Joana Ribeiro Guedes

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Information about journal articles, updated at 24-09-2023, from platform CIÊNCIAVITAE.

IL-4 Shapes Microglia-Dependent Pruning of the Cerebellum During Postnatal Development

Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Reis, Tiago; Cardoso, Ana Maria; Lebre, Carolina; et al, SSRN Electronic Journal. 2022. . 10.2139/ssrn.4281069 . SSRN Electronic Journal

Microglia-dependent remodeling of neuronal circuits

Guedes, J. R.; Ferreira, P.A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João, Journal of Neurochemistry. 2022. . 10.1111/jnc.15689 . Journal of Neurochemistry

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, Nature Communications. 2022. . 10.1038/s41467-022-31791-6 . Nature Communications

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al, Molecular Psychiatry. 2022. . 10.1038/s41380-022-01487-w . Molecular Psychiatry

The old guard: Age-related changes in microglia and their consequences

Costa, Jéssica; Martins, Solange; Ferreira, Pedro A.; Cardoso, Ana M.S.; Guedes, Joana R.; Peça, João; Cardoso, Ana L., Mechanisms of Ageing and Development. 197. 2021. . 10.1016/j.mad.2021.111512 . Mechanisms of Ageing and Development

Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling

Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al, Neuropsychopharmacology. 2020. . 10.1038/s41386-020-0727-7 . Neuropsychopharmacology

Glioblastoma hijacks microglial gene expression to support tumor growth

Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, J. R.; et al, Journal of Neuroinflammation. 1. 17. 2020. . 10.1186/s12974-020-01797-2 . Journal of Neuroinflammation

MiRNA-31 improves cognition and abolishes amyloid-ß pathology by targeting APP and BACE1 in an animal model of Alzheimer’s disease

Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cunha, Pedro; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; et al, Molecular Therapy - Nucleic Acids. 2020. IF=5.919 . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Mohamed Edfawy; Joana R. Guedes; Marta I. Pereira; Mariana Laranjo; Mário J. Carvalho; Xian Gao; Pedro A. Ferreira; et al, Nature Communications. 2019. IF=11.878 . 10.1038/s41467-019-09382-9 . Nature Communications

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al, Ageing Research Reviews. 214 - 277. 47. 2018. IF=10.39 . 10.1016/j.arr.2018.07.004 . published Ageing Research Reviews

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies

Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph, Frontiers in Neurology. 9. 2018. IF=2.635 . 10.3389/fneur.2018.00549 . published Frontiers in Neurology

miRNAs: New biomarkers and therapeutic targets in dementia

Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C., Current Pharmaceutical Design. 669 - 692. 5. 23. 2017. IF=2.412 . 10.2174/1381612823666170111094702 . published Current Pharmaceutical Design

MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L., Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 7 - 17. 3. 2016. IF=5.28 . 10.1016/j.dadm.2015.11.004 . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

Cardoso, Ana L*; Guedes, Joana R*; de Lima, Maria C Pedroso; *equal contribution, Current Opinion in Pharmacology. 1 - 9. 26. 2016. IF=5.203 . 10.1016/j.coph.2015.09.001 . published Current Opinion in Pharmacology

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

Guedes, Joana R.; Custódia, Carlos M.; Silva, Ricardo J.; de Almeida, Luís P.; Pedroso de Lima, Maria C.; Cardoso, Ana L., Human Molecular Genetics. 6286 - 6301. 23. 23. 2014. IF=4.544 . 10.1093/hmg/ddu348 . Human Molecular Genetics

Involvement of MicroRNA in Microglia-Mediated Immune Response

Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C., Clinical and Developmental Immunology. 1 - 11. 2013. 2013. IF=3.603 . 10.1155/2013/186872 . published Clinical and Developmental Immunology

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

Cardoso, A. L.; Guedes, J. R.; de Almeida, L. P.; Pedroso de Lima, M. C., Immunology. 73 - 88. 1. 135. 2012. 10.1111/j.1365-2567.2011.03514.x. IF=4.147 . 10.1111/j.1365-2567.2011.03514.x . published Immunology

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Information of exclusive responsibility of the researcher 24-09-2023 , from platform CIÊNCIAVITAE.

2023/03/01 - 2025/12

Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits


Principal investigator

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2022/03/01 -

BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids



Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/02/01 -

Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies



Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2019

The influence of maternal bonding in microglia-mediated synaptic pruning

Fundação Bial 264/2016



Funders: Bial

2016 - 2019

Early-life stress and social hierarchies: the role of cortico-striatal circuits

Fundação Bial 266/2016



Funders: Bial

2016/06 - 2017/03

Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation


Post-doc Fellow


Funders: Fundação para a Ciência e a Tecnologia

2013 - 2016

Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease



Funders: Fundação para a Ciência e a Tecnologia

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