Metabolism, Aging and Disease

Body Barrier Immunometabolism

Early-life Immune Defence

Intestinal Epithelium

Immune Sensing


Innate-like T Cells

Research lines

Micronutrient Sensing and Early Life Immune Defence

Innate-like T cells and Cancer


Early Life Immune System and Microbiota


Body barriers allow organisms to interact with the surrounding world to sense, breath, reproduce and meet their nutritional needs. However, failure of such borders can lead to infectious diseases and cancer.

In the intestine, a healthy interplay between immune cells, epithelial cells, diet and microbes is key in preserving the intestinal epithelial barrier integrity, while also forming a front line of defence against invading pathogens.

Conventional T cells require about a week upon encounter with antigen to provide effective protection. In contrast, innate-like T cells acquire effector properties preprogrammed during development in thymus being poised for rapid and immediate response to changes at the epithelium. However, how this program is initiated is currently unclear.

The Body Barrier Immunometabolism Lab explores how innate like T cells sense dietary cues and how such signals are integrated in their development and function. In recent past, the team showed that, in addition to their developmentally regulated genetic program, immune cells are controlled by environmental cues (Nature 2014; Cell Reports 2015 and J Immunol 2016).

The team mainly focuses on unraveling the mechanisms by which micronutrients shape the development of innate-like T cells and function at mucosal barriers, such as the intestine, exploiting underlying intrinsic molecular pathways in health and disease.

We address these questions combining multi-facetted in vivo- and in vitro-based cellular and molecular technologies. These include state-of-the-art mouse genetics, flow cytometry, confocal and light sheet microscopy as well as gene expression profiling of immune and epithelial subsets.


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Information about journal articles, updated at 17-10-2021, from platform CIÊNCIAVITAE.

(Corresponding Author) Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines

Bruno Bernardes de Jesus; Bruno Miguel Neves; Manuela Ferreira; Sandrina Nóbrega-Pereira, 2020. Cancers. 3581 - 3581. 12. 12. 2020. . 10.3390/cancers12123581 . Cancers

(Co-First Author) Vitamin A controls the presence of RORgt innate lymphoid cells and lymphoid tissue in the small intestine

Goverse, G.; Labao-Almeida, C.; Ferreira, M.; Molenaar, R.; Wahlen, S.; Konijn, T.; Koning, J.; Veiga-Fernandes, H.; Mebius, R.E., 2016. Journal of Immunology. 5148 - 5155. 12. 196. 2016. . 10.4049/jimmunol.1501106 . Journal of Immunology

NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors

Xu, W.; Domingues, R.G.; Fonseca-Pereira, D.; Ferreira, M.; Ribeiro, H.; Lopez-Lastra, S.; Motomura, Y.; et al, 2015. Cell reports. 2043 - 2054. 12. 10. 2015. . 10.1016/j.celrep.2015.02.057 . Cell reports

(Co-First Author) Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Van De Pavert, S.A.; Ferreira, M.; Domingues, R.G.; Ribeiro, H.; Molenaar, R.; Moreira-Santos, L.; Almeida, F.F.; et al, 2014. Nature. 123 - 127. 1. 508. 2014. . 10.1038/nature13158 . Nature

(First Author) Pre-birth world and the development of the immune system: Mum's diet affects our adult health: New insight on how the diet during pregnancy permanently influences offspring health and immune fitness Prospects & Overviews M. Ferreira and H. Veiga-Fernandes

Ferreira, M.; Veiga-Fernandes, H., 2014. BioEssays. 1213 - 1220. 12. 36. 2014. . 10.1002/bies.201400115 . BioEssays

(First Author) Stroma cell priming in enteric lymphoid organ morphogenesis

Ferreira, M.; Domingues, R.G.; Veiga-Fernandes, H., 2012. Frontiers in Immunology. JUL. 3. 2012. . 10.3389/fimmu.2012.00219 . Frontiers in Immunology

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems

Patel, A.; Harker, N.; Moreira-Santos, L.; Ferreira, M.; Alden, K.; Timmis, J.; Foster, K.; et al, 2012. Science Signaling. 235. 5. 2012. . 10.1126/scisignal.2002734 . Science Signaling

(Second Author) The basement membrane of hair follicle stem cells is a muscle cell niche

Fujiwara, H.; Ferreira, M.; Donati, G.; Marciano, D.K.; Linton, J.M.; Sato, Y.; Hartner, A.; et al, 2011. Cell. 577 - 589. 4. 144. 2011. . 10.1016/j.cell.2011.01.014 . Cell

Spatial coupling of mTOR and autophagy augments secretory phenotypes

Narita, M.; Young, A.R.J.; Arakawa, S.; Samarajiwa, S.A.; Nakashima, T.; Yoshida, S.; Hong, S.; et al, 2011. Science. 966 - 970. 6032. 332. 2011. . 10.1126/science.1205407 . Science

TNF-a regulates the effects of irradiation in the mouse bone marrow microenvironment

Cachaço, A.S.; Carvalho, T.; Santos, A.C.; Igreja, C.; Fragoso, R.; Rio, C.O.; Ferreira, M.; et al, 2010. PLoS ONE. 2. 5. 2010. . 10.1371/journal.pone.0008980 . PLoS ONE

(3rd Author) Autophagy mediates the mitotic senescence transition

Young, A.R.J.; Narita, M.; Ferreira, M.; Kirschner, K.; Sadaie, M.; Darot, J.F.J.; Tavaré, S.; et al, 2009. Genes and Development. 798 - 803. 7. 23. 2009. . 10.1101/gad.519709 . Genes and Development

(First Author) An activating ß1 integrin mutation increases the conversion of benign to malignant skin tumors

Ferreira, M.; Fujiwara, H.; Morita, K.; Watt, F.M., 2009. Cancer Research. 1334 - 1342. 4. 69. 2009. . 10.1158/0008-5472.CAN-08-3051 . Cancer Research

(First Author) Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?

Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J., 2005. Cardiovascular Toxicology. 63 - 73. 1. 5. 2005. . Cardiovascular Toxicology



Young Investigator Travel Award | Society for Mucosal Immunology | UK


SPI Best Paper Award 2014 | Portuguese Society of Immunology | PT


SPI Travel Grant | Portuguese Society of Immunology | PT


EMBO Prize Poster Award | EMBO Young Scientists’ Forum | iMM Lisbon | PT

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