Modelação Computacional e Matemática
Biologia Redox
Membranas Biológicas
Metabolismo
Biologia de Sistemas
Relação entre o design e a função na sinalização redox e proteção antioxidante
Modelação da permeabilidade através de barreiras fisiológicas
Ferramentas computacionais para sistemas biomoleculares
Informação sobre artigos em revista, actualizada a 17-12-2023, a partir da plataforma CIÊNCIAVITAE.
Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling
Travasso, R.D.M.; Sampaio dos Aidos, F.; Bayani, A.; Abranches, P.; Salvador, A., 2017. Redox Biology. 233 - 245. 12. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014574052&partnerID=MN8TOARS . 10.1016/j.redox.2017.01.003 . published Redox Biology
Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II
Benfeitas, R.; Selvaggio, G.; Antunes, F.; Coelho, P.M.B.M.; Salvador, A., 2014. Free Radical Biology and Medicine. 35 - 49. 74. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904329372&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2014.06.007 . published Free Radical Biology and Medicine
Phenotypes and tolerances in the design space of biochemical systems
Savageau, M.A.; Coelho, P.M.B.M.; Fasani, R.A.; Tolla, D.A.; Salvador, A., 2009. Proceedings of the National Academy of Sciences of the United States of America. 6435 - 6440. 16. 106. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108427&partnerID=MN8TOARS . 10.1073/pnas.0809869106 . published Proceedings of the National Academy of Sciences of the United States of America
How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?
Tânia Sousa; Marcos Gouveia; Rui D.M. Travasso; Armindo Salvador, 2022. Redox Biology. 2022. https://doi.org/10.1016/j.redox.2022.102527 . 10.1016/j.redox.2022.102527 . published Redox Biology
Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types
Selvaggio, Gianluca; Coelho, Pedro M.B.M.; Salvador, Armindo, 2018. Redox Biology. 297 - 315. 15. 2018. http://dx.doi.org/10.1016/j.redox.2017.12.008 . 10.1016/j.redox.2017.12.008 . published Redox Biology
Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2
Peskin, Alexander V.; Meotti, Flávia C.; de Souza, Luiz F.; Anderson, Robert F.; Winterbourn, Christine C.; Salvador, Armindo, 2020. Free Radical Biology and Medicine. 115 - 125. 158. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2020.07.007 . 10.1016/j.freeradbiomed.2020.07.007 . published Free Radical Biology and Medicine
In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity
A. Ledo; E. Fernandes; A. Salvador; J. Laranjinha; R.M. Barbosa, 2022. Redox Biology. 50. 2022. https://doi.org/10.1016/j.redox.2022.102250 . 10.1016/j.redox.2022.102250 . published Redox Biology
Glucose-6-Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity
Lee, Heng Yang; Ithnin, Azlin; Azma, Raja Zahrathul; Othman, Ainoon; Salvador, Armindo; Cheah, Fook Choe, 2022. Frontiers in Pediatrics. 10. 2022. http://dx.doi.org/10.3389/fped.2022.875877 . 10.3389/fped.2022.875877 . published Frontiers in Pediatrics
Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes
Salvador, A.; Savageau, M.A., 2003. Proceedings of the National Academy of Sciences of the United States of America. 14463 - 14468. SUPPL. 2. 100. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345060788&partnerID=MN8TOARS . 10.1073/pnas.2335687100 . published Proceedings of the National Academy of Sciences of the United States of America
Evolution of enzymes in a series is driven by dissimilar functional demands
Salvador, A.; Savageau, M.A., 2006. Proceedings of the National Academy of Sciences of the United States of America. 2226 - 2231. 7. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144458377&partnerID=MN8TOARS . 10.1073/pnas.0510776103 . published Proceedings of the National Academy of Sciences of the United States of America
Tools for kinetic modeling of biochemical networks
Alves, R.; Antunes, F.; Salvador, A., 2006. Nature Biotechnology. 667 - 672. 6. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745075591&partnerID=MN8TOARS . 10.1038/nbt0606-667 . published Nature Biotechnology
Calculation of Permeability Coefficients from Solute Equilibration Dynamics: An Assessment of Various Methods
Margarida M. Cordeiro; Armindo Salvador; Maria João Moreno, 2022. Membranes. 254 - 254. 3. 12. 2022. https://doi.org/10.3390/membranes12030254 . 10.3390/membranes12030254 . Membranes
Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations—Translocation of Cholesterol across Lipid Bilayers
Filipe, Hugo A. L.; Javanainen, Matti; Salvador, Armindo; Galvão, Adelino M.; Vattulainen, Ilpo; Loura, Luís M. S.; Moreno, Maria João, 2018. Journal of Chemical Theory and Computation. 3840 - 3848. 7. 14. 2018. http://dx.doi.org/10.1021/acs.jctc.8b00150 . 10.1021/acs.jctc.8b00150 . published Journal of Chemical Theory and Computation
Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport
Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C., 2014. Journal of Lipid Research. 1033 - 1043. 6. 55. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS . 10.1194/jlr.M043067 . published Journal of Lipid Research
The mammalian peroxisomal membrane is permeable to both GSH and GSSG - Implications for intraperoxisomal redox homeostasis
Ferreira, Maria J.; Rodrigues, Tony A.; Pedrosa, Ana G.; Gales, Luís; Salvador, Armindo; Francisco, Tânia; Azevedo, Jorge E., 2023. Redox Biology. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102764 . 10.1016/j.redox.2023.102764 . published Redox Biology
5 15 de 15 Publicações em destaque
Informação sobre artigos em revista, actualizada a 17-12-2023, a partir da plataforma CIÊNCIAVITAE.
Pillars of theoretical biology: "Biochemical systems analysis, I, II and III"
Armindo Salvador, 2024. Journal of Theoretical Biology. 576. 2024. https://doi.org/10.1016/j.jtbi.2023.111655 . 10.1016/j.jtbi.2023.111655 . published Journal of Theoretical Biology
The architecture of redox microdomains: Cascading gradients and peroxiredoxins' redox-oligomeric coupling integrate redox signaling and antioxidant protection
Matthew Griffith; Adérito Araújo; Rui Travasso; Armindo Salvador, 2023. Redox Biology. 69. 2023. https://doi.org/10.1016/j.redox.2023.103000 . 10.1016/j.redox.2023.103000 . published Redox Biology
The mammalian peroxisomal membrane is permeable to both GSH and GSSG - Implications for intraperoxisomal redox homeostasis
Ferreira, Maria J.; Rodrigues, Tony A.; Pedrosa, Ana G.; Gales, Luís; Salvador, Armindo; Francisco, Tânia; Azevedo, Jorge E., 2023. Redox Biology. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102764 . 10.1016/j.redox.2023.102764 . published Redox Biology
Ligand's Partition to the Lipid Bilayer Should Be Accounted for When Estimating Their Affinity to Proteins
Moreno, Maria João; Salvador, Armindo, 2023. Molecules. 7. 28. 2023. http://dx.doi.org/10.3390/molecules28073136 . 10.3390/molecules28073136 . Molecules
Analysis of the Equilibrium Distribution of Ligands in Heterogeneous Media: Approaches and Pitfalls
Maria João Moreno; Luís M. S. Loura; Jorge Martins; Armindo Salvador; Adrian Velazquez-Campoy, 2022. International Journal of Molecular Sciences. 17. 23. 2022. https://doi.org/10.3390/ijms23179757 . 10.3390/ijms23179757 . published International Journal of Molecular Sciences
Modeling Gd<sup>3+</sup> Complexes for Molecular Dynamics Simulations: Toward a Rational Optimization of MRI Contrast Agents
Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Salvador, Armindo; Geraldes, Carlos F. G. C.; Moreno, Maria João; Loura, Luís M. S., 2022. Inorganic Chemistry. 2022. http://dx.doi.org/10.1021/acs.inorgchem.2c01597 . 10.1021/acs.inorgchem.2c01597 . Inorganic Chemistry
Glucose-6-Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity
Lee, Heng Yang; Ithnin, Azlin; Azma, Raja Zahrathul; Othman, Ainoon; Salvador, Armindo; Cheah, Fook Choe, 2022. Frontiers in Pediatrics. 10. 2022. http://dx.doi.org/10.3389/fped.2022.875877 . 10.3389/fped.2022.875877 . published Frontiers in Pediatrics
How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?
Tânia Sousa; Marcos Gouveia; Rui D.M. Travasso; Armindo Salvador, 2022. Redox Biology. 2022. https://doi.org/10.1016/j.redox.2022.102527 . 10.1016/j.redox.2022.102527 . published Redox Biology
Calculation of Permeability Coefficients from Solute Equilibration Dynamics: An Assessment of Various Methods
Margarida M. Cordeiro; Armindo Salvador; Maria João Moreno, 2022. Membranes. 254 - 254. 3. 12. 2022. https://doi.org/10.3390/membranes12030254 . 10.3390/membranes12030254 . Membranes
In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity
A. Ledo; E. Fernandes; A. Salvador; J. Laranjinha; R.M. Barbosa, 2022. Redox Biology. 50. 2022. https://doi.org/10.1016/j.redox.2022.102250 . 10.1016/j.redox.2022.102250 . published Redox Biology
Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2
Peskin, Alexander V.; Meotti, Flávia C.; de Souza, Luiz F.; Anderson, Robert F.; Winterbourn, Christine C.; Salvador, Armindo, 2020. Free Radical Biology and Medicine. 115 - 125. 158. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2020.07.007 . 10.1016/j.freeradbiomed.2020.07.007 . published Free Radical Biology and Medicine
Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations—Translocation of Cholesterol across Lipid Bilayers
Filipe, Hugo A. L.; Javanainen, Matti; Salvador, Armindo; Galvão, Adelino M.; Vattulainen, Ilpo; Loura, Luís M. S.; Moreno, Maria João, 2018. Journal of Chemical Theory and Computation. 3840 - 3848. 7. 14. 2018. http://dx.doi.org/10.1021/acs.jctc.8b00150 . 10.1021/acs.jctc.8b00150 . published Journal of Chemical Theory and Computation
Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types
Selvaggio, Gianluca; Coelho, Pedro M.B.M.; Salvador, Armindo, 2018. Redox Biology. 297 - 315. 15. 2018. http://dx.doi.org/10.1016/j.redox.2017.12.008 . 10.1016/j.redox.2017.12.008 . published Redox Biology
Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling
Travasso, R.D.M.; Sampaio dos Aidos, F.; Bayani, A.; Abranches, P.; Salvador, A., 2017. Redox Biology. 233 - 245. 12. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014574052&partnerID=MN8TOARS . 10.1016/j.redox.2017.01.003 . published Redox Biology
Mass Isotopomer Analysis of Nucleosides Isolated from RNA and DNA Using GC/MS
Miranda-Santos, Ines; Gramacho, Silvia; Pineiro, Marta; Martinez-Gomez, Karla; Fritz, Michel; Hollemeyer, Klaus; Salvador, Armindo; Heinzle, Elmar, 2015. Analytical Chemistry. 617 - 623. 1. 87. 2015. https://doi.org/10.1021/ac503305w . 10.1021/ac503305w . published Analytical Chemistry
Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II
Benfeitas, R.; Selvaggio, G.; Antunes, F.; Coelho, P.M.B.M.; Salvador, A., 2014. Free Radical Biology and Medicine. 35 - 49. 74. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904329372&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2014.06.007 . published Free Radical Biology and Medicine
Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport
Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C., 2014. Journal of Lipid Research. 1033 - 1043. 6. 55. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS . 10.1194/jlr.M043067 . published Journal of Lipid Research
Beyond Overton's Rule: Quantitative Modeling of Passive Permeation through Tight Cell Monolayers
Filipe, H. A. L.; Salvador, A.; Silvestre, J. M.; Vaz, W. L. C.; Moreno, M. J., 2014. Molecular Pharmaceutics. 3696 - 3706. 10. 11. 2014. http://dx.doi.org/10.1021/mp500437e . 10.1021/mp500437e . published Molecular Pharmaceutics
Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes
Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A., 2010. PLoS ONE. 9. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958545833&partnerID=MN8TOARS . 10.1371/journal.pone.0013031 . published PLoS ONE
Phenotypes and tolerances in the design space of biochemical systems
Savageau, M.A.; Coelho, P.M.B.M.; Fasani, R.A.; Tolla, D.A.; Salvador, A., 2009. Proceedings of the National Academy of Sciences of the United States of America. 6435 - 6440. 16. 106. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108427&partnerID=MN8TOARS . 10.1073/pnas.0809869106 . published Proceedings of the National Academy of Sciences of the United States of America
Quantifying global tolerance of biochemical systems: Design implications for moiety-transfer cycles
Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A., 2009. PLoS Computational Biology. 3. 5. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549119474&partnerID=MN8TOARS . 10.1371/journal.pcbi.1000319 . published PLoS Computational Biology
Tools for kinetic modeling of biochemical networks
Alves, R.; Antunes, F.; Salvador, A., 2006. Nature Biotechnology. 667 - 672. 6. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745075591&partnerID=MN8TOARS . 10.1038/nbt0606-667 . published Nature Biotechnology
Why does superoxide dismutase overexpression often increase hydrogen peroxide concentrations? An alternative explanation
Gardner, R.; Moradas-Ferreira, P.; Salvador, A., 2006. Journal of Theoretical Biology. 798 - 800. 3. 242. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747879504&partnerID=MN8TOARS . 10.1016/j.jtbi.2006.04.007 . published Journal of Theoretical Biology
Evolution of enzymes in a series is driven by dissimilar functional demands
Salvador, A.; Savageau, M.A., 2006. Proceedings of the National Academy of Sciences of the United States of America. 2226 - 2231. 7. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144458377&partnerID=MN8TOARS . 10.1073/pnas.0510776103 . published Proceedings of the National Academy of Sciences of the United States of America
Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes
Salvador, A.; Savageau, M.A., 2003. Proceedings of the National Academy of Sciences of the United States of America. 14463 - 14468. SUPPL. 2. 100. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345060788&partnerID=MN8TOARS . 10.1073/pnas.2335687100 . published Proceedings of the National Academy of Sciences of the United States of America
Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation
Gardner, R.; Salvador, A.; Moradas-Ferreira, P., 2002. Free Radical Biology and Medicine. 1351 - 1357. 12. 32. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037096203&partnerID=MN8TOARS . 10.1016/S0891-5849(02)00861-4 . published Free Radical Biology and Medicine
Hydroperoxyl, superoxide and pH gradients in the mitochondrial matrix: A theoretical assessment
Salvador, A.; Sousa, J.; Pinto, R.E., 2001. Free Radical Biology and Medicine. 1208 - 1215. 10. 31. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035890104&partnerID=MN8TOARS . 10.1016/S0891-5849(01)00707-9 . published Free Radical Biology and Medicine
Synergism analysis of biochemical systems. II. Tensor formulation and treatment of stoichiometric constraints
Salvador, A., 2000. Mathematical Biosciences. 131 - 158. 2. 163. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034092624&partnerID=MN8TOARS . 10.1016/S0025-5564(99)00057-7 . published Mathematical Biosciences
Synergism analysis of biochemical systems. I. Conceptual framework
Salvador, A., 2000. Mathematical Biosciences. 105 - 129. 2. 163. 2000. 10.1016/s0025-5564(99)00056-5 . published Mathematical Biosciences
Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model
Antunes, F.; Salvador, A.; Marinho, H.S.; Alves, R.; Pinto, R.E., 1996. Free Radical Biology and Medicine. 917 - 943. 7. 21. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029908304&partnerID=MN8TOARS . 10.1016/S0891-5849(96)00185-2 . published Free Radical Biology and Medicine
PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria
Antunes, F.; Salvador, A.; Pinto, R.E., 1995. Free Radical Biology and Medicine. 669 - 677. 5. 19. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028991435&partnerID=MN8TOARS . 10.1016/0891-5849(95)00040-5 . published Free Radical Biology and Medicine
Kinetic modelling of in vitro lipid peroxidation experiments--'low level' validation of a model of in vivo lipid peroxidation.
Salvador, A.; Antunes, F.; Pinto, R.E., 1995. Free radical research. 151 - 172. 2. 23. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029355440&partnerID=MN8TOARS . 10.3109/10715769509064029 . published Free radical research
5 32 de 32 Publicações
Margarida Cordeiro
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