Overview

Liliana Simões Mendonça, Assistant Researcher at Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, email: liliana.mendonca@cnc.uc.pt, EDUCATION: Ph.D. in Pharmacy, Pharmaceutical Technology specialty, 2010; Pharm.D., Faculty of Pharmacy, University of Coimbra, Portugal, 2004. WORK EXPERIENCE IN HIGHER EDUCATION INSTITUTIONS: March 2019 - today: Assistant Researcher at Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. June 2017-February 2019: Post-Doctoral Researcher at Center for Neuroscience and Cell Biology, University of Coimbra, Projects: "Early Detection, Neuro-modulation and Advanced Therapies for Neuropathologies" and "The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease". 2016 - 2018: Teaching Assistant at the MSc of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Coimbra. April 2011 - March 2017: Post-Doctoral fellow at Center for Neuroscience and Cell Biology, Coimbra, Project: "The neuroregeneration, neuroprotection, and functional recovery potential of human iPSC-derived NSC in Machado Joseph Disease". January 2005- May 2010: Ph.D. student at the Faculty of Pharmacy, University of Coimbra, Project: "Novel nanotechnological approaches for Chronic Myeloid Leukemia treatment: Molecular and cellular targeting for gene silencing of overexpressed genes". She received funding as Principal Investigator for 4 Research Projects, all in the field of brain neuroprotection and regeneration with stem cell transplantation. She has published 17 articles in journals with peer-review, 2 book chapters, and 1 book (A Handbook of Gene and Cell Therapy). Four of the published papers have an impact factor above 10, and she is the first author of 2 of these papers. She has 2 patents registered and one national provisional patent request, and she also received 9 awards and/or honors. Presently, Liliana is the supervisor of 2 Ph.D. students, 1 Post- Doctoral Researcher, 1 Master's student, and the co-supervisor of 1 Ph.D. student. She is the former supervisor of 2 Bachelor's students, 5 Master's students, and 2 Master's Researchers. She is Guest Associate Editor in Frontiers in Molecular Neuroscience, Brain Disease Mechanisms, in the Research Topic Advanced (Gene and Cell) Therapies for Central Nervous System Applications. She has been a reviewer in the Journals: Medicine, Frontiers in Neuroscience, Molecular Neurobiology, Aging, ACS Biomaterials Science & Engineering, Pharmaceutics, Photonics, and Biomedicine. Liliana works in the areas of Medical and Health Sciences with emphasis on Medical Biotechnology, namely on Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism and Stealth and Intelligent nanovesicles to deliver therapeutic molecules. She has been actively collaborating in projects aiming at the development of Cellular and Gene Therapy-based Medicinal Products commonly known as Advanced Therapy Medicinal Products. An example of this is the work developed in collaboration with the French Biotechnology company Brainvectis Therapeutics for the preclinical development of an advanced therapy medicinal product composed of Adeno-associated virus (AAV) able to promote the overexpression of CYP46A1 protein, which restores brain cholesterol metabolism turnover, affected in several neurodegenerative diseases (patent: WO/2018/138371). In her Ciência Vitae curriculum, the most frequent terms in the context of scientific and technological output are human neuroepithelial stem cells; induced pluripotent stem cells; brain regeneration; neuroprotection; neurodegenerative diseases; Machado-Joseph disease; cerebellar transplantation of human stem cells; cell therapy; gene therapy; lipid-based vehicles; Stealth and Intelligent nanovesicles to deliver therapeutic molecules to the brain, and therapies to improve neuropathology and motor phenotype of brain diseases.

Publications

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Information about journal articles, updated at 19-03-2023, from platform CIÊNCIAVITAE.

Editorial: Global excellence in gene and cell therapy: Europe

Mendonça, Liliana; Boltze, Johannes; Nóbrega, Clévio, Frontiers in Medicine. 10. 2023. http://dx.doi.org/10.3389/fmed.2023.1154360 . 10.3389/fmed.2023.1154360 . published Frontiers in Medicine

Editorial: Advanced (gene and cell) therapies for central nervous system applications

Mendonça, Liliana; Webster, Christopher; Boltze, Johannes; Nóbrega, Clévio, Frontiers in Molecular Neuroscience. 16. 2023. http://dx.doi.org/10.3389/fnmol.2023.1140949 . 10.3389/fnmol.2023.1140949 . published Frontiers in Molecular Neuroscience

The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits

Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al, Brain. 2022. http://dx.doi.org/10.1093/brain/awac473 . 10.1093/brain/awac473 . published Brain

Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases

Brás, João; Henriques, Daniel; Moreira, Ricardo; Santana, Magda M.; Silva-Pedrosa, Rita; Adão, Diana; Braz, Sandra; et al, Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-16369-y . 10.1038/s41598-022-16369-y . Scientific Reports

Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases

Moreira, Ricardo; Mendonça, Liliana S.; Pereira de Almeida, Luís, International Journal of Molecular Sciences. 22. 22. 2021. http://dx.doi.org/10.3390/ijms222212288 . 10.3390/ijms222212288 . International Journal of Molecular Sciences

Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach

Coutinho, Maria Francisca; Santos, Juliana Inês; S. Mendonça, Liliana; Matos, Liliana; Prata, Maria João; S. Jurado, Amália; Pedroso de Lima, Maria C.; Alves, Sandra, International Journal of Molecular Sciences. 16. 21. 2020. http://dx.doi.org/10.3390/ijms21165732 . 10.3390/ijms21165732 . published International Journal of Molecular Sciences

RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3

Nóbrega, Clévio; Codêsso, José Miguel; Mendonça, Liliana; Pereira de Almeida, Luís, Human Gene Therapy. 841 - 854. 7. 30. 2019. http://dx.doi.org/10.1089/hum.2018.157 . 10.1089/hum.2018.157 . published Human Gene Therapy

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado–Joseph disease models

Mendonça, Liliana S; Nóbrega, Clévio; Tavino, Silvia; Brinkhaus, Maximilian; Matos, Carlos; Tomé, Sandra; Moreira, Ricardo; et al, Human Molecular Genetics. 3691 - 3703. 22. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz097 . 10.1093/hmg/ddz097 . Human Molecular Genetics

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; et al, Acta Neuropathologica. 837 - 858. 5. 138. 2019. http://dx.doi.org/10.1007/s00401-019-02019-7 . 10.1007/s00401-019-02019-7 . published Acta Neuropathologica

Understanding how birds rebuild fat stores during migration: insights from an experimental study

Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A., Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-46487-z . 10.1038/s41598-019-46487-z . published Scientific Reports

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models

Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A; Alves-Cruzeiro, João; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al, Human Molecular Genetics. 51 - 63. 1. 28. 2018. http://dx.doi.org/10.1093/hmg/ddy328 . 10.1093/hmg/ddy328 . Human Molecular Genetics

Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review

Alves-Cruzeiro, João M. Da Conceição; Mendonça, Liliana; Pereira de Almeida, Luís; Nóbrega, Clévio, Frontiers in Neuroscience. 10. 2016. http://dx.doi.org/10.3389/fnins.2016.00572 . 10.3389/fnins.2016.00572 . published Frontiers in Neuroscience

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Data in Brief. 700 - 705. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS . 10.1016/j.dib.2016.01.017 . Data in Brief

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Biomaterials. 124 - 137. 82. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS . 10.1016/j.biomaterials.2015.12.021 . published Biomaterials

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease

Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L., Brain. 3537 - 3554. 12. 138. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951031850&partnerID=MN8TOARS . 10.1093/brain/awv298 . published Brain

Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice

Mendonça, Liliana S.; Nóbrega, Clévio; Hirai, Hirokazu; Kaspar, Brian K.; Pereira de Almeida, Luís, Brain. 320 - 335. 2. 138. 2014. http://dx.doi.org/10.1093/brain/awu352 . 10.1093/brain/awu352 . published Brain

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al, Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 . 10.1038/mtna.2013.30 . published Molecular Therapy - Nucleic Acids

Targeted lipid-based systems for siRNA delivery

Mendonça, L.S.; Pedroso de Lima, M.C.; Simões, S., Journal of Drug Delivery Science and Technology. 65 - 73. 1. 22. 2012. http://dx.doi.org/10.1016/s1773-2247(12)50006-7 . 10.1016/s1773-2247(12)50006-7 . published Journal of Drug Delivery Science and Technology

Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment

Mendonça, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Sérgio, Bioconjugate Chemistry. 157 - 168. 1. 21. 2010. http://dx.doi.org/10.1021/bc9004365 . 10.1021/bc9004365 . published Bioconjugate Chemistry

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio, Biotechnology and Bioengineering. 884 - 893. 5. 107. 2010. http://dx.doi.org/10.1002/bit.22858 . 10.1002/bit.22858 . published Biotechnology and Bioengineering

All projects

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Information of exclusive responsibility of the researcher 19-03-2023 , from platform CIÊNCIAVITAE.

2023/01 -

Exploring CITED2 role in glioblastoma stem cell biology

2022.09209.PTDC

Researcher

Universidade do Algarve - Campus de Gambelas

2022/01/01 -

Identification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment

EXPL/MED-NEU/1240/2021

Researcher

Universidade do Algarve - Campus de Gambelas

Funders: Fundação para a Ciência e a Tecnologia

2018/10/13 - 2021/10/13

The role of stress granules in polyglutamine diseases: from pathogenesis to molecular therapy

PTDC/MED-NEU/29480/2017

Researcher

Universidade do Algarve Centro de Investigação em Biomedicina

Funders: Fundação para a Ciência e a Tecnologia

2018/06 - 2022/06

"The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease"

POCI-01-0145-FEDER-030737

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2019

Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK

Ataxia UK2017-2019

Researcher

Universidade do Algarve Centro de Investigação em Biomedicina

Funders: Ataxia UK

2016/01/01 - 2018/12/31

Imaging Gene Therapy in the Brain

P2020­PTDC/BBB­ NAN/0932/2014

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2016/05/10 - 2018/06/30

Does the transplantation of mutant ataxin-3-depleted patient-derived NSC alleviates Machado Joseph disease (MJD)?

20126 [ 2016 ]

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: AFM-Téléthon

2016/01/01 - 2017/12/31

The transplantation of induced pluripotent stem cells (IPSC)-derived neural stem cells (NSC) in Machado Joseph disease (MJD)

NAF2016

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation

2015/03/01 - 2019

Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases

info:eu-repo/grantAgreement/FCT/3599-PPCDT/138566/PT

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2015

Funding of RD Units Strategic Plan - 2013/2015 - OE

CNC. IBILI UID/NEU/04539/2013

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia

2013/01/01 - 2014/12/31

Strategic Project - LA 1 - 2013-2014

info:eu-repo/grantAgreement/FCT/COMPETE/132990/PT

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013/12/31 - 2014/12/31

Transplantation of neural stem cells (NSC) as a new therapeutic strategy for Machado-Joseph disease (MJD)

CPD0021001 (08)

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation

2012/01 - 2015/07

Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells

grant.Provided by PTCRIS: 116512

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2012/04 - 2015/08

Non-invasive-Non-viral Silencing of Machado-Joseph disease

grant.Provided by PTCRIS: 116535

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2009/07 - 2011/12

Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)

grant.Provided by PTCRIS: 109361

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Faculdade de Ciencias e Tecnologia; Universidade de Aveiro; Universidade do Minho; Universidade de Lisboa Faculdade de Farmácia

Funders: Fundação para a Ciência e a Tecnologia

2005/07 - 2008/06

DNA manipulation in bulk and at interfaces

grant.Provided by PTCRIS: 58689

Researcher

Universidade de Coimbra Faculdade de Ciencias e Tecnologia; Universidade de Coimbra Centro de Química de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

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