbioe.2019.00261 . 10.3389/fbioe.2019.00261 . Frontiers in Bioengineering and Biotechnology

Activity and Cell-Death Pathway in Leishmania infantum Induced by Sugiol: Vectorization Using Yeast Cell Wall Particles Obtained From Saccharomyces cerevisiae

Scariot, Débora Botura; Volpato, Hélito; Fernandes, Nilma de Souza; Soares, Edna Filipa Pais; Ueda-Nakamura, Tânia; Dias-Filho, Benedito Prado; Din, Zia Ud; et al, 2019. Frontiers in Cellular and Infection Microbiology. 9. 2019. http://dx.doi.org/10.3389/fcimb.2019.00208 . 10.3389/fcimb.2019.00208 . Frontiers in Cellular and Infection Microbiology

Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model

Scariot, Débora B.; Volpato, Hélito; Fernandes, Nilma S.; Lazarin-Bidóia, Danielle; Borges, Olga; Sousa, Maria do Céu; Rosa, Fernanda A.; et al, 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-56647-w . 10.1038/s41598-019-56647-w . published Scientific Reports

Adjuvant Activity of Poly-e-caprolactone/Chitosan Nanoparticles Characterized by Mast Cell Activation and IFN-¿ and IL-17 Production

Sandra Jesus; Edna Soares; Gerrit Borchard; Olga Borges, 2018. Molecular Pharmaceutics. 2018. https://doi.org/10.1021/acs.molpharmaceut.7b00730 . 10.1021/acs.molpharmaceut.7b00730 . Molecular Pharmaceutics

Exosomes as adjuvants for the recombinant hepatitis B antigen: first report

Sandra Jesus; Edna Soares; Maria Teresa Cruz; Olga Borges, 2018. European Journal of Pharmaceutics and Biopharmaceutics. 2018. https://doi.org/10.1016/j.ejpb.2018.09.029 . 10.1016/j.ejpb.2018.09.029 . European Journal of Pharmaceutics and Biopharmaceutics

Oral hepatitis B vaccine: chitosan or glucan based delivery systems for efficient HBsAg immunization following subcutaneous priming

Soares, Edna; Jesus, Sandra; Borges, Olga, 2018. International Journal of Pharmaceutics. 261 - 271. 1-2. 535. 2018. http://dx.doi.org/10.1016/j.ijpharm.2017.11.009 . 10.1016/j.ijpharm.2017.11.009 . International Journal of Pharmaceutics

Chitosan:ß-glucan particles as a new adjuvant for the hepatitis B antigen

Edna Soares; Sandra Jesus; Olga Borges, 2018. European Journal of Pharmaceutics and Biopharmaceutics. 33 - 43. 131. 2018. https://doi.org/10.1016/j.ejpb.2018.07.018 . 10.1016/j.ejpb.2018.07.018 . European Journal of Pharmaceutics and Biopharmaceutics

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles

Lebre, F.; Pedroso de Lima, M.C.; Lavelle, Ed C.; Borges, O., 2018. International Journal of Pharmaceutics. 7 - 15. 1-2. 552. 2018. http://dx.doi.org/10.1016/j.ijpharm.2018.09.044 . 10.1016/j.ijpharm.2018.09.044 . International Journal of Pharmaceutics

In vitro anti-Leishmania activity of T6 synthetic compound encapsulated in yeast-derived ß-(1,3)-d-glucan particles

Volpato, Hélito; Scariot, Débora Botura; Soares, Edna Filipa Pais; Jacomini, Andrey Petita; Rosa, Fernanda Andreia; Sarragiotto, Maria Helena; Ueda-Nakamura, Tânia; et al, 2018. International Journal of Biological Macromolecules. 1264 - 1275. 119. 2018. http://dx.doi.org/10.1016/j.ijbiomac.2018.08.019 . 10.1016/j.ijbiomac.2018.08.019 . International Journal of Biological Macromolecules

Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination

Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; de Lima, M.C. Pedroso; Borges, O., 2017. International Journal of Pharmaceutics. 103 - 114. 1-2. 527. 2017. http://dx.doi.org/10.1016/j.ijpharm.2017.05.028 . 10.1016/j.ijpharm.2017.05.028 . International Journal of Pharmaceutics

The Inclusion of Chitosan in Poly-e-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure

Jesus, Sandra; Fragal, Elizangela H.; Rubira, Adley F.; Muniz, Edvani C.; Valente, Artur J. M.; Borges, Olga, 2017. AAPS PharmSciTech. 101 - 113. 1. 19. 2017. http://dx.doi.org/10.1208/s12249-017-0822-1 . 10.1208/s12249-017-0822-1 . AAPS PharmSciTech

Poly-¿-caprolactone/chitosan nanoparticles provide strong adjuvant effect for hepatitis B antigen

Jesus, Sandra; Soares, Edna; Borchard, Gerrit; Borges, Olga, 2017. Nanomedicine. 2335 - 2348. 19. 12. 2017. http://dx.doi.org/10.2217/nnm-2017-0138 . 10.2217/nnm-2017-0138 . Nanomedicine

Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-e-caprolactone based nanoparticles

Jesus, S.; Soares, E.; Costa, J.; Borchard, G.; Borges, O., 2016. International Journal of Pharmaceutics. 59 - 69. 1-2. 504. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961918592&partnerID=MN8TOARS . 10.1016/j.ijpharm.2016.03.013 . International Journal of Pharmaceutics

Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice

Lebre, F.; Borchard, G.; Faneca, H.; Pedroso De Lima, M.C.; Borges, O., 2016. Molecular Pharmaceutics. 472 - 482. 2. 13. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957308940&partnerID=MN8TOARS . 10.1021/acs.molpharmaceut.5b00707 . Molecular Pharmaceutics

The effect of methacrylation on the behavior of Gum Arabic as pH-responsive matrix for colon-specific drug delivery

Gerola, A.P.; Silva, D.C.; Matsushita, A.F.Y.; Borges, O.; Rubira, A.F.; Muniz, E.C.; Valente, A.J.M., 2016. European Polymer Journal. 326 - 339. 78. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961886552&partnerID=MN8TOARS . 10.1016/j.eurpolymj.2016.03.041 . European Polymer Journal

Interactions between copper(II) dibrominated salen complex and copolymeric micelles of P-123 and F-127

Vilsinski, B.H.; Murtinho, D.M.B.; Serra, M.E.S.; Soares, E.F.P.; Cruz, P.F.; Braga, G.; Borges, O.; et al, 2016. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015694066&partnerID=MN8TOARS . 10.1016/j.colsurfa.2017.02.079 . Colloids and Surfaces A: Physicochemical and Engineering Aspects

Effect of particulate adjuvant on the anthrax protective antigen dose required for effective nasal vaccination

Dulce Bento; Herman F. Staats; Olga Borges, 2015. Vaccine. 3609 - 3613. 31. 33. 2015. https://doi.org/10.1016/j.vaccine.2015.06.037 . 10.1016/j.vaccine.2015.06.037 . Vaccine

Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity

Bento, D.; Staats, H.F.; Gonçalves, T.; Borges, O., 2015. European Journal of Pharmaceutics and Biopharmaceutics. 149 - 164. 93. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927513193&partnerID=MN8TOARS . 10.1016/j.ejpb.2015.03.024 . European Journal of Pharmaceutics and Biopharmaceutics

Synthesis and controlled curcumin supramolecular complex release from pH-sensitive modified gum-arabic-based hydrogels

Gerola, A.P.; Silva, D.C.; Jesus, S.; Carvalho, R.A.; Rubira, A.F.; Muniz, E.C.; Borges, O.; Valente, A.J.M., 2015. RSC Advances. 94519 - 94533. 115. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946854772&partnerID=MN8TOARS . 10.1039/c5ra14331d . RSC Advances

Nasal vaccines against hepatitis B: An update

Almeida, M.S.; Borges, O., 2015. Current Pharmaceutical Biotechnology. 882 - 890. 10. 16. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939779701&partnerID=MN8TOARS . Current Pharmaceutical Biotechnology

Freeze Dried Chitosan/ Poly-e-Caprolactone and Poly-e-Caprolactone Nanoparticles: Evaluation of their Potential as DNA and Antigen Delivery Systems

S, Jesus; O, Borges, 2013. Journal of Genetic Syndromes & Gene Therapy. 7. 4. 2013. http://dx.doi.org/10.4172/2157-7412.1000164 . 10.4172/2157-7412.1000164 . published Journal of Genetic Syndromes & Gene Therapy

Validation of a new 96-well plate spectrophotometric method for the quantification of compound 48/80 associated with particles

Bento, D.; Borchard, G.; Gonçalves, T.; Borges, O., 2013. AAPS PharmSciTech. 649 - 655. 2. 14. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879080664&partnerID=MN8TOARS . 10.1208/s12249-013-9950-4 . AAPS PharmSciTech

A New Strategy Based on Smrho Protein Loaded Chitosan Nanoparticles as a Candidate Oral Vaccine against Schistosomiasis

Oliveira, C.R.; Rezende, C.M.F.; Silva, M.R.; Pêgo, A.P.; Borges, O.; Goes, A.M., 2012. PLoS Neglected Tropical Diseases. 11. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870751323&partnerID=MN8TOARS . 10.1371/journal.pntd.0001894 . PLoS Neglected Tropical Diseases

Oral vaccination based on DNA-chitosan nanoparticles against schistosoma mansoni infection

Oliveira, C.R.; Rezende, C.M.F.; Silva, M.R.; Borges, O.M.; Pêgo, A.P.; Goes, A.M., 2012. The Scientific World Journal. 2012. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861034466&partnerID=MN8TOARS . 10.1100/2012/938457 . The Scientific World Journal

Incorporation of a mast cell activator in chitosan based delivery systems for mucosal immunization - 4th BBBB International Conference on Pharmaceutical Sciences

Borges, Olga, 2011. European Journal of Pharmaceutical Sciences. 142 - 143. 44. 2011. http://dx.doi.org/10.1016/j.ejps.2011.08.002 . 10.1016/j.ejps.2011.08.002 . published European Journal of Pharmaceutical Sciences

Effect of the inclusion of chitosan into poly-epsilon-caprolactone particles on adsorption efficacy of 4 different model antigens - 4th BBBB International Conference on Pharmaceutical Sciences

Borges, Olga, 2011. European Journal of Pharmaceutical Sciences. 135 - 136. 44. 2011. http://dx.doi.org/10.1016/j.ejps.2011.08.002 . 10.1016/j.ejps.2011.08.002 . European Journal of Pharmaceutical Sciences

Recent Developments in the Nasal Immunization against Anthrax

Jesus, Sandra; Borges, Olga, 2011. World Journal of Vaccines. 79 - 91. 03. 01. 2011. http://dx.doi.org/10.4236/wjv.2011.13008 . 10.4236/wjv.2011.13008 . published World Journal of Vaccines

Hepatitis B needle-free vaccines: a step closer

Borges, Olga; Borchard, Gerrit, 2011. Clinical Investigation. 767 - 770. 6. 1. 2011. http://dx.doi.org/10.4155/cli.11.58 . 10.4155/cli.11.58 . published Clinical Investigation

Development of chitosan nanoparticle-DNA complexes for nasal immunization against Hepatitis B - 4th BBBB International Conference on Pharmaceutical Sciences

Borges, Olga, 2011. European Journal of Pharmaceutical Sciences. 139 - 140. 44. 2011. http://dx.doi.org/10.1016/j.ejps.2011.08.002 . 10.1016/j.ejps.2011.08.002 . published European Journal of Pharmaceutical Sciences

Progress towards a needle-free hepatitis B vaccine

Lebre, F.; Borchard, G.; De Lima, M.C.P.; Borges, O., 2011. Pharmaceutical Research. 986 - 1012. 5. 28. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955607675&partnerID=MN8TOARS . 10.1007/s11095-010-0314-4 . Pharmaceutical Research

Mucosal vaccines: Recent progress in understanding the natural barriers

Borges, O.; Lebre, F.; Bento, D.; Borchard, G.; Junginger, H.E., 2010. Pharmaceutical Research. 211 - 223. 2. 27. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949272140&partnerID=MN8TOARS . 10.1007/s11095-009-0011-3 . Pharmaceutical Research

Alginate coated chitosan nanoparticles are an effective subcutaneous adjuvant for hepatitis B surface antigen

Borges, O.; Silva, M.; de Sousa, A.; Borchard, G.; Junginger, H.E.; Cordeiro-da-Silva, A., 2008. International Immunopharmacology. 1773 - 1780. 13-14. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55249098468&partnerID=MN8TOARS . 10.1016/j.intimp.2008.08.013 . International Immunopharmacology

Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles

Borges, O.; Cordeiro-da-Silva, A.; Tavares, J.; Santarém, N.; de Sousa, A.; Borchard, G.; Junginger, H.E., 2008. European Journal of Pharmaceutics and Biopharmaceutics. 405 - 416. 2. 69. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249088985&partnerID=MN8TOARS . 10.1016/j.ejpb.2008.01.019 . European Journal of Pharmaceutics and Biopharmaceutics

Induction of lymphocytes activated marker CD69 following exposure to chitosan and alginate biopolymers

Borges, O.; Borchard, G.; de Sousa, A.; Junginger, H.E.; Cordeiro-da-Silva, A., 2007. International Journal of Pharmaceutics. 254 - 264. 1-2. 337. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248584919&partnerID=MN8TOARS . 10.1016/j.ijpharm.2007.01.021 . International Journal of Pharmaceutics

Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles

Borges, O.; Tavares, J.; de Sousa, A.; Borchard, G.; Junginger, H.E.; Cordeiro-da-Silva, A., 2007. European Journal of Pharmaceutical Sciences. 278 - 290. 4-5. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748974510&partnerID=MN8TOARS . 10.1016/j.ejps.2007.08.005 . European Journal of Pharmaceutical Sciences

Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination

Borges, O.; Cordeiro-da-Silva, A.; Romeijn, S.G.; Amidi, M.; de Sousa, A.; Borchard, G.; Junginger, H.E., 2006. Journal of Controlled Release. 348 - 358. 3. 114. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748131292&partnerID=MN8TOARS . 10.1016/j.jconrel.2006.06.011 . Journal of Controlled Release

Permeation of sodium dodecyl sulfate through polyaniline-modified cellulose acetate membranes

Valente, A.J.M.; Burrows, H.D.; Polishchuk, A.Ya.; Domingues, C.P.; Borges, O.M.F.; Eusébio, M.E.S.; Maria, T.M.R.; Lobo, V.M.M.; Monkman, A.P., 2005. Polymer. 5918 - 5928. 16. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21744450884&partnerID=MN8TOARS . 10.1016/j.polymer.2005.05.103 . published Polymer

Preparation of coated nanoparticles for a new mucosal vaccine delivery system

Borges, O.; Borchard, G.; Verhoef, J.C.; De Sousa, A.; Junginger, H.E., 2005. International Journal of Pharmaceutics. 155 - 166. 1-2. 299. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844435468&partnerID=MN8TOARS . 10.1016/j.ijpharm.2005.04.037 . International Journal of Pharmaceutics

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