Obesity, Diabetes and Complications

Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway

Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling

Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell

Neurotensin, substance P, and insulin enhance cell migration

Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science

Immune aging in diabetes and its implications in wound healing

Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences

Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes

Alphonse Laya; Honoré Wangso; Iva Fernandes; Raphaël Djakba; Joana Oliveira; Eugenia Carvalho; Wen yi Kang, 2023. Journal of Food Quality. 2023. https://doi.org/10.1155/2023/5236509 . 10.1155/2023/5236509 . Journal of Food Quality

Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study

Jessica Da Silva; Diana Santos; Margarida Vilaça; André Carvalho; Rui Carvalho; Maria de Jesus Dantas; M. Graça Pereira; Eugénia Carvalho, 2023. Advances in Wound Care. 2023. https://doi.org/10.1089/wound.2023.0043 . 10.1089/wound.2023.0043 . Advances in Wound Care

Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

M. Graça Pereira; Margarida Vilaça; Diogo Braga; Ana Madureira; Jéssica Da Silva; Diana Santos; Eugénia Carvalho, 2023. Wound Repair and Regeneration. 2023. https://doi.org/10.1111/wrr.13141 . 10.1111/wrr.13141 . Wound Repair and Regeneration

Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model

Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho, 2023. Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-22-0122 . 10.1530/JME-22-0122 . Journal of Molecular Endocrinology

Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity

Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho, 2023. Life Sciences. 2023. https://doi.org/10.1016/j.lfs.2022.121246 . 10.1016/j.lfs.2022.121246 . Life Sciences

Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?

Pedro Barbosa; Eugenia Carvalho, 2023. Diabetology. 2023. https://doi.org/10.3390/diabetology4010005 . 10.3390/diabetology4010005 . Diabetology

Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers

Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal, 2023. Antibiotics. 2023. https://doi.org/10.3390/antibiotics12030467 . 10.3390/antibiotics12030467 . Antibiotics

Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study

Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho, 2023. European Journal of Clinical Investigation. 2023. https://doi.org/10.1111/eci.14128 . 10.1111/eci.14128 . European Journal of Clinical Investigation

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho, 2022. Metabolites. 2022. https://doi.org/10.3390/metabo12020184 . 10.3390/metabo12020184 . Metabolites

Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers

M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho, 2022. International Journal of Environmental Research and Public Health. 2022. https://doi.org/10.3390/ijerph19148556 . 10.3390/ijerph19148556 . International Journal of Environmental Research and Public Health

Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers

Ermelindo Carreira Leal; Eugenia Carvalho, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231912043 . 10.3390/ijms231912043 . International Journal of Molecular Sciences

Mitochondrial respiration in thoracic perivascular adipose tissue of diabetic mice

Pinho, Aryane Cruz Oliveira; Santos, Diana; Baldeiras, Ines; Burgeiro, Ana; Leal, Emelindo C.; Carvalho, Eugenia, 2022. Journal of Endocrinology. 2022. https://publons.com/wos-op/publon/51171420/ . 10.1530/JOE-21-0446 . Journal of Endocrinology

Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial

Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO, 2021. Annals of the Brazilian Academy of Sciences. 1. 94. 2021. https://doi.org/10.1590/0001-3765202220201819 . 10.1590/0001-3765202220201819 . accepted Annals of the Brazilian Academy of Sciences

mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate

Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia, 2021. Stem Cell Reviews and Reports. 2021. https://doi.org/10.1007/s12015-021-10131-z . 10.1007/s12015-021-10131-z . accepted Stem Cell Reviews and Reports

Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds

Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho, 2021. Current Diabetes Reviews. 2021. https://doi.org/10.2174/1573399817666210806112813 . 10.2174/1573399817666210806112813 . Current Diabetes Reviews

Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue

Diana Santos; Eugenia Carvalho, 2021. The Journal of Physiology. 2021. https://doi.org/10.1113/JP280917 . 10.1113/JP280917 . The Journal of Physiology

Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway

Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry

Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice

Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet, 2021. JBMR Plus. 7. 5. 2021. http://dx.doi.org/10.1002/jbm4.10508 . 10.1002/jbm4.10508 . JBMR Plus

Redox Imbalance and Methylation Disturbances in Early Childhood Obesity

Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, 2021. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/2207125 . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity

Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.

Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology

Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot Ulcers

Da Silva, Jessica; Leal, Ermelindo C.; Carvalho, Eugenia; Jessica Da Silva; Leal, Ermelindo C; Eugénia Carvalho, 2021. Biomolecules. 2021. http://hdl.handle.net/10316/103768 . https://doi.org/10.3390/biom11121894 . Biomolecules

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P., 2020. Microorganisms. 10. 8. 2020. http://dx.doi.org/10.3390/microorganisms8101500 . 10.3390/microorganisms8101500 . Microorganisms

Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes

Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia, 2020. Pharmacological Research. 159. 2020. http://dx.doi.org/10.1016/j.phrs.2020.104977 . 10.1016/j.phrs.2020.104977 . Pharmacological Research

Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk

Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi, 2020. BMC Nutrition. 1. 6. 2020. http://dx.doi.org/10.1186/s40795-020-00338-7 . 10.1186/s40795-020-00338-7 . BMC Nutrition

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp, 2020. Cells. 10. 9. 2020. http://dx.doi.org/10.3390/cells9102228 . 10.3390/cells9102228 . Cells

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling

Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell

Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain

Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi, 2019. Brain Research Bulletin. 2019. https://doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al, 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-42309-4 . 10.1038/s41598-019-42309-4 . Scientific Reports

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano

A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women

Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet, 2019. American Journal of Physiology-Endocrinology and Metabolism. E503 - E512. 3. 317. 2019. http://dx.doi.org/10.1152/ajpendo.00084.2019 . 10.1152/ajpendo.00084.2019 . American Journal of Physiology-Endocrinology and Metabolism

Immune aging in diabetes and its implications in wound healing

Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology

Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia, 2019. Cellular & Molecular Immunology. 2019. http://dx.doi.org/10.1038/s41423-019-0233-1 . 10.1038/s41423-019-0233-1 . Cellular & Molecular Immunology

Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model

Carvalho, Eugenia, 2019. Cellular Physiology and Biochemistry. 503 - 516. 3. 52. 2019. http://dx.doi.org/10.33594/000000036 . 10.33594/000000036 . Cellular Physiology and Biochemistry

Neurotensin, substance P, and insulin enhance cell migration

Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science

Calcineurin is an important factor involved in glucose uptake in human adipocytes

Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira, 2018. Molecular and Cellular Biochemistry. 157 - 168. 1-2. 445. 2018. https://doi.org/10.1007/s11010-017-3261-0 . 10.1007/s11010-017-3261-0 . Molecular and Cellular Biochemistry

Wanted: MicroRNAs to the aid of the diabetic foot

Louise T. Dalgaard; Eugenia Carvalho, 2018. Trends in Cardiovascular Medicine. 2018. https://doi.org/10.1016/j.tcm.2018.09.002 . 10.1016/j.tcm.2018.09.002 . Trends in Cardiovascular Medicine

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.

Pereira SG; Moura J; Carvalho E; Empadinhas N, 2017. Frontiers in microbiology. 2017. http://europepmc.org/abstract/med/28983285 . 10.3389/fmicb.2017.01791 . Frontiers in microbiology

Impaired T-cell differentiation in diabetic foot ulceration.

Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. http://europepmc.org/abstract/med/26996067 . 10.1038/cmi.2015.116 . Cellular & molecular immunology

Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults

Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet, 2017. Current Developments in Nutrition. 11. 1. 2017. http://dx.doi.org/10.3945/cdn.117.002071 . 10.3945/cdn.117.002071 . Current Developments in Nutrition

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E, 2017. Nutrients. 2017. http://europepmc.org/abstract/med/28635632 . 10.3390/nu9060638 . Nutrients

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. http://europepmc.org/abstract/med/27686967 . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta

Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.

Emanuelli T; Burgeiro A; Carvalho E, 2016. Archives of dermatological research. 2016. http://europepmc.org/abstract/med/27655635 . 10.1007/s00403-016-1686-z . Archives of dermatological research

Mast Cells Regulate Wound Healing in Diabetes.

Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al, 2016. Diabetes. 2016. http://europepmc.org/abstract/med/27207516 . 10.2337/db15-0340 . Diabetes

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.

Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/26814014 . 10.1152/ajpendo.00384.2015 . American journal of physiology. Endocrinology and metabolism

Reply to Katlandur, Ozbek, and Keser.

Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/27182058 . 10.1152/ajpendo.00113.2016 . American journal of physiology. Endocrinology and metabolism

Mast Cell Stabilization: A Potential Treatment for Diabetic Wounds

Tellechea, Ana; Kafanas, Antonios; Leal, Ermelindo C.; Auster, Michael E.; Kuchibhotla, Sarada; Ostrovsky, Yana; Carvalho, Eugenia; et al, 2015. Diabetes. A182 - A183. 2. 64. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359482700702&KeyUID=WOS:000359482700702 . Diabetes

Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat

Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F., 2015. Journal of Physiology and Pharmacology. 285 - 299. 2. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927565139&partnerID=MN8TOARS . Journal of Physiology and Pharmacology

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?

Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F, 2015. Journal of diabetes research. 2015. http://europepmc.org/abstract/med/26075286 . 10.1155/2015/806979 . Journal of diabetes research

Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype

Carvalho, Eugenia, 2015. Am J Pathol. 2015. http://www.ncbi.nlm.nih.gov/pubmed/25871534 . Am J Pathol

Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing

Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E.; Moura, Liane I F; et al, 2014. Acta Biomaterialia. 843 - 857. 2. 10. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896548394&partnerID=MN8TOARS . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model

Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E., 2014. Biochemical Pharmacology. 216 - 228. 2. 88. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895553061&partnerID=MN8TOARS . 10.1016/j.bcp.2014.01.020 . Biochemical Pharmacology

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment

Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Biochemical Pharmacology. 61 - 73. 1. 91. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905441039&partnerID=MN8TOARS . 10.1016/j.bcp.2014.06.014 . Biochemical Pharmacology

The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes

Moura, L.I.; Cruz, M.T.; Carvalho, E., 2014. Experimental Biology and Medicine. 6 - 12. 1. 239. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891928865&partnerID=MN8TOARS . 10.1177/1535370213510665 . Experimental Biology and Medicine

Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model

Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al, 2014. International Journal of Molecular Sciences. 8979 - 8997. 5. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901366149&partnerID=MN8TOARS . 10.3390/ijms15058979 . International Journal of Molecular Sciences

Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression

Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2014. International Journal of Inflammation. 2014. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907386743&partnerID=MN8TOARS . 10.1155/2014/248240 . International Journal of Inflammation

Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats

Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Metabolism: Clinical and Experimental. 702 - 715. 5. 63. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899413762&partnerID=MN8TOARS . 10.1016/j.metabol.2014.02.004 . Metabolism: Clinical and Experimental

The role of micrornas in diabetic complications—special emphasis on wound healing

Moura, J.; Børsheim, E.; Carvalho, E., 2014. Genes. 926 - 956. 4. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919594907&partnerID=MN8TOARS . 10.3390/genes5040926 . Genes

Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers

Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, 2013. PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS . 10.1371/journal.pone.0083314 . PLoS ONE

Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review

Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C., 2013. Acta Biomaterialia. 7093 - 7114. 7. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878278772&partnerID=MN8TOARS . 10.1016/j.actbio.2013.03.033 . Acta Biomaterialia

Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing

Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., 2013. Archives of Dermatological Research. 557 - 569. 7. 305. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883240109&partnerID=MN8TOARS . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions

Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884259661&partnerID=MN8TOARS . 10.1155/2013/941764 . BioMed Research International

Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus

Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al, 2013. Transplantation Proceedings. 1149 - 1156. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876882818&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.085 . Transplantation Proceedings

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model

Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E., 2013. Transplantation Proceedings. 1142 - 1148. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876870991&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.009 . Transplantation Proceedings

Increased skin inflammation and blood vessel density in human and experimental diabetes

Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, 2013. International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds

The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W.; et al, 2013. Molecular and Cellular Endocrinology. 260 - 269. 2. 365. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871359857&partnerID=MN8TOARS . 10.1016/j.mce.2012.10.030 . Molecular and Cellular Endocrinology

Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker

Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F., 2013. Cardiovascular Diabetology. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874618884&partnerID=MN8TOARS . 10.1186/1475-2840-12-44 . Cardiovascular Diabetology

Spatial memory impairments in a prediabetic rat model

Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, 2013. Neuroscience. 565 - 577. 250. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.07.055 . Neuroscience

Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease

Cherian, S.; Lopaschuk, G.D.; Carvalho, E., 2012. American Journal of Physiology - Endocrinology and Metabolism. 8. 303. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867609320&partnerID=MN8TOARS . 10.1152/ajpendo.00061.2012 . American Journal of Physiology - Endocrinology and Metabolism

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F., 2012. Journal of Pharmacology and Pharmacotherapeutics. 143 - 148. 2. 3. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878801249&partnerID=MN8TOARS . 10.4103/0976-500X.95513 . Journal of Pharmacology and Pharmacotherapeutics

Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells

Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE

Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.

Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia, 2011. Diabetologia. 458 - 458. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia

Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression

da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2011. Biochimica et Biophysica Acta - Molecular Cell Research. 1863 - 1871. 10. 1813. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051782996&partnerID=MN8TOARS . 10.1016/j.bbamcr.2011.06.018 . Biochimica et Biophysica Acta - Molecular Cell Research

The Role of Neurotensin in Wound Healing in Diabetic and iNOS Knockout Mice

Leal, Ermelindo; Tellechea, Ana; Moura, Liane; Veves, Aristidis; Carvalho, Eugenia, 2010. Diabetes. 2010. https://publons.com/wos-op/publon/6216558/ . Diabetes

Study of the antidiabetic capacity of the VO(dmpp)2 complex

Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., 2010. Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955091334&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2010.05.004 . Journal of Inorganic Biochemistry

Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing

Da Silva, L.; Carvalho, E.; Cruz, M.T., 2010. Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy

Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes

Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M.; Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C., 2009. Journal of Inorganic Biochemistry. 1687 - 1692. 12. 103. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350566106&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2009.09.015 . Journal of Inorganic Biochemistry

Elimination of glucose contamination from adipocyte glycogen extracts

Nunes, P.M.; Carvalho, E.; Jones, J.G.; Nunes, Patricia M.; Carvalho, Eugénia; Jones, John G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS . 10.1016/j.carres.2008.04.004 . Carbohydrate Research

Substance P as a Novel Anti-obesity Target

Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E., 2008. Gastroenterology. 3. 134. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749152943&partnerID=MN8TOARS . 10.1053/j.gastro.2007.12.032 . Gastroenterology

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B., 2005. American Journal of Physiology - Endocrinology and Metabolism. 4 52-4. 289. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044440661&partnerID=MN8TOARS . 10.1152/ajpendo.00116.2005 . American Journal of Physiology - Endocrinology and Metabolism

Evidence of impaired adipogenesis in insulin resistance

Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U., 2004. Biochemical and Biophysical Research Communications. 1045 - 1051. 4. 317. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484345&partnerID=MN8TOARS . 10.1016/j.bbrc.2004.03.152 . Biochemical and Biophysical Research Communications

GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase

Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al, 2004. Journal of Biological Chemistry. 21598 - 21605. 20. 279. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442636649&partnerID=MN8TOARS . 10.1074/jbc.M312269200 . Journal of Biological Chemistry

A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin

Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al, 2003. FASEB Journal. 1434 - 1440. 11. 17. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042209622&partnerID=MN8TOARS . 10.1096/fj.02-1132com . FASEB Journal

Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.

Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes

Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C., 2000. Biochemical and Biophysical Research Communications. 315 - 320. 2. 268. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034673376&partnerID=MN8TOARS . 10.1006/bbrc.2000.2145 . Biochemical and Biophysical Research Communications

Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects

Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U., 2000. Diabetologia. 1107 - 1115. 9. 43. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033811737&partnerID=MN8TOARS . 10.1007/s001250051501 . Diabetologia

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor

Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P., 2000. Journal of Biological Chemistry. 10093 - 10098. 14. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616384&partnerID=MN8TOARS . 10.1074/jbc.275.14.10093 . Journal of Biological Chemistry

Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4

Carvalho, E.; Rondinone, C.; Smith, U., 2000. Molecular and Cellular Biochemistry. 7 - 16. 1-2. 206. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034055787&partnerID=MN8TOARS . Molecular and Cellular Biochemistry

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U., 1999. FASEB Journal. 2173 - 2178. 15. 13. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779156&partnerID=MN8TOARS . FASEB Journal

Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus

Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P., 1999. Diabetologia. 819 - 825. 7. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032765342&partnerID=MN8TOARS . 10.1007/s001250051232 . Diabetologia

Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme

Carvalho, E.; Aasa, R.; Göthe, P.-O., 1996. Journal of Inorganic Biochemistry. 147 - 153. 2. 62. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029971610&partnerID=MN8TOARS . 10.1016/0162-0134(95)00143-3 . Journal of Inorganic Biochemistry

Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme

Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L., 1995. European Journal of Biochemistry. 780 - 785. 3. 234. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557383&partnerID=MN8TOARS . European Journal of Biochemistry

Assessment of oxidative capacity in obese children

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