Biomarkers
Translational Research
Proteomics/Metabolomics
Mass Spectrometry
Big Data
Translational biomarkers and therapy for Hypoxic-ischemic encephalopathy (HIE)
Biomarker research for psychiatric diseases including schizophrenia, bipolar disorder, and autism spectrum disorder
Translational research for biomarkers of neurodegenerative disorders, including Parkinson's Disease and Alzheimer's Disease
Elucidation of long-term psychotropic medication mechanisms
Interactomics approaches to identify new signaling pathways
Our research group has developed advanced mass spectrometry approaches to be used in multiple biomedical questions.
The approaches range from small molecule quantification, as neurotransmitters and metabolites, to proteome profiling, identification of post-translation modifications, and intact protein analysis to identify proteoforms.
The questions have been mainly focused on understanding cell biology mechanisms through interactomics or proteomics screenings; identification of disease biomarkers directly from human samples or through translational research approaches; elucidation of psychotropic long-term therapy brain modulation; and identification and quantification of drugs and metabolites in health and disease.
Device for the Isolation of Cells from Tissue Explants
Device to isolate adherent cells from tissue explants, using a non-enzymatic method Improvements: - design allows the distribution of tissue fragments within pre-determined positions and immobilises them between the device and the cell growth area of a tissue culture container - tissue fragments are immobilized throughout the time in culture, favouring cell migration from the explants to the tissue culture container Application of the device for improving the isolation of cells from tissue explants
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