Metabolism, Aging and Disease

Obesity, Diabetes and Complications


Insulin Resistance


MicroRNAs, Mitochondrial Respiration

Research lines

Life-spam research interests

Would healing and tissue regeneration under diabetes conditions

Oxidative capacity of circulating cells over the life-spam


The Obesity, Diabetes and Complications research team, headed by Dr. Eugenia Carvalho, has been studying the role of adipose tissue (AT) as an endocrine and inflammatory organ. AT is highly involved in insulin resistance and diabetes complications development. Her team is using in vitro systems, preclinical models as well as, clinical studies to understand states of AT dysfunction across the lifespan. They are studying the impact of AT immunometabolism on systemic deleterious metabolic effects in people with different degrees of insulin resistance. Her team is evaluating the differences between the various AT depots, and their respective mitochondrial activities. In addition, she believes the oxidative capacity of cells/tissues could be useful markers of disease, before any symptoms of disease arise, and therefore much before diagnosis. She has been evaluating mitochondrial function in circulating cells in adults and in children with obesity. The main goal is to understand early alterations in immune metabolism and how this relates with metabolic disturbances across the lifespan. Furthermore, Dr. Carvalho believes that environmental factors, such as, lack of specific nutrients, pharmacological drugs and lifestyle strongly influence mitochondrial and immune metabolic health, as well as the specific fat cell phenotype. Therefore, understanding the impact of nutraceuticals to improve metabolic health is goal.

Her team has also been evaluating tissue regeneration and wound healing in the context of insulin resistance and diabetes, with the goal of enhancing early diagnosis of subjects at risk for chronic complications in order to improve the personalized treatment of subjects with foot wounds. They have been assessing the role of microRNAs and antimicrobial peptides in wound healing and infection, in preclinical animal models and in the clinical setting in subjects with diabetes.


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Information about journal articles, updated at 25-07-2021, from platform CIÊNCIAVITAE.

Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota

Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, 2021. Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development

mTOR signaling as a regulator of Hematopoietic Stem Cell fat

H. Fernandes; João Moura Alves (EF1E-2954-7885); Carvalho, Eugenia, 2021. Stem Cell Reviews and Reports. 2021. accepted Stem Cell Reviews and Reports

Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial

Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia, 2021. Annals of the Brazilian Academy of Sciences. 2021. accepted Annals of the Brazilian Academy of Sciences

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling

Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. . 10.1111/acel.13261 . Aging Cell

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. . 10.1016/j.lfs.2020.117813 . Life Sciences

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp, 2020. Cells. 10. 9. 2020. . 10.3390/cells9102228 . Cells

Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk

Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi, 2020. BMC Nutrition. 1. 6. 2020. . 10.1186/s40795-020-00338-7 . BMC Nutrition

Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes

Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia, 2020. Pharmacological Research. 159. 2020. . 10.1016/j.phrs.2020.104977 . Pharmacological Research

Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P., 2020. Microorganisms. 10. 8. 2020. . 10.3390/microorganisms8101500 . Microorganisms

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain

Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi, 2019. Brain Research Bulletin. 2019. . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin

A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women

Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet, 2019. American Journal of Physiology-Endocrinology and Metabolism. E503 - E512. 3. 317. 2019. . 10.1152/ajpendo.00084.2019 . American Journal of Physiology-Endocrinology and Metabolism

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. . 10.1021/acsnano.9b00376 . ACS Nano

Immune aging in diabetes and its implications in wound healing

Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. . 10.1016/j.clim.2019.02.002 . Clinical Immunology

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al, 2019. Scientific Reports. 1. 9. 2019. . 10.1038/s41598-019-42309-4 . Scientific Reports

Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model

Carvalho, Eugenia, 2019. Cellular Physiology and Biochemistry. 503 - 516. 3. 52. 2019. . 10.33594/000000036 . Cellular Physiology and Biochemistry

Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia, 2019. Cellular & Molecular Immunology. 2019. . 10.1038/s41423-019-0233-1 . Cellular & Molecular Immunology

Calcineurin is an important factor involved in glucose uptake in human adipocytes

Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira, 2018. Molecular and Cellular Biochemistry. 157 - 168. 1-2. 445. 2018. . 10.1007/s11010-017-3261-0 . Molecular and Cellular Biochemistry

Neurotensin, substance P, and insulin enhance cell migration

Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. . 10.1002/psc.3093 . Journal of Peptide Science

Wanted: MicroRNAs to the aid of the diabetic foot

Louise T. Dalgaard; Eugenia Carvalho, 2018. Trends in Cardiovascular Medicine. 2018. . 10.1016/j.tcm.2018.09.002 . Trends in Cardiovascular Medicine

Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults

Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet, 2017. Current Developments in Nutrition. 11. 1. 2017. . 10.3945/cdn.117.002071 . Current Developments in Nutrition

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.

Pereira SG; Moura J; Carvalho E; Empadinhas N, 2017. Frontiers in microbiology. 2017. . 10.3389/fmicb.2017.01791 . Frontiers in microbiology

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E, 2017. Nutrients. 2017. . 10.3390/nu9060638 . Nutrients

Impaired T-cell differentiation in diabetic foot ulceration.

Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. . 10.1038/cmi.2015.116 . Cellular & molecular immunology

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta

Reply to Katlandur, Ozbek, and Keser.

Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A, 2016. American journal of physiology. Endocrinology and metabolism. 2016. . 10.1152/ajpendo.00113.2016 . American journal of physiology. Endocrinology and metabolism

Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.

Emanuelli T; Burgeiro A; Carvalho E, 2016. Archives of dermatological research. 2016. . 10.1007/s00403-016-1686-z . Archives of dermatological research

Mast Cells Regulate Wound Healing in Diabetes.

Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al, 2016. Diabetes. 2016. . 10.2337/db15-0340 . Diabetes

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.

Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al, 2016. American journal of physiology. Endocrinology and metabolism. 2016. . 10.1152/ajpendo.00384.2015 . American journal of physiology. Endocrinology and metabolism

Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype

Carvalho, Eugenia, 2015. Am J Pathol. 2015. . Am J Pathol

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?

Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F, 2015. Journal of diabetes research. 2015. . 10.1155/2015/806979 . Journal of diabetes research

Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat

Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F., 2015. Journal of Physiology and Pharmacology. 285 - 299. 2. 66. 2015. . Journal of Physiology and Pharmacology

Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice

Moura, L.I.F.; Dias, A.M.A.; Suesca, E.; Casadiegos, S.; Leal, E.C.; Fontanilla, M.R.; Carvalho, L.; de Sousa, H.C.; Carvalho, E., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 32 - 43. 1. 1842. 2014. . 10.1016/j.bbadis.2013.10.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model

Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E., 2014. Biochemical Pharmacology. 216 - 228. 2. 88. 2014. . 10.1016/j.bcp.2014.01.020 . Biochemical Pharmacology

Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing

Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E., 2014. Acta Biomaterialia. 843 - 857. 2. 10. 2014. . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia

Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell surface in human adipocytes: Increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents

Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W., 2014. Journal of Clinical Endocrinology and Metabolism. E1885 - E1894. 10. 99. 2014. . 10.1210/jc.2014-1266 . Journal of Clinical Endocrinology and Metabolism

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment

Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Biochemical Pharmacology. 61 - 73. 1. 91. 2014. . 10.1016/j.bcp.2014.06.014 . Biochemical Pharmacology

Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model

Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al, 2014. International Journal of Molecular Sciences. 8979 - 8997. 5. 15. 2014. . 10.3390/ijms15058979 . International Journal of Molecular Sciences

The role of micrornas in diabetic complications—special emphasis on wound healing

Moura, J.; Børsheim, E.; Carvalho, E., 2014. Genes. 926 - 956. 4. 5. 2014. . 10.3390/genes5040926 . Genes

Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression

Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2014. International Journal of Inflammation. 2014. 2014. . 10.1155/2014/248240 . International Journal of Inflammation

The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes

Moura, L.I.; Cruz, M.T.; Carvalho, E., 2014. Experimental Biology and Medicine. 6 - 12. 1. 239. 2014. . 10.1177/1535370213510665 . Experimental Biology and Medicine

Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats

Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Metabolism: Clinical and Experimental. 702 - 715. 5. 63. 2014. . 10.1016/j.metabol.2014.02.004 . Metabolism: Clinical and Experimental

Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review

Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C., 2013. Acta Biomaterialia. 7093 - 7114. 7. 9. 2013. . 10.1016/j.actbio.2013.03.033 . Acta Biomaterialia

Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker

Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F., 2013. Cardiovascular Diabetology. 1. 12. 2013. . 10.1186/1475-2840-12-44 . Cardiovascular Diabetology

Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing

Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., 2013. Archives of Dermatological Research. 557 - 569. 7. 305. 2013. . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research

Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers

Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, 2013. PLoS ONE. 12. 8. 2013. . 10.1371/journal.pone.0083314 . PLoS ONE

Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus

Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al, 2013. Transplantation Proceedings. 1149 - 1156. 3. 45. 2013. . 10.1016/j.transproceed.2013.02.085 . Transplantation Proceedings

The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W., 2013. Molecular and Cellular Endocrinology. 260 - 269. 2. 365. 2013. . 10.1016/j.mce.2012.10.030 . Molecular and Cellular Endocrinology

Spatial memory impairments in a prediabetic rat model

Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, 2013. Neuroscience. 565 - 577. 250. 2013. . 10.1016/j.neuroscience.2013.07.055 . Neuroscience

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model

Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E., 2013. Transplantation Proceedings. 1142 - 1148. 3. 45. 2013. . 10.1016/j.transproceed.2013.02.009 . Transplantation Proceedings

Increased skin inflammation and blood vessel density in human and experimental diabetes

Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, 2013. International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions

Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., 2013. BioMed Research International. 2013. 2013. . 10.1155/2013/941764 . BioMed Research International

MTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W., 2012. Molecular and Cellular Endocrinology. 96 - 105. 1. 355. 2012. . 10.1016/j.mce.2012.01.024 . Molecular and Cellular Endocrinology

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F., 2012. Journal of Pharmacology and Pharmacotherapeutics. 143 - 148. 2. 3. 2012. . 10.4103/0976-500X.95513 . Journal of Pharmacology and Pharmacotherapeutics

Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease

Cherian, S.; Lopaschuk, G.D.; Carvalho, E., 2012. American Journal of Physiology - Endocrinology and Metabolism. 8. 303. 2012. . 10.1152/ajpendo.00061.2012 . American Journal of Physiology - Endocrinology and Metabolism

Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression

da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2011. Biochimica et Biophysica Acta - Molecular Cell Research. 1863 - 1871. 10. 1813. 2011. . 10.1016/j.bbamcr.2011.06.018 . Biochimica et Biophysica Acta - Molecular Cell Research

Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells

Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. . 10.1371/journal.pone.0016114 . PLoS ONE

Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing

Da Silva, L.; Carvalho, E.; Cruz, M.T., 2010. Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy

Study of the antidiabetic capacity of the VO(dmpp)2 complex

Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., 2010. Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. . 10.1016/j.jinorgbio.2010.05.004 . Journal of Inorganic Biochemistry

Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes

Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M., 2009. Journal of Inorganic Biochemistry. 1687 - 1692. 12. 103. 2009. . 10.1016/j.jinorgbio.2009.09.015 . Journal of Inorganic Biochemistry

Elimination of glucose contamination from adipocyte glycogen extracts

Nunes, P.M.; Carvalho, E.; Jones, J.G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. . 10.1016/j.carres.2008.04.004 . Carbohydrate Research

Substance P as a Novel Anti-obesity Target

Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E., 2008. Gastroenterology. 3. 134. 2008. . 10.1053/j.gastro.2007.12.032 . Gastroenterology

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B., 2005. American Journal of Physiology - Endocrinology and Metabolism. 4 52-4. 289. 2005. . 10.1152/ajpendo.00116.2005 . American Journal of Physiology - Endocrinology and Metabolism

GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase

Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al, 2004. Journal of Biological Chemistry. 21598 - 21605. 20. 279. 2004. . 10.1074/jbc.M312269200 . Journal of Biological Chemistry

Evidence of impaired adipogenesis in insulin resistance

Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U., 2004. Biochemical and Biophysical Research Communications. 1045 - 1051. 4. 317. 2004. . 10.1016/j.bbrc.2004.03.152 . Biochemical and Biophysical Research Communications

A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin

Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al, 2003. FASEB Journal. 1434 - 1440. 11. 17. 2003. . 10.1096/fj.02-1132com . FASEB Journal

Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.

Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4

Carvalho, E.; Rondinone, C.; Smith, U., 2000. Molecular and Cellular Biochemistry. 7 - 16. 1-2. 206. 2000. . Molecular and Cellular Biochemistry

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor

Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P., 2000. Journal of Biological Chemistry. 10093 - 10098. 14. 275. 2000. . 10.1074/jbc.275.14.10093 . Journal of Biological Chemistry

PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes

Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C., 2000. Biochemical and Biophysical Research Communications. 315 - 320. 2. 268. 2000. . 10.1006/bbrc.2000.2145 . Biochemical and Biophysical Research Communications

Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects

Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U., 2000. Diabetologia. 1107 - 1115. 9. 43. 2000. . 10.1007/s001250051501 . Diabetologia

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U., 1999. FASEB Journal. 2173 - 2178. 15. 13. 1999. . FASEB Journal

Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus

Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P., 1999. Diabetologia. 819 - 825. 7. 42. 1999. . 10.1007/s001250051232 . Diabetologia

Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme

Carvalho, E.; Aasa, R.; Göthe, P.-O., 1996. Journal of Inorganic Biochemistry. 147 - 153. 2. 62. 1996. . 10.1016/0162-0134(95)00143-3 . Journal of Inorganic Biochemistry

Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme

Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L., 1995. European Journal of Biochemistry. 780 - 785. 3. 234. 1995. . European Journal of Biochemistry

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