Neurociências e Doença

Neuroendocrinologia e Envelhecimento

Envelhecimento

Hipotálamo

Neuropeptídeos

Restrição calórica

Relógios Biológicos

Ritmo circadiano

Cilios Primários

Exossomas

Inflamação

Senescência

Sono

Doenças neurodegenerativas e do Sono, Progeria

Longevidade saudável

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Líder

Cláudia Cavadas

Investigador(a)


Linhas de interesse

Funções do hipotálamo como reguladores do envelhecimento e longevidade

Estratégias Neuroendócrinas e Fármacos para bloquear, adiar ou inverter os marcadores celulares do envelhecimento e doenças associadas

Sono e Ritmos Biológicos no Envelhecimento e Doenças associadas

Estratégias alimentares ou nutricionais, como a restrição calórica, e mecanismos relacionados, na prevenção de doenças associadas ao envelhecimento e promoção da longevidade saudável

Senescência, Cilios Primários e Inflamação Crónica no Envelhecimento e nas Doenças

Visão Geral

O Grupo de Neuroendocrinologia e Envelhecimento tem como missão contribuir para o desenvolvimento de investigação na área do envelhecimento, nomeadamente demonstrar que a intervenção no sistema neuroendócrino, e funções associadas, em modelos experimentais pode atrasar, parar e, em alguns exemplos, inverter as manifestações do envelhecimento e dos  distúrbios e doenças associados ao envelhecimento.

Objetivos

  • Investigar a contribuição do eixo neuroendócrino para o envelhecimento e distúrbios relacionados com o envelhecimento;
  • Investigar novas estratégias para atrasar o envelhecimento e os distúrbios relacionados com o envelhecimento, direcionado ao hipotálamo ou aos mecanismos relacionados com as funções do hipotálamo (ritmo circadiano, sono, ingestão de alimentos);
  • Utilizar estratégias miméticas de restrição calórica, como neuropeptídeos, novos ativadores de sirtuins-1, e restabelecimento do ritmo circadiano para prevenir o envelhecimento e doenças ou disfunções associadas ao envelhecimento (disfunção do metabolismo, osteoartrite (OA), disfunções do sono, doenças neurodegenerativas);
  • Compreender se e como o Síndrome de Apneia Obstrutiva do Sono (SAOS)  ou a insónia induzem ou aceleram os mecanismos moleculares do envelhecimento.

O grupo tem competências no estabelecimento de modelos celulares e animais de envelhecimento e distúrbios relacionados à idade (progéria, doenças neurodegenerativas, OSA, OA, insónia, disfunção metabólica e obesidade), marcadores fisiológicos, celulares e moleculares (nomeadamente autofagia , senescência, inflamação), abordagens de transferência de genes, análise do ritmo circadiano, química medicinal,  estudos pré-clínicos e atividades de envolvimento do público com a ciência.

Artigos em Destaque

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Informação sobre artigos em revista, actualizada a 26-05-2024, a partir da plataforma CIÊNCIAVITAE.

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Ferreira-Marques M; Aveleira CA; Carmo-Silva S; Botelho M; Pereira de Almeida L; Cavadas C; Ferreira-Marques, Marisa; et al, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://europepmc.org/abstract/med/27441412 . 10.18632/aging.100996 . Aging

Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes

Sara Carmo-Silva; Marisa Ferreira-Marques; Clévio Nóbrega; Mariana Botelho; Daniela Costa; Célia A Aveleira; Stefan M Pulst; Luís Pereira de Almeida; Claudia Cavadas, 2023. Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-21-0272 . 10.1530/JME-21-0272 . Journal of Molecular Endocrinology

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Lucas, Vasco; Cavadas, Cláudia; Aveleira, Célia Alexandra, 2023. Pharmacological Reviews. 675 - 713. 4. 75. 2023. http://dx.doi.org/10.1124/pharmrev.122.000622 . 10.1124/pharmrev.122.000622 . Pharmacological Reviews


Publicações

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Informação sobre artigos em revista, actualizada a 26-05-2024, a partir da plataforma CIÊNCIAVITAE.

Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

Leal, Helena; Carvalhas-Almeida, Catarina; Álvaro, Ana Rita; Cavadas, Cláudia, 2024. Trends in Endocrinology & Metabolism. 2024. http://dx.doi.org/10.1016/j.tem.2024.01.001 . 10.1016/j.tem.2024.01.001 . published Trends in Endocrinology & Metabolism

Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

Cavadas, Claudia; Álvaro, Ana Rita ; Leal, Helena; Carvalhas de Almeida, Catarina, 2024. Trends Endocrinolology Metabolism. 2024. https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00001-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1043276024000018%3Fshowall%3Dtrue . published Trends Endocrinolology Metabolism

Understanding neuron-glia crosstalk and biological clocks in insomnia

Catarina Carvalhas-Almeida; Joana Serra; Joaquim Moita; Cláudia Cavadas; Ana Rita Álvaro, 2023. Neuroscience & Biobehavioral Reviews. 2023. https://doi.org/10.1016/j.neubiorev.2023.105100 . 10.1016/j.neubiorev.2023.105100 . Neuroscience & Biobehavioral Reviews

Ghrelin delays premature aging in <scp>Hutchinson-Gilford</scp> progeria syndrome

Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Botelho, Mariana; Carmo-Silva, Sara; Águas, Rodolfo; et al, 2023. Aging Cell. 12. 22. 2023. http://dx.doi.org/10.1111/acel.13983 . 10.1111/acel.13983 . published Aging Cell

Molecular Mechanisms Underlying the Anti-Inflammatory Properties of (R)-(-)-Carvone: Potential Roles of JNK1, Nrf2 and NF-¿B

Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes, 2023. Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15010249 . 10.3390/pharmaceutics15010249 . Pharmaceutics

Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes

Sara Carmo-Silva; Marisa Ferreira-Marques; Clévio Nóbrega; Mariana Botelho; Daniela Costa; Célia A Aveleira; Stefan M Pulst; Luís Pereira de Almeida; Claudia Cavadas, 2023. Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-21-0272 . 10.1530/JME-21-0272 . Journal of Molecular Endocrinology

Synthesis of Carvone Derivatives and In Silico and In Vitro Screening of Anti-Inflammatory Activity in Murine Macrophages

Gabriela Moço; Cátia Sousa; Ana Capitão; Stephen S MacKinnon; Alcino Leitão; A. F. Mendes, 2023. International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/3/2263 . 10.3390/ijms24032263 . International Journal of Molecular Sciences

Lipodystrophy as a target to delay premature aging

Daniela G. Costa; Marisa Ferreira-Marques; Cláudia Cavadas, 2023. Trends in Endocrinology & Metabolism. 2023. https://doi.org/10.1016/j.tem.2023.10.006 . 10.1016/j.tem.2023.10.006 . Trends in Endocrinology & Metabolism

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Lucas, Vasco; Cavadas, Cláudia; Aveleira, Célia Alexandra, 2023. Pharmacological Reviews. 675 - 713. 4. 75. 2023. http://dx.doi.org/10.1124/pharmrev.122.000622 . 10.1124/pharmrev.122.000622 . Pharmacological Reviews

Primary cilia shape hallmarks of health and aging.

Silva DF; Cavadas C; Claudia Cavadas, 2023. Trends in molecular medicine. 2023. https://doi.org/10.1016/j.molmed.2023.04.001 . 10.1016/j.molmed.2023.04.001 . Trends in molecular medicine

PET Imaging of the Neuropeptide Y System: A Systematic Review.

Fonseca ICF; Castelo-Branco M; Cavadas C; Abrunhosa AJ, 2022. Molecules (Basel, Switzerland). 2022. http://europepmc.org/abstract/med/35744852 . 10.3390/molecules27123726 . Molecules (Basel, Switzerland)

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas, 2022. Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02257-y . 10.1007/s40520-022-02257-y . Aging Clinical and Experimental Research

Ataxin-2 in the hypothalamus at the crossroads between metabolism & circadian rhythm (under revision)

Carmo-Silva, Sara; Ferreira-Marques, M; Nóbrega, Clévio David Rodrigues ; Botelho M; Costa, D; Aveleira C; Pulst, Stefan; Almeida, Luís Pereira de; Cavadas, Claudia, 2022. Journal of Molecular Endocrinology. 2022. under revision Journal of Molecular Endocrinology

The impact of insomnia on frailty and the hallmarks of aging

Catarina Carvalhas-Almeida; Cláudia Cavadas; Ana Rita Álvaro, 2022. Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02310-w . 10.1007/s40520-022-02310-w . Aging Clinical and Experimental Research

The impact of insomnia on frailty and the hallmarks of aging

Catarina Carvalhas-Almeida; Cláudia Cavadas; Ana Rita Álvaro, 2022. Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02310-w . 10.1007/s40520-022-02310-w . Aging Clinical and Experimental Research

Skin senescence: mechanisms and impact on whole-body aging

Ana Catarina Franco; Célia Aveleira; Cláudia Cavadas, 2022. Trends in Molecular Medicine. 2022. https://doi.org/10.1016/j.molmed.2021.12.003 . 10.1016/j.molmed.2021.12.003 . Trends in Molecular Medicine

Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases

Brás, João; Henriques, Daniel; Moreira, Ricardo; Santana, Magda M.; Silva-Pedrosa, Rita; Adão, Diana; Braz, Sandra; et al, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-16369-y . 10.1038/s41598-022-16369-y . Scientific Reports

Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis

Gaspar, Laetitia S.; Santos-Carvalho, Ana; Santos, Bárbara; Carvalhas-Almeida, Catarina; Barros-Viegas, Ana Teresa; Oliveiros, Bárbara; Donato, Helena; et al, 2022. Sleep Medicine Reviews. 64. 2022. http://dx.doi.org/10.1016/j.smrv.2022.101659 . 10.1016/j.smrv.2022.101659 . Sleep Medicine Reviews

Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases

Cátia Sousa; Alexandrina Ferreira Mendes, 2022. Biomolecules. 2022. https://doi.org/10.3390/biom12070921 . 10.3390/biom12070921 . Biomolecules

A look on food intake and satiety: from humans to rodent models

Cavadas, Claudia; Almeida, Cláudia; Cavadas, Cláudia; Carmo-Silva, Sara, 2022. Nutrition Reviews. 1942 - 1957. 8. 80. 2022. http://dx.doi.org/10.1093/nutrit/nuac010 . 10.1093/nutrit/nuac010 . Nutrition Reviews

Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis.

Gaspar LS; Santos-Carvalho A; Santos B; Carvalhas-Almeida C; Barros-Viegas AT; Oliveiros B; Donato H; et al, 2022. Sleep medicine reviews. 2022. http://europepmc.org/abstract/med/35753150 . 10.1016/j.smrv.2022.101659 . Sleep medicine reviews

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway.

Leal H; Cardoso J; Valério P; Quatorze M; Carmona V; Cunha-Santos J; Pereira de Almeida L; et al, 2022. International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/35743232 . 10.3390/ijms23126790 . International journal of molecular sciences

Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun scaffold fabrication

Semitela, Ângela; Ramalho, Gonçalo; Capitão, Ana; Sousa, Cátia; Mendes, Alexandrina F; AAP Marques, Paula; Completo, António, 2022. Journal of Tissue Engineering. 13. 2022. http://dx.doi.org/10.1177/20417314211069342 . 10.1177/20417314211069342 . Journal of Tissue Engineering

Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea (EBioMedicine)

Laetitia S. Gaspar; Janina Hesse; Müge Yalçin; Bárbara Santos; Catarina Carvalhas-Almeida; Mafalda Ferreira; Joaquim Moita; et al, 2021. EBioMedicine. 2021. https://doi.org/10.1016/j.ebiom.2021.103248 . 10.1016/j.ebiom.2021.103248 . in press EBioMedicine

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Cavadas, Claudia, 2021. Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Long-term Continuous Positive Airway Pressure Treatment Ameliorates Biological Clock Disruptions in Obstructive Sleep Apnea

C014-4DE9-206C; Janina Hesse; Müge Yalçin; 0F1A-8AFD-63A0; Catarina Carvalhas-Almeida; Mafalda Ferreira; B01F-45DC-F6D7; et al, 2021. Ebiomedicine. 2021. in press Ebiomedicine

Multi-layered electrospinning and electrospraying approach: Effect of polymeric supplements on chondrocyte suspension

Semitela, Ângela; Leal Pereira, Andreia; Sousa, Cátia; Mendes, Alexandrina F.; Marques, Paula A.A.P.; Completo, António, 2021. Journal of Biomaterials Applications. 2021. http://dx.doi.org/10.1177/08853282211064403 . 10.1177/08853282211064403 . Journal of Biomaterials Applications

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Gaspar, Laetitia S.; Sousa, Cátia; Álvaro, Ana Rita; Cavadas, Cláudia; Mendes, Alexandrina Ferreira, 2021. Pharmacological Research. 164. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research

Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease.

Cavadas, Claudia, 2021. Scientific reports. 2021. https://europepmc.org/articles/PMC7870889 . 10.1038/s41598-021-82339-5 . Scientific reports

Effects of short-term exposure to genistein and overfeeding diet on the neural and retinal progenitor competence of adult zebrafish (Danio rerio)

Luzio, A.; Figueiredo, M.; Matos, M.M.; Coimbra, A.M.; Álvaro, A.R.; Monteiro, S.M., 2021. Neurotoxicology and Teratology. 88. 2021. http://dx.doi.org/10.1016/j.ntt.2021.107030 . 10.1016/j.ntt.2021.107030 . published Neurotoxicology and Teratology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Copper impair autophagy on zebrafish (Danio rerio) gill epithelium

Luzio, A.; Parra, S.; Costa, B.; Santos, D.; Álvaro, A.R.; Monteiro, S.M., 2021. Environmental Toxicology and Pharmacology. 86. 2021. http://dx.doi.org/10.1016/j.etap.2021.103674 . 10.1016/j.etap.2021.103674 . published Environmental Toxicology and Pharmacology

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

Cavadas, Claudia, 2021. Aging. 2021. https://doi.org/10.18632/aging.202805 . 10.18632/aging.202805 . Aging

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Laetitia S. Gaspar; Cátia Sousa; Ana Rita Álvaro; Cláudia Cavadas; Alexandrina Ferreira Mendes, 2021. Pharmacological Research. 105369 - 105369. 2021. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research

The NutriClock Study Protocol - Assessing the Impact of a Chrononutrition Intervention in Patients With Cardiometabolic Disturbances

Lages, Marlene; Gaspar, Laetitia; Carmo-Silva, Sara; Frontini, Roberta; Álvaro, Ana; Cavadas, Cláudia; Fonseca, Rui; et al, 2021. Current Developments in Nutrition. 468 - 468. Supplement. 5. 2021. http://dx.doi.org/10.1093/cdn/nzab039_004 . 10.1093/cdn/nzab039_004 . Current Developments in Nutrition

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes, 2021. Biomedicines. 777 - 777. 7. 9. 2021. https://doi.org/10.3390/biomedicines9070777 . 10.3390/biomedicines9070777 . Biomedicines

Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases

Ribeiro, R.F.N.; Cavadas, C.; Silva, M.M.C., 2021. Drug Discovery Today. 1620 - 1641. 7. 26. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104421181&partnerID=MN8TOARS . 10.1016/j.drudis.2021.03.015 . Drug Discovery Today

Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and rescues hepatic mitochondrial bioenergetics

Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Matos, P.; et al, 2021. Nutrients. 12. 13. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119606449&partnerID=MN8TOARS . 10.3390/nu13124192 . Nutrients

The Superpowers of Our Sleep

Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . published Frontiers for Young Minds

Expression and function of the nonclassical estrogen receptor, GPR30, in human cartilage and chondrocytes

Madalena Ribeiro; Cátia Sousa; Ana T. Rufino; Fernando Judas; Alexandrina F. Mendes, 2020. Journal of Cellular Physiology. 2020. https://doi.org/10.1002/jcp.29691 . 10.1002/jcp.29691 . Journal of Cellular Physiology

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 1073 - 1078. 6. 75. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Cavadas, Claudia, 2020. Pharmacological research. 2020. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological research

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models

Santana, M.M.; Paixão, S.; Cunha-Santos, J.; Silva, T.P.; Trevino-Garcia, A.; Gaspar, L.S.; Nóbrega, C.; et al, 2020. Journal of Translational Medicine. 1. 18. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083210032&partnerID=MN8TOARS . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity

Mendes, Alexandrina Ferreira , 2020. Scientific Reports. 10. 2020. https://rdcu.be/b3Rts . published Scientific Reports

Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar rats

Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Figueirinha, A.; et al, 2020. Pharmaceutics. 1 - 29. 11. 12. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096072381&partnerID=MN8TOARS . 10.3390/pharmaceutics12111094 . Pharmaceutics

The Superpowers of Our Sleep

Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . Frontiers for Young Minds

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Cavadas, Claudia, 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences

The importance of determining circadian parameters in pharmacological studies

Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

The importance of determining circadian parameters in pharmacological studies

Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2827 - 2847. 16. 176. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Mendes, Alexandrina Ferreira , 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences

The importance of determining circadian parameters in pharmacological studies

Mendes, Alexandrina, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress

Spadari, R.C.; Cavadas, C.; de Carvalho, A.E.T.S.; Ortolani, D.; de Moura, A.L.; Vassalo, P.F., 2018. Cellular and Molecular Neurobiology. 109 - 120. 1. 38. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032021647&partnerID=MN8TOARS . 10.1007/s10571-017-0557-2 . Cellular and Molecular Neurobiology

Editorial: The Physiology of Inflammation—The Final Common Pathway to Disease

Mendes, Alexandrina, 2018. Frontiers in Physiology. 2018. 10.3389/fphys.2018.01741 . Frontiers in Physiology

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Exercise-Induced Immune Response

Mendes, Alexandrina, 2018. Journal of Functional Morphology and Kinesiology. 2018. http://www.mdpi.com/2411-5142/3/3/42 . 10.3390/jfmk3030042 . Journal of Functional Morphology and Kinesiology

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.

Pólvora-Brandão D; Joaquim M; Godinho I; Aprile D; Álvaro AR; Onofre I; Raposo AC; et al, 2018. Human molecular genetics. 2018. http://europepmc.org/abstract/med/30102380 . 10.1093/hmg/ddy274 . Human molecular genetics

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components

Costa, S.; Cavadas, C.; Cavaleiro, C.; Salgueiro, L.; do Céu Sousa, M., 2018. Experimental Parasitology. 34 - 40. 190. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047422613&partnerID=MN8TOARS . 10.1016/j.exppara.2018.05.002 . Experimental Parasitology

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice

Marques, A.P.; Cunha-Santos, J.; Leal, H.; Sousa-Ferreira, L.; Pereira de Almeida, L.; Cavadas, C.; Rosmaninho-Salgado, J., 2018. Biochimica et Biophysica Acta - General Subjects. 403 - 413. 3. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037668547&partnerID=MN8TOARS . 10.1016/j.bbagen.2017.11.012 . Biochimica et Biophysica Acta - General Subjects

Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes

Rufino, Ana; Ribeiro, Madalena; Pinto Ferreira, João; Judas, Fernando; Mendes, Alexandrina, 2017. Journal of Functional Morphology and Kinesiology. 2. 2. 2017. http://dx.doi.org/10.3390/jfmk2020015 . 10.3390/jfmk2020015 . Journal of Functional Morphology and Kinesiology

Obstructive Sleep Apnea and Hallmarks of Aging

Gaspar, Laetitia S.; Álvaro, Ana Rita; Moita, Joaquim; Cavadas, Cláudia, 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://dx.doi.org/10.1016/j.molmed.2017.06.006 . 10.1016/j.molmed.2017.06.006 . published Trends in Molecular Medicine

Obstructive Sleep Apnea and Hallmarks of Aging

Gaspar, L.S.; Álvaro, A.R.; Moita, J.; Cavadas, C., 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025131167&partnerID=MN8TOARS . 10.1016/j.molmed.2017.06.006 . Trends in Molecular Medicine

Unraveling the Role of Ataxin-2 in Metabolism

Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C., 2017. Trends in Endocrinology and Metabolism. 309 - 318. 4. 28. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS . 10.1016/j.tem.2016.12.006 . Trends in Endocrinology and Metabolism

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line

Ana Patrícia Marques; Joana Rosmaninho-Salgado; Marta Estrada; Vera Cortez; Rui Jorge Nobre; Cláudia Cavadas, 2017. Biochimica et Biophysica Acta (BBA) - General Subjects. 673 - 682. 3. 1861. 2017. https://doi.org/10.1016/j.bbagen.2016.12.005 . 10.1016/j.bbagen.2016.12.005 . Biochimica et Biophysica Acta (BBA) - General Subjects

The NAD<sup>+</sup>-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Lemos, V.; de Oliveira, R.M.; Naia, L.; Szegö, E.; Ramos, E.; Pinho, S.; Magro, F.; et al, 2017. Human Molecular Genetics. 4105 - 4117. 21. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034211658&partnerID=MN8TOARS . 10.1093/hmg/ddx298 . Human Molecular Genetics

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Ferreira-Marques M; Aveleira CA; Carmo-Silva S; Botelho M; Pereira de Almeida L; Cavadas C; Ferreira-Marques, Marisa; et al, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://europepmc.org/abstract/med/27441412 . 10.18632/aging.100996 . Aging

Insulin decreases autophagy and leads to cartilage degradation

Ribeiro, M.; López de Figueroa, P.; Blanco, F.J.; Mendes, A.F.; Caramés, B., 2016. Osteoarthritis and Cartilage. 731 - 739. 4. 24. 2016. http://dx.doi.org/10.1016/j.joca.2015.10.017 . 10.1016/j.joca.2015.10.017 . Osteoarthritis and Cartilage

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway

Cunha-Santos, J.; Duarte-Neves, J.; Carmona, V.; Guarente, L.; De Almeida, L.P.; Cavadas, C., 2016. Nature Communications. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968928647&partnerID=MN8TOARS . 10.1038/ncomms11445 . Nature Communications

The Adenosinergic System in Diabetic Retinopathy

Vindeirinho, J.; Santiago, A. R.; Cavadas, C.; Ambrósio, A. F.; Santos, P. F., 2016. Journal of Diabetes Research. 1 - 8. 2016. 2016. http://dx.doi.org/10.1155/2016/4270301 . 10.1155/2016/4270301 . published Journal of Diabetes Research

Antileishmanial activity of antiretroviral drugs combined with miltefosine

Costa, Sonya; Machado, Marisa; Cavadas, Cláudia; do Céu Sousa, Maria, 2016. Parasitology Research. 3881 - 3887. 10. 115. 2016. http://dx.doi.org/10.1007/s00436-016-5153-8 . 10.1007/s00436-016-5153-8 . published Parasitology Research

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . Nature Reviews Endocrinology

Corrigendum to "Intracellular mechanisms coupled to NPY Y<inf>2</inf> and Y<inf>5</inf> receptor activation and lipid accumulation in murine adipocytes" [neuropeptides 46/6 (2012) 359-366]

Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., 2016. Neuropeptides. 101 - 101. 57. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950130030&partnerID=MN8TOARS . 10.1016/j.npep.2015.11.089 . Neuropeptides

Assessment of cell line competence for studies of pharmacological GPR30 modulation

Sousa, Cátia; Ribeiro, Madalena; Rufino, Ana Teresa; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira, 2016. Journal of Receptors and Signal Transduction. 181 - 188. 2. 37. 2016. http://dx.doi.org/10.1080/10799893.2016.1203943 . 10.1080/10799893.2016.1203943 . Journal of Receptors and Signal Transduction

Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

Ribeiro, M.; López de Figueroa, P.; Nogueira-Recalde, U.; Centeno, A.; Mendes, A.F.; Blanco, F.J.; Caramés, B., 2016. Osteoarthritis and Cartilage. 2116 - 2125. 12. 24. 2016. http://dx.doi.org/10.1016/j.joca.2016.06.019 . 10.1016/j.joca.2016.06.019 . Osteoarthritis and Cartilage

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Articular Cartilage Tissue Engineering and Mechanical Stimulation

Mendes, Alexandrina, 2016. Journal of Functional Morphology and Kinesiology. 2016. http://www.mdpi.com/2411-5142/1/2/162 . 10.3390/jfmk1020162 . Journal of Functional Morphology and Kinesiology

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Joana Duarte-Neves; Luís Pereira de Almeida; Cláudia Cavadas, 2016. Neurobiology of Disease. 210 - 224. 95. 2016. https://doi.org/10.1016%2Fj.nbd.2016.07.022 . 10.1016/j.nbd.2016.07.022 . Neurobiology of Disease

Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53

Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R., 2016. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 138 - 146. 185-186. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS . 10.1016/j.cbpc.2016.03.010 . Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

Hypothalamic involvement in premature aging laminopathies

Cavadas, Claudia; Cavadas C, 2015. Orphanet Journal of Rare Diseases. Suppl 2. 10. 2015. http://dx.doi.org/10.1186/1750-1172-10-s2-o6 . 10.1186/1750-1172-10-s2-o6 . published Orphanet Journal of Rare Diseases

Neuropeptide Y: An Anti-Aging Player?

Botelho, Mariana; Cavadas, Cláudia, 2015. Trends in Neurosciences. 701 - 711. 11. 38. 2015. http://dx.doi.org/10.1016/j.tins.2015.08.012 . 10.1016/j.tins.2015.08.012 . published Trends in Neurosciences

Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction

Alexandrina F Mendes; Susana C Rosa; Ana T Rufino; Madalena Ribeiro; Fernando Judas, 2015. BMC Musculoskeletal Disorders. S1. 16. 2015. https://doi.org/10.1186%2F1471-2474-16-s1-s1 . 10.1186/1471-2474-16-s1-s1 . BMC Musculoskeletal Disorders

Tissue Engineered Cartilage in Unconfined Compression: Biomechanical Analysis

Cátia Bandeiras; António Completo; António Ramos; Ana Teresa Rufino; Madalena Ribeiro; João Pinto Ferreira; Alexandrina Ferreira Mendes, 2015. Materials Today: Proceedings. 355 - 364. 1. 2. 2015. https://doi.org/10.1016%2Fj.matpr.2015.04.032 . 10.1016/j.matpr.2015.04.032 . Materials Today: Proceedings

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; Álvaro, A.R.; Cavadas, C., 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology

Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases

Rufino, Ana T.; Ferreira, Isabel; Judas, Fernando; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina F., 2015. Pharmaceutical Biology. 1220 - 1230. 8. 53. 2015. http://dx.doi.org/10.3109/13880209.2014.970701 . 10.3109/13880209.2014.970701 . Pharmaceutical Biology

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

Gomes, Pedro; Fleming Outeiro, Tiago; Cavadas, Cláudia, 2015. Trends in Pharmacological Sciences. 756 - 768. 11. 36. 2015. http://dx.doi.org/10.1016/j.tips.2015.08.001 . 10.1016/j.tips.2015.08.001 . published Trends in Pharmacological Sciences

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; et al, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology

Neuropeptide Y system in the retina: From localization to function

Santos-Carvalho, Ana; Ambrósio, António Francisco; Cavadas, Cláudia, 2015. Progress in Retinal and Eye Research. 19 - 37. 47. 2015. http://dx.doi.org/10.1016/j.preteyeres.2015.03.001 . 10.1016/j.preteyeres.2015.03.001 . published Progress in Retinal and Eye Research

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective ActionsIn Vitro

Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; et al, 2015. ASN Neuro. 4. 7. 2015. http://dx.doi.org/10.1177/1759091415598292 . 10.1177/1759091415598292 . published ASN Neuro

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease

Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa; den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Cavadas, Cláudia; Pereira de Almeida, Luís, 2015. Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://dx.doi.org/10.1093/hmg/ddv271 . 10.1093/hmg/ddv271 . published Human Molecular Genetics

Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

Mendes, Alexandrina; Rufino, A.T.; Ribeiro, M.; Sousa, C.; Judas, F.; Salgueiro, L.; Cavaleiro, C.; Mendes, A.F., 2015. European Journal of Pharmacology. 141 - 150. 750. 2015. http://www.sciencedirect.com/science/article/pii/S0014299915000412 . http://dx.doi.org/10.1016/j.ejphar.2015.01.018 . European Journal of Pharmacology

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . published Autophagy

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Santos-Carvalho, A.; Álvaro, A.R.; Martins, J.; Ambrósio, A.F.; Cavadas, C., 2014. Progress in Neurobiology. 70 - 79. 112. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890802011&partnerID=MN8TOARS . 10.1016/j.pneurobio.2013.10.002 . Progress in Neurobiology

Role of hypothalamic neurogenesis in feeding regulation

Sousa-Ferreira, L.; Almeida, L.P.D.; Cavadas, C., 2014. Trends in Endocrinology and Metabolism. 80 - 88. 2. 25. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892986633&partnerID=MN8TOARS . 10.1016/j.tem.2013.10.005 . Trends in Endocrinology and Metabolism

Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress

Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901323540&partnerID=MN8TOARS . 10.1016/j.neuroscience.2014.04.042 . Neuroscience

Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro

Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . accepted PLoS ONE

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia, 2014. Progress in Neurobiology. 70 - 79. Jan. 112. 2014. 10.1016/j.pneurobio.2013.10.002 . published Progress in Neurobiology

Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro

Sousa-Ferreira, L; Aveleira, C.; Botelho, M; Álvaro, Ana Rita Costa Silva; de Almeida, P.L.; Cavadas, C., 2014. PLoS One. eCollection2014 - eCollection2014. 3. 9. 2014. 10.1371/journal.pone.0088917 . published PLoS One

Anti-inflammatory and Chondroprotective Activity of (+)-a-Pinene: Structural and Enantiomeric Selectivity

Mendes, Alexandrina, 2014. Journal of Natural Products. 2014. 10.1021/np400828x . Journal of Natural Products

Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach

Mendes, Alexandrina, 2014. PlosOne. 2014. 10.1371/journal.pone.0109048 . PlosOne

Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System

Vindeirinho, J.; Costa, G.N.; Correia, M.B.; Cavadas, C.; Santos, P.F., 2013. PLoS ONE. 6. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879548830&partnerID=MN8TOARS . 10.1371/journal.pone.0067499 . PLoS ONE

Neuropeptide y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

Santos-Carvalho, A.; Elvas, F.; Álvaro, A.R.; Ambrósio, A.F.; Cavadas, C., 2013. Cell Death and Disease. 5. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879394627&partnerID=MN8TOARS . 10.1038/cddis.2013.160 . Cell Death and Disease

Neuropeptide Y receptors Y1 and Y2 are present in neurons and glial cells in rat retinal cells in culture

Santos-Carvalho, A.; Aveleira, C.A.; Elvas, F.; Ambrósio, A.F.; Cavadas, C., 2013. Investigative Ophthalmology and Visual Science. 429 - 443. 1. 54. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874719907&partnerID=MN8TOARS . 10.1167/iovs.12-10776 . Investigative Ophthalmology and Visual Science

Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: Possible role in glucose sensing

Rufino, A.T.; Rosa, S.C.; Judas, F.; Mobasheri, A.; Lopes, M.C.; Mendes, A.F., 2013. Journal of Cellular Biochemistry. 1879 - 1889. 8. 114. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879133940&partnerID=MN8TOARS . 10.1002/jcb.24532 . Journal of Cellular Biochemistry

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

Santos-Carvalho, A; Elvas, F; ¿?lvaro, A R; Ambrósio, A F; Cavadas, C., 2013. Cell Death and Disease. e636 - e636. 5. 4. 2013. 10.1038/cddis.2013.160 . published Cell Death and Disease

Progenitor cells in chromospheres: In response to Arthur S. Tischler

Santana, M.M.; Ehrhart-Bornstein, M.; Cavadas, C., 2013. Stem Cells Translational Medicine. 1020 - 1021. 12. 2. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888415377&partnerID=MN8TOARS . 10.5966/sctm.2013-0062 . Stem Cells Translational Medicine

Physiology and pathophysiology of musculoskeletal aging: current research trends and future priorities

Mobasheri, Ali; Mendes, Alexandrina F.; Mobasheri, A.; Mendes, A.F., 2013. Frontiers in Physiology. 4. 2013. http://dx.doi.org/10.3389/fphys.2013.00073 . 10.3389/fphys.2013.00073 . Frontiers in Physiology

Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla

Santana, M.M.; Chung, K.-F.; Vukicevic, V.; Rosmaninho-Salgado, J.; Kanczkowski, W.; Cortez, V.; Hackmann, K.; et al, 2012. Stem Cells Translational Medicine. 783 - 791. 11. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873024306&partnerID=MN8TOARS . 10.5966/sctm.2012-0022 . Stem Cells Translational Medicine

Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes

Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., 2012. Neuropeptides. 359 - 366. 6. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869870468&partnerID=MN8TOARS . 10.1016/j.npep.2012.08.006 . Neuropeptides

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

Costa, G.N.; Vindeirinho, J.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F., 2012. Molecular and Cellular Neuroscience. 113 - 123. 1. 50. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860624256&partnerID=MN8TOARS . 10.1016/j.mcn.2012.04.003 . Molecular and Cellular Neuroscience

Potassium channels in articular chondrocytes

Mobasheri, A.; Lewis, R.; Ferreira-Mendes, A.; Rufino, A.; Dart, C.; Barrett-Jolley, R., 2012. Channels. 416 - 425. 6. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871438042&partnerID=MN8TOARS . 10.4161/chan.22340 . Channels

Regulation of catecholamine release in human adrenal chromaffin cells by ß-adrenoceptors

Cortez, V.; Santana, M.; Marques, A.P.; Mota, A.; Rosmaninho-Salgado, J.; Cavadas, C., 2012. Neurochemistry International. 387 - 393. 4. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857026869&partnerID=MN8TOARS . 10.1016/j.neuint.2011.12.018 . Neurochemistry International

Dipeptidyl-peptidase-IV by cleaving neuropeptide y induces lipid accumulation and PPAR-¿ expression

Cavadas, Claudia, 2012. BBA. 49 - 54. 1. 37. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865246554&partnerID=MN8TOARS . 10.1016/j.peptides.2012.06.014 . BBA

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and orexin-a and differentiate to functional neurons

Sousa-Ferreira, L.; Álvaro, A.R.; Aveleira, C.; Santana, M.; Brandão, I.; Kügler, S.; de Almeida, L.P.; Cavadas, C., 2011. PLoS ONE. 5. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955917559&partnerID=MN8TOARS . 10.1371/journal.pone.0019745 . PLoS ONE

Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE

Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat

Martins, J.; Castelo-Branco, M.; Batista, A.; Oliveiros, B.; Santiago, A.R.; Galvão, J.; Fernandes, E.; et al, 2011. PLoS ONE. 12. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84455161646&partnerID=MN8TOARS . 10.1371/journal.pone.0029583 . PLoS ONE

Cortical strut allografting in reconstructive orthopaedic surgery

Judas, F.; Saavedra, M.J.; Mendes, A.F.; Dias, R., 2011. Acta Reumatologica Portuguesa. 24 - 28. 1. 36. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955647442&partnerID=MN8TOARS . Acta Reumatologica Portuguesa

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 19745 - 19745. 5. 6. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21589937 . 10.1371/journal.pone.0019745 . published PLoS ONE

Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE

Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin

Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Osteoarthritis and Cartilage. 719 - 727. 6. 19. 2011. 10.1016/j.joca.2011.02.004 . published Osteoarthritis and Cartilage

Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Journal of Cellular Biochemistry. 2813 - 2824. 10. 112. 2011. 10.1002/jcb.23196 . published Journal of Cellular Biochemistry

Adipose Tissue Changes Induced By the DPPIV Inhibitors (Gliptins): In Vivo and In Vitro Studies

Salgado, Joana; Estrada, Marta; Marques, Ana; Cortez, Vera; Reis, Flavio; Pereira, Frederico; Santana, Magda; Cavadas, Claudia, 2011. Obesity. 2011. https://publons.com/wos-op/publon/33859176/ . Obesity

Screening of Five Essential Oils for Identification of Potential Inhibitors of IL-1-induced Nf-¿B Activation and NO Production in Human Chondrocytes: Characterization of the Inhibitory Activity of a -Pinene

Neves, Ângela; Rosa, Susana C.; Gonçalves, Juliana; Rufino, Ana T.; Judas, Fernando M.; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina Ferreira, 2010. Planta Medica. 303 - 308. 03. 76. 2010. 10.1055/s-0029-1186085 . published Planta Medica

Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage

Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Ali Mobasheri; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Arthritis Research & Therapy. 1 - 11. R80. 11. 2009. http://arthritis-research.com/content/11/3/R80 . 10.1186/ar2713 . published Arthritis Research & Therapy

Neuropeptide Y inhibits [Ca 2+]i changes in rat retinal neurons through NPY Y1 , Y4 and Y5 receptors

Álvaro, Ana Rita ; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19344373 . 10.1111/j.1471-4159.2009.06079.x . published Journal of Neurochemistry

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: role of neuropeptide Y and nitric oxide

Rosmaninho-Salgado, Joana; Araújo, Inês M.; ¿?lvaro, Ana Rita; Mendes, Alexandrina Ferreira; Ferreira, Lígia; Grouzmann, Eric; Mota, Alfredo; Duarte, Emília. P.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry

Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide y in noradrenergic neurons

Ruohonen, S.T.; Savontaus, E.; Rinne, P.; Rosmaninho-Salgado, J.; Cavadas, C.; Ruskoaho, H.; Koulu, M.; Pesonen, U., 2009. Neuroendocrinology. 351 - 360. 3. 89. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349122908&partnerID=MN8TOARS . 10.1159/000188602 . Neuroendocrinology

Neuropeptide y inhibits [Ca2+]i changes in rat retinal neurons through NPY Y1, Y4, and Y5 receptors

Álvaro, A.R.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549153628&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06079.x . Journal of Neurochemistry

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide

Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; Duarte, E.P.; Cavadas, C., 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . Journal of Neurochemistry

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide

Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; et al, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry

Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin

Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Osteoarthritis and Cartilage. 1657 - 1661. 12. 17. 2009. 10.1016/j.joca.2009.08.016 . published Osteoarthritis and Cartilage

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Álvaro, A. R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18249070 . 10.1016/j.neuroscience.2007.12.027 . published Neuroscience

Nitric oxide synthase isoforms and NF-¿B activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide

Rosa, Susana C.; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2008. Nitric Oxide. 276 - 283. 3. 19. 2008. 10.1016/j.niox.2008.07.005 . published Nitric Oxide

Neuropeptide Y stimulates retinal neural cell proliferation - Involvement of nitric oxide

Álvaro, A.R.; Martins, J.; Araújo, I.M.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649189136&partnerID=MN8TOARS . 10.1111/j.1471-4159.2008.05334.x . Journal of Neurochemistry

Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines.

Mobasheri, A.; Bondy, C.A.; Moley, K.; Mendes, A.F.; Rosa, S.C.; Richardson, S.M.; Hoyland, J.A.; Barrett-Jolley, R.; Shakibaei, M., 2008. Advances in anatomy, embryology, and cell biology. 200. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149170369&partnerID=MN8TOARS . Advances in anatomy, embryology, and cell biology

Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide

¿?lvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18331583 . 10.1111/j.1471-4159.2008.05334.x . published Journal of Neurochemistry

Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: A role for microglia

Xapelli, S.; Bernardino, L.; Ferreira, R.; Grade, S.; Silva, A.P.; Salgado, J.R.; Cavadas, C.; et al, 2008. European Journal of Neuroscience. 2089 - 2102. 8. 27. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049112780&partnerID=MN8TOARS . 10.1111/j.1460-9568.2008.06172.x . European Journal of Neuroscience

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39649105016&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.12.027 . Neuroscience

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17353067 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International

Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells

Rosmaninho-Salgado, J.; Álvaro, A.R.; Grouzmann, E.; Duarte, E.P.; Cavadas, C., 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846606438&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.015 . Peptides

Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells

Rosmaninho-Salgado, Joana; ¿?lvaro, Ana Rita; Grouzmann, Eric; Duarte, Emilia P.; Cavadas, Cláudia, 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17207896 . 10.1016/j.peptides.2006.11.015 . published Peptides

Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts: Effect of Cryoprotective Agents

Judas, Fernando M.; Rosa, Susana C.; TEIXEIRA, L; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2007. Transplantation Proceedings. 2531 - 2534. 8. 39. 2007. 10.1016/j.transproceed.2007.07.028 . published Transplantation Proceedings

Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells

Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Duarte, E.P.; Cavadas, C.; Álvaro, A.R., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . published Journal of Neurochemistry

NPY Y<inf>1</inf> receptor is not involved in the hemodynamic response to an acute cold pressor test in mice

Cavadas, C.; Waeber, B.; Pedrazzini, T.; Grand, D.; Aubert, J.-F.; Buclin, T.; Grouzmann, E., 2007. Peptides. 315 - 319. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846574363&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.022 . Peptides

Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells

Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Duarte, E.P.; Cavadas, C., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . Journal of Neurochemistry

Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization

Moreno, António J.; Oliveira, Paulo J.; Nova, Carlos D.; ¿?lvaro, Ana R.; Moreira, Renata A.; Santos, Sandra M. D.; Macedo, Tice, 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17427176 . 10.1002/jbt.20159 . published Journal of Biochemical and Molecular Toxicology

Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion

Cavadas, C.; Céfai, D.; Rosmaninho-Salgado, J.; Vieira-Coelho, M.A.; Moura, E.; Busso, N.; Pedrazzini, T.; et al, 2006. Proceedings of the National Academy of Sciences of the United States of America. 10497 - 10502. 27. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745899338&partnerID=MN8TOARS . 10.1073/pnas.0600913103 . Proceedings of the National Academy of Sciences of the United States of America

Neuropeptide Y expression, localization and cellular transducing effects in HUVEC

Silva, A.P.; Kaufmann, J.E.; Vivancos, C.; Fakan, S.; Cavadas, C.; Shaw, P.; Brunner, H.R.; Vischer, U.; Grouzmann, E., 2005. Biology of the Cell. 457 - 467. 6. 97. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21044442442&partnerID=MN8TOARS . 10.1042/BC20040102 . Biology of the Cell

Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats

Silva, A.P.; Xapelli, S.; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; et al, 2005. Journal of Neurochemistry. 163 - 170. 1. 93. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144388681&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.03005.x . Journal of Neurochemistry

The putative neuroprotective role of neuropeptide Y in the central nervous system

Silva, A.P.; Xapelli, S.; Grouzmann, E.; Cavadas, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 331 - 347. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144457255&partnerID=MN8TOARS . 10.2174/1568007054546153 . Current Drug Targets: CNS and Neurological Disorders

Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular chondrocytes: Implications for the regulation of iNOS expression

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Cell Biology and Toxicology. 203 - 214. 4. 19. 2003. 10.1023/B:CBTO.0000003730.21261.fa . published Cell Biology and Toxicology

Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Journal of Cellular Biochemistry. 783 - 793. 4. 88. 2003. 10.1002/jcb.10428 . published Journal of Cellular Biochemistry

Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice

Grouzmann, E.; Cavadas, C.; Grand, D.; Moratel, M.; Aubert, J.-F.; Brunner, H.R.; Mazzolai, L., 2003. Pflugers Archiv European Journal of Physiology. 254 - 258. 2. 447. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842265696&partnerID=MN8TOARS . 10.1007/s00424-003-1140-x . Pflugers Archiv European Journal of Physiology

Dexamethasone prevents interleukin-1ß-induced nuclear factor-¿B activation by upregulating I¿B-a synthesis, in lymphoblastic cells

Castro-caldas, M.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 37 - 46. 1. 12. 2003. 10.1080/0962935031000096953 . published Mediators of Inflammation

Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK

Castro-caldas, M.; Mendes, Alexandrina Ferreira; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 329 - 337. 6. 12. 2003. 10.1080/09629350310001633351 . published Mediators of Inflammation

Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT<inf>1</inf>receptor

Cavadas, C.; Grand, D.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., 2003. Regulatory Peptides. 61 - 65. 1-3. 111. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037471366&partnerID=MN8TOARS . 10.1016/S0167-0115(02)00253-7 . Regulatory Peptides

NPY, NPY receptors, and DPP IV activity are modulated by LPS, TNF-a and IFN-¿ in HUVEC

Silva, A.P.; Cavadas, C.; Baïsse-Agushi, B.; Spertini, O.; Brunner, H.R.; Grouzmann, E., 2003. Regulatory Peptides. 71 - 79. 1-3. 116. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242329827&partnerID=MN8TOARS . 10.1016/S0167-0115(03)00191-5 . Regulatory Peptides

Neuropeptide Y and its receptors as potential therapeutic drug targets

Silva, A.P.; Cavadas, C.; Grouzmann, E., 2002. Clinica Chimica Acta. 3 - 25. 1-2. 326. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036889596&partnerID=MN8TOARS . 10.1016/S0009-8981(02)00301-7 . Clinica Chimica Acta

Catecholamine and Neuropeptide Y Secretion from Human Adrenal Chromaffin Cells

CAVADAS, CLÁUDIA; RIBEIRO, CARLOS ALBERTO FONTES; COTRIM, MARIA DULCE; MOSIMANN, FRANÇOIS; BRUNNER, HANS R.; GROUZMANN, ERIC; Cavadas C; et al, 2002. Annals of the New York Academy of Sciences. 332 - 334. 1. 971. 2002. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04488.x . 10.1111/j.1749-6632.2002.tb04488.x . Annals of the New York Academy of Sciences

Role of Mitogen-Activated Protein Kinases and Tyrosine Kinases on IL-1-Induced NF-¿B Activation and iNOS Expression in Bovine Articular Chondrocytes

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Nitric Oxide. 35 - 44. 1. 6. 2002. 10.1006/niox.2001.0378 . published Nitric Oxide

Differential secretion of catecholamine and neuropeptide Y in response to KCl from mice chromaffin cells.

Cavadas C; Silva AP; Cotrim MD; Ribeiro CA; Brunner HR; Grouzmann E, 2002. 2002. http://europepmc.org/abstract/med/12438145 . 10.1111/j.1749-6632.2002.tb04489.x .

Dibasic cleavage site is required for sorting to the regulated secretory pathway for both pro- and neuropeptide Y

Brakch, N.; Allemandou, F.; Cavadas, C.; Grouzmann, E.; Brunner, H.R., 2002. Journal of Neurochemistry. 1166 - 1175. 6. 81. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036316744&partnerID=MN8TOARS . 10.1046/j.1471-4159.2002.00919.x . Journal of Neurochemistry

Loss of dipeptidylpeptidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P in the nasal mucosa.

Grouzmann, E.; Monod, M.; Landis, B.; Wilk, S.; Brakch, N.; Nicoucar, K.; Giger, R.; et al, 2002. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1132 - 1134. 9. 16. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036634815&partnerID=MN8TOARS . published The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Role of nitric oxide in the activation of NF-¿B, AP-1 and NOS II expression in articular chondrocytes

Mendes, A.F.; Carvalho, A.P.; Caramona, M.M.; Lopes, M.C.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2002. Inflammation Research. 369 - 375. 7. 51. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036019462&partnerID=MN8TOARS . 10.1007/PL00000317 . published Inflammation Research

Diacerhein and Rhein Prevent Interleukin-1beta-Induced Nuclear Factor-kappaB Activation by Inhibiting the Degradation of Inhibitor kappaB-alpha

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Pharmacology and Toxicology. 22 - 28. 1. 91. 2002. 10.1034/j.1600-0773.2002.910104.x . published Pharmacology and Toxicology

Diphenyleneiodonium inhibits NF-¿B activation and iNOS expression induced by IL-1ß: involvement of reactive oxygen species

Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2001. Mediators of Inflammation. 209 - 215. 4. 10. 2001. 10.1080/09629350120080401 . published Mediators of Inflammation

Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma

Grouzmann, E.; Fathi, M.; Gillet, M.; De Torrenté, A.; Cavadas, C.; Brunner, H.; Buclin, T.; et al, 2001. Clinical Chemistry. 1075 - 1082. 6 I. 47. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035010093&partnerID=MN8TOARS . Clinical Chemistry

Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y

Bergonzelli, G.E.; Pralong, F.P.; Glauser, M.; Cavadas, C.; Grouzmann, E.; Gaillard, R.C.; Bergonzelli GE; et al, 2001. Diabetes. 2666 - 2672. 12. 50. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035656192&partnerID=MN8TOARS . 10.2337/diabetes.50.12.2666 . Diabetes

Cardiovascular effects of fentanyl in conscious rats

Baechtold, F.; Cavadas, C.; Gasser, D.; Markert, M.; Grouzmann, E.; Peterson, K.L.; Waeber, B.; Feihl, F., 2001. Pflugers Archiv European Journal of Physiology. 155 - 162. 1. 443. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035161078&partnerID=MN8TOARS . 10.1007/s004240100693 . Pflugers Archiv European Journal of Physiology

NPY regulates catecholamine secretion from human adrenal chromaffin cells

Cavadas, C.; Silva, A.P.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., 2001. Journal of Clinical Endocrinology and Metabolism. 5956 - 5963. 12. 86. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035217710&partnerID=MN8TOARS . 10.1210/jc.86.12.5956 . Journal of Clinical Endocrinology and Metabolism

In vitro study of the interaction of Tilia europeae L. aqueous extract with GABA(A) receptors in rat brain

Cavadas, C.; Fontes Ribeiro, C.A.; Santos, M.S.; Cunha, A.P.; Macedo, T.; Caramona, M.M.; Cotrim, M.D., 1997. Phytotherapy Research. 17 - 21. 1. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031051651&partnerID=MN8TOARS . 10.1002/(SICI)1099-1573(199702)11:1<17::AID-PTR948>3.0.CO;2-6 . Phytotherapy Research

Changes in the subcellular distribution of the rat uterus oestrogen receptor as induced by oestradiol, tamoxifen and ZD 182, 780

Ferreira Mendes, A.; Caramona, M.M.; Celeste Lopes, M., 1996. Journal of Pharmacy and Pharmacology. 302 - 305. 3. 48. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029891372&partnerID=MN8TOARS . Journal of Pharmacy and Pharmacology

In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABA(A) receptor in rat brain

Cavadas, C.; Araujo, I.; Cotrim, M.D.; Amaral, T.; Cunha, A.P.; Macedo, T.; Fontes Ribeiro, C., 1995. Arzneimittel-Forschung/Drug Research. 753 - 755. 7. 45. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063620&partnerID=MN8TOARS . Arzneimittel-Forschung/Drug Research

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