Diabetes and complications
Insulin resistance
Adipocyte physiology
Nutraceuticals and health, Mitochondrial respiration, Biomarkers, Health literacy
Metabolism across the lifespan (Adipose)
Wound healing and tissue regeneration in diabetes (Skin)
Oxidative capacity of circulating cells over the lifespan
Nutraceuticals and insulin resistance
Health literacy
The Obesity, Diabetes and Complications research team, headed by Dr. Eugenia Carvalho, has been studying the role of adipose tissue (AT) as an endocrine and inflammatory organ. AT is highly involved in insulin resistance and diabetes complications development. Her team is using in vitro systems, preclinical models as well as, clinical studies to understand states of AT dysfunction across the lifespan. They are studying the impact of AT immunometabolism on systemic deleterious metabolic effects in people with different degrees of insulin resistance. Her team is evaluating the differences between the various AT depots, and their respective mitochondrial activities. In addition, she believes the oxidative capacity of cells/tissues could be useful markers of disease, before any symptoms of disease arise, and therefore much before diagnosis. She has been evaluating mitochondrial function in circulating cells in adults and in children with obesity. The main goal is to understand early alterations in immune metabolism and how this relates with metabolic disturbances across the lifespan. Furthermore, Dr. Carvalho believes that environmental factors, such as, lack of specific nutrients, pharmacological drugs and lifestyle strongly influence mitochondrial and immune metabolic health, as well as the specific fat cell phenotype. Therefore, understanding the impact of nutraceuticals to improve metabolic health is goal.
Her team has also been evaluating tissue regeneration and wound healing in the context of insulin resistance and diabetes, with the goal of enhancing early diagnosis of subjects at risk for chronic complications in order to improve the personalized treatment of subjects with foot wounds. They have been assessing the role of microRNAs and antimicrobial peptides in wound healing and infection, in preclinical animal models and in the clinical setting in subjects with diabetes.
Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.
Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. http://europepmc.org/abstract/med/27686967 . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, 2021. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/2207125 . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity
Impaired T-cell differentiation in diabetic foot ulceration.
Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. http://europepmc.org/abstract/med/26996067 . 10.1038/cmi.2015.116 . Cellular & molecular immunology
Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry
Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling
Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell
Neurotensin, substance P, and insulin enhance cell migration
Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science
Immune aging in diabetes and its implications in wound healing
Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology
Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota
Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, 2021. Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing
Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences
5 11 out of 11 Featured Publications
Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.
Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model
Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho, 2023. Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-22-0122 . 10.1530/JME-22-0122 . Journal of Molecular Endocrinology
Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?
Pedro Barbosa; Eugenia Carvalho, 2023. Diabetology. 2023. https://doi.org/10.3390/diabetology4010005 . 10.3390/diabetology4010005 . Diabetology
Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal, 2023. Antibiotics. 2023. https://doi.org/10.3390/antibiotics12030467 . 10.3390/antibiotics12030467 . Antibiotics
Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity
Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho, 2023. Life Sciences. 2023. https://doi.org/10.1016/j.lfs.2022.121246 . 10.1016/j.lfs.2022.121246 . Life Sciences
The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention
Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho, 2022. Metabolites. 2022. https://doi.org/10.3390/metabo12020184 . 10.3390/metabo12020184 . Metabolites
Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers
M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho, 2022. International Journal of Environmental Research and Public Health. 2022. https://doi.org/10.3390/ijerph19148556 . 10.3390/ijerph19148556 . International Journal of Environmental Research and Public Health
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers
Ermelindo Carreira Leal; Eugenia Carvalho, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231912043 . 10.3390/ijms231912043 . International Journal of Molecular Sciences
Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice
Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet, 2021. JBMR Plus. 7. 5. 2021. http://dx.doi.org/10.1002/jbm4.10508 . 10.1002/jbm4.10508 . JBMR Plus
Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry
mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate
Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia, 2021. Stem Cell Reviews and Reports. 2021. https://doi.org/10.1007/s12015-021-10131-z . 10.1007/s12015-021-10131-z . accepted Stem Cell Reviews and Reports
Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota
Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, 2021. Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development
Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial
Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO, 2021. Annals of the Brazilian Academy of Sciences. 1. 94. 2021. https://doi.org/10.1590/0001-3765202220201819 . 10.1590/0001-3765202220201819 . accepted Annals of the Brazilian Academy of Sciences
Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue
Diana Santos; Eugenia Carvalho, 2021. The Journal of Physiology. 2021. https://doi.org/10.1113/JP280917 . 10.1113/JP280917 . The Journal of Physiology
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, 2021. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/2207125 . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity
Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds
Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho, 2021. Current Diabetes Reviews. 2021. https://doi.org/10.2174/1573399817666210806112813 . 10.2174/1573399817666210806112813 . Current Diabetes Reviews
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing
Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences
Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P., 2020. Microorganisms. 10. 8. 2020. http://dx.doi.org/10.3390/microorganisms8101500 . 10.3390/microorganisms8101500 . Microorganisms
Mechanistic Actions of microRNAs in Diabetic Wound Healing
Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp, 2020. Cells. 10. 9. 2020. http://dx.doi.org/10.3390/cells9102228 . 10.3390/cells9102228 . Cells
Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling
Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell
Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk
Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi, 2020. BMC Nutrition. 1. 6. 2020. http://dx.doi.org/10.1186/s40795-020-00338-7 . 10.1186/s40795-020-00338-7 . BMC Nutrition
Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes
Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia, 2020. Pharmacological Research. 159. 2020. http://dx.doi.org/10.1016/j.phrs.2020.104977 . 10.1016/j.phrs.2020.104977 . Pharmacological Research
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model
Carvalho, Eugenia, 2019. Cellular Physiology and Biochemistry. 503 - 516. 3. 52. 2019. http://dx.doi.org/10.33594/000000036 . 10.33594/000000036 . Cellular Physiology and Biochemistry
Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain
Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi, 2019. Brain Research Bulletin. 2019. https://doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration
Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia, 2019. Cellular & Molecular Immunology. 2019. http://dx.doi.org/10.1038/s41423-019-0233-1 . 10.1038/s41423-019-0233-1 . Cellular & Molecular Immunology
microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation
Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al, 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-42309-4 . 10.1038/s41598-019-42309-4 . Scientific Reports
Immune aging in diabetes and its implications in wound healing
Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women
Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet, 2019. American Journal of Physiology-Endocrinology and Metabolism. E503 - E512. 3. 317. 2019. http://dx.doi.org/10.1152/ajpendo.00084.2019 . 10.1152/ajpendo.00084.2019 . American Journal of Physiology-Endocrinology and Metabolism
Calcineurin is an important factor involved in glucose uptake in human adipocytes
Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira, 2018. Molecular and Cellular Biochemistry. 157 - 168. 1-2. 445. 2018. https://doi.org/10.1007/s11010-017-3261-0 . 10.1007/s11010-017-3261-0 . Molecular and Cellular Biochemistry
Neurotensin, substance P, and insulin enhance cell migration
Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science
Wanted: MicroRNAs to the aid of the diabetic foot
Louise T. Dalgaard; Eugenia Carvalho, 2018. Trends in Cardiovascular Medicine. 2018. https://doi.org/10.1016/j.tcm.2018.09.002 . 10.1016/j.tcm.2018.09.002 . Trends in Cardiovascular Medicine
Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults
Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet, 2017. Current Developments in Nutrition. 11. 1. 2017. http://dx.doi.org/10.3945/cdn.117.002071 . 10.3945/cdn.117.002071 . Current Developments in Nutrition
Impaired T-cell differentiation in diabetic foot ulceration.
Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. http://europepmc.org/abstract/med/26996067 . 10.1038/cmi.2015.116 . Cellular & molecular immunology
Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.
Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E, 2017. Nutrients. 2017. http://europepmc.org/abstract/med/28635632 . 10.3390/nu9060638 . Nutrients
Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.
Pereira SG; Moura J; Carvalho E; Empadinhas N, 2017. Frontiers in microbiology. 2017. http://europepmc.org/abstract/med/28983285 . 10.3389/fmicb.2017.01791 . Frontiers in microbiology
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.
Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/26814014 . 10.1152/ajpendo.00384.2015 . American journal of physiology. Endocrinology and metabolism
Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.
Emanuelli T; Burgeiro A; Carvalho E, 2016. Archives of dermatological research. 2016. http://europepmc.org/abstract/med/27655635 . 10.1007/s00403-016-1686-z . Archives of dermatological research
Reply to Katlandur, Ozbek, and Keser.
Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/27182058 . 10.1152/ajpendo.00113.2016 . American journal of physiology. Endocrinology and metabolism
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. http://europepmc.org/abstract/med/27686967 . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta
Mast Cells Regulate Wound Healing in Diabetes.
Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al, 2016. Diabetes. 2016. http://europepmc.org/abstract/med/27207516 . 10.2337/db15-0340 . Diabetes
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Carvalho, Eugenia, 2015. Am J Pathol. 2015. http://www.ncbi.nlm.nih.gov/pubmed/25871534 . Am J Pathol
The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?
Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F, 2015. Journal of diabetes research. 2015. http://europepmc.org/abstract/med/26075286 . 10.1155/2015/806979 . Journal of diabetes research
Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat
Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F., 2015. Journal of Physiology and Pharmacology. 285 - 299. 2. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927565139&partnerID=MN8TOARS . Journal of Physiology and Pharmacology
Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing
Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E.; Moura, Liane I F; et al, 2014. Acta Biomaterialia. 843 - 857. 2. 10. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896548394&partnerID=MN8TOARS . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia
The role of micrornas in diabetic complications—special emphasis on wound healing
Moura, J.; Børsheim, E.; Carvalho, E., 2014. Genes. 926 - 956. 4. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919594907&partnerID=MN8TOARS . 10.3390/genes5040926 . Genes
Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model
Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E., 2014. Biochemical Pharmacology. 216 - 228. 2. 88. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895553061&partnerID=MN8TOARS . 10.1016/j.bcp.2014.01.020 . Biochemical Pharmacology
Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression
Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2014. International Journal of Inflammation. 2014. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907386743&partnerID=MN8TOARS . 10.1155/2014/248240 . International Journal of Inflammation
Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment
Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Biochemical Pharmacology. 61 - 73. 1. 91. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905441039&partnerID=MN8TOARS . 10.1016/j.bcp.2014.06.014 . Biochemical Pharmacology
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model
Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al, 2014. International Journal of Molecular Sciences. 8979 - 8997. 5. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901366149&partnerID=MN8TOARS . 10.3390/ijms15058979 . International Journal of Molecular Sciences
The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes
Moura, L.I.; Cruz, M.T.; Carvalho, E., 2014. Experimental Biology and Medicine. 6 - 12. 1. 239. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891928865&partnerID=MN8TOARS . 10.1177/1535370213510665 . Experimental Biology and Medicine
Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats
Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Metabolism: Clinical and Experimental. 702 - 715. 5. 63. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899413762&partnerID=MN8TOARS . 10.1016/j.metabol.2014.02.004 . Metabolism: Clinical and Experimental
Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review
Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C., 2013. Acta Biomaterialia. 7093 - 7114. 7. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878278772&partnerID=MN8TOARS . 10.1016/j.actbio.2013.03.033 . Acta Biomaterialia
Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus
Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al, 2013. Transplantation Proceedings. 1149 - 1156. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876882818&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.085 . Transplantation Proceedings
Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions
Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884259661&partnerID=MN8TOARS . 10.1155/2013/941764 . BioMed Research International
Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing
Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., 2013. Archives of Dermatological Research. 557 - 569. 7. 305. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883240109&partnerID=MN8TOARS . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research
Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model
Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E., 2013. Transplantation Proceedings. 1142 - 1148. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876870991&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.009 . Transplantation Proceedings
Increased skin inflammation and blood vessel density in human and experimental diabetes
Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, 2013. International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds
Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker
Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F., 2013. Cardiovascular Diabetology. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874618884&partnerID=MN8TOARS . 10.1186/1475-2840-12-44 . Cardiovascular Diabetology
Spatial memory impairments in a prediabetic rat model
Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, 2013. Neuroscience. 565 - 577. 250. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.07.055 . Neuroscience
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W.; et al, 2013. Molecular and Cellular Endocrinology. 260 - 269. 2. 365. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871359857&partnerID=MN8TOARS . 10.1016/j.mce.2012.10.030 . Molecular and Cellular Endocrinology
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers
Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, 2013. PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS . 10.1371/journal.pone.0083314 . PLoS ONE
Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease
Cherian, S.; Lopaschuk, G.D.; Carvalho, E., 2012. American Journal of Physiology - Endocrinology and Metabolism. 8. 303. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867609320&partnerID=MN8TOARS . 10.1152/ajpendo.00061.2012 . American Journal of Physiology - Endocrinology and Metabolism
Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model
Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F., 2012. Journal of Pharmacology and Pharmacotherapeutics. 143 - 148. 2. 3. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878801249&partnerID=MN8TOARS . 10.4103/0976-500X.95513 . Journal of Pharmacology and Pharmacotherapeutics
Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression
da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2011. Biochimica et Biophysica Acta - Molecular Cell Research. 1863 - 1871. 10. 1813. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051782996&partnerID=MN8TOARS . 10.1016/j.bbamcr.2011.06.018 . Biochimica et Biophysica Acta - Molecular Cell Research
Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells
Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE
Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing
Da Silva, L.; Carvalho, E.; Cruz, M.T., 2010. Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy
Study of the antidiabetic capacity of the VO(dmpp)2 complex
Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., 2010. Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955091334&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2010.05.004 . Journal of Inorganic Biochemistry
Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes
Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M.; Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C., 2009. Journal of Inorganic Biochemistry. 1687 - 1692. 12. 103. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350566106&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2009.09.015 . Journal of Inorganic Biochemistry
Substance P as a Novel Anti-obesity Target
Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E., 2008. Gastroenterology. 3. 134. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749152943&partnerID=MN8TOARS . 10.1053/j.gastro.2007.12.032 . Gastroenterology
Elimination of glucose contamination from adipocyte glycogen extracts
Nunes, P.M.; Carvalho, E.; Jones, J.G.; Nunes, Patricia M.; Carvalho, Eugénia; Jones, John G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS . 10.1016/j.carres.2008.04.004 . Carbohydrate Research
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle
Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B., 2005. American Journal of Physiology - Endocrinology and Metabolism. 4 52-4. 289. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044440661&partnerID=MN8TOARS . 10.1152/ajpendo.00116.2005 . American Journal of Physiology - Endocrinology and Metabolism
GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase
Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al, 2004. Journal of Biological Chemistry. 21598 - 21605. 20. 279. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442636649&partnerID=MN8TOARS . 10.1074/jbc.M312269200 . Journal of Biological Chemistry
Evidence of impaired adipogenesis in insulin resistance
Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U., 2004. Biochemical and Biophysical Research Communications. 1045 - 1051. 4. 317. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484345&partnerID=MN8TOARS . 10.1016/j.bbrc.2004.03.152 . Biochemical and Biophysical Research Communications
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin
Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al, 2003. FASEB Journal. 1434 - 1440. 11. 17. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042209622&partnerID=MN8TOARS . 10.1096/fj.02-1132com . FASEB Journal
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.
Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P., 2000. Journal of Biological Chemistry. 10093 - 10098. 14. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616384&partnerID=MN8TOARS . 10.1074/jbc.275.14.10093 . Journal of Biological Chemistry
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes
Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C., 2000. Biochemical and Biophysical Research Communications. 315 - 320. 2. 268. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034673376&partnerID=MN8TOARS . 10.1006/bbrc.2000.2145 . Biochemical and Biophysical Research Communications
Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
Carvalho, E.; Rondinone, C.; Smith, U., 2000. Molecular and Cellular Biochemistry. 7 - 16. 1-2. 206. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034055787&partnerID=MN8TOARS . Molecular and Cellular Biochemistry
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects
Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U., 2000. Diabetologia. 1107 - 1115. 9. 43. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033811737&partnerID=MN8TOARS . 10.1007/s001250051501 . Diabetologia
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus
Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P., 1999. Diabetologia. 819 - 825. 7. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032765342&partnerID=MN8TOARS . 10.1007/s001250051232 . Diabetologia
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U., 1999. FASEB Journal. 2173 - 2178. 15. 13. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779156&partnerID=MN8TOARS . FASEB Journal
Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme
Carvalho, E.; Aasa, R.; Göthe, P.-O., 1996. Journal of Inorganic Biochemistry. 147 - 153. 2. 62. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029971610&partnerID=MN8TOARS . 10.1016/0162-0134(95)00143-3 . Journal of Inorganic Biochemistry
Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme
Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L., 1995. European Journal of Biochemistry. 780 - 785. 3. 234. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557383&partnerID=MN8TOARS . European Journal of Biochemistry
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