Metabolism, Aging and Disease

Intermediary Metabolism





Krebs Cycle


John Jones


Research lines

Quantifying fructose metabolism by mesenteric adipocytes in mouse models

Development of oxygen-18 enriched water as a tracer of carbohydrate biosynthesis

Coupling of pentose phosphate pathway and fatty acid synthesis fluxes in different disease states

Quantifying nutrient metabolism in cultured fish


Intermediary metabolism refers to the intracellular processes by which nutrient carbons are biochemically transformed into storage or structural cell products. Our mission is to develop methodologies for measuring these processes in living systems. Our objectives include the application these measurements to better understand nutrient metabolism in diseases such as Type 2 Diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), whose increased incidences are in part related to changes in food intake. Our techniques are based on the use of non-radioactive stable-isotope metabolic tracers coupled with noninvasive assays of key metabolites that encode the labeling information from the tracers. Our expertise is in the use of high-resolution nuclear magnetic resonance (NMR) techniques coupled with chemical derivatization of specific metabolites to acquire more precise information on the metabolic fate of the isotopic tracers. This in turn allows the development of more detailed and realistic metabolic flux models to describe nutrient metabolism. Currently, we are focused on the metabolism of fructose by the liver and other tissues. Fructose consumption in Western Societieshas sharply increased in recent decades and is implicated in the surge of T2D and NAFLD in these communities. Transformation of fructose into saturated fatty acids may play an important role in the onset and progression of these diseases.


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Information about journal articles, updated at 27-11-2022, from platform CIÊNCIAVITAE.

De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers

Getachew Debas Belew; John G. Jones, 2022. European Journal of Clinical Investigation. 2022. . 10.1111/eci.13733 . European Journal of Clinical Investigation

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al, 2022. Redox Biology. 2022. . 10.1016/J.REDOX.2022.102400 . Redox Biology

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A., 2022. European Journal of Clinical Investigation. 2022. . 10.1111/ECI.13731 . European Journal of Clinical Investigation

Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage

Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al, 2022. Free Radical Biology and Medicine. 2022. . 10.1016/J.FREERADBIOMED.2021.12.304 . Free Radical Biology and Medicine

A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction

Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G., 2022. NMR in Biomedicine. 2022. . 10.1002/NBM.4648 . NMR in Biomedicine

Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice

Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al, 2022. NMR in Biomedicine. 2022. . 10.1002/NBM.4837 . NMR in Biomedicine

Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects

Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones, 2021. Journal of Clinical Medicine. 2021. . 10.3390/jcm10040596 . Journal of Clinical Medicine

Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

John G. Jones, 2021. Metabolites. 751 - 751. 11. 11. 2021. . 10.3390/metabo11110751 . Metabolites

Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells

Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A., 2021. Molecular Neurobiology. 2021. . 10.1007/S12035-021-02630-4 . Molecular Neurobiology

Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits

Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al, 2021. Metabolism. 2021. . 10.1016/J.METABOL.2021.154735 . Metabolism

Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance

Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G., 2021. NMR in Biomedicine. 2021. . 10.1002/NBM.4632 . NMR in Biomedicine

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo, 2021. The Journal of Pathology. 2021. . 10.1002/PATH.5777 . The Journal of Pathology

Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans

Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al, 2021. The Journal of Clinical Endocrinology & Metabolism. 2021. . 10.1210/CLINEM/DGAB100 . The Journal of Clinical Endocrinology & Metabolism

The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. . 10.3390/ijms21155272 . International Journal of Molecular Sciences

p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose

Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G., 2020. Analytical Biochemistry. 590. 2020. . 10.1016/j.ab.2019.113511 . Analytical Biochemistry

Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance

Jones, John, 2020. JCI Insight. 2020. . 10.1172/jci.insight.134520 . JCI Insight

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Jones, John, 2020. Scientific Reports. 2020. . 10.1038/s41598-020-69820-3 . Scientific Reports

Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics

Jones, John, 2020. Frontiers in Physiology. 2020. . 10.3389/fphys.2020.00205 . Frontiers in Physiology

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose

Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones, 2020. Magnetic Resonance in Medicine. 2765 - 2771. 5. 84. 2020. . 10.1002/mrm.28286 . Magnetic Resonance in Medicine

Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals

Jones, John, 2020. NMR in Biomedicine. 2020. . 10.1002/nbm.4395 . NMR in Biomedicine

Understanding how birds rebuild fat stores during migration: insights from an experimental study

Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A., 2019. Scientific Reports. 1. 9. 2019. . 10.1038/s41598-019-46487-z . Scientific Reports

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata

Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al, 2019. Biomolecules. 297 - 297. 8. 9. 2019. . 10.3390/biom9080297 . Biomolecules

A Mitochondrial Approach to Cardiovascular Risk and Disease

Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, 2019. Current Pharmaceutical Design. 3175 - 3194. 29. 25. 2019. . 10.2174/1389203720666190830163735 . Current Pharmaceutical Design

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones, 2019. Journal of Lipid Research. 2050 - 2056. 12. 60. 2019. . 10.1194/jlr.RA119000354 . Journal of Lipid Research

Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish

Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G., 2019. Aquaculture. 488 - 495. 498. 2019. . 10.1016/j.aquaculture.2018.08.066 . Aquaculture

27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019

Jones, John, 2019. Cardiovascular Endocrinology & Metabolism. 2019. . 10.1097/xce.0000000000000179 . Cardiovascular Endocrinology & Metabolism

Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)

Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M., 2019. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 170 - 176. 231. 2019. . 10.1016/j.cbpa.2019.02.025 . Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue

Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G., 2019. Metabolic Engineering. 69 - 76. 56. 2019. . 10.1016/j.ymben.2019.08.018 . Metabolic Engineering

Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream

Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G., 2018. Scientific Reports. 8. 2018. . 10.1038/s41598-017-19087-y . Scientific Reports

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al, 2018. Magnetic Resonance in Medicine. 639 - 644. 1. 81. 2018. . 10.1002/mrm.27378 . Magnetic Resonance in Medicine

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al, 2018. Journal of Clinical Investigation. 5335 - 5350. 12. 128. 2018. . 10.1172/JCI63562 . Journal of Clinical Investigation

Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets

Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al, 2018. Journal of Proteome Research. 2880 - 2891. 8. 17. 2018. . 10.1021/acs.jproteome.8b00354 . Journal of Proteome Research

Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2

Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A., 2017. Journal of Experimental Biology. 1072 - 1078. 6. 220. 2017. . 10.1242/jeb.150490 . Journal of Experimental Biology

Improving Metabolic Control Through Functional Foods.

Jones, John G; Silva, Joao C P, 2017. Current medicinal chemistry. 2017. . 10.2174/0929867324666170523130123 . Current medicinal chemistry

Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype

Flachs, P.; Adamcova, K.; Zouhar, P.; Marques, C.; Janovska, P.; Viegas, I.; Jones, Jg; et al, 2017. International Journal of Obesity. 372 - 380. 3. 41. 2017. . 10.1038/ijo.2016.228 . International Journal of Obesity

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

Hernandez, Elisa Alvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; et al, 2017. Journal of Clinical Investigation. 695 - 708. 2. 127. 2017. . 10.1172/JCI89444 . Journal of Clinical Investigation

Evidence of extensive plasma glucose recycling following a glucose load in seabass

Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Jones, John G., 2017. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 41 - 48. 211. 2017. . 10.1016/j.cbpa.2017.05.009 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G., 2016. British Journal of Pharmacology. 267 - 278. 2. 173. 2016. . 10.1111/BPH.13362 . British Journal of Pharmacology

Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).

Viegas, Ivan; Jarak, Ivana; Rito, Joao; Carvalho, Rui A; Meton, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G, 2016. Journal of lipid research. 1264 - 72. 7. 57. 2016. . 10.1194/jlr.M067850 . Journal of lipid research

Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance

Varghese, Ron T.; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; Rizza, Robert A.; Jones, John G.; Venal, Adrian, 2016. Diabetes. 887 - 892. 4. 65. 2016. . 10.2337/DB15-1593 . Diabetes

Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone.

Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G, 2016. Magnetic resonance in medicine. 1781 - 6. 4. 75. 2016. . 10.1002/mrm.25749 . Magnetic resonance in medicine

Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS

Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno, 2016. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone

Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G., 2016. Magnetic Resonance in Medicine. 1781 - 1786. 4. 75. 2016. . Magnetic Resonance in Medicine

Determination of muscle protein synthesis rates in fish using (H2O)-H-2 and H-2 NMR analysis of alanine

Marques, Catia; Viegas, Filipa; Rito, Joao; Jones, John; Viegas, Ivan, 2016. Analytical Biochemistry. 111 - 114. 509. 2016. . 10.1016/j.ab.2016.07.011 . Analytical Biochemistry

Chitosan-Mediated shRNA Knockdown of Cytosolic Alanine Aminotransferase Improves Hepatic Carbohydrate Metabolism

Gonzalez, Juan D.; Silva-Marrero, Jonas I.; Meton, Isidoro; Caballero-Solares, Albert; Viegas, Ivan; Fernandez, Felipe; Minarro, Montserrat; et al, 2016. Marine Biotechnology. 85 - 97. 1. 18. 2016. . 10.1007/s10126-015-9670-8 . Marine Biotechnology

Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans

Varghese, Ron T.; Man, Chiara Dalla; Sharma, Anu; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; et al, 2016. Journal of Clinical Endocrinology & Metabolism. 4816 - 4824. 12. 101. 2016. . 10.1210/jc.2016-1998 . Journal of Clinical Endocrinology & Metabolism

Hepatic glucose and lipid metabolism

Jones, John G.; Jones, John G, 2016. Diabetologia. 1098 - 1103. 6. 59. 2016. . 10.1007/s00125-016-3940-5 . Diabetologia

Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-C-13] acetate

Burgess, Shawn C.; Merritt, Mathew E.; Jones, John G.; Browning, Jeffrey D.; Sherry, A. Dean; Malloy, Craig R., 2015. Nature Medicine. 20 - 21. 2. 21. 2015. . 10.1038/NM.3789 . Nature Medicine

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G., 2015. Nmr in Biomedicine. 1111 - 1116. 9. 28. 2015. . 10.1002/nbm.3355 . Nmr in Biomedicine

Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.)

Viegas, Ivan; Rito, Joao; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Meton, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G., 2015. British Journal of Nutrition. 1345 - 1354. 9. 113. 2015. . 10.1017/S0007114515000574 . British Journal of Nutrition

Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics

Coelho, Margarida; Nunes, Patricia; Mendes, Vera M.; Manadas, Bruno; Heerschap, Arend; Jones, John G., 2015. Journal of Diabetes Research. 2015. . 10.1155/2015/542029 . Journal of Diabetes Research

Noninvasive stable-isotope tracer methods for the study of hepatic intermediary metabolism

Jones, J. G., 2015. European Journal of Clinical Investigation. 26 - 26. 45. 2015. . European Journal of Clinical Investigation

Reduced alpha-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

Schneeberger, Marc; Gomez-Valades, Alicia G.; Altirriba, Jordi; Sebastian, David; Ramirez, Sara; Garcia, Ainhoa; Esteban, Yaiza; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. . 10.1016/j.celrep.2015.06.041 . Cell Reports

Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice

Nunes, Patricia M.; Wright, Alan J.; Veltien, Andor; van Asten, Jack J. A.; Tack, Cees J.; Jones, John G.; Heerschap, Arend, 2014. Faseb Journal. 1988 - 1997. 5. 28. 2014. . 10.1096/FJ.13-241208 . Faseb Journal

Resolving Futile Glucose Cycling and Glycogenolytic Contributions to Plasma Glucose Levels Following a Glucose Load

Nunes, Patricia M.; Jarak, Ivana; Heerschap, Arend; Jones, John G., 2014. Magnetic Resonance in Medicine. 1368 - 1373. 4. 71. 2014. 10.1002/mrm.24789 . Magnetic Resonance in Medicine

Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding

Viegas, Ivan; Caballero-Solares, Albert; Rito, Joao; Giralt, Marina; Pardal, Miguel A.; Meton, Isidoro; Jones, John G.; Baanante, Isabel V., 2014. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 38 - 44. 174. 2014. . 10.1016/j.cbpa.2014.04.004 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

Duarte, Joao A. G.; Carvalho, Filipa; Pearson, Mackenzie; Horton, Jay D.; Browning, Jeffrey D.; Jones, John G.; Burgess, Shawn C., 2014. Journal of Lipid Research. 2541 - 2553. 12. 55. 2014. 10.1194/jlr.M052308 . Journal of Lipid Research

Identifying Sources of Hepatic Lipogenic Acetyl-CoA Using Stable Isotope Tracers and NMR

John G. Jones, 2014. Advances in Radiology. 2014. . 10.1155/2014/109252 . Advances in Radiology

Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes

Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita, 2013. American Journal of Physiology-Endocrinology and Metabolism. E465 - E474. 4. 305. 2013. 10.1152/ajpendo.00245.2013 . American Journal of Physiology-Endocrinology and Metabolism

Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia

Basu, Rita; Barosa, Cristina; Jones, John; Dube, Simmi; Carter, Rickey; Basu, Ananda; Rizza, Robert A., 2013. Journal of Clinical Endocrinology & Metabolism. E409 - E417. 3. 98. 2013. . 10.1210/JC.2012-3056 . Journal of Clinical Endocrinology & Metabolism

Noninvasive measurement of murine hepatic acetyl-CoA C 13 -enrichment following overnight feeding with C 13 -enriched fructose and glucose

Carvalho, F.; Duarte, J.; Simoes, A.R.; Cruz, P.F.; Jones, J.G., 2013. BioMed Research International. 2013. 2013. . 10.1155/2013/638085 . BioMed Research International

Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.)

Viegas, I.; Rito, J.; González, J.D.; Jarak, I.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2013. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 399 - 405. 3. 166. 2013. . 10.1016/j.cbpa.2013.07.013 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Disposition of [U-(2)H7]glucose into hepatic glycogen in rat and in seabass.

Martins, Fatima O; Rito, Joao; Jarak, Ivana; Viegas, Ivan; Pardal, Miguel A; Macedo, M Paula; Jones, John G, 2013. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 316 - 22. 2. 166. 2013. 10.1016/j.cbpa.2013.07.002 . Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2H enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis

Delgado, T.C.; Martins, F.O.; Carvalho, F.; Gonçalves, A.; Scott, D.K.; O'Doherty, R.; Paula Macedo, M.; Jones, J.G., 2013. American Journal of Physiology - Endocrinology and Metabolism. 4. 304. 2013. . 10.1152/ajpendo.00185.2012 . American Journal of Physiology - Endocrinology and Metabolism

Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method

Barosa, Cristina; Jones, John G.; Rizza, Robert; Basu, Ananda; Basu, Rita; Barosa, C.; Jones, J.G.; et al, 2013. Magnetic Resonance in Medicine. 315 - 319. 2. 70. 2013. . 10.1002/mrm.24485 . Magnetic Resonance in Medicine

Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat

Delgado, T.C.; Barosa, C.; Nunes, P.M.; Scott, D.K.; O'Doherty, R.M.; Cerdán, S.; Geraldes, C.F.; Jones, J.G., 2012. Expert Opinion on Drug Metabolism and Toxicology. 1223 - 1230. 10. 8. 2012. . 10.1517/17425255.2012.709500 . Expert Opinion on Drug Metabolism and Toxicology

Resolving the Sources of Plasma Glucose Excursions following a Glucose Tolerance Test in the Rat with Deuterated Water and [U-C-13]Glucose

Delgado, Teresa C.; Barosa, Cristina; Nunes, Patricia M.; Cerdan, Sebastian; Geraldes, Carlos F. G. C.; Jones, John G., 2012. Plos One. 3. 7. 2012. 10.1371/journal.pone.0034042 . Plos One

Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation

Gonzalez, Juan D.; Caballero, Albert; Viegas, Ivan; Meton, Isidoro; Jones, John G.; Barra, Joana; Fernandez, Felipe; Baanante, Isabel V., 2012. British Journal of Nutrition. 1747 - 1756. 12. 107. 2012. 10.1017/S000711451100496X . British Journal of Nutrition

Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects

Barosa, C.; Silva, C.; Fagulha, A.; Barros, L.; Caldeira, M.M.; Carvalheiro, M.; Jones, J.G., 2012. Metabolism: Clinical and Experimental. 250 - 254. 2. 61. 2012. . 10.1016/j.metabol.2011.06.022 . Metabolism: Clinical and Experimental

Glycated hemoglobin and associated risk factors in older adults

Martins, Raul A.; Jones, John G.; Cumming, Sean P.; Coelho e Silva, Manuel J.; Teixeira, Ana M.; Verissimo, Manuel T., 2012. Cardiovascular Diabetology. 11. 2012. 10.1186/1475-2840-11-13 . Cardiovascular Diabetology

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration

Soares, Ana F.; Carvalho, Rui A.; Veiga, Francisco J.; Alves, Marco G.; Martins, Fatima O.; Viegas, Ivan; Gonzalez, Juan D.; et al, 2012. American Journal of Physiology-Endocrinology and Metabolism. E875 - E885. 7. 303. 2012. 10.1152/ajpendo.00161.2012 . American Journal of Physiology-Endocrinology and Metabolism

Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis

Reis, C.P.; Neufeld, R.; Veiga, F.; Figueiredo, I.V.; Jones, J.; Soares, A.F.; Nunes, P.; Damgé, C.; Carvalho, R.A., 2012. Journal of Microencapsulation. 167 - 176. 2. 29. 2012. . 10.3109/02652048.2011.638992 . Journal of Microencapsulation

Role of entrapped vapor bubbles during microdroplet evaporation

Putnam, Shawn A.; Byrd, Larry W.; Briones, Alejandro M.; Hanchak, Michael S.; Ervin, Jamie S.; Jones, John G., 2012. Applied Physics Letters. 2012. . 10.1063/1.4745009 . Applied Physics Letters

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, Ana P.; Duarte, Filipe V.; Nunes, Patricia; Hubbard, Basil P.; Teodoro, Joao S.; Varela, Ana T.; Jones, John G.; et al, 2012. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 185 - 195. 2. 1822. 2012. 10.1016/j.bbadis.2011.10.008 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes

Viegas, I.; Rito, J.; Jarak, I.; Leston, S.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2012. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 22 - 29. 1. 163. 2012. . 10.1016/j.cbpa.2012.04.023 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water

Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes

Kacerovsky, M; Jones, J; Schmid, AI; Barosa, C; Lettner, A; Kacerovsky-Bielesz, G; Szendroedi, J; et al, 2011. Diabetes. 1752 - 1758. 6. 60. 2011. 10.2337/db10-1001 . Diabetes

Ursodeoxycholic acid treatment of hepatic steatosis: A 13C NMR metabolic study

Nunes, P.M.; Jones, J.G.; Rolo, A.P.; Palmeira, C.M.M.; Carvalho, R.A., 2011. NMR in Biomedicine. 1145 - 1158. 9. 24. 2011. . 10.1002/nbm.1672 . NMR in Biomedicine

Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes

Kacerovsky, M.; Brehm, A.; Chmelik, M.; Schmid, A.I.; Szendroedi, J.; Kacerovsky-Bielesz, G.; Nowotny, P.; et al, 2011. Journal of Internal Medicine. 189 - 199. 2. 269. 2011. . 10.1111/j.1365-2796.2010.02298.x . Journal of Internal Medicine

2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine

Silva, A.M.; Martins, F.; Jones, J.G.; Carvalho, R., 2011. Magnetic Resonance in Medicine. 1526 - 1530. 6. 66. 2011. . 10.1002/mrm.22955 . Magnetic Resonance in Medicine

Contribution of proteolytic and metabolic sources to hepatic glutamine by 2H NMR analysis of urinary phenylacetylglutamine 2H-enrichment from 2H2O

Barosa, C.; Almeida, M.; Caldeira, M.M.; Gomes, F.; Jones, J.G., 2010. Metabolic Engineering. 53 - 61. 1. 12. 2010. . 10.1016/j.ymben.2009.08.009 . Metabolic Engineering

Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat

Delgado, T.C.; Pinheiro, D.; Caldeira, M.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; López-Larrubia, P.; Cerdán, S.; Jones, J.G., 2009. NMR in Biomedicine. 310 - 317. 3. 22. 2009. . 10.1002/nbm.826 . NMR in Biomedicine

Quantifying Endogenous Glucose Production and Contributing Source Fluxes from a Single H-2 NMR Spectrum


Toxicological assessment of orally delivered nanoparticulate insulin

Reis, Catarina P.; Figueiredo, Isabel V.; Carvalho, Rui A.; Jones, John; Nunes, Patricia; Soares, Ana F.; Silva, Cristina F.; et al, 2008. Nanotoxicology. 205 - 217. 4. 2. 2008. . 10.1080/17435390802398309 . Nanotoxicology

Elimination of glucose contamination from adipocyte glycogen extracts

Nunes, P.M.; Carvalho, E.; Jones, J.G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. . 10.1016/j.carres.2008.04.004 . Carbohydrate Research

Toxicological in vivo studies of an oral insulin nanosystern

Reis, Catarina Pinto; Veiga, Francisco; Nunes, Patricia; Soares, Ana Francisca; Laranjeira, Tania; Carvalho, Rui; Jones, John; et al, 2007. Toxicology Letters. S90 - S90. 172. 2007. 10.1016/j.toxlet.2007.05.250 . Toxicology Letters

Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat

SENA, CM; BAROSA, C; NUNES, E; SEICA, R; JONES, JG, 2007. DIABETES & METABOLISM. 296 - 302. 33. 2007. 10.1016/j.diabet.2007.03.002 . DIABETES & METABOLISM

NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers

Jones, J.; Barosa, C.; Gomes, F.; Carina Mendes, A.; Delgado, T.; Diogo, L.; Garcia, P.; et al, 2006. Journal of Carbohydrate Chemistry. 203 - 217. 2-3. 25. 2006. . 10.1080/07328300600732840 . Journal of Carbohydrate Chemistry

Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis

Fonseca, C.P.; Jones, J.G.; Carvalho, R.A.; Jeffrey, F.M.H.; Montezinho, L.P.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Neurochemistry International. 385 - 393. 6. 47. 2005. . 10.1016/j.neuint.2005.06.005 . Neurochemistry International

Uptake and metabolic effects of insulin mimetic oxovanadium compounds in human erythrocytes

Delgado, T.C.; Tomaz, A.I.; Correia, I.; Costa Pessoa, J.; Jones, J.G.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Journal of Inorganic Biochemistry. 2328 - 2339. 12. 99. 2005. . 10.1016/j.jinorgbio.2005.08.014 . Journal of Inorganic Biochemistry

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative


Sources of glucose production in cirrhosis by (H2O)-H-2 ingestion and H-2 NMR analysis of plasma glucose


An integrated H-2 and C-13 NMR study of gluconeogenesis and TCA cycle flux in humans

Jones, JG; Solomon, MA; Cole, SM; Sherry, AD; Malloy, CR; Jones, J.G.; Solomon, M.A.; et al, 2001. American Journal of Physiology-Endocrinology and Metabolism. E848 - E856. 4. 281. 2001. . American Journal of Physiology-Endocrinology and Metabolism

Quantifying tracer levels of (H2O)-H-2 enrichment from microliter amounts of plasma and urine by H-2 NMR

Jones, JG; Merritt, M; Malloy, C, 2001. Magnetic Resonance in Medicine. 156 - 158. 1. 45. 2001. . 10.1002/1522-2594(200101)45:1<156::AID-MRM1020>3.3.CO;2-Q . Magnetic Resonance in Medicine

Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen

O'Doherty, RM; Jensen, PB; Anderson, P; Jones, JG; Berman, HK; Kearney, D; Newgard, CB; et al, 2000. Journal of Clinical Investigation. 479 - 488. 4. 105. 2000. . 10.1172/JCI8673 . Journal of Clinical Investigation

13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen

Jones, J.G.; Solomon, M.A.; Dean Sherry, A.; Jeffrey, F.M.H.; Malloy, C.R.; Jones, JG; Solomon, MA; et al, 1998. American Journal of Physiology - Endocrinology and Metabolism. E843 - E852. 5 38-5. 275. 1998. . American Journal of Physiology - Endocrinology and Metabolism

Oxidation of lactate and acetate in rat skeletal muscle: Analysis by 13C-nuclear magnetic resonance spectroscopy

Bertocci, L.A.; Jones, J.G.; Malloy, C.R.; Victor, R.G.; Thomas, G.D.; Bertocci, LA; Jones, JG; et al, 1997. Journal of Applied Physiology. 32 - 39. 1. 83. 1997. . Journal of Applied Physiology

Measurement of gluconeogenesis and pyruvate recycling in the rat liver: A simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate

Jones, J.G.; Naidoo, R.; Sherry, A.D.; Jeffrey, F.M.H.; Cottam, G.L.; Malloy, C.R., 1997. FEBS Letters. 131 - 137. 1. 412. 1997. . 10.1016/S0014-5793(97)00764-3 . FEBS Letters

Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by C-13 isotopomer analysis and O-2 consumption in the heart


Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts



SHERRY, AD; SUMEGI, B; MILLER, B; COTTAM, GL; GAVVA, S; JONES, JG; MALLOY, CR, 1994. Biochemistry. 6268 - 6275. 20. 33. 1994. . 10.1021/bi00186a029 . Biochemistry


BURTON, KP; JONES, JG; LE, TH; SHERRY, AD; MALLOY, CR, 1994. Circulation Research. 97 - 104. 1. 75. 1994. . 10.1161/01.RES.75.1.97 . Circulation Research

Orientation-conserved transfer of symmetric krebs cycle intermediates in mammalian tissue

Sherry, A.D.; Sumegi, B.; Miller, B.; Cottam, G.L.; Gavva, S.; Jones, J.G.; Malloy, C.R., 1994. Biochemistry. 6268 - 6275. 20. 33. 1994. . Biochemistry

Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers

Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R., 1993. Biochemistry. 12240 - 12244. 45. 32. 1993. . Biochemistry


JONES, JG; SHERRY, AD; JEFFREY, FMH; STOREY, CJ; MALLOY, CR, 1993. Biochemistry. 12240 - 12244. 45. 32. 1993. . 10.1021/bi00096a037 . Biochemistry


JONES, JG; BELLION, E, 1991. BIOCHEMICAL JOURNAL. 475 - 481. 280. 1991. . 10.1042/BJ2800475 . BIOCHEMICAL JOURNAL




JONES, JG; BELLION, E, 1991. JOURNAL OF BACTERIOLOGY. 4959 - 4969. 16. 173. 1991. . 10.1128/JB.173.16.4959-4969.1991 . JOURNAL OF BACTERIOLOGY

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