Center for Neuroscience and Cell Biology, University of Coimbra


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Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes

Alphonse Laya; Honoré Wangso; Iva Fernandes; Raphaël Djakba; Joana Oliveira; Eugenia Carvalho; Wen yi Kang, Journal of Food Quality. 2023. . 10.1155/2023/5236509 . Journal of Food Quality

Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers

Jessica Da Silva; Ermelindo C. Leal; Eugénia Carvalho; Eduardo A. Silva, International Journal of Molecular Sciences. 2023. . 10.3390/ijms24129900 . International Journal of Molecular Sciences

Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study

Jessica Da Silva; Diana Santos; Margarida Vilaça; André Carvalho; Rui Carvalho; Maria de Jesus Dantas; M. Graça Pereira; Eugénia Carvalho, Advances in Wound Care. 2023. . 10.1089/wound.2023.0043 . Advances in Wound Care

Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

M. Graça Pereira; Margarida Vilaça; Diogo Braga; Ana Madureira; Jéssica Da Silva; Diana Santos; Eugénia Carvalho, Wound Repair and Regeneration. 2023. . 10.1111/wrr.13141 . Wound Repair and Regeneration

Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study

Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho, European Journal of Clinical Investigation. 2023. . 10.1111/eci.14128 . European Journal of Clinical Investigation

Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers

Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal, Antibiotics. 2023. . 10.3390/antibiotics12030467 . Antibiotics

Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model

Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho, Journal of Molecular Endocrinology. 2023. . 10.1530/JME-22-0122 . Journal of Molecular Endocrinology

Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity

Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho, Life Sciences. 2023. . 10.1016/j.lfs.2022.121246 . Life Sciences

Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?

Pedro Barbosa; Eugenia Carvalho, Diabetology. 2023. . 10.3390/diabetology4010005 . Diabetology

Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers

Ermelindo Carreira Leal; Eugenia Carvalho, International Journal of Molecular Sciences. 2022. . 10.3390/ijms231912043 . International Journal of Molecular Sciences

Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers

M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho, International Journal of Environmental Research and Public Health. 2022. . 10.3390/ijerph19148556 . International Journal of Environmental Research and Public Health

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho, Metabolites. 2022. . 10.3390/metabo12020184 . Metabolites

Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial

Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO, Annals of the Brazilian Academy of Sciences. 1. 94. 2021. . 10.1590/0001-3765202220201819 . accepted Annals of the Brazilian Academy of Sciences

Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota

Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development

Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway

Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, The Journal of Nutritional Biochemistry. 2021. . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry

Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice

Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet, JBMR Plus. 7. 5. 2021. . 10.1002/jbm4.10508 . JBMR Plus

mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate

Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia, Stem Cell Reviews and Reports. 2021. . 10.1007/s12015-021-10131-z . accepted Stem Cell Reviews and Reports

Redox Imbalance and Methylation Disturbances in Early Childhood Obesity

Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, Oxidative Medicine and Cellular Longevity. 2021. . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity

Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue

Diana Santos; Eugenia Carvalho, The Journal of Physiology. 2021. . 10.1113/JP280917 . The Journal of Physiology

Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds

Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho, Current Diabetes Reviews. 2021. . 10.2174/1573399817666210806112813 . Current Diabetes Reviews

Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk

Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi, BMC Nutrition. 1. 6. 2020. . 10.1186/s40795-020-00338-7 . BMC Nutrition

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling

Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, Aging Cell. 11. 19. 2020. . 10.1111/acel.13261 . Aging Cell

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp, Cells. 10. 9. 2020. . 10.3390/cells9102228 . Cells

Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P., Microorganisms. 10. 8. 2020. . 10.3390/microorganisms8101500 . Microorganisms

Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes

Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia, Pharmacological Research. 159. 2020. . 10.1016/j.phrs.2020.104977 . Pharmacological Research

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, Life Sciences. 254. 2020. . 10.1016/j.lfs.2020.117813 . Life Sciences

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, Brain Research Bulletin. 106 - 115. 161. 2020. . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia, Cellular & Molecular Immunology. 2019. . 10.1038/s41423-019-0233-1 . Cellular & Molecular Immunology

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al, Scientific Reports. 1. 9. 2019. . 10.1038/s41598-019-42309-4 . Scientific Reports

Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model

Carvalho, Eugenia, Cellular Physiology and Biochemistry. 503 - 516. 3. 52. 2019. . 10.33594/000000036 . Cellular Physiology and Biochemistry

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, ACS Nano. 8694 - 8707. 8. 13. 2019. . 10.1021/acsnano.9b00376 . ACS Nano

Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain

Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi, Brain Research Bulletin. 2019. . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin

A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women

Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet, American Journal of Physiology-Endocrinology and Metabolism. E503 - E512. 3. 317. 2019. . 10.1152/ajpendo.00084.2019 . American Journal of Physiology-Endocrinology and Metabolism

Immune aging in diabetes and its implications in wound healing

Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., Clinical Immunology. 43 - 54. 200. 2019. . 10.1016/j.clim.2019.02.002 . Clinical Immunology

Neurotensin, substance P, and insulin enhance cell migration

Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. . 10.1002/psc.3093 . Journal of Peptide Science

Calcineurin is an important factor involved in glucose uptake in human adipocytes

Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira, Molecular and Cellular Biochemistry. 157 - 168. 1-2. 445. 2018. . 10.1007/s11010-017-3261-0 . Molecular and Cellular Biochemistry

Wanted: MicroRNAs to the aid of the diabetic foot

Louise T. Dalgaard; Eugenia Carvalho, Trends in Cardiovascular Medicine. 2018. . 10.1016/j.tcm.2018.09.002 . Trends in Cardiovascular Medicine

Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults

Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet, Current Developments in Nutrition. 11. 1. 2017. . 10.3945/cdn.117.002071 . Current Developments in Nutrition

Impaired T-cell differentiation in diabetic foot ulceration.

Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, Cellular & molecular immunology. 2017. . 10.1038/cmi.2015.116 . Cellular & molecular immunology

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E, Nutrients. 2017. . 10.3390/nu9060638 . Nutrients

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.

Pereira SG; Moura J; Carvalho E; Empadinhas N, Frontiers in microbiology. 2017. . 10.3389/fmicb.2017.01791 . Frontiers in microbiology

Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.

Emanuelli T; Burgeiro A; Carvalho E, Archives of dermatological research. 2016. . 10.1007/s00403-016-1686-z . Archives of dermatological research

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, Biochimica et biophysica acta. 2016. . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta

Mast Cells Regulate Wound Healing in Diabetes.

Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al, Diabetes. 2016. . 10.2337/db15-0340 . Diabetes

Reply to Katlandur, Ozbek, and Keser.

Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A, American journal of physiology. Endocrinology and metabolism. 2016. . 10.1152/ajpendo.00113.2016 . American journal of physiology. Endocrinology and metabolism

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.

Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al, American journal of physiology. Endocrinology and metabolism. 2016. . 10.1152/ajpendo.00384.2015 . American journal of physiology. Endocrinology and metabolism

Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat

Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F., Journal of Physiology and Pharmacology. 285 - 299. 2. 66. 2015. . Journal of Physiology and Pharmacology

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?

Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F, Journal of diabetes research. 2015. . 10.1155/2015/806979 . Journal of diabetes research

Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype

Carvalho, Eugenia, Am J Pathol. 2015. . Am J Pathol

Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats

Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., Metabolism: Clinical and Experimental. 702 - 715. 5. 63. 2014. . 10.1016/j.metabol.2014.02.004 . Metabolism: Clinical and Experimental

Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression

Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., International Journal of Inflammation. 2014. 2014. . 10.1155/2014/248240 . International Journal of Inflammation

The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes

Moura, L.I.; Cruz, M.T.; Carvalho, E., Experimental Biology and Medicine. 6 - 12. 1. 239. 2014. . 10.1177/1535370213510665 . Experimental Biology and Medicine

The role of micrornas in diabetic complications—special emphasis on wound healing

Moura, J.; Børsheim, E.; Carvalho, E., Genes. 926 - 956. 4. 5. 2014. . 10.3390/genes5040926 . Genes

Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model

Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al, International Journal of Molecular Sciences. 8979 - 8997. 5. 15. 2014. . 10.3390/ijms15058979 . International Journal of Molecular Sciences

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment

Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., Biochemical Pharmacology. 61 - 73. 1. 91. 2014. . 10.1016/j.bcp.2014.06.014 . Biochemical Pharmacology

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model

Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E., Biochemical Pharmacology. 216 - 228. 2. 88. 2014. . 10.1016/j.bcp.2014.01.020 . Biochemical Pharmacology

Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing

Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E.; Moura, Liane I F; et al, Acta Biomaterialia. 843 - 857. 2. 10. 2014. . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia

Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review

Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C., Acta Biomaterialia. 7093 - 7114. 7. 9. 2013. . 10.1016/j.actbio.2013.03.033 . Acta Biomaterialia

Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers

Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, PLoS ONE. 12. 8. 2013. . 10.1371/journal.pone.0083314 . PLoS ONE

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions

Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., BioMed Research International. 2013. 2013. . 10.1155/2013/941764 . BioMed Research International

Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus

Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al, Transplantation Proceedings. 1149 - 1156. 3. 45. 2013. . 10.1016/j.transproceed.2013.02.085 . Transplantation Proceedings

Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing

Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., Archives of Dermatological Research. 557 - 569. 7. 305. 2013. . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research

The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W.; et al, Molecular and Cellular Endocrinology. 260 - 269. 2. 365. 2013. . 10.1016/j.mce.2012.10.030 . Molecular and Cellular Endocrinology

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model

Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E., Transplantation Proceedings. 1142 - 1148. 3. 45. 2013. . 10.1016/j.transproceed.2013.02.009 . Transplantation Proceedings

Increased skin inflammation and blood vessel density in human and experimental diabetes

Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds

Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker

Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F., Cardiovascular Diabetology. 1. 12. 2013. . 10.1186/1475-2840-12-44 . Cardiovascular Diabetology

Spatial memory impairments in a prediabetic rat model

Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, Neuroscience. 565 - 577. 250. 2013. . 10.1016/j.neuroscience.2013.07.055 . Neuroscience

Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease

Cherian, S.; Lopaschuk, G.D.; Carvalho, E., American Journal of Physiology - Endocrinology and Metabolism. 8. 303. 2012. . 10.1152/ajpendo.00061.2012 . American Journal of Physiology - Endocrinology and Metabolism

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F., Journal of Pharmacology and Pharmacotherapeutics. 143 - 148. 2. 3. 2012. . 10.4103/0976-500X.95513 . Journal of Pharmacology and Pharmacotherapeutics

Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression

da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., Biochimica et Biophysica Acta - Molecular Cell Research. 1863 - 1871. 10. 1813. 2011. . 10.1016/j.bbamcr.2011.06.018 . Biochimica et Biophysica Acta - Molecular Cell Research

Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells

Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., PLoS ONE. 1. 6. 2011. . 10.1371/journal.pone.0016114 . PLoS ONE

Study of the antidiabetic capacity of the VO(dmpp)2 complex

Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. . 10.1016/j.jinorgbio.2010.05.004 . Journal of Inorganic Biochemistry

Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing

Da Silva, L.; Carvalho, E.; Cruz, M.T., Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy

Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes

Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M.; Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C., Journal of Inorganic Biochemistry. 1687 - 1692. 12. 103. 2009. . 10.1016/j.jinorgbio.2009.09.015 . Journal of Inorganic Biochemistry

Substance P as a Novel Anti-obesity Target

Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E., Gastroenterology. 3. 134. 2008. . 10.1053/j.gastro.2007.12.032 . Gastroenterology

Elimination of glucose contamination from adipocyte glycogen extracts

Nunes, P.M.; Carvalho, E.; Jones, J.G.; Nunes, Patricia M.; Carvalho, Eugénia; Jones, John G., Carbohydrate Research. 1486 - 1489. 9. 343. 2008. . 10.1016/j.carres.2008.04.004 . Carbohydrate Research

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B., American Journal of Physiology - Endocrinology and Metabolism. 4 52-4. 289. 2005. . 10.1152/ajpendo.00116.2005 . American Journal of Physiology - Endocrinology and Metabolism

Evidence of impaired adipogenesis in insulin resistance

Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U., Biochemical and Biophysical Research Communications. 1045 - 1051. 4. 317. 2004. . 10.1016/j.bbrc.2004.03.152 . Biochemical and Biophysical Research Communications

GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase

Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al, Journal of Biological Chemistry. 21598 - 21605. 20. 279. 2004. . 10.1074/jbc.M312269200 . Journal of Biological Chemistry

A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin

Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al, FASEB Journal. 1434 - 1440. 11. 17. 2003. . 10.1096/fj.02-1132com . FASEB Journal

Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.

Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects

Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U., Diabetologia. 1107 - 1115. 9. 43. 2000. . 10.1007/s001250051501 . Diabetologia

PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes

Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C., Biochemical and Biophysical Research Communications. 315 - 320. 2. 268. 2000. . 10.1006/bbrc.2000.2145 . Biochemical and Biophysical Research Communications

Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4

Carvalho, E.; Rondinone, C.; Smith, U., Molecular and Cellular Biochemistry. 7 - 16. 1-2. 206. 2000. . Molecular and Cellular Biochemistry

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor

Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P., Journal of Biological Chemistry. 10093 - 10098. 14. 275. 2000. . 10.1074/jbc.275.14.10093 . Journal of Biological Chemistry

Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus

Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P., Diabetologia. 819 - 825. 7. 42. 1999. . 10.1007/s001250051232 . Diabetologia

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U., FASEB Journal. 2173 - 2178. 15. 13. 1999. . FASEB Journal

Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme

Carvalho, E.; Aasa, R.; Göthe, P.-O., Journal of Inorganic Biochemistry. 147 - 153. 2. 62. 1996. . 10.1016/0162-0134(95)00143-3 . Journal of Inorganic Biochemistry

Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme

Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L., European Journal of Biochemistry. 780 - 785. 3. 234. 1995. . European Journal of Biochemistry

All projects

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Information of exclusive responsibility of the researcher 17-12-2023 , from platform CIÊNCIAVITAE.

2024/01/01 - 2025/12/31

Empoderar as comunidades para prevenção e cuidados da diabetes, uma abordagem integral e sustentável em Bissau


Co-Principal Investigator (Co-PI)

2023 - 2025

Diabetes management, prevention, and education in Guinea-Bissau

Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat

Co-Principal Investigator (Co-PI)

2023/03/01 - 2024/10/31

Purinergic signaling and metabolism, mycobiota control and obesity


Co-Principal Investigator (Co-PI)

Universidade de Coimbra

Funders: Biocodex Centre de recherche

2022 - 2027

PAS-GRAS - De-risking metabolic, environmental, and behavioral determinants of obesity in children, adolescents and young-adults


Co-Principal Investigator (Co-PI)

Universidade de Coimbra

2022/08 - 2024/10

ANGIOHEAL A new view on chronic wound healing treatment: Synergistic interplay between low-dose ionizing radiation and pre-vascularized dermal spheroids.


Integration into Research Grant Fellow

2022/05/01 - 2022/09/30

Twinning Innovation - Protein enrichment of baked goods for people with special needs


Co-Principal Investigator (Co-PI)

Universidade de Coimbra; Universität Hohenheim

2022/04/01 - 2024/01/01

Diabetes diagnosis, management, prevention, and education in Guinea-Bissau


2019/01/01 - 2020/12/01

MicroRNAs as markers of disturbed adipose tissue function and inflammation - a potential mechanism for diabetes development in obesity

COM Child Health project grant


University of Arkansas for Medical Sciences

2019/01/01 - 2019/12/01

Role of Regulatory T-cells in Obesity-Linked Insulin Resistance and Diabetes

COM Sturgis project grant


University of Arkansas for Medical Sciences

Funders: N/A

2019/03/01 - 2020/12/01

CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients

Portuguese Transplant Society


2019/01 - 2020/12

MicroRNAs as markers of disturbed adipose tissue function and inflammation - a potential mechanism for diabetes development in obesity

COM Child Health project grant


University of Arkansas for Medical Sciences

Funders: N/A

2019/01 - 2019/12

Role of Regulatory T-cells in Obesity-Linked Insulin Resistance and Diabetes

COM Sturgis project grant

Funders: N/A

2019/03 - 2020/12

CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients

Portuguese Transplant Society

Funders: N/A

2018 - 2021

Antipsychotic drug induced metabolic dysfunction – in vivo studies with 2 specific drugs



2018/02/01 - 2020/01/01

Effects of PTP1b modulation on Wound Healing, in vitro and in vivo systems



Diabetes UK

Funders: Diabetes UK

2018/11/01 - 2021/12/01

Contribution of Psychological Factors in Diabetic Foot Ulcer Healing; in Physiological Indicators of Wound Healing Prognosis and Quality of Life: A Randomized Longitudinal Effectiveness Evaluation

02/SAICT/2017 – SAICT


Fundação para a Ciência e a Tecnologia

2017 - 2019/12

Microbiome of the diabetic foot ulcer in human subjects.



2017 - 2019/12/31

Assessment of oxidative capacity in obese children.



2017 - 2019/12

Establishing the presence of mitochondrial dysfunction and oxidative stress and the relationships with resting energy expenditure and fatty acid oxidation in childhood obesity.



2017 - 2019/12

European and Portuguese funds for Human Resources



2016 - 2018

Combination therapy synergistically accelerates diabetic wound closure.

European Research Program in Microvascular Complications of Diabetes supported by Novartis


European Foundation for the Study of Diabetes

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